Integrin alpha1beta1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor-mediated Rac activation

scientific article published on 5 March 2007

Integrin alpha1beta1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor-mediated Rac activation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/MCB.01476-06
P932PMC publication ID1899972
P698PubMed publication ID17339338
P5875ResearchGate publication ID6468098

P2093author name stringRebecca S Dise
Raymond C Harris
Roy Zent
D Brent Polk
Yan Su
Amar B Singh
Mark R Frey
Ambra Pozzi
Maria R Ibanez
Tristin D Abair
Xiwu Chen
P2860cites workAlpha2beta1-integrin signaling by itself controls G1/S transition in a human adenocarcinoma cell line (Caco-2): implication of NADPH oxidase-dependent production of ROS.Q40656808
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Distribution and quantification of alpha 1-integrin subunit in rat organsQ42486501
UV activates growth factor receptors via reactive oxygen intermediatesQ42772075
The Dbl-related protein, Lfc, localizes to microtubules and mediates the activation of Rac signaling pathways in cellsQ42820819
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EGF receptor mediates adhesion-dependent activation of the Rac GTPase: a role for phosphatidylinositol 3-kinase and Vav2.Q44573128
Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells.Q44630472
Prevention of renal vascular and glomerular fibrosis by epidermal growth factor receptor inhibitionQ44807372
Mesangial cell NADPH oxidase upregulation in high glucose is protein kinase C dependent and required for collagen IV expressionQ46677686
Aldosterone stimulates reactive oxygen species production through activation of NADPH oxidase in rat mesangial cellsQ46681426
In high glucose protein kinase C-zeta activation is required for mesangial cell generation of reactive oxygen speciesQ46826513
Targeted expression of activated Rac3 in mammary epithelium leads to defective postlactational involution and benign mammary gland lesionsQ47397860
Deletion of integrin alpha 1 by homologous recombination permits normal murine development but gives rise to a specific deficit in cell adhesion.Q52201902
Rac1 GTPase regulates cell genomic stability and senescence.Q53594389
Glomerular injury is exacerbated in diabetic integrin alpha1-null mice.Q53617932
Platelet-derived growth factor and reactive oxygen species (ROS) regulate Ras protein levels in primary human fibroblasts via ERK1/2. Amplification of ROS and Ras in systemic sclerosis fibroblasts.Q54650316
The expression of NADPH oxidase components in human glomerular mesangial cells: detection of protein and mRNA for p47phox, p67phox, and p22phoxQ72125888
Arachidonic acid-dependent activation of a p22(phox)-based NAD(P)H oxidase mediates angiotensin II-induced mesangial cell protein synthesis and fibronectin expression via Akt/PKBQ80302357
ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangementsQ21632356
Identification of renox, an NAD(P)H oxidase in kidneyQ22254385
Role of Rac1 and oxygen radicals in collagenase-1 expression induced by cell shape changeQ24313072
Negative regulation of EGFR signalling through integrin-alpha1beta1-mediated activation of protein tyrosine phosphatase TCPTPQ24321559
Mechanism of epidermal growth factor regulation of Vav2, a guanine nucleotide exchange factor for RacQ28216158
Generation and characterization of Rac3 knockout mice.Q28511522
Rac2 is an essential regulator of neutrophil nicotinamide adenine dinucleotide phosphate oxidase activation in response to specific signaling pathwaysQ28609618
Rho GTPases control polarity, protrusion, and adhesion during cell movementQ29614244
Beta8 integrin binds Rho GDP dissociation inhibitor-1 and activates Rac1 to inhibit mesangial cell myofibroblast differentiationQ30439181
Activation of Rac1 by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expression.Q30453215
Coactivation of Rac1 and Cdc42 at lamellipodia and membrane ruffles induced by epidermal growth factor.Q30539004
The molecular basis for adhesion-mediated suppression of reactive oxygen species generation by human neutrophilsQ33630157
A novel superoxide-producing NAD(P)H oxidase in kidneyQ33921569
Integrins regulate Rac targeting by internalization of membrane domainsQ34295045
Assembly of the phagocyte NADPH oxidase: molecular interaction of oxidase proteinsQ34411802
H-Ras, R-Ras, and TC21 differentially regulate ureteric bud cell branching morphogenesisQ34483633
Current molecular models for NADPH oxidase regulation by Rac GTPaseQ34915029
Elevated matrix metalloprotease and angiostatin levels in integrin alpha 1 knockout mice cause reduced tumor vascularizationQ35051209
Lack of integrin alpha1beta1 leads to severe glomerulosclerosis after glomerular injury.Q35103022
Vascular NAD(P)H oxidases: specific features, expression, and regulationQ35175526
A possible target of antioxidative therapy for diabetic vascular complications-vascular NAD(P)H oxidaseQ35181276
ROS generation by nonphagocytic NADPH oxidase: potential relevance in diabetic nephropathyQ35182347
Effect of endogenous and exogenous EGF on the growth of EGF receptor-hyperproducing human squamous cell carcinoma implanted in nude miceQ36081678
PTPs versus PTKs: the redox side of the coinQ36199863
Integrin alpha1beta1 mediates a unique collagen-dependent proliferation pathway in vivoQ36256242
A Rac switch regulates random versus directionally persistent cell migrationQ36320639
Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPasesQ36323820
Regulation of NADPH oxidases: the role of Rac proteinsQ36412266
Differential distribution and modulation of expression of alpha 1/beta 1 integrin on human endothelial cellsQ36532803
Regulation of the phagocyte NADPH oxidase by Rac GTPaseQ36598790
Nox4 mediates angiotensin II-induced activation of Akt/protein kinase B in mesangial cellsQ38352918
Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK.Q40387432
An activating mutant of Rac1 that fails to interact with Rho GDP-dissociation inhibitor stimulates membrane ruffling in mammalian cellsQ40615070
Rac1 deletion in mouse neutrophils has selective effects on neutrophil functions.Q40646102
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectreactive oxygen speciesQ424361
P304page(s)3313-3326
P577publication date2007-03-05
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleIntegrin alpha1beta1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor-mediated Rac activation
P478volume27

Reverse relations

cites work (P2860)
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