| scholarly article | Q13442814 |
| P356 | DOI | 10.1074/JBC.M110.125609 |
| P8608 | Fatcat ID | release_szklfarrgneyjo2vsmq2ay3rfm |
| P932 | PMC publication ID | 2975195 |
| P698 | PubMed publication ID | 20807762 |
| P50 | author | Kazuyuki Kitatani | Q41463535 |
| Daniel Canals | Q42821696 | ||
| Yusuf A. Hannun | Q87620042 | ||
| Russell William Jenkins | Q90427415 | ||
| P2093 | author name string | Patrick Roddy | |
| David M Perry | |||
| Jolanta Idkowiak-Baldys | |||
| Chiara Luberto | |||
| Fabio Simbari | |||
| P2860 | cites work | Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid | Q24320202 |
| Involvement of acid beta-glucosidase 1 in the salvage pathway of ceramide formation | Q24320259 | ||
| Zn2+-stimulated sphingomyelinase is secreted by many cell types and is a product of the acid sphingomyelinase gene | Q28116333 | ||
| Characterization of common SMPD1 mutations causing types A and B Niemann-Pick disease and generation of mutation-specific mouse models | Q28117276 | ||
| Acid and neutral sphingomyelinases: roles and mechanisms of regulation | Q28253522 | ||
| Principles of bioactive lipid signalling: lessons from sphingolipids | Q28265743 | ||
| Functional characterization of the N-glycosylation sites of human acid sphingomyelinase by site-directed mutagenesis | Q28303559 | ||
| Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: evidence for membrane cycling from Golgi to ER | Q29615171 | ||
| Carboxyl-terminal disulfide bond of acid sphingomyelinase is critical for its secretion and enzymatic function. | Q30366243 | ||
| Acid sphingomyelinase activity triggers microparticle release from glial cells | Q30486802 | ||
| Processing of gene expression data generated by quantitative real-time RT-PCR. | Q30699578 | ||
| Sphingolipids in inflammation: roles and implications | Q30956968 | ||
| Natural ceramide reverses Fas resistance of acid sphingomyelinase(-/-) hepatocytes. | Q31629166 | ||
| Role of increased sphingomyelinase activity in apoptosis and organ failure of patients with severe sepsis | Q33341419 | ||
| Sphingomyelin metabolism at the plasma membrane: implications for bioactive sphingolipids | Q33798777 | ||
| Acute systemic inflammation up-regulates secretory sphingomyelinase in vivo: a possible link between inflammatory cytokines and atherogenesis | Q33909112 | ||
| Secretory sphingomyelinase | Q34042910 | ||
| Sphingomyelinases: enzymology and membrane activity | Q34156320 | ||
| Interactions of acid sphingomyelinase and lipid bilayers in the presence of the tricyclic antidepressant desipramine | Q34298313 | ||
| Sustained receptor stimulation leads to sequestration of recycling endosomes in a classical protein kinase C- and phospholipase D-dependent manner | Q34986708 | ||
| Biologically active sphingolipids in cancer pathogenesis and treatment | Q35852313 | ||
| Constitutive acid sphingomyelinase enhances early and late macrophage killing of Salmonella enterica serovar Typhimurium | Q36313910 | ||
| Physiological and pathophysiological aspects of ceramide | Q36341274 | ||
| Lysosomes and lysosomal proteins in cancer cell death (new players of an old struggle). | Q36368016 | ||
| Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation | Q36380942 | ||
| Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway | Q36562936 | ||
| The unexpected role of acid sphingomyelinase in cell death and the pathophysiology of common diseases | Q36879383 | ||
| The pathogenesis and treatment of acid sphingomyelinase-deficient Niemann-Pick disease | Q36882500 | ||
| Acid sphingomyelinase promotes lipoprotein retention within early atheromata and accelerates lesion progression | Q36924524 | ||
| Single proteins might have dual but related functions in intracellular and extracellular microenvironments | Q37351491 | ||
| Roles and regulation of secretory and lysosomal acid sphingomyelinase | Q37454661 | ||
| The cellular trafficking and zinc dependence of secretory and lysosomal sphingomyelinase, two products of the acid sphingomyelinase gene | Q38335637 | ||
| A novel role for protein kinase Cdelta-mediated phosphorylation of acid sphingomyelinase in UV light-induced mitochondrial injury. | Q40094292 | ||
| Activation of acid sphingomyelinase by protein kinase Cdelta-mediated phosphorylation | Q40170534 | ||
| Sphingomyelins in bilayers and biological membranes | Q40292631 | ||
| Elevated sphingomyelinase activity and ceramide concentration in serum of patients undergoing high dose spatially fractionated radiation treatment: implications for endothelial apoptosis | Q40386161 | ||
| Lysosomal sphingomyelinase is not solicited for apoptosis signaling | Q40831391 | ||
| Stress-induced apoptosis is not mediated by endolysosomal ceramide | Q40907513 | ||
| A model of the acid sphingomyelinase phosphoesterase domain based on its remote structural homolog purple acid phosphatase | Q41949021 | ||
| Expression of recombinant human acid sphingomyelinase in insect Sf21 cells: purification, processing and enzymatic characterization | Q42059900 | ||
| Secretory sphingomyelinase is upregulated in chronic heart failure: a second messenger system of immune activation relates to body composition, muscular functional capacity, and peripheral blood flow | Q42165275 | ||
| Human vascular endothelial cells are a rich and regulatable source of secretory sphingomyelinase. Implications for early atherogenesis and ceramide-mediated cell signaling | Q42450640 | ||
| Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. | Q42555356 | ||
| Comprehensive quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry | Q43274913 | ||
| Elevated sphingomyelinase and hypercytokinemia in hemophagocytic lymphohistiocytosis | Q44079910 | ||
| Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase | Q44087049 | ||
| Increased sphingomyelin content impairs HDL biogenesis and maturation in human Niemann-Pick disease type B. | Q46828933 | ||
| The active site of lysosomal sphingomyelinase: evidence for the involvement of hydrophobic and ionic groups | Q50931581 | ||
| Detection of abasic sites and oxidative DNA base damage using an ELISA-like assay. | Q54247140 | ||
| CD95 Signaling via Ceramide-rich Membrane Rafts | Q57371964 | ||
| A new Zn2+-stimulated sphingomyelinase in fetal bovine serum | Q69334524 | ||
| Release of Sphingomyelin Phosphodiesterase (Acid Sphingomyelinase) by Ammonium Chloride from CL 1D Mouse L-Cells and Human Fibroblasts. Partial Purification and Characterization of the Exported Enzymes | Q70164187 | ||
| Processing of human acid sphingomyelinase in normal and I-cell fibroblasts | Q72238174 | ||
| The tricyclic antidepressant desipramine causes proteolytic degradation of lysosomal sphingomyelinase in human fibroblasts | Q72768846 | ||
| Serum Zn(2+)-stimulated sphingomyelinase deficiency in type B Niemann-Pick disease | Q73133198 | ||
| Sphingomyelinase, an enzyme implicated in atherogenesis, is present in atherosclerotic lesions and binds to specific components of the subendothelial extracellular matrix | Q73175616 | ||
| Sphingomyelinase assay using radiolabeled substrate | Q73186688 | ||
| Sphingomyelinase converts lipoproteins from apolipoprotein E knockout mice into potent inducers of macrophage foam cell formation | Q73295355 | ||
| Selective induction of the secretion of cathepsins B and L by cytokines in synovial fibroblast-like cells | Q73582840 | ||
| Characterization of sphingomyelinase activity released by thrombin-stimulated platelets | Q73814754 | ||
| Secretory Zn2+-dependent sphingomyelinase activity in the serum of patients with type 2 diabetes is elevated | Q73895330 | ||
| Secretory sphingomyelinase, a product of the acid sphingomyelinase gene, can hydrolyze atherogenic lipoproteins at neutral pH. Implications for atherosclerotic lesion development | Q74105836 | ||
| Creation of a mouse model for non-neurological (type B) Niemann-Pick disease by stable, low level expression of lysosomal sphingomyelinase in the absence of secretory sphingomyelinase: relationship between brain intra-lysosomal enzyme activity and c | Q74171911 | ||
| Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry | Q79860458 | ||
| Acid sphingomyelinase is a key regulator of cytotoxic granule secretion by primary T lymphocytes | Q84068693 | ||
| P433 | issue | 46 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | ceramides | Q424213 |
| P304 | page(s) | 35706-35718 | |
| P577 | publication date | 2010-08-31 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Regulated secretion of acid sphingomyelinase: implications for selectivity of ceramide formation | |
| P478 | volume | 285 |
| Q41094700 | A new twist to the emerging functions of ceramides in cancer: novel role for platelet acid sphingomyelinase in cancer metastasis |
| Q34536996 | A novel mechanism of lysosomal acid sphingomyelinase maturation: requirement for carboxyl-terminal proteolytic processing. |
| Q33789017 | A potent sphingomyelinase inhibitor from Cordyceps mycelia contributes its cytoprotective effect against oxidative stress in macrophages |
| Q41853330 | ALTERED BLOOD SPHINGOLIPIDOMICS AND ELEVATED PLASMA INFLAMMATORY CYTOKINES IN COMBAT VETERANS WITH POST-TRAUMATIC STRESS DISORDER |
| Q57463140 | Acid Sphingomyelinase Inhibition Stabilizes Hepatic Ceramide Content and Improves Hepatic Biotransformation Capacity in a Murine Model of Polymicrobial Sepsis |
| Q37870853 | Acid sphingomyelinase in macrophage biology |
| Q40637739 | Acid sphingomyelinase promotes endothelial stress response in systemic inflammation and sepsis |
| Q92082191 | Alteration of Sphingolipids in Biofluids: Implications for Neurodegenerative Diseases |
| Q48022739 | Alteration of sphingolipid metabolism as a putative mechanism underlying LPS-induced BBB disruption |
| Q35515785 | Alternative splicing of SMPD1 in human sepsis |
| Q24316264 | Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes |
| Q35604572 | Ceramide kinase regulates the production of tumor necrosis factor α (TNFα) via inhibition of TNFα-converting enzyme |
| Q34963246 | Ceramide synthase-dependent ceramide generation and programmed cell death: involvement of salvage pathway in regulating postmitochondrial events |
| Q34070467 | Defining a role for acid sphingomyelinase in the p38/interleukin-6 pathway |
| Q39413836 | Differential regulation of acid sphingomyelinase in macrophages stimulated with oxidized low-density lipoprotein (LDL) and oxidized LDL immune complexes: role in phagocytosis and cytokine release |
| Q59812054 | Early postoperative changes of sphingomyelins and ceramides after laparoscopic sleeve gastrectomy |
| Q28293977 | Evaluation of the role of secretory sphingomyelinase and bioactive sphingolipids as biomarkers in hemophagocytic lymphohistiocytosis |
| Q36401748 | Evidence for coordination of lysosomal (ASMase) and plasma membrane (NSMase2) forms of sphingomyelinase from mutant mice |
| Q48435795 | Fingolimod attenuates ceramide-induced blood-brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes |
| Q37259811 | Gastric bypass surgery reduces plasma ceramide subspecies and improves insulin sensitivity in severely obese patients |
| Q30531999 | Hyperresponsiveness of mice deficient in plasma-secreted sphingomyelinase reveals its pivotal role in early phase of host response |
| Q28542500 | Identification and biochemical characterization of an acid sphingomyelinase-like protein from the bacterial plant pathogen Ralstonia solanacearum that hydrolyzes ATP to AMP but not sphingomyelin to ceramide |
| Q54979802 | Identification of an acid sphingomyelinase ceramide kinase pathway in the regulation of the chemokine CCL5. |
| Q38793821 | Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury |
| Q26852322 | Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogons |
| Q37389500 | Interferon-Beta Increases Plasma Ceramides of Specific Chain Length in Multiple Sclerosis Patients, Unlike Fingolimod or Natalizumab. |
| Q42554659 | Lactosylceramide interacts with and activates cytosolic phospholipase A2α. |
| Q92956862 | Plasma membrane damage repair is mediated by an acid sphingomyelinase in Entamoeba histolytica |
| Q38763707 | Platelet-derived sphingosine-1-phosphate and inflammation: from basic mechanisms to clinical implications |
| Q34787157 | Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase |
| Q36147515 | Safety study of adeno-associated virus serotype 2-mediated human acid sphingomyelinase expression in the nonhuman primate brain |
| Q39421907 | Sphingolipid abnormalities in cancer multidrug resistance: Chicken or egg? |
| Q28118272 | Sphingomyelin phosphodiesterase acid-like 3A (SMPDL3A) is a novel nucleotide phosphodiesterase regulated by cholesterol in human macrophages |
| Q34107449 | Structural characterization and antioxidative activity of low-molecular-weights beta-1,3-glucan from the residue of extracted Ganoderma lucidum fruiting bodies |
| Q35645445 | Targeting (cellular) lysosomal acid ceramidase by B13: design, synthesis and evaluation of novel DMG-B13 ester prodrugs |
| Q98462816 | The impact of EPA and DHA on ceramide lipotoxicity in metabolic syndrome |
| Q38071694 | The role of sphingolipids in drug metabolism and transport |
| Q37928817 | The role of sphingolipids in respiratory disease |
| Q27703636 | The structure and catalytic mechanism of human sphingomyelin phosphodiesterase like 3a--an acid sphingomyelinase homologue with a novel nucleotide hydrolase activity |
| Q26771645 | Trafficking and Functions of Bioactive Sphingolipids: Lessons from Cells and Model Membranes |
| Q42315013 | Tricyclic Antidepressants Promote Ceramide Accumulation to Regulate Collagen Production in Human Hepatic Stellate Cells. |
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