| review article | Q7318358 |
| scholarly article | Q13442814 |
| P2093 | author name string | Yuan Lin | |
| Yi Zheng | |||
| P2860 | cites work | Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas | Q22010904 |
| DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas | Q23910292 | ||
| DLC-1: a Rho GTPase-activating protein and tumour suppressor | Q23917637 | ||
| Promoter hypermethylation of DLC-1, a candidate tumor suppressor gene, in several common human cancers | Q24170294 | ||
| DLC-1 gene inhibits human breast cancer cell growth and in vivo tumorigenicity | Q24293186 | ||
| Post-translational modifications of p21rho proteins | Q24293581 | ||
| Chelerythrine perturbs lamellar actomyosin filaments by selective inhibition of myotonic dystrophy kinase-related Cdc42-binding kinase | Q24298714 | ||
| Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation | Q24316134 | ||
| Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor | Q24336590 | ||
| Cdc42 is highly expressed in colorectal adenocarcinoma and downregulates ID4 through an epigenetic mechanism | Q81513057 | ||
| Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA | Q83378068 | ||
| RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis | Q24531821 | ||
| Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases | Q24597996 | ||
| Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf | Q24598824 | ||
| A landscape of driver mutations in melanoma | Q24603357 | ||
| Core signaling pathways in human pancreatic cancers revealed by global genomic analyses | Q24606006 | ||
| The 'invisible hand': regulation of RHO GTPases by RHOGDIs | Q24606819 | ||
| Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma | Q24607661 | ||
| COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer | Q24608391 | ||
| Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a | Q24613036 | ||
| ELMO1 and Dock180, a bipartite Rac1 guanine nucleotide exchange factor, promote human glioma cell invasion | Q24623558 | ||
| Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy | Q24631326 | ||
| Evolution of the Rho family of ras-like GTPases in eukaryotes | Q24646801 | ||
| Rho GDP dissociation inhibitor 2 suppresses metastasis via unconventional regulation of RhoGTPases. | Q24658329 | ||
| Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia | Q24670279 | ||
| beta2-chimaerin is a novel target for diacylglycerol: binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain | Q24675064 | ||
| Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease | Q26853181 | ||
| Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-lineage kinase 1 crystallography, and oral in vivo activity in 1-methyl-4-phenyltetrahydropyridine models | Q27651696 | ||
| Targeting Large Kinase Active Site with Rigid, Bulky Octahedral Ruthenium Complexes | Q27652698 | ||
| Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor | Q27657391 | ||
| Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth | Q27661276 | ||
| RKI-1447 Is a Potent Inhibitor of the Rho-Associated ROCK Kinases with Anti-Invasive and Antitumor Activities in Breast Cancer | Q27670969 | ||
| RAC1P29S is a spontaneously activating cancer-associated GTPase | Q27675701 | ||
| Fragment-Based and Structure-Guided Discovery and Optimization of Rho Kinase Inhibitors | Q27676858 | ||
| FRAX597, a Small Molecule Inhibitor of the p21-activated Kinases, Inhibits Tumorigenesis of Neurofibromatosis Type 2 (NF2)-associated Schwannomas | Q27679769 | ||
| AT13148 is a novel, oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity | Q27681734 | ||
| Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy? | Q27690752 | ||
| The RAC1 P29S hotspot mutation in melanoma confers resistance to pharmacological inhibition of RAF | Q27853045 | ||
| Mutational landscape of aggressive cutaneous squamous cell carcinoma | Q27853082 | ||
| Rho GTPases and the actin cytoskeleton | Q27860579 | ||
| Rho GTPases: biochemistry and biology | Q27860645 | ||
| AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading | Q27860652 | ||
| Rho GTPases in cell biology | Q27860969 | ||
| Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family. | Q43590657 | ||
| Tiam1 overexpression potentiates heregulin-induced lymphoid enhancer factor-1/beta -catenin nuclear signaling in breast cancer cells by modulating the intercellular stability | Q43592342 | ||
| Cell motility as a prognostic factor in Stage I nonsmall cell lung carcinoma: the role of gelsolin expression | Q44475954 | ||
| Phase 2 randomized clinical study of a Rho kinase inhibitor, K-115, in primary open-angle glaucoma and ocular hypertension | Q45816538 | ||
| Progression of breast tumors is accompanied by a decrease in expression of the Rho guanine exchange factor Tiam1. | Q46198417 | ||
| Advances in the study of Rho kinase and its inhibitors | Q46785139 | ||
| Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro. | Q46891043 | ||
| Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation | Q47244406 | ||
| Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice. | Q47297588 | ||
| Overexpression of Rac-1 small GTPase binding protein in oral squamous cell carcinoma | Q47412975 | ||
| The expression of rho proteins decreases with human brain tumor progression: potential tumor markers. | Q48649169 | ||
| Changes in gene expression during progression of ovarian carcinoma. | Q49222374 | ||
| Requirement for Rac1 in a K-ras induced lung cancer in the mouse. | Q53329326 | ||
| Prognostic value of rho GTPases and rho guanine nucleotide dissociation inhibitors in human breast cancers. | Q53372297 | ||
| Rho GTPases are over-expressed in human tumors. | Q53423587 | ||
| Cell type-specific functions of Rho GTPases revealed by gene targeting in mice. | Q53583432 | ||
| Methylation status of T-lymphoma invasion and metastasis 1 promoter and its overexpression in colorectal cancer. | Q54392566 | ||
| Signaling mechanisms of inhibition of phospholipase D activation by CHS-111 in formyl peptide-stimulated neutrophils. | Q54640228 | ||
| RecurrentRHOAmutations in pediatric Burkitt lymphoma treated according to the NHL-BFM protocols | Q57270481 | ||
| The RHOA G17V gene mutation occurs frequently in peripheral T-cell lymphoma and is associated with a characteristic molecular signature | Q58010789 | ||
| Fused transcript of abl and bcr genes in chronic myelogenous leukaemia | Q59064021 | ||
| DLC-1 is deleted in primary hepatocellular carcinoma and exerts inhibitory effects on the proliferation of hepatoma cell lines with deleted DLC-1 | Q73299529 | ||
| GGTI-298 induces G0-G1 block and apoptosis whereas FTI-277 causes G2-M enrichment in A549 cells | Q73352842 | ||
| Significant association of Rho/ROCK pathway with invasion and metastasis of bladder cancer | Q73653075 | ||
| Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities | Q79182194 | ||
| A novel ROCK inhibitor, Y-39983, promotes regeneration of crushed axons of retinal ganglion cells into the optic nerve of adult cats | Q79948604 | ||
| Overexpression of RhoA, Rac1, and Cdc42 GTPases is associated with progression in testicular cancer | Q80370519 | ||
| Amplification of 11q13 in ovarian carcinoma | Q80807833 | ||
| Intraocular pressure-lowering effects and safety of topical administration of a selective ROCK inhibitor, SNJ-1656, in healthy volunteers | Q80848704 | ||
| Epigenetic inhibition of nuclear receptor small heterodimer partner is associated with and regulates hepatocellular carcinoma growth | Q40004974 | ||
| 7-Chloro-6-piperidin-1-yl-quinoline-5,8-dione (PT-262), a novel synthetic compound induces lung carcinoma cell death associated with inhibiting ERK and CDC2 phosphorylation via a p53-independent pathway | Q40025418 | ||
| Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases. | Q40068834 | ||
| CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling. | Q40093918 | ||
| Lack of extracellular signal-regulated kinase mitogen-activated protein kinase signaling shows a new type of melanoma | Q40169723 | ||
| Persistent activation of Rac1 in squamous carcinomas of the head and neck: evidence for an EGFR/Vav2 signaling axis involved in cell invasion. | Q40181775 | ||
| Expression profile of the tumor suppressor genes DLC-1 and DLC-2 in solid tumors | Q40224460 | ||
| Expression level of ECT2 proto-oncogene correlates with prognosis in glioma patients | Q40224538 | ||
| The Rho kinase inhibitor fasudil inhibits tumor progression in human and rat tumor models | Q40229870 | ||
| A novel protein geranylgeranyltransferase-I inhibitor with high potency, selectivity, and cellular activity | Q40308550 | ||
| Activation of Vav/Rho GTPase signaling by CXCL12 controls membrane-type matrix metalloproteinase-dependent melanoma cell invasion | Q40333122 | ||
| Inhibitory effects of mevastatin and a geranylgeranyl transferase I inhibitor (GGTI-2166) on mononuclear osteoclast formation induced by receptor activator of NF kappa B ligand (RANKL) or tumor necrosis factor-alpha (TNF-alpha). | Q40482728 | ||
| High-resolution genomic and expression profiling reveals 105 putative amplification target genes in pancreatic cancer | Q40490949 | ||
| Expression of seven main Rho family members in gastric carcinoma | Q40587668 | ||
| Mechanism of p21-activated Kinase 6-mediated Inhibition of Androgen Receptor Signaling | Q40624022 | ||
| Enhancement of cisplatin-induced cytotoxicity by ROCK inhibitor through suppression of focal adhesion kinase-independent mechanism in lung carcinoma cells | Q40636219 | ||
| Effect of Wf-536, a novel ROCK inhibitor, against metastasis of B16 melanoma | Q40642853 | ||
| The haematopoietic specific signal transducer Vav1 is expressed in a subset of human neuroblastomas | Q40664173 | ||
| The K252a derivatives, inhibitors for the PAK/MLK kinase family selectively block the growth of RAS transformants | Q40710062 | ||
| Nonrandom 4p13 rearrangements of the RhoH/TTF gene, encoding a GTP-binding protein, in non-Hodgkin's lymphoma and multiple myeloma | Q40881085 | ||
| Inhibition of Ras and related G-proteins as a therapeutic strategy for blocking malignant glioma growth | Q41027322 | ||
| Inhibitors of p21-activated kinases (PAKs). | Q41653022 | ||
| The expression and prognostic value of the guanine nucleotide exchange factors (GEFs) Trio, Vav1 and TIAM-1 in human breast cancer | Q42089356 | ||
| Neurotrophic 3,9-bis[(alkylthio)methyl]-and-bis(alkoxymethyl)-K-252a derivatives | Q42439874 | ||
| Knockdown of PAK4 or PAK1 inhibits the proliferation of mutant KRAS colon cancer cells independently of RAF/MEK/ERK and PI3K/AKT signaling | Q42517811 | ||
| Rational design of small molecule inhibitors targeting the Rac GTPase-p67(phox) signaling axis in inflammation. | Q42609911 | ||
| Ocular hypotensive effect of the Rho kinase inhibitor AR-12286 in patients with glaucoma and ocular hypertension | Q42728702 | ||
| Cancer: Drug for an 'undruggable' protein | Q42734596 | ||
| Rac1 is crucial for Ras-dependent skin tumor formation by controlling Pak1-Mek-Erk hyperactivation and hyperproliferation in vivo | Q43103589 | ||
| Activating ROCK1 somatic mutations in human cancer | Q43169790 | ||
| Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia | Q27861126 | ||
| p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis | Q28141296 | ||
| Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1 | Q28141931 | ||
| Restoration of DLC-1 gene expression induces apoptosis and inhibits both cell growth and tumorigenicity in human hepatocellular carcinoma cells | Q28188547 | ||
| Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA | Q28190494 | ||
| Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growth | Q28199263 | ||
| P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium | Q28206589 | ||
| Activated PAK4 regulates cell adhesion and anchorage-independent growth | Q28213663 | ||
| Cdc42 and Rac1 are necessary for autotaxin-induced tumor cell motility in A2058 melanoma cells | Q28217513 | ||
| 2-amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl} acetamide (OSU-03012), a celecoxib derivative, directly targets p21-activated kinase | Q28239236 | ||
| p21-activated kinases in cancer | Q28242189 | ||
| Pak1 phosphorylation of snail, a master regulator of epithelial-to-mesenchyme transition, modulates snail's subcellular localization and functions | Q28245491 | ||
| Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin | Q28247829 | ||
| LCH-7749944, a novel and potent p21-activated kinase 4 inhibitor, suppresses proliferation and invasion in human gastric cancer cells | Q28252997 | ||
| PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling | Q28253621 | ||
| Roles of the Rac1 and Rac3 GTPases in human tumor cell invasion | Q28262533 | ||
| Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP | Q28272211 | ||
| Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization | Q28275839 | ||
| An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase | Q28276857 | ||
| RhoGDI signaling provides targets for cancer therapy | Q28277950 | ||
| The structure of dimeric ROCK I reveals the mechanism for ligand selectivity | Q28279001 | ||
| p120-catenin is a binding partner and substrate for Group B Pak kinases | Q28285787 | ||
| Biphasic expression of RhoGDI2 in the progression of breast cancer and its negative relation with lymph node metastasis | Q28301256 | ||
| Ectopic expression of VAV1 reveals an unexpected role in pancreatic cancer tumorigenesis | Q28302583 | ||
| Targeting Cdc42 with the small molecule drug AZA197 suppresses primary colon cancer growth and prolongs survival in a preclinical mouse xenograft model by downregulation of PAK1 activity | Q28302802 | ||
| PAK signalling during the development and progression of cancer | Q28307460 | ||
| Identification and characterization of mechanism of action of P61-E7, a novel phosphine catalysis-based inhibitor of geranylgeranyltransferase-I | Q28477527 | ||
| A Rac1/Cdc42 GTPase-specific small molecule inhibitor suppresses growth of primary human prostate cancer xenografts and prolongs survival in mice | Q28533254 | ||
| Tiam1 regulates cell adhesion, migration and apoptosis in colon tumor cells | Q28941786 | ||
| Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs | Q29547308 | ||
| GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors | Q29547630 | ||
| Rho GTPases and their effector proteins | Q29547740 | ||
| Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension | Q29614247 | ||
| The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway | Q29614258 | ||
| The mutational landscape of head and neck squamous cell carcinoma | Q29614654 | ||
| Biology of the p21-activated kinases | Q29616035 | ||
| Rational design and characterization of a Rac GTPase-specific small molecule inhibitor | Q29616494 | ||
| The Ras superfamily at a glance | Q29617344 | ||
| The relationship of BRMS1 and RhoGDI2 gene expression to metastatic potential in lineage related human bladder cancer cell lines | Q30308022 | ||
| p190RhoGAP can act to inhibit PDGF-induced gliomas in mice: a putative tumor suppressor encoded on human chromosome 19q13.3. | Q30450445 | ||
| The anaplastic lymphoma kinase controls cell shape and growth of anaplastic large cell lymphoma through Cdc42 activation | Q30484934 | ||
| PAK kinase regulates Rac GTPase and is a potential target in human schwannomas | Q30490902 | ||
| Small molecules discovered in a pathway screen target the Rho pathway in cytokinesis | Q30494581 | ||
| Small molecule targeting Cdc42-intersectin interaction disrupts Golgi organization and suppresses cell motility | Q30533280 | ||
| Proteomic analysis and identification of new biomarkers and therapeutic targets for invasive ovarian cancer | Q30698088 | ||
| Inhibition of intrahepatic metastasis of human hepatocellular carcinoma by Rho-associated protein kinase inhibitor Y-27632. | Q32075412 | ||
| An alternative transcript derived from the trio locus encodes a guanosine nucleotide exchange factor with mouse cell-transforming potential | Q33205908 | ||
| Inhibitors of protein geranylgeranyltransferase I and Rab geranylgeranyltransferase identified from a library of allenoate-derived compounds | Q33317126 | ||
| Overexpression of Rho GDP-dissociation inhibitor alpha is associated with tumor progression and poor prognosis of colorectal cancer | Q33354559 | ||
| High-throughput screening for small-molecule inhibitors of LARG-stimulated RhoA nucleotide binding via a novel fluorescence polarization assay | Q33406057 | ||
| In vivo antitumor effect of a novel inhibitor of protein geranylgeranyltransferase-I | Q33439394 | ||
| Pharmacological characterization of SAR407899, a novel rho-kinase inhibitor | Q33481580 | ||
| Endothelial-Rac1 is not required for tumor angiogenesis unless alphavbeta3-integrin is absent | Q33546368 | ||
| Targeting protein prenylation for cancer therapy | Q33679239 | ||
| Postprenylation CAAX processing is required for proper localization of Ras but not Rho GTPases | Q33734499 | ||
| Clinical validation of colorectal cancer biomarkers identified from bioinformatics analysis of public expression data | Q33815048 | ||
| NF2-deficient cells depend on the Rac1-canonical Wnt signaling pathway to promote the loss of contact inhibition of proliferation | Q33818953 | ||
| Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells | Q33868788 | ||
| Rho kinase inhibitor HA-1077 prevents Rho-mediated myosin phosphatase inhibition in smooth muscle cells | Q33887405 | ||
| p190-A, a human tumor suppressor gene, maps to the chromosomal region 19q13.3 that is reportedly deleted in some gliomas | Q33923367 | ||
| A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions | Q33943677 | ||
| Rho GTPases as targets of bacterial protein toxins | Q33999593 | ||
| Essential role of Cdc42 in Ras-induced transformation revealed by gene targeting | Q34311732 | ||
| The RacGEF Tiam1 inhibits migration and invasion of metastatic melanoma via a novel adhesive mechanism. | Q34344754 | ||
| Targeted genetic dependency screen facilitates identification of actionable mutations in FGFR4, MAP3K9, and PAK5 in lung cancer | Q34356166 | ||
| Signaling role of Cdc42 in regulating mammalian physiology | Q34509197 | ||
| Vav3 oncogene is overexpressed and regulates cell growth and androgen receptor activity in human prostate cancer | Q34536287 | ||
| Rho GTPases in transformation and metastasis. | Q34554757 | ||
| Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer. | Q34571293 | ||
| In vitro and in vivo effects of geranylgeranyltransferase I inhibitor P61A6 on non-small cell lung cancer cells | Q34680671 | ||
| The novel and specific Rho-kinase inhibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazine as a probing molecule for Rho-kinase-involved pathway | Q34792910 | ||
| RPEL proteins are the molecular targets for CCG-1423, an inhibitor of Rho signaling | Q35099772 | ||
| Deep sequencing of gastric carcinoma reveals somatic mutations relevant to personalized medicine | Q35153864 | ||
| Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma | Q35166408 | ||
| A novel small-molecule MRCK inhibitor blocks cancer cell invasion | Q35307266 | ||
| Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration | Q35550759 | ||
| Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase | Q35921528 | ||
| Rho family GTPases regulate mammary epithelium cell growth and metastasis through distinguishable pathways | Q35944136 | ||
| Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation | Q35947877 | ||
| Rho GTPase expression in tumourigenesis: evidence for a significant link | Q36126283 | ||
| Cardiovascular effects of a novel potent and highly selective azaindole-based inhibitor of Rho-kinase | Q36171342 | ||
| Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis | Q36360416 | ||
| Vav1/2/3-null Mice Define an Essential Role for Vav Family Proteins in Lymphocyte Development and Activation but a Differential Requirement in MAPK Signaling in T and B Cells | Q36371509 | ||
| Identification of somatic mutations in non-small cell lung carcinomas using whole-exome sequencing | Q36401981 | ||
| Cycloartane-3,24,25-triol inhibits MRCKα kinase and demonstrates promising anti prostate cancer activity in vitro | Q36462888 | ||
| C1 domains exposed: from diacylglycerol binding to protein-protein interactions | Q36544002 | ||
| Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters | Q36624071 | ||
| Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors | Q36637356 | ||
| ??? | Q28204180 | ||
| Current knowledge of the large RhoGAP family of proteins | Q36707513 | ||
| Characterization of a Cdc42 protein inhibitor and its use as a molecular probe | Q36708621 | ||
| Motility-related proteins as markers for head and neck squamous cell cancer | Q36739644 | ||
| Gene products of chromosome 11q and their association with CCND1 gene amplification and tamoxifen resistance in premenopausal breast cancer | Q37038663 | ||
| The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma. | Q37061110 | ||
| Dimensions in cell migration. | Q37135420 | ||
| Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis | Q37168748 | ||
| The actin cytoskeleton in cancer cell motility | Q37170851 | ||
| Cell type-specific signaling function of RhoA GTPase: lessons from mouse gene targeting | Q37404956 | ||
| Guanine nucleotide exchange factors for RhoGTPases: good therapeutic targets for cancer therapy? | Q37806397 | ||
| Is there a future for prenyltransferase inhibitors in cancer therapy? | Q38028003 | ||
| Advances in the studies of roles of Rho/Rho-kinase in diseases and the development of its inhibitors. | Q38161260 | ||
| Role of p-21-activated kinases in cancer progression | Q38188216 | ||
| Rho family GTPases: making it to the third dimension | Q38283635 | ||
| Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, rho-, and rac-dependent signaling pathways | Q38307195 | ||
| A novel amplification target, ARHGAP5, promotes cell spreading and migration by negatively regulating RhoA in Huh-7 hepatocellular carcinoma cells | Q38359171 | ||
| Involvement of epithelial cell transforming sequence-2 oncoantigen in lung and esophageal cancer progression. | Q38423306 | ||
| Tetrahydroisoquinoline Derivatives As Highly Selective and Potent Rho Kinase Inhibitors | Q38466880 | ||
| Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors. | Q38475558 | ||
| Identification of novel ROCK inhibitors with anti-migratory and anti-invasive activities | Q38634358 | ||
| Rho kinase inhibitors block melanoma cell migration and inhibit metastasis | Q38891126 | ||
| CDC42 inhibition suppresses progression of incipient intestinal tumors | Q38966986 | ||
| Loss of ARHGDIA expression is associated with poor prognosis in HCC and promotes invasion and metastasis of HCC cells | Q38991762 | ||
| P21-activated kinase 1 (PAK1) as a therapeutic target in BRAF wild-type melanoma | Q39174795 | ||
| A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma | Q39241800 | ||
| PAK4 kinase activity and somatic mutation promote carcinoma cell motility and influence inhibitor sensitivity | Q39332921 | ||
| Characterization of the roles of RHOC and RHOA GTPases in invasion, motility, and matrix adhesion in inflammatory and aggressive breast cancers | Q39691137 | ||
| Pharmacological inhibition of Rho-kinase signaling with Y-27632 blocks melanoma tumor growth. | Q39744687 | ||
| An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory domain covalently. | Q39805071 | ||
| Identification of PAK4 as a putative target gene for amplification within 19q13.12-q13.2 in oral squamous-cell carcinoma. | Q39826256 | ||
| Consensus transcriptome signature of perineural invasion in pancreatic carcinoma | Q39840603 | ||
| Abnormal expression of p120-catenin, E-cadherin, and small GTPases is significantly associated with malignant phenotype of human lung cancer | Q39891997 | ||
| Correlation between ECT2 gene expression and methylation change of ECT2 promoter region in pancreatic cancer | Q39931298 | ||
| Copy number alterations in pancreatic cancer identify recurrent PAK4 amplification | Q39932364 | ||
| PAK1 interacts with beta-catenin and is required for the regulation of the beta-catenin signalling pathway by gastrins | Q39976683 | ||
| Rho GTPases in PC-3 prostate cancer cell morphology, invasion and tumor cell diapedesis | Q39984874 | ||
| P433 | issue | 9 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | drug discovery | Q1418791 |
| P304 | page(s) | 991-1010 | |
| P577 | publication date | 2015-01-01 | |
| P1433 | published in | Expert Opinion on Drug Discovery | Q5421204 |
| P1476 | title | Approaches of targeting Rho GTPases in cancer drug discovery | |
| P478 | volume | 10 |
| Q47799871 | A continuous luminescence assay for monitoring kinase activity: signalling the ADP/ATP ratio using a discrete europium complex |
| Q89068491 | Aged murine hematopoietic stem cells drive aging-associated immune remodeling |
| Q62117793 | Boosting Antitumor Drug Efficacy with Chemically Engineered Multidomain Proteins |
| Q33688815 | Clinical relevance of the transcriptional signature regulated by CDC42 in colorectal cancer |
| Q97885449 | Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion |
| Q37675217 | DOCK2 interacts with FLT3 and modulates the survival of FLT3-expressing leukemia cells |
| Q64084217 | Drugging the Small GTPase Pathways in Cancer Treatment: Promises and Challenges |
| Q92178752 | Dual Actions of Ketorolac in Metastatic Ovarian Cancer |
| Q50356583 | Fasudil inhibits proliferation and migration of Hep-2 laryngeal carcinoma cells. |
| Q64232958 | Identification of prognostic biomarkers in colorectal cancer using a long non-coding RNA-mediated competitive endogenous RNA network |
| Q41004137 | Integrated mate-pair and RNA sequencing identifies novel, targetable gene fusions in peripheral T-cell lymphoma. |
| Q47652910 | Intracellular mature IL-37 suppresses tumor metastasis via inhibiting Rac1 activation |
| Q96128329 | Investigation of the role and mechanism of ARHGAP5-mediated colorectal cancer metastasis |
| Q26771102 | Lysophosphatidylinositol Signalling and Metabolic Diseases |
| Q90114241 | Modulation of the Pol II CTD Phosphorylation Code by Rac1 and Cdc42 Small GTPases in Cultured Human Cancer Cells and Its Implication for Developing a Synthetic-Lethal Cancer Therapy |
| Q38682208 | Molecular perturbation strategies to examine spatiotemporal features of Rho GEF and Rho GTPase activity in living cells. |
| Q28550876 | Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases |
| Q59126829 | Ovarian Tumor Microenvironment Signaling: Convergence on the Rac1 GTPase |
| Q60959651 | Post-Translational Modification and Subcellular Distribution of Rac1: An Update |
| Q93081221 | RHO Family GTPases in the Biology of Lymphoma |
| Q92479490 | RHOA in Gastric Cancer: Functional Roles and Therapeutic Potential |
| Q41387997 | Rho GTPases as therapeutic targets in cancer (Review). |
| Q38780866 | Rho GTPases: Anti- or pro-neoplastic targets? |
| Q53320449 | Role of Rac1 Pathway in Epithelial-to-Mesenchymal Transition and Cancer Stem-like Cell Phenotypes in Gastric Adenocarcinoma. |
| Q96636287 | Small Molecule Inhibitors Targeting Gαi2 Protein Attenuate Migration of Cancer Cells |
| Q60045514 | Stromal PTEN Regulates Extracellular Matrix Organization in the Mammary Gland |
| Q26745863 | Structural Mechanisms and Drug Discovery Prospects of Rho GTPases |
| Q38668940 | Targeting the RhoGTPase/ROCK pathway for the treatment of VHL/HIF pathway-driven cancers. |
| Q45324338 | The R-enantiomer of ketorolac delays mammary tumor development in mouse mammary tumor virus-polyoma middle T antigen (MMTV-PyMT) mice. |
| Q90107111 | The role of collagen in cancer: from bench to bedside |
| Q38846822 | The role of small GTPases of the Rho/Rac family in TGF-β-induced EMT and cell motility in cancer |
| Q38910120 | Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma |
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