Endosomal Acidification and Activation of NADPH Oxidase Isoforms Are Upstream Events in Hyperosmolarity-induced Hepatocyte Apoptosis

scientific article published in Journal of Biological Chemistry

Endosomal Acidification and Activation of NADPH Oxidase Isoforms Are Upstream Events in Hyperosmolarity-induced Hepatocyte Apoptosis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M601451200
P698PubMed publication ID16772302

P50authorStephan BeckerQ23929261
P2093author name stringRoland Reinehr
Juliane Braun
Andrea Eberle
Susanne Grether-Beck
Dieter Haüssinger
P2860cites workTyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phoxQ24291589
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Bile salt-induced apoptosis involves NADPH oxidase isoform activationQ28574660
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Multiphoton excitation spectra in biological samplesQ30783535
Deoxycholic acid activates the c-Jun N-terminal kinase pathway via FAS receptor activation in primary hepatocytes. Role of acidic sphingomyelinase-mediated ceramide generation in FAS receptor activationQ44683463
Activation of the leukocyte NADPH oxidase by phorbol ester requires the phosphorylation of p47PHOX on serine 303 or 304.Q46874695
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CD95-mediated apoptosis in vivo involves acid sphingomyelinase.Q54047040
Effect of tricyclic antidepressants on sphingomyelinase and other sphingolipid hydrolases in C6 cultured glioma cells.Q55489317
Natural ceramide reverses Fas resistance of acid sphingomyelinase(-/-) hepatocytes.Q31629166
Protein kinase C zeta phosphorylates a subset of selective sites of the NADPH oxidase component p47phox and participates in formyl peptide-mediated neutrophil respiratory burstQ31806719
Bile acid-induced rat hepatocyte apoptosis is inhibited by antioxidants and blockers of the mitochondrial permeability transitionQ32075959
Osmotic induction of signaling cascades: role in regulation of cell functionQ33537182
Diverse functions of JNK signaling and c-Jun in stress response and apoptosisQ33771779
Ceramide in the eukaryotic stress responseQ33826715
Novel homologs of gp91phox.Q34069745
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Chloride channels and hepatocellular function: prospects for molecular identificationQ34516261
The cellular hydration state: a critical determinant for cell death and survivalQ34658989
Current molecular models for NADPH oxidase regulation by Rac GTPaseQ34915029
Membrane properties of sphingomyelinsQ34980686
Role of sphingomyelinase and ceramide in modulating rafts: do biophysical properties determine biologic outcome?Q34980694
The superoxide-generating NADPH oxidase: structural aspects and activation mechanismQ35003216
Involvement of microtubules in the link between cell volume and pH of acidic cellular compartments in rat and human hepatocytesQ35767601
Physiological functions of CLC Cl- channels gleaned from human genetic disease and mouse modelsQ36041123
Intravesicular acidification correlates with binding of ADP-ribosylation factor to microsomal membranesQ37113422
Involvement of NADPH oxidase isoforms and Src family kinases in CD95-dependent hepatocyte apoptosisQ40417179
Fluorescence resonance energy transfer analysis of proapoptotic CD95-EGF receptor interactions in Huh7 cells.Q40468705
The Src family kinase Yes triggers hyperosmotic activation of the epidermal growth factor receptor and CD95.Q40574684
The role of cellular hydration in the regulation of cell functionQ40976565
Regulation of ceramide production and apoptosisQ41748407
Signal transduction of stress via ceramideQ41841345
Effect of cell volume on Acridine Orange fluorescence in hepatocytesQ41936937
Regulation of vesicular pH in liver macrophages and parenchymal cells by ammonia and anisotonicity as assessed by fluorescein isothiocyanate-dextran fluorescenceQ41969785
Characterization of the swelling-induced alkalinization of endocytotic vesicles in fluorescein isothiocyanate-dextran-loaded rat hepatocytesQ42058661
Correction of CFTR malfunction and stimulation of Ca-activated Cl channels restore HCO3- secretion in cystic fibrosis bile ductular cellsQ42515580
Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis.Q42555356
Effects of aniso-osmolarity and hydroperoxides on intracellular pH in isolated rat hepatocytes as assessed by (2′,7′)-bis(carboxyethyl)-5(6)-carboxyfluorescein and fluorescein isothiocyanate-dextran fluorescenceQ42830921
The effect of the inhibitor diphenylene iodonium on the superoxide-generating system of neutrophils. Specific labelling of a component polypeptide of the oxidaseQ42854050
ClC-3 chloride channels facilitate endosomal acidification and chloride accumulationQ43672464
Phosphorylation of p47phox sites by PKC alpha, beta II, delta, and zeta: effect on binding to p22phox and on NADPH oxidase activationQ44022525
Hyperosmolarity triggers CD95 membrane trafficking and sensitizes rat hepatocytes toward CD95L-induced apoptosisQ44116623
Activation of p47(PHOX), a cytosolic subunit of the leukocyte NADPH oxidase. Phosphorylation of ser-359 or ser-370 precedes phosphorylation at other sites and is required for activity.Q44287543
Hyperosmolarity and CD95L trigger CD95/EGF receptor association and tyrosine phosphorylation of CD95 as prerequisites for CD95 membrane trafficking and DISC formationQ44315288
Involvement of integrins in osmosensing and signaling toward autophagic proteolysis in rat liverQ44422873
Involvement of integrins and Src in tauroursodeoxycholate-induced and swelling-induced choleresisQ44429825
Bile salt-induced hepatocyte apoptosis involves epidermal growth factor receptor-dependent CD95 tyrosine phosphorylationQ44569551
P433issue32
P407language of work or nameEnglishQ1860
P921main subjectapoptotic processQ14599311
P304page(s)23150-23166
P577publication date2006-06-13
P1433published inJournal of Biological ChemistryQ867727
P1476titleEndosomal Acidification and Activation of NADPH Oxidase Isoforms Are Upstream Events in Hyperosmolarity-induced Hepatocyte Apoptosis
P478volume281

Reverse relations

cites work (P2860)
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