The Dbl-related protein, Lfc, localizes to microtubules and mediates the activation of Rac signaling pathways in cells

scientific article published on January 1999

The Dbl-related protein, Lfc, localizes to microtubules and mediates the activation of Rac signaling pathways in cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.274.4.2279
P8608Fatcat IDrelease_2lnc7zsbirezzlvufrtuwgunfy
P698PubMed publication ID9890991
P5875ResearchGate publication ID13398106

P2093author name stringKay R
Cerione RA
Bagrodia S
Glaven JA
Whitehead I
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)2279-2285
P577publication date1999-01-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe Dbl-related protein, Lfc, localizes to microtubules and mediates the activation of Rac signaling pathways in cells
P478volume274

Reverse relations

cites work (P2860)
Q37327655A conserved hydrophobic surface of the LARG pleckstrin homology domain is critical for RhoA activation in cells.
Q73177714A method for movement
Q37089844AMPA receptor and GEF-H1/Lfc complex regulates dendritic spine development through RhoA signaling cascade
Q24551183Abl interactor 1 binds to sos and inhibits epidermal growth factor- and v-Abl-induced activation of extracellular signal-regulated kinases
Q30453215Activation of Rac1 by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expression.
Q40387432Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK.
Q35537239Altered prefrontal cortical MARCKS and PPP1R9A mRNA expression in schizophrenia and bipolar disorder
Q73089615Bacterial expressed DH and DH/PH domains
Q28217513Cdc42 and Rac1 are necessary for autotaxin-induced tumor cell motility in A2058 melanoma cells
Q28138296Cdc42-interacting protein 4 mediates binding of the Wiskott-Aldrich syndrome protein to microtubules
Q34858133Cell-cell adhesion and signalling
Q39863804Characterization of Pseudomonas aeruginosa exoenzyme S as a bifunctional enzyme in J774A.1 macrophages
Q33861777Clasp-mediated microtubule bundling regulates persistent motility and contact repulsion in Drosophila macrophages in vivo.
Q28580961Cloning of rat ARHGAP4/C1, a RhoGAP family member expressed in the nervous system that colocalizes with the Golgi complex and microtubules
Q24337154Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1
Q35084942Control of synapse development and plasticity by Rho GTPase regulatory proteins.
Q33782337Disruption of the Shc/Grb2 complex during abelson virus transformation affects proliferation, but not apoptosis
Q30444212E-cadherin engagement stimulates proliferation via Rac1
Q44573128EGF receptor mediates adhesion-dependent activation of the Rac GTPase: a role for phosphatidylinositol 3-kinase and Vav2.
Q39449435Elevated expression of RGS19 impairs the responsiveness of stress-activated protein kinases to serum
Q33604753Endocytosis and nuclear trafficking of adeno-associated virus type 2 are controlled by rac1 and phosphatidylinositol-3 kinase activation
Q39996509Enteropathogenic Escherichia coli activates the RhoA signaling pathway via the stimulation of GEF-H1.
Q28568931Evidence for the involvement of Tiam1 in axon formation
Q44195381Functional analysis of cdc42 residues required for Guanine nucleotide exchange
Q90281584GEF-H1 Signaling upon Microtubule Destabilization Is Required for Dendritic Cell Activation and Specific Anti-tumor Responses
Q30579259GEF-H1 functions in apical constriction and cell intercalations and is essential for vertebrate neural tube closure
Q24319756GEF-H1 mediated control of NOD1 dependent NF-kappaB activation by Shigella effectors
Q40306495Glycogen synthase kinase-3 acts upstream of ADP-ribosylation factor 6 and Rac1 to regulate epithelial cell migration
Q27329542High glucose-mediated oxidative stress impairs cell migration
Q38284377I'm coming to GEF you: Regulation of RhoGEFs during cell migration
Q28646556Identification and characterization of hPEM-2, a guanine nucleotide exchange factor specific for Cdc42
Q36324231Identification of a tight junction-associated guanine nucleotide exchange factor that activates Rho and regulates paracellular permeability
Q40537882Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1
Q35856880Integrin alpha1beta1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor-mediated Rac activation
Q24292355Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDI
Q22010849Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons
Q28590088Lfc and Tctex-1 regulate the genesis of neurons from cortical precursor cells
Q42809573Light Chain 3 associates with a Sos1 guanine nucleotide exchange factor: its significance in the Sos1-mediated Rac1 signaling leading to membrane ruffling
Q28506616Loss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targeting
Q24532348Membrane recruitment of DOCK180 by binding to PtdIns(3,4,5)P3
Q33880071Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblasts
Q36316658Microtubule targeting of substrate contacts promotes their relaxation and dissociation
Q34719915Microtubule-actin cross-talk at focal adhesions
Q35041087Microtubules meet substrate adhesions to arrange cell polarity
Q40755431Modulation of substrate adhesion dynamics via microtubule targeting requires kinesin-1
Q37216665Myosin-interacting guanine exchange factor (MyoGEF) regulates the invasion activity of MDA-MB-231 breast cancer cells through activation of RhoA and RhoC
Q30475829Neutrophil microtubules suppress polarity and enhance directional migration
Q37048514Nuclear factor of activated T cells c1 mediates p21-activated kinase 1 activation in the modulation of chemokine-induced human aortic smooth muscle cell F-actin stress fiber formation, migration, and proliferation and injury-induced vascular wall re
Q24292682Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton
Q34085676PTP-PEST controls motility, adherens junction assembly, and Rho GTPase activity in colon cancer cells
Q27312034PTP-PEST couples membrane protrusion and tail retraction via VAV2 and p190RhoGAP.
Q36893354Polymerizing microtubules activate site-directed F-actin assembly in nerve growth cones
Q38458035Probing the GTPase cycle with real-time NMR: GAP and GEF activities in cell extracts
Q39285163Promotion of neurite and filopodium formation by CD47: roles of integrins, Rac, and Cdc42.
Q27309510ROCK1 and 2 differentially regulate actomyosin organization to drive cell and synaptic polarity
Q52166799Rac is required for constitutive macropinocytosis by dendritic cells but does not control its downregulation.
Q37903873Regulation of small GTPases at epithelial cell-cell junctions
Q34598160Regulation of substrate adhesion dynamics during cell motility
Q40853476Regulation of the Rac1-specific exchange factor Tiam1 involves both phosphoinositide 3-kinase-dependent and -independent components
Q33946486Rho proteins: linking signaling with membrane trafficking
Q37152871RhoA Signaling and Synaptic Damage Occur Within Hours in a Live Pig Model of CNS Injury, Retinal Detachment
Q34285899RhoGEF specificity mutants implicate RhoA as a target for Dbs transforming activity
Q35709644Role of the cytoskeleton during leukocyte responses
Q28508471SHPS-1 regulates integrin-mediated cytoskeletal reorganization and cell motility
Q24806838Scambio, a novel guanine nucleotide exchange factor for Rho
Q28279079Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor
Q37213109Subcellular distribution of the Rho-GEF Lfc in primate prefrontal cortex: effect of neuronal activation
Q37764703Synaptic plasticity, a symphony in GEF.
Q24322063TIM, a Dbl-related protein, regulates cell shape and cytoskeletal organization in a Rho-dependent manner
Q28567800The EF-hand Ca(2+)-binding protein p22 associates with microtubules in an N-myristoylation-dependent manner
Q42823880The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling.
Q39731302The Ras-like GTPase Gem is involved in cell shape remodelling and interacts with the novel kinesin-like protein KIF9.
Q33863444The Rho GTP exchange factor Lfc promotes spindle assembly in early mitosis
Q28594950The Rho-specific GEF Lfc interacts with neurabin and spinophilin to regulate dendritic spine morphology
Q40285373The guanine nucleotide exchange factor RasGRF1 directly binds microtubules via DHPH2-mediated interaction.
Q24290441The kinase activation loop is the key to mixed lineage kinase-3 activation via both autophosphorylation and hematopoietic progenitor kinase 1 phosphorylation
Q43969682The p21-activated kinase, Shk1, is required for proper regulation of microtubule dynamics in the fission yeast, Schizosaccharomyces pombe
Q34183960The prostate-derived sterile 20-like kinase (PSK) regulates microtubule organization and stability
Q38304058The tail domain of myosin M catalyses nucleotide exchange on Rac1 GTPases and can induce actin-driven surface protrusions
Q42803959Translocation of the Rac1 guanine nucleotide exchange factor Tiam1 induced by platelet-derived growth factor and lysophosphatidic acid
Q40871208Two actions of frabin: direct activation of Cdc42 and indirect activation of Rac.
Q42813127p38 MAPK-mediated activation of NF-kappaB by the RhoGEF domain of Bcr.
Q91596218βPix-d promotes tubulin acetylation and neurite outgrowth through a PAK/Stathmin1 signaling pathway

Search more.