De novo-synthesized ceramide is involved in cannabinoid-induced apoptosis.

scientific article published on April 2002

De novo-synthesized ceramide is involved in cannabinoid-induced apoptosis. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1042/0264-6021:3630183
P932PMC publication ID1222465
P698PubMed publication ID11903061
P5875ResearchGate publication ID11461077

P50authorCristina SánchezQ39078704
Guillermo VelascoQ40549742
P2093author name stringManuel Guzmán
Teresa Gómez del Pulgar
Amador Haro
P2860cites workThe AMP-activated protein kinase prevents ceramide synthesis de novo and apoptosis in astrocytesQ24290792
Human and murine serine-palmitoyl-CoA transferase--cloning, expression and characterization of the key enzyme in sphingolipid synthesisQ28114891
Purification of the serine palmitoyltransferase complex responsible for sphingoid base synthesis by using affinity peptide chromatography techniquesQ28139000
Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosisQ28139061
SPTLC1 is mutated in hereditary sensory neuropathy, type 1Q28204237
Mutations in SPTLC1, encoding serine palmitoyltransferase, long chain base subunit-1, cause hereditary sensory neuropathy type IQ28204289
Structure of a cannabinoid receptor and functional expression of the cloned cDNAQ28240076
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptorsQ28292914
Molecular characterization of a peripheral receptor for cannabinoidsQ28298338
Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activationQ28372120
A mammalian homolog of the yeast LCB1 encodes a component of serine palmitoyltransferase, the enzyme catalyzing the first step in sphingolipid synthesisQ28587825
Isolation and structure of a brain constituent that binds to the cannabinoid receptorQ29547476
Cannabinoid receptor ligands: clinical and neuropharmacological considerations, relevant to future drug discovery and developmentQ31522100
Signalling sphingomyelinases: which, where, how and why?Q33601457
Ceramide in the eukaryotic stress responseQ33826715
Physiology and pathophysiology of sphingolipid metabolism and signalingQ33930354
The endocannabinoid system as a target for therapeutic drugs.Q33934278
The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation.Q34066911
Apoptosis in the nervous systemQ34068965
Ceramide: a new second messenger of cannabinoid actionQ34133972
Control of the cell survival/death decision by cannabinoidsQ34195687
Fatty acid-induced beta cell apoptosis: a link between obesity and diabetesQ35923385
Inhibition of the p44/42 MAP kinase pathway protects hippocampal neurons in a cell-culture model of seizure activityQ36327960
Ataxia telangiectasia-mutated gene product inhibits DNA damage-induced apoptosis via ceramide synthaseQ38323889
Production of ceramides causes apoptosis during early neural differentiation in vitroQ40872435
Ceramide inhibits protein kinase B/Akt by promoting dephosphorylation of serine 473.Q40883173
Delta9-tetrahydrocannabinol induces apoptosis in C6 glioma cells.Q41002908
Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosisQ41128299
Medicinal applications of delta-9-tetrahydrocannabinol and marijuanaQ41468383
Regulation of ceramide production and apoptosisQ41748407
Involvement of sphingomyelin hydrolysis and the mitogen-activated protein kinase cascade in the Delta9-tetrahydrocannabinol-induced stimulation of glucose metabolism in primary astrocytes.Q42463589
Mammalian cell mutants resistant to a sphingomyelin-directed cytolysin. Genetic and biochemical evidence for complex formation of the LCB1 protein with the LCB2 protein for serine palmitoyltransferaseQ42819525
Rap1 mediates sustained MAP kinase activation induced by nerve growth factorQ42830846
The CB(1) cannabinoid receptor of astrocytes is coupled to sphingomyelin hydrolysis through the adaptor protein fan.Q43578243
UVB irradiation up-regulates serine palmitoyltransferase in cultured human keratinocytes.Q46000073
Evidence for the lack of involvement of sphingomyelin hydrolysis in the tumor necrosis factor-induced secretion of nerve growth factor in primary astrocyte cultures.Q47778008
Involvement of de novo ceramide biosynthesis in tumor necrosis factor-alpha/cycloheximide-induced cerebral endothelial cell deathQ47954345
Ceramide signaling downstream of the p75 neurotrophin receptor mediates the effects of nerve growth factor on outgrowth of cultured hippocampal neuronsQ48109056
Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures: evidence for a MAP kinase-dependent mechanism.Q48395929
Cannabinoid receptors and their endogenous agonistsQ48464429
Δ9 -Tetrahydrocannabinol induces apoptosis in human prostate PC-3 cells via a receptor-independent mechanismQ62398804
De novo-synthesized ceramide signals apoptosis in astrocytes via extracellular signal-regulated kinaseQ73127880
Serine palmitoyltransferaseQ73186643
Anandamide induces apoptosis in human cells via vanilloid receptors. Evidence for a protective role of cannabinoid receptorsQ74061522
Activation of the de novo biosynthesis of sphingolipids mediates angiotensin II type 2 receptor-induced apoptosisQ77841204
The CB1 cannabinoid receptor is coupled to the activation of protein kinase B/AktQ95716793
P433issuePt 1
P407language of work or nameEnglishQ1860
P921main subjectcannabinoidsQ422936
ceramidesQ424213
P304page(s)183-188
P577publication date2002-04-01
P1433published inBiochemical JournalQ864221
P1476titleDe novo-synthesized ceramide is involved in cannabinoid-induced apoptosis
P478volume363

Reverse relations

cites work (P2860)
Q39881733Amphiregulin is a factor for resistance of glioma cells to cannabinoid-induced apoptosis.
Q26750399Anticancer mechanisms of cannabinoids
Q34358271Antiproliferative effects of cannabinoid agonists on deep infiltrating endometriosis.
Q38806270Antitumorigenic targets of cannabinoids - current status and implications
Q89605000Cannabinoid Signaling in Glioma Cells
Q34979866Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells
Q40214988Cannabinoid receptor agonist-induced apoptosis of human prostate cancer cells LNCaP proceeds through sustained activation of ERK1/2 leading to G1 cell cycle arrest
Q37546194Cannabinoid receptor ligands as potential anticancer agents--high hopes for new therapies?
Q35100892Cannabinoids and cancer: pros and cons of an antitumour strategy
Q36977756Cannabinoids and gliomas.
Q33310983Cannabinoids as potential new therapy for the treatment of gliomas
Q27694715Cannabinoids, endocannabinoids, and cancer
Q34542671Cannabinoids: potential anticancer agents
Q36892931Cannabis and endocannabinoid modulators: Therapeutic promises and challenges
Q40623956Ceramide Is Involved inR(+)-Methanandamide-Induced Cyclooxygenase-2 Expression in Human Neuroglioma Cells
Q38021345Ceramide function in the brain: when a slight tilt is enough.
Q34955724Ceramide regulation of apoptosis versus differentiation: a walk on a fine line. Lessons from neurobiology
Q40586806Ceramide sensitizes astrocytes to oxidative stress: protective role of cannabinoids
Q37164208Critical appraisal of the potential use of cannabinoids in cancer management
Q36498885Cyclooxygenase-2 (COX-2)-independent anticarcinogenic effects of selective COX-2 inhibitors
Q44799706De novo ceramide accumulation due to inhibition of its conversion to complex sphingolipids in apoptotic photosensitized cells.
Q35114241Designing anticancer drugs via the achilles heel: ceramide, allylic ketones, and mitochondria
Q37405849Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization
Q46427095Endocannabinoid metabolism in human glioblastomas and meningiomas compared to human non-tumour brain tissue
Q26739831Endocannabinoid system as a regulator of tumor cell malignancy - biological pathways and clinical significance
Q38593139Endocannabinoids and Cancer.
Q55467310Expression of cannabinoid receptors and neurotrophins in human gliomas.
Q40604593Gamma-irradiation enhances apoptosis induced by cannabidiol, a non-psychotropic cannabinoid, in cultured HL-60 myeloblastic leukemia cells
Q48128574Gαs signalling of the CB1 receptor and the influence of receptor number
Q37339555Hepatic cannabinoid-1 receptors mediate diet-induced insulin resistance by increasing de novo synthesis of long-chain ceramides
Q93065228Identification of Novel Predictive Biomarkers for Endometrial Malignancies: N-Acylethanolamines
Q24321982Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities
Q38990460In vitro and in vivo efficacy of non-psychoactive cannabidiol in neuroblastoma
Q34998169Inhibition of human tumour prostate PC-3 cell growth by cannabinoids R(+)-Methanandamide and JWH-015: involvement of CB2
Q24529892Killing tumours by ceramide-induced apoptosis: a critique of available drugs
Q57364601Metabolism and physiological functions of sphingolipids
Q33939529Mitochondrial ceramide-rich macrodomains functionalize Bax upon irradiation
Q38008481New trends for the medical treatment of endometriosis
Q39902384Phosphatidylinositol 3-kinase/AKT pathway regulates the endoplasmic reticulum to golgi traffic of ceramide in glioma cells: a link between lipid signaling pathways involved in the control of cell survival.
Q39824459Potentiation of cannabinoid-induced cytotoxicity in mantle cell lymphoma through modulation of ceramide metabolism
Q38918051Proapoptotic effect of endocannabinoids in prostate cancer cells
Q46788902R(+)-methanandamide elicits a cyclooxygenase-2-dependent mitochondrial apoptosis signaling pathway in human neuroglioma cells
Q34202240Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism
Q38195691Sphingolipids: key regulators of apoptosis and pivotal players in cancer drug resistance
Q38154188Systematic review of the literature on clinical and experimental trials on the antitumor effects of cannabinoids in gliomas
Q40290354The CB2 cannabinoid receptor signals apoptosis via ceramide-dependent activation of the mitochondrial intrinsic pathway.
Q64072053The Endocannabinoid System as a Target in Cancer Diseases: Are We There Yet?
Q36666503The cannabinoid receptors are required for ultraviolet-induced inflammation and skin cancer development
Q55415383The current state and future perspectives of cannabinoids in cancer biology.
Q45287768The endocannabinoid anandamide induces apoptosis of rat decidual cells through a mechanism involving ceramide synthesis and p38 MAPK activation
Q37393042The endocannabinoid system and sex steroid hormone-dependent cancers.
Q24648473The endocannabinoid system as an emerging target of pharmacotherapy
Q35204851The endocannabinoid system, anandamide and the regulation of mammalian cell apoptosis
Q64284375The onus of cannabinoids in interrupting the molecular odyssey of breast cancer: A critical perspective on UPR and beyond
Q38196323The role of monoacylglycerol lipase (MAGL) in the cancer progress
Q24642219The sphingolipid salvage pathway in ceramide metabolism and signaling
Q84066889Towards the use of cannabinoids as antitumour agents
Q46684067p38 MAPK is involved in CB2 receptor-induced apoptosis of human leukaemia cells

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