Nuclear sphingolipid metabolism

scientific article published on 09 September 2011

Nuclear sphingolipid metabolism is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1146/ANNUREV-PHYSIOL-020911-153321
P932PMC publication ID3981831
P698PubMed publication ID21888508
P5875ResearchGate publication ID51611287

P2093author name stringMarion B Sewer
Natasha C Lucki
P2860cites workStructure and Function in the NucleusQ22065563
Molecular cloning and characterization of a human mitochondrial ceramidaseQ22253989
Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHPQ24295257
Substrate specificity, membrane topology, and activity regulation of human alkaline ceramidase 2 (ACER2)Q24296689
Diacylglycerol kinase-theta is localized in the speckle domains of the nucleusQ24304343
Subcellular localization of ceramide kinase and ceramide kinase-like protein requires interplay of their Pleckstrin Homology domain-containing N-terminal regions together with C-terminal domainsQ24317774
The SPTLC3 subunit of serine palmitoyltransferase generates short chain sphingoid basesQ24319169
Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificitiesQ24321982
Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17Q24323350
Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processingQ24337103
Phosphorylation of nuclear phospholipase C beta1 by extracellular signal-regulated kinase mediates the mitogenic action of insulin-like growth factor IQ24550973
An Overview of Sphingolipid Metabolism: From Synthesis to BreakdownQ24628769
Mammalian ceramide synthasesQ24633453
Ceramide forms channels in mitochondrial outer membranes at physiologically relevant concentrationsQ24646262
Phosphoinositide signaling pathways in nuclei are associated with nuclear speckles containing pre-mRNA processing factorsQ24652341
Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphateQ24653552
Overexpression of acid ceramidase protects from tumor necrosis factor-induced cell deathQ24676003
Structure of SF-1 Bound by Different Phospholipids: Evidence for Regulatory LigandsQ27652795
Nuclear diacylglycerol kinase-theta is activated in response to alpha-thrombinQ28119170
Sphingomyelin synthase in rat liver nuclear membrane and chromatinQ28146124
Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid releaseQ28186552
Principles of bioactive lipid signalling: lessons from sphingolipidsQ28265743
Protein kinase C regulates the nuclear localization of diacylglycerol kinase-zetaQ28280588
Dihydroceramide hinders ceramide channel formation: Implications on apoptosisQ28301592
Translational aspects of sphingolipid metabolismQ28307405
Subcellular organelle lipidomics in TLR-4-activated macrophagesQ28397617
Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathwayQ28510620
A genetic model of substrate deprivation therapy for a glycosphingolipid storage disorderQ28511052
Nuclear diacylglycerol kinase-theta is activated in response to nerve growth factor stimulation of PC12 cellsQ28570852
Ceramide 1-phosphate is required for the translocation of group IVA cytosolic phospholipase A2 and prostaglandin synthesisQ30492050
Biodiversity of sphingoid bases ("sphingosines") and related amino alcoholsQ30843994
Sphingoid bases and de novo ceramide synthesis: enzymes involved, pharmacology and mechanisms of actionQ30912127
Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathwaysQ33552843
Nuclear phosphoinositides: a signaling enigma wrapped in a compartmental conundrum.Q33636764
Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.Q33773569
Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2.Q33796082
Phospholipid interactions in rat liver nuclear matrixQ72619556
Effect of phospholipid vesicles on endogenous RNA polymerase activity of isolated rat liver nucleiQ72645750
Role of chromatin phospholipids on template availability and ultrastructure of isolated nucleiQ72675292
Protein kinase C substrates and ganglioside inhibitors in bovine mammary nucleiQ72680866
Nuclear ADP-ribosylation factor (ARF)- and oleate-dependent phospholipase D (PLD) in rat liver cells. Increases of ARF-dependent PLD activity in regenerating liver cellsQ73067644
Chromatin neutral sphingomyelinase and its role in hepatic regenerationQ73510942
Beta-amyloid-induced synthesis of the ganglioside GD3 is a requisite for cell cycle reactivation and apoptosis in neuronsQ74130806
Nuclear sphingomyelin protects RNA from RNase actionQ77135182
Distribution of gangliosides among subcellular fractions from rat liver and bovine mammary glandQ77920024
A possible role of nuclear ceramide and sphingosine in hepatocyte apoptosis in rat liverQ78053115
Ceramide regulation of nuclear protein importQ80209196
Crystallographic identification and functional characterization of phospholipids as ligands for the orphan nuclear receptor steroidogenic factor-1Q81420599
Apoptosis induced clustering of IP(3)R1 in nuclei of non-differentiated PC12 cellsQ83388036
Ceramide N-acyl chain length: a determinant of bidimensional transitions, condensed domain morphology, and interfacial thicknessQ83485355
Coordinated chromatin control: structural and functional linkage of DNA and histone methylationQ33802703
Integration of lipidomics and transcriptomics data towards a systems biology model of sphingolipid metabolismQ33814929
The crystal structures of human steroidogenic factor-1 and liver receptor homologue-1.Q33836243
Sodium-calcium exchange: a molecular perspectiveQ33938688
Nuclear envelope signaling-role of phospholipid metabolism.Q33951078
Ceramide synthases: roles in cell physiology and signalingQ34141622
Extracellular and Intracellular Actions of Sphingosine-1-PhosphateQ34183703
Nuclear phospholipase C and signalingQ34244229
Membranes in balance: mechanisms of sphingolipid homeostasisQ34330398
Subcellular localization of human neutral ceramidase expressed in HEK293 cellsQ34413039
Developmentally regulated ceramide synthase 6 increases mitochondrial Ca2+ loading capacity and promotes apoptosisQ34575828
Functions of the multifaceted family of sphingosine kinases and some close relativesQ34585774
"Inside-out" signaling of sphingosine-1-phosphate: therapeutic targetsQ34593159
Cerebellar neurons lacking complex gangliosides degenerate in the presence of depolarizing levels of potassiumQ34595643
Steroidogenic factor 1: an essential mediator of endocrine developmentQ34643951
Visualization of ceramide channels by transmission electron microscopyQ34709260
Nuclear lipid metabolism and signalingQ34720510
Diacylglycerol kinases in nuclear lipid-dependent signal transduction pathwaysQ34836492
Ceramide synthase-dependent ceramide generation and programmed cell death: involvement of salvage pathway in regulating postmitochondrial eventsQ34963246
New advances on structural and biological functions of ceramide in apoptotic/necrotic cell death and cancerQ34975049
Overexpression of the wild-type SPT1 subunit lowers desoxysphingolipid levels and rescues the phenotype of HSAN1Q35013547
Ceramide in apoptosis: an overview and current perspectivesQ35047136
Nuclear lipid signallingQ35120151
ACTH modulation of transcription factors responsible for steroid hydroxylase gene expression in the adrenal cortexQ35136737
Mice lacking major brain gangliosides develop parkinsonismQ35161290
Nuclear inositides: facts and perspectivesQ35632067
Metabolism and signaling activities of nuclear lipidsQ35772232
The role of intranuclear lipids.Q35935663
Phospholipase D2-dependent inhibition of the nuclear hormone receptor PPARgamma by cyclic phosphatidic acidQ36246883
Signaling and interplay mediated by phospholipases A2, C, and D in LA-N-1 cell nucleiQ36269722
Ceramide-enriched membrane domainsQ36286893
Gangliosides of the nuclear membrane: a crucial locus of cytoprotective modulationQ36366607
The sphingosine and diacylglycerol kinase superfamily of signaling kinases: localization as a key to signaling functionQ36415172
Nuclear protein kinase C.Q36436155
Ceramide involvement in apoptosis and apoptotic diseases.Q36513216
Sphingolipids of the nucleus and their role in nuclear signalingQ36524697
Complications, urinary continence, and oncologic outcome of 1000 laparoscopic transperitoneal radical prostatectomies-experience at the Charité Hospital Berlin, Campus Mitte.Q36538623
Nuclear sphingolipids: metabolism and signalingQ36662666
Acid sphingomyelinase involvement in tumor necrosis factor alpha-regulated vascular and steroid disruption during luteolysis in vivoQ36693839
Mutually exclusive and cassette exons underlie alternatively spliced isoforms of the Na/Ca exchangerQ36742087
Nuclear diacylglycerol kinases: emerging downstream regulators in cell signaling networksQ36748417
Cyclic phosphatidic acid - a unique bioactive phospholipidQ36947041
Lipins: multifunctional lipid metabolism proteinsQ37082958
Sodium-calcium exchanger complexed with GM1 ganglioside in nuclear membrane transfers calcium from nucleoplasm to endoplasmic reticulumQ37229265
Ceramide kinase and the ceramide-1-phosphate/cPLA2alpha interaction as a therapeutic targetQ37239622
Cellular response to double-stranded RNA.Q37253936
Contributions of extracellular matrix signaling and tissue architecture to nuclear mechanisms and spatial organization of gene expression controlQ37308540
Mammalian diacylglycerol kinases: molecular interactions and biological functions of selected isoforms.Q37347993
Nuclear phosphatidylcholine and sphingomyelin metabolism of thyroid cells changes during stratospheric balloon flightQ37462298
New findings on nuclear gangliosides: overview on metabolism and functionQ37826788
Restoring endocrine response in breast cancer cells by inhibition of the sphingosine kinase-1 signaling pathway.Q39808203
Sialidase occurs in both membranes of the nuclear envelope and hydrolyzes endogenous GD1aQ39811728
The nuclear ceramide/diacylglycerol balance depends on the physiological state of thyroid cells and changes during UV-C radiation-induced apoptosis.Q39953706
GD3 nuclear localization after apoptosis induction in HUT-78 cells.Q40015003
Effect of ceramide N-acyl chain and polar headgroup structure on the properties of ordered lipid domains (lipid rafts).Q40095080
Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomasQ40169778
The sphingomyelin signal transduction pathway mediates apoptosis for tumor necrosis factor, Fas, and ionizing radiationQ40403609
Nuclear sphingomyelin-synthase and protein kinase C delta in melanoma cellsQ40419407
Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signalingQ40445604
Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.Q40459310
Presence of sodium-calcium exchanger/GM1 complex in the nuclear envelope of non-neural cells: nature of exchanger-GM1 interaction.Q40468087
C6 cells express a sodium-calcium exchanger/GM1 complex in the nuclear envelope but have no exchanger in the plasma membrane: comparison to astrocytesQ40567687
cAMP-dependent transcription of steroidogenic genes in the human adrenal cortex requires a dual-specificity phosphatase in addition to protein kinase A.Q40708100
Induced and spontaneous neuritogenesis are associated with enhanced expression of ganglioside GM1 in the nuclear membraneQ41348369
Mitogen-stimulated events in nuclei of Swiss 3T3 cells. Evidence for a direct link between changes of inositol lipids, protein kinase C requirement and the onset of DNA synthesisQ41680080
Nonlinear optical imaging and Raman microspectrometry of the cell nucleus throughout the cell cycleQ41984209
Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cellsQ41995354
Nuclear diacylglycerol is increased during cell proliferation in vivoQ42102681
A role for nuclear phosphatidylinositol-specific phospholipase C in the G2/M phase transitionQ42445558
Ceramide content is increased in skeletal muscle from obese insulin-resistant humansQ42454790
Sphingosine regulates the transcription of CYP17 by binding to steroidogenic factor-1.Q42499194
Rapid changes in phospholipid metabolism in the nuclei of Swiss 3T3 cells induced by treatment of the cells with insulin-like growth factor I.Q42802924
SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolismQ42810891
Stimulation of nuclear sphingosine kinase activity by platelet-derived growth factorQ42826338
Effect of retinoic acid on the Ca2+-independent phospholipase A2 in nuclei of LA-N-1 neuroblastoma cellsQ43611882
The presence and the role of chromatin cholesterol in rat liver regenerationQ43897808
Generation of diacylglycerol molecular species through the cell cycle: a role for 1-stearoyl, 2-arachidonyl glycerol in the activation of nuclear protein kinase C-betaII at G2/M.Q43899680
A possible role of cholesterol-sphingomyelin/phosphatidylcholine in nuclear matrix during rat liver regenerationQ44416677
The presence of ceramidase activity in liver nuclear membraneQ44479112
Chromatin sphingomyelin changes in cell proliferation and/or apoptosis induced by ciprofibrateQ44481472
Reverse sphingomyelin-synthase in rat liver chromatinQ44546942
Identification of cholera toxin-binding sites in the nucleus of intestinal epithelial cellsQ44600249
Increase of nuclear ceramide through caspase-3-dependent regulation of the "sphingomyelin cycle" in Fas-induced apoptosisQ44761803
Ceramide inhibits IL-2 production by preventing protein kinase C-dependent NF-kappaB activation: possible role in protein kinase Ctheta regulation.Q45025124
Susceptibility of cerebellar granule neurons from GM2/GD2 synthase-null mice to apoptosis induced by glutamate excitotoxicity and elevated KCl: rescue by GM1 and LIGA20.Q45130172
The nuclear receptor steroidogenic factor 1 acts at multiple levels of the reproductive axisQ46182351
Effects of ceramide, ceramidase inhibition and expression of ceramide kinase on cytosolic phospholipase A2alpha; additional role of ceramide-1-phosphate in phosphorylation and Ca2+ signalingQ46186943
Acyl chain length affects ceramide action on sterol/sphingomyelin-rich domains.Q46830641
Ceramide synthesis in the endoplasmic reticulum can permeabilize mitochondria to proapoptotic proteins.Q46855408
Isoform-specific regulation of the Na+/Ca2+ exchanger in rat astrocytes and neurons by PKA.Q47949519
Age-dependent reduction in sialidase activity of nuclear membranes from mouse brainQ48567190
Potentiation of a sodium-calcium exchanger in the nuclear envelope by nuclear GM1 gangliosideQ48577116
Identification and purification of a calcium-binding protein in hepatic nuclear membranes.Q50784972
Characterization of nuclear gangliosides in rat brain: concentration, composition, and developmental changes.Q52124193
CD95 Signaling via Ceramide-rich Membrane RaftsQ57371964
High fat diet induces ceramide and sphingomyelin formation in rat’s liver nucleiQ62034159
Sphingomyelin-cholesterol and double stranded RNA relationship in the intranuclear complexQ64388143
The polyphosphoinositide cycle exists in the nuclei of Swiss 3T3 cells under the control of a receptor (for IGF-I) in the plasma membrane, and stimulation of the cycle increases nuclear diacylglycerol and apparently induces translocation of proteinQ68256578
Lipid composition of further purified bovine liver nuclear membranesQ68640852
Existence of Mg2+-dependent, neutral sphingomyelinase in nuclei of rat ascites hepatoma cellsQ69362182
Screening for pheochromocytoma in the MEN 2 syndromeQ69379397
Subcellular distribution and biosynthesis of rat liver gangliosidesQ69417551
Inositol 1,4,5-trisphosphate receptor is located to the inner nuclear membrane vindicating regulation of nuclear calcium signaling by inositol 1,4,5-trisphosphate. Discrete distribution of inositol phosphate receptors to inner and outer nuclear membQ70870915
Analysis of the phospholipid of the nuclear envelope and endoplasmic reticulum of liver cells by high pressure liquid chromatographyQ70918194
Portal vein branch occlusion induces cell proliferation of cholestatic rat liverQ70979844
Phospholipid composition, phospholipase A2 and sphingomyelinase activities in rat liver nuclear membrane and matrixQ71580448
Phospholipids and nuclear RNAQ71658510
Neutral sphingomyelinase: Localization in rat liver nuclei and involvement in regeneration/proliferationQ71834460
Edwards syndrome with double trisomy D and E (mosaicism)Q71977131
GM1 Ganglioside in the Nuclear Membrane Modulates Nuclear Calcium Homeostasis During Neurite OutgrowthQ71978534
Rat liver chromatin phospholipidsQ72559607
P921main subjectsphingolipidsQ410395
P304page(s)131-151
P577publication date2011-09-09
P1433published inAnnual Review of PhysiologyQ567364
P1476titleNuclear sphingolipid metabolism
P478volume74