Regulation of Adherens Junctions in Trabecular Meshwork Cells by Rac GTPase and their influence on Intraocular Pressure

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Regulation of Adherens Junctions in Trabecular Meshwork Cells by Rac GTPase and their influence on Intraocular Pressure is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.13188/2334-2838.1000002
P932PMC publication ID4057051
P698PubMed publication ID24932460

P2093author name stringDavid L Epstein
Padmanabhan P Pattabiraman
Ponugoti Vasantha Rao
P2860cites workSphingosine-1-phosphate effects on the inner wall of Schlemm's canal and outflow facility in perfused human eyesQ37479030
Regulation of endothelial permeability via paracellular and transcellular transport pathwaysQ37690727
Role of GTPases in control of microvascular permeabilityQ37714178
Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors.Q38475558
Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases.Q40068834
Regulation of the human neutrophil NADPH oxidase by the Rac GTP-binding proteinsQ40668296
Functional morphology of the trabecular meshwork in primate eyesQ40827200
Glucocorticoids regulate transendothelial fluid flow resistance and formation of intercellular junctions.Q40936022
PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinaseQ41355420
Protein markers and differentiation in culture for Schlemm's canal endothelial cellsQ41906333
Interactions between endothelia of the trabecular meshwork and of Schlemm's canal: a new insight into the regulation of aqueous outflow in the eyeQ41988691
Regulation of myosin light chain phosphorylation in the trabecular meshwork: role in aqueous humour outflow facilityQ42473455
Regulation of reactive-oxygen-species generation in fibroblasts by Rac1.Q42809514
Characterization of EHT 1864, a novel small molecule inhibitor of Rac family small GTPasesQ42815050
Regulation of c-myc expression by PDGF through Rho GTPases.Q42828450
Effects of rho-associated protein kinase inhibitor Y-27632 on intraocular pressure and outflow facilityQ43513992
Rho and Rac but not Cdc42 regulate endothelial cell permeability.Q43546609
Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632.Q43556575
Fibronectin overexpression inhibits trabecular meshwork cell monolayer permeability.Q45117260
Effect of hydrostatic pressure gradients and Na2EDTA on permeability of human Schlemm's canal cell monolayersQ45129373
Endothelia of Schlemm's canal and trabecular meshwork: distinct molecular, functional, and anatomic features.Q45976356
Effects of novel ethacrynic acid derivatives on human trabecular meshwork cell shape, actin cytoskeletal organization, and transcellular fluid flowQ46835148
Effects of platelet-derived growth factor on aqueous humor dynamicsQ48028706
Dexamethasone inhibits trabecular cell retraction.Q52523290
Regulation of vascular endothelial barrier functionQ72761942
Endothelial adherens junctions: implications in the control of vascular permeability and angiogenesisQ73979766
Primary open-angle glaucomaQ80122027
Rho GTPase-mediated cytoskeletal organization in Schlemm's canal cells play a critical role in the regulation of aqueous humor outflow facilityQ83300196
The number of people with glaucoma worldwide in 2010 and 2020Q24679554
Cells in focus: endothelial cellQ28207496
Non-muscle myosin II takes centre stage in cell adhesion and migrationQ28262326
Autotaxin-lysophosphatidic acid axis is a novel molecular target for lowering intraocular pressureQ28482420
Rational design and characterization of a Rac GTPase-specific small molecule inhibitorQ29616494
Human Schlemm's canal cells express the endothelial adherens proteins, VE-cadherin and PECAM-1.Q30905682
Dexamethasone alters F-actin architecture and promotes cross-linked actin network formation in human trabecular meshwork tissueQ31135594
Expression of nonphagocytic NADPH oxidase system in the ocular lens.Q33198536
Role of lysophospholipid growth factors in the modulation of aqueous humor outflow facilityQ33204315
Ras, superoxide and signal transductionQ33541041
Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cellsQ33727728
The effect of Rho-associated protein kinase inhibitor on monkey Schlemm's canal endothelial cellsQ34227494
Cytoskeletal regulation of pulmonary vascular permeabilityQ34377340
Sphingosine-1-phosphate enhancement of cortical actomyosin organization in cultured human Schlemm's canal endothelial cell monolayersQ34662298
Current molecular models for NADPH oxidase regulation by Rac GTPaseQ34915029
Ca2+-dependent and Ca2+-independent regulation of smooth muscle contractionQ34937802
Rho GTPases and the regulation of endothelial permeabilityQ35127959
Aqueous humor outflow: what do we know? Where will it lead us?Q36166251
'What controls aqueous humour outflow resistance?'.Q36357303
rac1 regulates a cytokine-stimulated, redox-dependent pathway necessary for NF-kappaB activationQ36564448
Intracellular redox regulation by the family of small GTPasesQ36598875
Protein tyrosine phosphorylation and reversible oxidation: two cross-talking posttranslation modificationsQ36658117
Cultured porcine trabecular meshwork cells display altered lysosomal function when subjected to chronic oxidative stress.Q36695637
Dexamethasone-induced ocular hypertension in perfusion-cultured human eyes.Q36714628
Novel molecular insights into RhoA GTPase-induced resistance to aqueous humor outflow through the trabecular meshworkQ36977724
Regulation of endothelial junctional permeabilityQ37122803
The role of adherens junctions and VE-cadherin in the control of vascular permeabilityQ37195511
The role of the actomyosin system in regulating trabecular fluid outflowQ37222835
NADPH oxidase-dependent signaling in endothelial cells: role in physiology and pathophysiologyQ37265507
The regulation of vascular endothelial growth factor-induced microvascular permeability requires Rac and reactive oxygen speciesQ37377623
A requirement for the rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophyQ37384785
Discovering the molecular components of intercellular junctions--a historical view.Q37412670
P433issue1
P577publication date2013-06-01
P1433published inJournal of ocular biologyQ27725161
P1476titleRegulation of Adherens Junctions in Trabecular Meshwork Cells by Rac GTPase and their influence on Intraocular Pressure
P478volume1

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cites work (P2860)
Q41543498Effects of dexamethasone and HA1077 on actin cytoskeleton and β-catenin in cultured human trabecular meshwork cells
Q90304508Extracellular vesicle-mediated crosstalk between NPCE cells and TM cells result in modulation of Wnt signalling pathway and ECM remodelling
Q37420927Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms

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