| scholarly article | Q13442814 |
| P2093 | author name string | S I Shedlofsky | |
| R A Blouin | |||
| C J McClain | |||
| D B Hill | |||
| B C Israel | |||
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| A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock | Q40793728 | ||
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| Induction of tolerance in mice and rats to the effect of endotoxin to decrease the hepatic microsomal mixed-function oxidase system. Evidence for a possible macrophage-derived factor in the endotoxin effect | Q69804567 | ||
| Cytokine appearance in human endotoxemia and primate bacteremia | Q70371866 | ||
| Potentiation and suppression of mouse liver cytochrome P-450 isozymes during the acute-phase response induced by bacterial endotoxin | Q70389082 | ||
| Endotoxin depression of hepatic mixed function oxidase system in C3H/HeJ and C3H/HeN mice | Q71478603 | ||
| Cigarette smoking and drug metabolism | Q71662498 | ||
| P433 | issue | 6 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | endotoxins | Q319997 |
| P304 | page(s) | 2209-2214 | |
| P577 | publication date | 1994-12-01 | |
| P1433 | published in | Journal of Clinical Investigation | Q3186904 |
| P1476 | title | Endotoxin administration to humans inhibits hepatic cytochrome P450-mediated drug metabolism | |
| P478 | volume | 94 |
| Q35640730 | "Cocktail" approaches and strategies in drug development: valuable tool or flawed science? |
| Q36055154 | A discordance of the cytochrome P450 2C19 genotype and phenotype in patients with advanced cancer |
| Q57463140 | Acid Sphingomyelinase Inhibition Stabilizes Hepatic Ceramide Content and Improves Hepatic Biotransformation Capacity in a Murine Model of Polymicrobial Sepsis |
| Q38627857 | Age-Related Changes in Hepatic Function: An Update on Implications for Drug Therapy. |
| Q34578555 | Alteration of drug biotransformation and elimination during infection and inflammation |
| Q36110529 | CYP3A-dependent drug metabolism is reduced in bacterial inflammation in mice |
| Q42015969 | Carvacrol ameliorates the PPAR-A and cytochrome P450 expression on D-galactosamine induced hepatotoxicity rats |
| Q28566231 | Cellular localization of hepatic cytochrome 1B1 expression and its regulation by aromatic hydrocarbons and inflammatory cytokines |
| Q40255963 | Comparative pharmacokinetic study of chlorogenic acid after oral administration of Lonicerae Japonicae Flos and Shuang-Huang-Lian in normal and febrile rats |
| Q44405540 | Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure |
| Q40619065 | Cytokines Alter the Expression and Activity of the Multidrug Resistance Transporters in Human Hepatoma Cell Lines; Analysis Using RT‐PCR and cDNA Microarrays |
| Q39472190 | Decreased antipyrine clearance following endotoxin administration: in vivo evidence of the role of nitric oxide. |
| Q23921829 | Depression of constitutive murine cytochromes P450 by Staphylococcal enterotoxin B |
| Q43842168 | Depression of the hepatic cytochrome P450 by an acute inflammatory reaction: characterization of the nature of mediators in human and rabbit serum, and in the liver |
| Q39048274 | Development of a Physiologically Based Pharmacokinetic Modelling Approach to Predict the Pharmacokinetics of Vancomycin in Critically Ill Septic Patients |
| Q78555434 | Down-regulation of phenobarbital-induced cytochrome P4502B mRNAs and proteins by endotoxin in mice: independence from nitric oxide production by inducible nitric oxide synthase |
| Q36608759 | Downregulation of drug transport and metabolism in mice bearing extra-hepatic malignancies |
| Q38107537 | Drug absorption, distribution, metabolism and excretion considerations in critically ill adults |
| Q38022659 | Drug disposition in pathophysiological conditions |
| Q37120909 | Drug metabolism alterations in nonalcoholic fatty liver disease |
| Q104072363 | Drug-drug interaction (DDI) with direct oral anticoagulant (DOAC) in patients with cancer |
| Q51644111 | Effect of Influenza Immunization on CYP3A4 Activity In Vivo |
| Q45973145 | Effect of SPG/indomethacin treatment on sepsis, interleukin-6 production, and expression of hepatic cytochrome P450 isoforms in differing strains of mice. |
| Q39062280 | Effect of active infection on cytochrome P450-mediated metabolism of cyclosporine in renal transplant patients. |
| Q54516280 | Elevation of ceramide in serum lipoproteins during acute phase response in humans and mice: role of serine–palmitoyl transferase |
| Q40755393 | Endotoxin-Mediated Downregulation of Hepatic Drug Transporters in HIV-1 Transgenic Rats. |
| Q73075532 | Extrahepatic ischemia-reperfusion injury reduces hepatic oxidative drug metabolism as determined by serial antipyrine clearance |
| Q42528104 | Gamma-tocopherol supplementation inhibits protein nitration and ascorbate oxidation in rats with inflammation |
| Q39558494 | Granulocyte colony-stimulating factor enhances endotoxin-induced decrease in biliary excretion of the antibiotic cefoperazone in rats. |
| Q35576362 | Hepatic (dys-)function during inflammation |
| Q51573118 | Hepatitis A impairs the function of human hepatic CYP2A6 in vivo. |
| Q40625170 | Higher incidence of elevated body temperature or increased C-reactive protein level in asthmatic children showing transient reduction of theophylline metabolism |
| Q77598597 | Identification of glutathione S-transferase isozymes and gamma-glutamylcysteine synthetase as negative acute-phase proteins in rat liver |
| Q35749503 | Immunological response as a source to variability in drug metabolism and transport |
| Q38634986 | Impact of physiological, pathological and environmental factors on the expression and activity of human cytochrome P450 2D6 and implications in precision medicine |
| Q43817660 | Impairment of cytochrome P-450-dependent liver activity in cirrhotic patients with Helicobacter pylori infection |
| Q37964754 | Inflammation-mediated changes in drug transporter expression/activity: implications for therapeutic drug response |
| Q35101739 | Inflammatory response: an unrecognised source of variability in the pharmacokinetics and pharmacodynamics of cancer chemotherapy |
| Q54319285 | Influence of capsaicin on fluctuation of digoxin pharmacokinetics in lipopolysaccharide-treated rats. |
| Q42457026 | Influence of sepsis on the plasma elimination pharmacokinetics of diaspirin crosslinked hemoglobin in rats |
| Q73072258 | Intrahepatic cholestasis of pregnancy impairs the activities of human placental xenobiotic and steroid metabolizing enzymes in vitro |
| Q37592262 | Long-term virus-induced alterations of CYP3A-mediated drug metabolism: a look at the virology, immunology and molecular biology of a multi-faceted problem |
| Q37799374 | Mechanisms of Monoclonal Antibody–Drug Interactions |
| Q71850710 | Minimal effect of acute experimental hepatitis induced by lipopolysaccharide/D-galactosamine on biotransformation in rats |
| Q64907557 | Modulation of CYP450 activities in patients with type 2 diabetes. |
| Q33783266 | Oncostatin M: signal transduction and biological activity |
| Q73942687 | Oral lichen planus and intake of drugs metabolized by polymorphic cytochrome P450 enzymes |
| Q33781271 | Pharmacogenetics of cytochromes P450. |
| Q34983258 | Pharmacokinetic and pharmacodynamic considerations when treating patients with sepsis and septic shock |
| Q36146910 | Pharmacokinetic variability of anticancer agents |
| Q35622678 | Pharmacologic issues in the critically ill. |
| Q35140259 | Progress in clinical neurosciences: sepsis-associated encephalopathy: evolving concepts |
| Q37121662 | Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. |
| Q91812150 | Recent advances in the treatment and prevention of venous thromboembolism in cancer patients: role of the direct oral anticoagulants and their unique challenges |
| Q41676809 | Regulation of cytochromes P450 during inflammation and infection. |
| Q36544874 | Regulation of drug metabolism and disposition during inflammation and infection |
| Q36233963 | Relationship of ketamine's plasma metabolites with response, diagnosis, and side effects in major depression |
| Q36593723 | Roles of nitric oxide in inflammatory downregulation of human cytochromes P450. |
| Q43641556 | Scavenging nitric oxide reduces hepatocellular injury after endotoxin challenge |
| Q49167766 | Stereoselective pharmacokinetics of oxprenolol, propranolol, and verapamil: species differences and influence of endotoxin |
| Q34100796 | TLR4-dependent and -independent regulation of hepatic cytochrome P450 in mice with chemically induced inflammatory bowel disease |
| Q51141028 | The Obesogenic Potency of Various High-Caloric Diet Compositions in Male Rats, and Their Effects on Expression of Liver and Kidney Proteins Involved in Drug Elimination. |
| Q92811652 | The Role of CYP450 Drug Metabolism in Precision Cardio-Oncology |
| Q38294979 | The effect of endotoxin on hepatocyte nuclear factor 1 nuclear protein binding: potential implications on CYP2E1 expression in the rat. |
| Q38331844 | The effect of high dose endotoxin on CYP3A2 expression in the rat. |
| Q54538444 | The effect of sepsis during parenteral nutrition on hepatic microsomal function in rats. |
| Q38045375 | The effects of gastric bypass surgery on drug absorption and pharmacokinetics |
| Q40876187 | The expression and regulation of drug metabolism in human placenta |
| Q37222966 | The potential role of transcription factor aryl hydrocarbon receptor in downregulation of hepatic cytochrome P-450 during sepsis. |
| Q37633942 | The role of hepatic cytochrome P-450 in sepsis |
| Q44073765 | The temporal relationship between bacterial lipopolysaccharide and monocrotaline exposures influences toxicity: shift in response from hepatotoxicity to nitric oxide-dependent lethality |
| Q42647526 | Time-variant increase in methylprednisolone clearance in patients with acute respiratory distress syndrome: a population pharmacokinetic study |
| Q34036192 | Tocopherol induced angiogenesis in placental vascular network in late pregnant ewes |
| Q44574549 | Toxic rise of clozapine plasma concentrations in relation to inflammation |
| Q36788414 | Toxicity as a result of immunostimulation by biologics |
| Q38390695 | Understanding Disease-Drug Interactions in Cancer Patients: Implications for Dosing Within the Therapeutic Window |
| Q73846452 | Validation of the five-drug "Pittsburgh cocktail" approach for assessment of selective regulation of drug-metabolizing enzymes |
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