Acid Sphingomyelinase Inhibition Stabilizes Hepatic Ceramide Content and Improves Hepatic Biotransformation Capacity in a Murine Model of Polymicrobial Sepsis

scientific article published on 15 October 2018

Acid Sphingomyelinase Inhibition Stabilizes Hepatic Ceramide Content and Improves Hepatic Biotransformation Capacity in a Murine Model of Polymicrobial Sepsis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3390/IJMS19103163
P932PMC publication ID6214114
P698PubMed publication ID30326559

P50authorAmelie LuppQ88477487
Markus H GrälerQ90287179
P2093author name stringRalf A Claus
Ha-Yeun Chung
Jorge Hurtado-Oliveros
C Julius Witt
Jonathan Wickel
P2860cites workIdentification of novel functional inhibitors of acid sphingomyelinaseQ21003953
Human recombinant protein C for severe sepsis and septic shock in adult and paediatric patientsQ24202128
Acid sphingomyelinase deficient mice: a model of types A and B Niemann–Pick diseaseQ24337312
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Acid sphingomyelinase serum activity predicts mortality in intensive care unit patients after systemic inflammation: a prospective cohort studyQ34482934
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Acid sphingomyelinase promotes endothelial stress response in systemic inflammation and sepsisQ40637739
ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitisQ41921041
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Sterol affinity for bilayer membranes is affected by their ceramide content and the ceramide chain lengthQ43203609
PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide.Q44712899
Cytochrome P-450 activity is differentially altered in severely injured patientsQ45309305
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Differential effects of cytokines on the inducible expression of CYP1A1, CYP1A2, and CYP3A4 in human hepatocytes in primary cultureQ71739388
Regulation of cytochrome P450 2C11 (CYP2C11) gene expression by interleukin-1, sphingomyelin hydrolysis, and ceramides in rat hepatocytesQ71743477
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The cytochrome P450 suicide inhibitor, 1-aminobenzotriazole, sensitizes rats to zymosan-induced toxicityQ77910282
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P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectsepsisQ183134
ceramidesQ424213
murine modelQ122890741
P577publication date2018-10-15
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titleAcid Sphingomyelinase Inhibition Stabilizes Hepatic Ceramide Content and Improves Hepatic Biotransformation Capacity in a Murine Model of Polymicrobial Sepsis
P478volume19

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cites work (P2860)
Q89635635Cathelicidin preserves intestinal barrier function in polymicrobial sepsis
Q92191089Glycosphingolipids and Infection. Potential New Therapeutic Avenues

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