Involvement of de novo ceramide biosynthesis in tumor necrosis factor-alpha/cycloheximide-induced cerebral endothelial cell death

scientific article published in June 1998

Involvement of de novo ceramide biosynthesis in tumor necrosis factor-alpha/cycloheximide-induced cerebral endothelial cell death is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.273.26.16521
P698PubMed publication ID9632721
P5875ResearchGate publication ID13651307

P50authorChung Y. HsuQ44389734
Dennis ChoiQ5258277
P2093author name stringXu J
Chen S
He L
Sensi SL
Yeh CH
Canzoniero LM
P433issue26
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
ceramidesQ424213
cell deathQ2383867
P304page(s)16521-16526
P577publication date1998-06-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleInvolvement of de novo ceramide biosynthesis in tumor necrosis factor-alpha/cycloheximide-induced cerebral endothelial cell death
P478volume273

Reverse relations

cites work (P2860)
Q43615470Activation of a p53-independent, sphingolipid-mediated cytolytic pathway in p53-negative mouse fibroblast cells treated with N-methyl-N-nitro-N-nitrosoguanidine
Q48379539Amyloid beta-peptide possesses a transforming growth factor-beta activity
Q38361116Amyloid-beta induces Smac release via AP-1/Bim activation in cerebral endothelial cells.
Q36321788Amyloid-beta peptide induces oligodendrocyte death by activating the neutral sphingomyelinase-ceramide pathway
Q34675805Andrographolide enhances nuclear factor-kappaB subunit p65 Ser536 dephosphorylation through activation of protein phosphatase 2A in vascular smooth muscle cells
Q28367278Angiostatin effects on endothelial cells mediated by ceramide and RhoA.
Q35630097Antiphospholipid reactivity against cardiolipin metabolites occurring during endothelial cell apoptosis
Q40407425Antisense RNA to inducible nitric oxide synthase reduces cytokine-mediated brain endothelial cell death
Q40321909Apoptosis occurs via the ceramide recycling pathway in human HaCaT keratinocytes
Q43143718Apoptosis signal-regulating kinase 1 in peptidoglycan-induced COX-2 expression in macrophages.
Q39990649C18 ceramide analysis in mammalian cells employing reversed-phase high-performance liquid chromatography tandem mass spectrometry.
Q51082157CD95(Fas/APO-1) signals ceramide generation independent of the effector stage of apoptosis.
Q35046229Carbamoylating chemoresistance induced by cobalt pretreatment in C6 glioma cells: putative roles of hypoxia-inducible factor-1.
Q77875070Ceramide and apoptosis
Q24646241Ceramide channels increase the permeability of the mitochondrial outer membrane to small proteins
Q28213775Ceramide generation by two distinct pathways in tumor necrosis factor alpha-induced cell death
Q34955711Ceramide in apoptosis: a revisited role.
Q35047136Ceramide in apoptosis: an overview and current perspectives
Q37797406Ceramide in stress response
Q33826715Ceramide in the eukaryotic stress response
Q35912091Ceramide metabolism regulates autophagy and apoptotic cell death induced by melatonin in liver cancer cells.
Q73955405Ceramide mimics tumour necrosis factor-alpha in the induction of cell cycle arrest in endothelial cells. Induction of the tumour suppressor p53 with decrease in retinoblastoma/protein levels
Q73186652Ceramide synthase
Q24609859Ceramide synthases at the centre of sphingolipid metabolism and biology
Q44854751Ceramide-induced intracellular oxidant formation, iron signaling, and apoptosis in endothelial cells: protective role of endogenous nitric oxide
Q24630011Ceramide: a common pathway for atherosclerosis?
Q44409392Characterization of Serine Palmitoyltransferase in Normal Human Tissues
Q35105929Characterization of the MM.1 human multiple myeloma (MM) cell lines: a model system to elucidate the characteristics, behavior, and signaling of steroid-sensitive and -resistant MM cells
Q90482420Contribution of Adipose Tissue Inflammation to the Development of Type 2 Diabetes Mellitus
Q28564730Coupling of two pools of P2X7 receptors to distinct intracellular signaling pathways in rat submandibular gland
Q54020659CrmA protects against apoptosis and ceramide formation in PC12 cells.
Q43597366Daunorubicin attenuates tumor necrosis factor-alpha-induced biosynthesis of plasminogen activator inhibitor-1 in human umbilical vein endothelial cells
Q41775676De novo-synthesized ceramide is involved in cannabinoid-induced apoptosis.
Q42835340Degradation of STAT5 proteins in 3T3-L1 adipocytes is induced by TNF-{alpha} and cycloheximide in a manner independent of STAT5A activation.
Q33876969Does ceramide play a role in neural cell apoptosis?
Q92213726Effect of combined testing of ceramides with high-sensitive troponin T on the detection of acute coronary syndrome in patients with chest pain in China: a prospective observational study
Q73186760Fermentation, partial purification, and use of serine palmitoyltransferase inhibitors from Isaria (= Cordyceps) sinclairii
Q35760648Honokiol traverses the blood-brain barrier and induces apoptosis of neuroblastoma cells via an intrinsic bax-mitochondrion-cytochrome c-caspase protease pathway
Q73355820Increased susceptibility of renal epithelial cells to TNFalpha-induced apoptosis following treatment with fumonisin B1
Q33976122Influence of fish oil on skeletal muscle mitochondrial energetics and lipid metabolites during high-fat diet
Q92994454Inhibition of de novo ceramide biosynthesis affects aging phenotype in an in vitro model of neuronal senescence
Q44087049Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase
Q34373466Interdiction of sphingolipid metabolism to improve standard cancer therapies
Q34214374Is there an astrocyte-neuron ketone body shuttle?
Q34403752LASS5 is the predominant ceramide synthase isoform involved in de novo sphingolipid synthesis in lung epithelia
Q73544921Mechanisms of apoptosis in embryonic cortical neurons (E6 and E7) in culture involve lipid signalling, protein phosphorylation and caspase activation
Q37357140Methylprednisolone protects oligodendrocytes but not neurons after spinal cord injury
Q34747143Mitochondria and ceramide: intertwined roles in regulation of apoptosis
Q38899171Molecular Mechanism for the Control of Eukaryotic Elongation Factor 2 Kinase by pH: Role in Cancer Cell Survival
Q28567137Naofen promotes TNF-α-mediated apoptosis of hepatocytes by activating caspase-3 in lipopolysaccharide-treated rats
Q44189430Paradoxical role of tumor necrosis factor alpha in fumonisin-induced hepatotoxicity in mice
Q40214834Phospholipase D protects ECV304 cells against TNFalpha-induced apoptosis
Q36341274Physiological and pathophysiological aspects of ceramide
Q33930354Physiology and pathophysiology of sphingolipid metabolism and signaling
Q34084790Phytosphingosine as a specific inhibitor of growth and nutrient import in Saccharomyces cerevisiae
Q49609040Plasma Sphingolipids are Associated With Gait Parameters in the Mayo Clinic Study of Aging.
Q37057113Plasma ceramides predict cardiovascular death in patients with stable coronary artery disease and acute coronary syndromes beyond LDL-cholesterol
Q46555140Pravastatin attenuates ceramide-induced cytotoxicity in mouse cerebral endothelial cells with HIF-1 activation and VEGF upregulation
Q48311591Protective effects of fish oil on pre-diabetes: a lipidomic analysis of liver ceramides in rats.
Q46958357Protein phosphatase 2A regulates bim expression via the Akt/FKHRL1 signaling pathway in amyloid-beta peptide-induced cerebrovascular endothelial cell death.
Q73731212Protein tyrosine kinase p56lck is required for ceramide-induced but not tumor necrosis factor-induced activation of NF-kappa B, AP-1, JNK, and apoptosis
Q48251173Pyrrolidine dithiocarbamate induces bovine cerebral endothelial cell death by increasing the intracellular zinc level
Q46797170Reactive oxygen species production by mitochondria in endothelial cells exposed to reoxygenation after hypoxia and glucose depletion is mediated by ceramide
Q28386983Regulation of IGF-I function by proinflammatory cytokines: at the interface of immunology and endocrinology
Q34714771Resveratrol attenuates oxidized LDL-evoked Lox-1 signaling and consequently protects against apoptotic insults to cerebrovascular endothelial cells
Q52604694Resveratrol protects against oxidized LDL-induced breakage of the blood-brain barrier by lessening disruption of tight junctions and apoptotic insults to mouse cerebrovascular endothelial cells.
Q44182978Role of ceramide in TNF-alpha-induced impairment of endothelium-dependent vasorelaxation in coronary arteries
Q24817163Screening of an endothelial cDNA library identifies the C-terminal region of Nedd5 as a novel autoantigen in systemic lupus erythematosus with psychiatric manifestations
Q35047153Serine palmitoyltransferase: role in apoptotic de novo ceramide synthesis and other stress responses
Q33601457Signalling sphingomyelinases: which, where, how and why?
Q91362364Similar plasma lipidomic profile in people living with HIV treated with a darunavir-based or an integrase inhibitor-based antiretroviral therapy
Q24537103Sphingolipid metabolism: roles in signal transduction and disruption by fumonisins
Q24537114Sphingolipid perturbations as mechanisms for fumonisin carcinogenesis
Q36861002Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism
Q40412339Sphingomyelins suppress the targeted disruption of lysosomes/endosomes by the photosensitizer NPe6 during photodynamic therapy
Q39372850Sphingosine mediates TNFα-induced lysosomal membrane permeabilization and ensuing programmed cell death in hepatoma cells.
Q42806473Subcellular compartmentalization of ceramide metabolism: MAM (mitochondria-associated membrane) and/or mitochondria?
Q44163309Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: potential role in disease pathogenesis
Q24290792The AMP-activated protein kinase prevents ceramide synthesis de novo and apoptosis in astrocytes
Q28290482The role of ceramide in cell signaling
Q42795897The role of de novo ceramide synthesis in the mechanism of action of the tricyclic xanthate D609.
Q44389680Thiol antioxidant reversal of pyrrolidine dithiocarbamate-induced reciprocal regulation of AP-1 and NF-kappaB.
Q30493665Triggering role of acid sphingomyelinase in endothelial lysosome-membrane fusion and dysfunction in coronary arteries.
Q42471500Zinc is required in pyrrolidine dithiocarbamate inhibition of NF-kappaB activation.

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