Adjustment of Dysregulated Ceramide Metabolism in a Murine Model of Sepsis-Induced Cardiac Dysfunction

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Adjustment of Dysregulated Ceramide Metabolism in a Murine Model of Sepsis-Induced Cardiac Dysfunction is …
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scholarly articleQ13442814

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P356DOI10.3390/IJMS18040839
P932PMC publication ID5412423
P698PubMed publication ID28420138

P50authorAmelie LuppQ88477487
P2093author name stringMatthias Kohl
Sebastian N Stehr
Markus H Gräler
Ralf A Claus
Andrea Schrepper
Ha-Yeun Chung
Anna S Kollmey
Markus F Bläss
P2860cites workAcid sphingomyelinase deficient mice: a model of types A and B Niemann–Pick diseaseQ24337312
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)Q26768286
Tissue sulfhydryl groupsQ26778486
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Liver dysfunction and phosphatidylinositol-3-kinase signalling in early sepsis: experimental studies in rodent models of peritonitisQ27307089
Exogenous and endogenous ceramides elicit volume-sensitive chloride current in ventricular myocytesQ30493572
Hyperresponsiveness of mice deficient in plasma-secreted sphingomyelinase reveals its pivotal role in early phase of host responseQ30531999
Defective TNF-alpha-mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout miceQ30881683
Natural ceramide reverses Fas resistance of acid sphingomyelinase(-/-) hepatocytes.Q31629166
Involvement of caspase 3- and 8-like proteases in ceramide-induced apoptosis of cardiomyocytesQ33181090
Role of increased sphingomyelinase activity in apoptosis and organ failure of patients with severe sepsisQ33341419
Efficacy of transthoracic echocardiography for diagnosing heart failure in septic shockQ33654283
Calcium and mitochondrial metabolism in ceramide-induced cardiomyocyte death.Q33986280
Ceramide as a second messenger: sticky solutions to sticky problemsQ34040269
Acidic sphingomyelinase controls hepatic stellate cell activation and in vivo liver fibrogenesisQ34086900
Functional Inhibitors of Acid Sphingomyelinase (FIASMAs): a novel pharmacological group of drugs with broad clinical applicationsQ34117398
Acid sphingomyelinase serum activity predicts mortality in intensive care unit patients after systemic inflammation: a prospective cohort studyQ34482934
Ceramide: second messenger or modulator of membrane structure and dynamics?Q34984863
Acid sphingomyelinase inhibitors normalize pulmonary ceramide and inflammation in cystic fibrosisQ34994393
Ceramide in apoptosis: an overview and current perspectivesQ35047136
Alternative splicing of SMPD1 in human sepsisQ35515785
Acid sphingomyelinase inhibition protects mice from lung edema and lethal Staphylococcus aureus sepsisQ35607603
Raft Domain Reorganization Driven by Short- and Long-Chain Ceramide: A Combined AFM and FCS StudyQ57366647
A fluorometric method for determination of oxidized and reduced glutathione in tissuesQ67805316
Central sympathoinhibition and peripheral neuronal uptake blockade after desipramine in rabbitsQ68295456
Cardiac troponins I and T are biological markers of left ventricular dysfunction in septic shockQ73742930
Alterations by norepinephrine of cardiac sympathetic nerve terminal function and myocardial beta-adrenergic receptor sensitivity in the ferret: normalization by antioxidant vitaminsQ73954439
Quantification of sphingosine-1-phosphate and related sphingolipids by liquid chromatography coupled to tandem mass spectrometryQ83974262
Characteristics of clinical sepsis reflected in a reliable and reproducible rodent sepsis modelQ84518230
Ceramide-mediated depression in cardiomyocyte contractility through PKC activation and modulation of myofilament protein phosphorylationQ35634087
Diastolic dysfunction and mortality in severe sepsis and septic shockQ35937776
Ceramide-enriched membrane domainsQ36286893
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Ceramide is a cardiotoxin in lipotoxic cardiomyopathyQ36870574
The unexpected role of acid sphingomyelinase in cell death and the pathophysiology of common diseasesQ36879383
Erythropoietin attenuates cardiac dysfunction in experimental sepsis in mice via activation of the β-common receptorQ36981847
Incidence, organ dysfunction and mortality in severe sepsis: a Spanish multicentre study.Q37106056
Inhibition of sphingomyelin hydrolysis: targeting the lipid mediator ceramide as a key regulator of cellular fateQ37515719
Cardiac dysfunction in severe sepsis and septic shockQ37562775
Sepsis in old age: review of human and animal studiesQ37665355
Ceramide in Pseudomonas aeruginosa infections and cystic fibrosisQ37760688
Ceramide: a simple sphingolipid with unique biophysical propertiesQ38186915
Correlation of left ventricular systolic dysfunction determined by low ejection fraction and 30-day mortality in patients with severe sepsis and septic shock: a systematic review and meta-analysisQ38205576
Myocardial depression in sepsis: from pathogenesis to clinical manifestations and treatmentQ38209176
The prognostic significance of troponin elevation in patients with sepsis: a meta-analysisQ38277127
Presynaptic Alpha-Receptor Subsensitivity After Long-Term Antidepressant TreatmentQ40174097
New insights on the use of desipramine as an inhibitor for acid ceramidaseQ40244998
Acid sphingomyelinase promotes endothelial stress response in systemic inflammation and sepsisQ40637739
Functions of ceramide in coordinating cellular responses to stressQ41243489
Secretory sphingomyelinase is upregulated in chronic heart failure: a second messenger system of immune activation relates to body composition, muscular functional capacity, and peripheral blood flowQ42165275
The challenge to verify ceramide's role of apoptosis induction in human cardiomyocytes--a pilot studyQ42213402
Sterol affinity for bilayer membranes is affected by their ceramide content and the ceramide chain lengthQ43203609
Decreased rates of substrate oxidation ex vivo predict the onset of heart failure and contractile dysfunction in rats with pressure overloadQ43207763
Brain natriuretic peptide: A marker of myocardial dysfunction and prognosis during severe sepsisQ43707142
Identification of a novel role for sphingolipid signaling in TNF alpha and ischemic preconditioning mediated cardioprotectionQ44022447
Differential pre- and postsynaptic effects of desipramine on cardiac sympathetic nerve terminals in RHF.Q44182994
Profound but reversible myocardial depression in patients with septic shockQ44250178
Desipramine attenuates loss of cardiac sympathetic neurotransmitters produced by congestive heart failure and NE infusion.Q44288602
Plasma brain natriuretic peptide and troponin levels in severe sepsis and septic shock: relationships with systolic myocardial dysfunction and intensive care unit mortalityQ44691609
Role of ceramide in ischemic preconditioningQ44864169
Cardiac troponin I predicts myocardial dysfunction and adverse outcome in septic shockQ44907506
Volume-sensitive chloride channels (ICl,vol) mediate doxorubicin-induced apoptosis through apoptotic volume decrease in cardiomyocytesQ45105221
Inhibition of ceramide de novo synthesis as a postischemic strategy to reduce myocardial reperfusion injury.Q46608425
Ceramide-induced preconditioning involves reactive oxygen speciesQ46722860
Cardiac sympathetic neuroprotective effect of desipramine in tachycardia-induced cardiomyopathy.Q46743951
Role of lipid rafts in ceramide and nitric oxide signaling in the ischemic and preconditioned heartsQ46842891
Inhibition of Acid Sphingomyelinase by Antidepressants Counteracts Stress-Induced Activation of P38-Kinase in Major DepressionQ47587515
Analysis of the lung pathology and alveolar macrophage function in the acid sphingomyelinase--deficient mouse model of Niemann-Pick diseaseQ49240068
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectsepsisQ183134
ceramidesQ424213
murine modelQ122890741
P577publication date2017-04-15
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titleAdjustment of Dysregulated Ceramide Metabolism in a Murine Model of Sepsis-Induced Cardiac Dysfunction
P478volume18

Reverse relations

cites work (P2860)
Q41993606Acid Sphingomyelinase Inhibition Prevents Development of Sepsis Sequelae in the Murine Liver
Q57463140Acid Sphingomyelinase Inhibition Stabilizes Hepatic Ceramide Content and Improves Hepatic Biotransformation Capacity in a Murine Model of Polymicrobial Sepsis
Q92889801Effect of sepsis on the action potential and cardiac serotonin response in rats
Q89304884MiR-146b protect against sepsis induced mice myocardial injury through inhibition of Notch1
Q57491817γ-glutamylcysteine exhibits anti-inflammatory effects by increasing cellular glutathione level

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