| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2000PNAS...97.8681W |
| P356 | DOI | 10.1073/PNAS.150098097 |
| P932 | PMC publication ID | 27008 |
| P698 | PubMed publication ID | 10890909 |
| P5875 | ResearchGate publication ID | 235613683 |
| P50 | author | Julio Licinio | Q15429111 |
| Ma-Li Wong | Q32848402 | ||
| P2093 | author name string | I Tabas | |
| E Hirsch | |||
| P W Gold | |||
| B Xie | |||
| K J Williams | |||
| A Johns | |||
| S Marathe | |||
| N Beatini | |||
| P Phu | |||
| P2860 | cites work | The response-to-retention hypothesis of early atherogenesis | Q24629974 |
| A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION | Q25939000 | ||
| Atherosclerosis — An Inflammatory Disease | Q26776972 | ||
| Zn2+-stimulated sphingomyelinase is secreted by many cell types and is a product of the acid sphingomyelinase gene | Q28116333 | ||
| Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock | Q28307404 | ||
| Biologic basis for interleukin-1 in disease | Q29619853 | ||
| Regulation of cytochrome P450 expression by sphingolipids. | Q34042915 | ||
| Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques | Q34327535 | ||
| Signal transduction in atherosclerosis: integration of cytokines and the eicosanoid network | Q36379996 | ||
| Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation | Q36380942 | ||
| The mouse interleukin 1 receptor antagonist protein: gene structure and regulation in vitro | Q36731234 | ||
| Inflammatory cytokines | Q36731936 | ||
| Copper and zinc body levels in inflammation: an overview of the data obtained from animal and human studies | Q36762274 | ||
| Functions of interleukin 1 receptor antagonist in gene knockout and overproducing mice | Q37306765 | ||
| Rabbit aorta and human atherosclerotic lesions hydrolyze the sphingomyelin of retained low-density lipoprotein. Proposed role for arterial-wall sphingomyelinase in subendothelial retention and aggregation of atherogenic lipoproteins. | Q37359981 | ||
| Gram-negative endotoxin: an extraordinary lipid with profound effects on eukaryotic signal transduction. | Q37374764 | ||
| Increased sphingomyelin content of plasma lipoproteins in apolipoprotein E knockout mice reflects combined production and catabolic defects and enhances reactivity with mammalian sphingomyelinase | Q37378380 | ||
| Involvement of the immune system in human atherogenesis: current knowledge and unanswered questions. | Q37630364 | ||
| Cellular and molecular mechanisms of cytokine networking | Q37778402 | ||
| An update of the enzymology and regulation of sphingomyelin metabolism | Q37923512 | ||
| In vivo biological activities of endotoxin | Q38153463 | ||
| The cellular trafficking and zinc dependence of secretory and lysosomal sphingomyelinase, two products of the acid sphingomyelinase gene | Q38335637 | ||
| Trafficking of lysosomal enzymes. | Q39679128 | ||
| Studies on Inflammation: X. The Cytological Picture of an Inflammatory Exudate in Relation to its Hydrogen Ion Concentration | Q39703337 | ||
| Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin | Q40402483 | ||
| Pathogenetic mechanisms of septic shock | Q40900222 | ||
| The cellular response in sepsis. | Q41100897 | ||
| Endotoxin: possible roles in initiation and development of atherosclerosis | Q41195257 | ||
| Cell death in atherosclerotic plaques. | Q41235084 | ||
| The structure and complete nucleotide sequence of the murine gene encoding interleukin-1 beta converting enzyme (ICE). | Q41477629 | ||
| Cytokines in autoimmune disease. | Q41605585 | ||
| Mechanisms of ceramide-mediated apoptosis | Q41606244 | ||
| Cell-mediated immunity in atherosclerosis. | Q41614969 | ||
| Cell biology of autoimmune diseases | Q41625265 | ||
| Regulation of ceramide production and apoptosis | Q41748407 | ||
| Depletion of plasma-membrane sphingomyelin rapidly alters the distribution of cholesterol between plasma membranes and intracellular cholesterol pools in cultured fibroblasts | Q41922039 | ||
| Cytosolic pH regulation in mouse macrophages. Proton extrusion by plasma-membrane-localized H(+)-ATPase | Q42016231 | ||
| Human vascular endothelial cells are a rich and regulatable source of secretory sphingomyelinase. Implications for early atherogenesis and ceramide-mediated cell signaling | Q42450640 | ||
| Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. | Q42555356 | ||
| A new promoter polymorphism in the gene of lipopolysaccharide receptor CD14 is associated with expired myocardial infarction in patients with low atherosclerotic risk profile | Q43615518 | ||
| Partial synthesis and properties of a series of N-acyl sphingomyelins | Q43868660 | ||
| Delineation of the proinflammatory cytokine cascade in fever induction | Q48300583 | ||
| Modification of the cholesterol efflux properties of human serum by enrichment with phospholipid. | Q48738487 | ||
| The distributions and diffusivities of small ions in chondroitin sulphate, hyaluronate and some proteoglycan solutions. | Q52548586 | ||
| Fluorine-, pyrene-, and nitroxide-labeled sphingomyelin: semi-synthesis and thermotropic properties. | Q54081869 | ||
| Regulation of autoimmunity by proinflammatory cytokines | Q61628138 | ||
| Sphingomyelinase Induces Aggregation and Fusion, but Phospholipase A2Only Aggregation, of Low Density Lipoprotein (LDL) Particles | Q62023751 | ||
| Sphingomyelinase enhances low density lipoprotein uptake and ability to induce cholesteryl ester accumulation in macrophages | Q67803038 | ||
| Microelectrode studies on the acid microenvironment beneath adherent macrophages and osteoclasts*1 | Q68325243 | ||
| Magnesium, zinc, and manganese in atherosclerosis of the aorta | Q69136891 | ||
| A new Zn2+-stimulated sphingomyelinase in fetal bovine serum | Q69334524 | ||
| An enzymatic assay for available zinc in plasma and serum | Q70823223 | ||
| The sphingomyelin-ceramide signaling pathway is involved in oxidized low density lipoprotein-induced cell proliferation | Q71245739 | ||
| The role of inflammation in atherosclerosis | Q71874581 | ||
| Effect of the apolipoprotein A-I and surface lipid composition of reconstituted discoidal HDL on cholesterol efflux from cultured fibroblasts | Q71955424 | ||
| Captopril inhibits the 72 kDa and 92 kDa matrix metalloproteinases | Q72758247 | ||
| Lipoprotein lipase and sphingomyelinase synergistically enhance the association of atherogenic lipoproteins with smooth muscle cells and extracellular matrix. A possible mechanism for low density lipoprotein and lipoprotein(a) retention and macropha | Q72932323 | ||
| Sphingomyelinase, an enzyme implicated in atherogenesis, is present in atherosclerotic lesions and binds to specific components of the subendothelial extracellular matrix | Q73175616 | ||
| Cytokine activation of endothelial cells: new molecules for an old paradigm | Q73447474 | ||
| HDL phospholipid content and composition as a major factor determining cholesterol efflux capacity from Fu5AH cells to human serum | Q73965795 | ||
| Secretory sphingomyelinase, a product of the acid sphingomyelinase gene, can hydrolyze atherogenic lipoproteins at neutral pH. Implications for atherosclerotic lesion development | Q74105836 | ||
| Different effects of cell-permeable ceramide analogs on platelet activation | Q74472531 | ||
| Natural ceramide is unable to escape the lysosome, in contrast to a fluorescent analogue | Q74582933 | ||
| Apoptosis in the atherosclerotic plaque: quantitative and qualitative aspects | Q77380909 | ||
| The response-to-retention hypothesis of atherogenesis reinforced | Q77542561 | ||
| Prevalence and risk factors of carotid plaque in women with systemic lupus erythematosus | Q77909409 | ||
| Polymorphism of the lipopolysaccharide receptor (CD14) and myocardial infarction. New evidence for a role of gram-negative bacterial infection? | Q77933042 | ||
| P433 | issue | 15 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | systemic inflammation | Q7663815 |
| P304 | page(s) | 8681-8686 | |
| P577 | publication date | 2000-07-01 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | Acute systemic inflammation up-regulates secretory sphingomyelinase in vivo: a possible link between inflammatory cytokines and atherogenesis | |
| P478 | volume | 97 |
| Q44445903 | A single intravenous dose of endotoxin rapidly alters serum lipoproteins and lipid transfer proteins in normal volunteers |
| Q35172082 | Accelerated atherogenesis in autoimmune rheumatic diseases |
| Q37870853 | Acid sphingomyelinase in macrophage biology |
| Q30370837 | Acid sphingomyelinase is activated in sickle cell erythrocytes and contributes to inflammatory microparticle generation in SCD. |
| Q36924524 | Acid sphingomyelinase promotes lipoprotein retention within early atheromata and accelerates lesion progression |
| Q57780123 | Activity of Secretory Sphingomyelinase Is Increased in Plasma of Alcohol-Dependent Patients |
| Q45365704 | Adeno-associated virus-mediated expression of acid sphingomyelinase decreases atherosclerotic lesion formation in apolipoprotein E(-/-) mice |
| Q28299660 | Adenovirus-mediated overexpression of sphingomyelin synthases 1 and 2 increases the atherogenic potential in mice |
| Q44187580 | Alveolar sphingolipids generated in response to TNF-alpha modifies surfactant biophysical activity |
| Q35554200 | Autoantibodies and thrombophilia in RA: TNFalpha and TNFalpha blockers |
| Q39768734 | Boswellic acid inhibits expression of acid sphingomyelinase in intestinal cells |
| Q37529769 | Cardiovascular abnormalities in patients with major depressive disorder: autonomic mechanisms and implications for treatment. |
| Q34615917 | Caspase 1 deficiency reduces inflammation-induced brain transcription |
| Q37061677 | Ceramide activates JNK to inhibit a cAMP-gated K+ conductance and Cl- secretion in intestinal epithelia |
| Q37797406 | Ceramide in stress response |
| Q44754234 | Ceramide lances the lungs |
| Q47170906 | Dietary and Endogenous Sphingolipid Metabolism in Chronic Inflammation |
| Q54516280 | Elevation of ceramide in serum lipoproteins during acute phase response in humans and mice: role of serine–palmitoyl transferase |
| Q28195411 | Endothelial dysfunction: a comprehensive appraisal |
| Q42183157 | Endotoxin activates de novo sphingolipid biosynthesis via nuclear factor kappa B-mediated upregulation of Sptlc2. |
| Q28293977 | Evaluation of the role of secretory sphingomyelinase and bioactive sphingolipids as biomarkers in hemophagocytic lymphohistiocytosis |
| Q42243859 | Exogenous sphingomyelinase causes impaired intestinal epithelial barrier function |
| Q37259811 | Gastric bypass surgery reduces plasma ceramide subspecies and improves insulin sensitivity in severely obese patients |
| Q34028839 | Genetic alterations of IL-1 receptor antagonist in mice affect plasma cholesterol level and foam cell lesion size |
| Q30531999 | Hyperresponsiveness of mice deficient in plasma-secreted sphingomyelinase reveals its pivotal role in early phase of host response |
| Q40691781 | Inactivation of Kex2p diminishes the virulence of Candida albicans |
| Q42144566 | Inflammation Combined with Ischemia Produces Myelin Injury and Plaque-Like Aggregates of Myelin, Amyloid-β and AβPP in Adult Rat Brain |
| Q26852322 | Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogons |
| Q34243457 | Inhibition of endothelial lipase activity by sphingomyelin in the lipoproteins |
| Q35983863 | Involvement of ceramide in cell death responses in the pulmonary circulation |
| Q55374165 | Lipidomic analysis of plasma lipids composition changes in septic mice. |
| Q34439404 | Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets |
| Q44750370 | Modification of LDL with human secretory phospholipase A(2) or sphingomyelinase promotes its arachidonic acid-releasing propensity |
| Q51801646 | Modulation of the activity and arachidonic acid selectivity of group X secretory phospholipase A2 by sphingolipids. |
| Q41688477 | Muscle Weakness in Rheumatoid Arthritis: The Role of Ca2+ and Free Radical Signaling. |
| Q35915842 | Network Analysis of a Comprehensive Knowledge Repository Reveals a Dual Role for Ceramide in Alzheimer's Disease |
| Q36066471 | Neutral sphingomyelinase 2 is required for cytokine-induced skeletal muscle calpain activation |
| Q33879138 | Oxidized LDL: diversity, patterns of recognition, and pathophysiology |
| Q44712899 | PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide. |
| Q34227743 | Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability. |
| Q37066869 | Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance |
| Q38763707 | Platelet-derived sphingosine-1-phosphate and inflammation: from basic mechanisms to clinical implications |
| Q46580893 | Raised CRP levels in obese patients: symptoms of depression have an independent positive association. |
| Q34285232 | Regulated secretion of acid sphingomyelinase: implications for selectivity of ceramide formation. |
| Q34787157 | Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase |
| Q34745605 | Regulation of phosphatidic Acid metabolism by sphingolipids in the central nervous system |
| Q34576402 | Regulation of the activity and fatty acid specificity of lecithin-cholesterol acyltransferase by sphingomyelin and its metabolites, ceramide and ceramide phosphate |
| Q46908112 | Relationship between the lipidome, inflammatory markers and insulin resistance |
| Q35762383 | Role of sphingomyelin and ceramide in the regulation of the activity and fatty acid specificity of group V secretory phospholipase A2. |
| Q37454661 | Roles and regulation of secretory and lysosomal acid sphingomyelinase |
| Q47374235 | Sphingolipids and their metabolism in physiology and disease |
| Q44965785 | Sphingolipids in the lungs. |
| Q37862117 | Sphingolipids: agents provocateurs in the pathogenesis of insulin resistance |
| Q88638111 | Sphingomyelin encrypts tissue factor: ATP-induced activation of A-SMase leads to tissue factor decryption and microvesicle shedding |
| Q44071784 | Sphingomyelinase and ceramide analogs induce vasoconstriction and leukocyte-endothelial interactions in cerebral venules in the intact rat brain: Insight into mechanisms and possible relation to brain injury and stroke |
| Q35994710 | Sphingomyelinase depresses force and calcium sensitivity of the contractile apparatus in mouse diaphragm muscle fibers |
| Q34991932 | Sphingomyelinase promotes oxidant production and skeletal muscle contractile dysfunction through activation of NADPH oxidase |
| Q34149763 | Sphingomyelinase stimulates oxidant signaling to weaken skeletal muscle and promote fatigue |
| Q33792389 | Sphingomyelinases: their regulation and roles in cardiovascular pathophysiology |
| Q41570690 | Sphingosine-1-phosphate receptor-2 function in myeloid cells regulates vascular inflammation and atherosclerosis |
| Q33967033 | Studies on the role of acid sphingomyelinase and ceramide in the regulation of tumor necrosis factor alpha (TNFalpha)-converting enzyme activity and TNFalpha secretion in macrophages |
| Q36456040 | Temporal gene expression in the hippocampus and peripheral organs to endotoxin-induced systemic inflammatory response in caspase-1-deficient mice |
| Q108831791 | The acid sphingomyelinase/ceramide system in COVID-19 |
| Q41065534 | The role of sphingolipids and ceramide in pulmonary inflammation in cystic fibrosis |
| Q38071694 | The role of sphingolipids in drug metabolism and transport |
| Q37928817 | The role of sphingolipids in respiratory disease |
| Q57587430 | The source of dietary fatty acids alters the activity of secretory sphingomyelinase in the rat |
| Q36879383 | The unexpected role of acid sphingomyelinase in cell death and the pathophysiology of common diseases |
| Q40651360 | Uptake and metabolism of low density lipoproteins with elevated ceramide content by human microvascular endothelial cells: implications for the regulation of apoptosis |
| Q36711877 | mTor signaling in skeletal muscle during sepsis and inflammation: where does it all go wrong? |
| Q88792982 | nSMase2 (Type 2-Neutral Sphingomyelinase) Deficiency or Inhibition by GW4869 Reduces Inflammation and Atherosclerosis in Apoe-/- Mice |
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