Acid sphingomyelinase promotes endothelial stress response in systemic inflammation and sepsis

scientific article published on 15 June 2016

Acid sphingomyelinase promotes endothelial stress response in systemic inflammation and sepsis is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1068965860
P356DOI10.2119/MOLMED.2016.00140
P932PMC publication ID5072414
P698PubMed publication ID27341515

P2093author name stringMarkus H Gräler
Hans-Peter Deigner
Clemens L Bockmeyer
Ralf A Claus
Gordon P Otto
Alexander C Bunck
Ha-Yeun Chung
Daniel C Hupe
Marcel Sprenger
Michael J Dorer
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Transformation-associated changes in sphingolipid metabolism sensitize cells to lysosomal cell death induced by inhibitors of acid sphingomyelinaseQ39096709
Acid sphingomyelinase is required for lipid Raft TLR4 complex formationQ40155108
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Ebolavirus requires acid sphingomyelinase activity and plasma membrane sphingomyelin for infectionQ40287482
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Fluorescent, short-chain C6-NBD-sphingomyelin, but not C6-NBD-glucosylceramide, is subject to extensive degradation in the plasma membrane: implications for signal transduction related to cell differentiationQ41317620
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GM1 and GD1a gangliosides modulate toxic and inflammatory effects of E. coli lipopolysaccharide by preventing TLR4 translocation into lipid rafts.Q46799613
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The next generation of sepsis clinical trial designs: what is next after the demise of recombinant human activated protein C?*.Q34057044
Acidic sphingomyelinase controls hepatic stellate cell activation and in vivo liver fibrogenesisQ34086900
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Acid sphingomyelinase serum activity predicts mortality in intensive care unit patients after systemic inflammation: a prospective cohort studyQ34482934
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Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppressionQ34682367
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The unexpected role of acid sphingomyelinase in cell death and the pathophysiology of common diseasesQ36879383
Inflammation, endothelium, and coagulation in sepsisQ37011058
Phosphotyrosine protein dynamics in cell membrane rafts of sphingosine-1-phosphate-stimulated human endothelium: role in barrier enhancementQ37134785
ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading.Q37188851
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P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
systemic inflammationQ7663815
P577publication date2016-06-15
P1433published inMolecular MedicineQ6895961
P1476titleAcid sphingomyelinase promotes endothelial stress response in systemic inflammation and sepsis
P478volume22

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cites work (P2860)
Q41993606Acid Sphingomyelinase Inhibition Prevents Development of Sepsis Sequelae in the Murine Liver
Q57463140Acid Sphingomyelinase Inhibition Stabilizes Hepatic Ceramide Content and Improves Hepatic Biotransformation Capacity in a Murine Model of Polymicrobial Sepsis
Q33624807Adjustment of Dysregulated Ceramide Metabolism in a Murine Model of Sepsis-Induced Cardiac Dysfunction
Q90198960Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitro
Q59353222Inflammatory cytokine expression in patients with sepsis at an intensive care unit

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