Exogenous sphingomyelinase causes impaired intestinal epithelial barrier function

scientific article published on October 2007

Exogenous sphingomyelinase causes impaired intestinal epithelial barrier function is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3748/WJG.V13.I39.5217
P932PMC publication ID4171303
P698PubMed publication ID17876892
P5875ResearchGate publication ID5965922

P50authorGerhard RoglerQ64750687
P2093author name stringGerd Schmitz
Gerhard Liebisch
Jurgen Bock
Joachim Schweimer
P2860cites workRetarded release phosphatidylcholine benefits patients with chronic active ulcerative colitisQ24685584
Functional rafts in cell membranesQ27860768
Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapyQ28140319
Effect of an enteric-coated fish-oil preparation on relapses in Crohn's diseaseQ28278595
Structure and function of sphingolipid- and cholesterol-rich membrane raftsQ29618518
Defective TNF-alpha-mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout miceQ30881683
Sindbis virus entry into cells triggers apoptosis by activating sphingomyelinase, leading to the release of ceramideQ33807705
Acute systemic inflammation up-regulates secretory sphingomyelinase in vivo: a possible link between inflammatory cytokines and atherogenesisQ33909112
Intestinal permeability, leaky gut, and intestinal disordersQ34027859
Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeabilityQ34561438
Raft ceramide in molecular medicineQ35559152
Quantitative analysis of biological membrane lipids at the low picomole level by nano-electrospray ionization tandem mass spectrometryQ36040256
Cytokines and growth factor modulators in intestinal inflammation and repairQ36043676
The cellular trafficking and zinc dependence of secretory and lysosomal sphingomyelinase, two products of the acid sphingomyelinase geneQ38335637
Rhinoviruses infect human epithelial cells via ceramide-enriched membrane platformsQ40423823
Depletion of Caco-2 cell cholesterol disrupts barrier function by altering the detergent solubility and distribution of specific tight-junction proteinsQ40500818
Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanismsQ40614064
The lipids C2- and C16-ceramide form large stable channels. Implications for apoptosisQ40649042
Inhibitors of glycosphingolipid biosynthesis reduce transepithelial electrical resistance in MDCK I and FRT cellsQ40682472
Acid sphingomyelinase is involved in CEACAM receptor-mediated phagocytosis of Neisseria gonorrhoeaeQ40863681
Tight junctions are membrane microdomainsQ40886204
Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiationQ41700006
Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis.Q42555356
Membrane restructuring via ceramide results in enhanced solute effluxQ43858126
High-throughput quantification of lysophosphatidylcholine by electrospray ionization tandem mass spectrometry.Q44225943
Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane raftsQ44300453
Effect of gamma-linolenic acid or docosahexaenoic acid on tight junction permeability in intestinal monolayer cells and their mechanism by protein kinase C activation and/or eicosanoid formationQ44319330
Acidic sphingomyelinase mediates entry of N. gonorrhoeae into nonphagocytic cellsQ44539962
Ceramide selectively displaces cholesterol from ordered lipid domains (rafts): implications for lipid raft structure and functionQ44709173
PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide.Q44712899
High-throughput quantification of phosphatidylcholine and sphingomyelin by electrospray ionization tandem mass spectrometry coupled with isotope correction algorithmQ45136777
High throughput quantification of cholesterol and cholesteryl ester by electrospray ionization tandem mass spectrometry (ESI-MS/MS).Q46928125
Pivotal role for acidic sphingomyelinase in cerebral ischemia-induced ceramide and cytokine production, and neuronal apoptosis.Q48970037
Ceramide enables fas to cap and kill.Q52542714
Polyunsaturated fatty acids reduce non-receptor-mediated transcellular permeation of protein across a model of intestinal epithelium in vitro.Q54042664
Therapeutic efficacy of N-3 polyunsaturated fatty acid in experimental Crohn's disease.Q54446964
Observation of Topical Catalysis by Sphingomyelinase Coupled To MicrospheresQ57365739
CD95 Signaling via Ceramide-rich Membrane RaftsQ57371964
Quantitative measurement of different ceramide species from crude cellular extracts by electrospray ionization tandem mass spectrometry (ESI-MS/MS)Q61863054
TNF activates NF-kappa B by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdownQ67505708
Different effects of enzyme-generated ceramides and diacylglycerols in phospholipid membrane fusion and leakageQ71742617
Tumor response to radiotherapy regulated by endothelial cell apoptosisQ73401346
Ceramide-rich membrane rafts mediate CD40 clusteringQ77373931
Sphingomyelinase induces lipid microdomain formation in a fluid phosphatidylcholine/sphingomyelin membraneQ77710438
P433issue39
P407language of work or nameEnglishQ1860
P304page(s)5217-5225
P577publication date2007-10-01
P1433published inWorld Journal of GastroenterologyQ15708885
P1476titleExogenous sphingomyelinase causes impaired intestinal epithelial barrier function
P478volume13

Reverse relations

cites work (P2860)
Q47157018Ablation of ceramide synthase 2 exacerbates dextran sodium sulphate-induced colitis in mice due to increased intestinal permeability.
Q39768734Boswellic acid inhibits expression of acid sphingomyelinase in intestinal cells
Q21131205Central role of the gut epithelial barrier in the pathogenesis of chronic intestinal inflammation: lessons learned from animal models and human genetics
Q34874519Expression of alkaline sphingomyelinase in yeast cells and anti-inflammatory effects of the expressed enzyme in a rat colitis model
Q26765948Fostering Inflammatory Bowel Disease: Sphingolipid Strategies to Join Forces
Q91639020Intestinal Acid Sphingomyelinase Protects From Severe Pathogen-Driven Colitis
Q43614631Intestinal barrier function is modulated by short-term exposure to fumonisin B₁ in Ussing chambers
Q33507287Lipid alterations in experimental murine colitis: role of ceramide and imipramine for matrix metalloproteinase-1 expression
Q42971462Metabolism, physiological role, and clinical implications of sphingolipids in gastrointestinal tract.
Q37980790Perspectives on immunomodulation early in life.
Q37852814Physiological functions and clinical implications of sphingolipids in the gut.
Q91810355Role of Ceramidases in Sphingolipid Metabolism and Human Diseases
Q50130199Sphingolipid de novo biosynthesis is essential for intestine cell survival and barrier function.
Q28073700Sphingolipids as Mediators in the Crosstalk between Microbiota and Intestinal Cells: Implications for Inflammatory Bowel Disease
Q40104108The Role of Sphingolipids on Innate Immunity to Intestinal Salmonella Infection.
Q54314252Ursolic acid inhibits acid sphingomyelinase in intestinal cells.

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