"Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets

scientific article

"Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1124/PR.107.07113
P932PMC publication ID2695666
P698PubMed publication ID18552276
P5875ResearchGate publication ID5303186

P50authorSarah SpiegelQ20950329
P2093author name stringSheldon Milstien
Kazuaki Takabe
Steven W Paugh
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Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinasesQ24311877
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Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cellsQ24319142
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Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signallingQ24337047
Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturationQ24629370
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Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangementQ24671831
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Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720Q28512961
Oxidative stress-dependent sphingosine kinase-1 inhibition mediates monoamine oxidase A-associated cardiac cell apoptosisQ28566922
Edg-8 receptors are preferentially expressed in oligodendrocyte lineage cells of the rat CNSQ28567378
IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responsesQ28586614
An essential role for the H218/AGR16/Edg-5/LP(B2) sphingosine 1-phosphate receptor in neuronal excitabilityQ28591860
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Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LP(B3)/EDG-3Q28593745
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Cell membrane signaling as target in cancer therapy: inhibitory effect of N,N-dimethyl and N,N,N-trimethyl sphingosine derivatives on in vitro and in vivo growth of human tumor cells in nude miceQ37648373
Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferationQ38411404
Inhibitory and stimulatory regulation of Rac and cell motility by the G12/13-Rho and Gi pathways integrated downstream of a single G protein-coupled sphingosine-1-phosphate receptor isoformQ39740344
Pre- and post-Golgi translocation of glucosylceramide in glycosphingolipid synthesis.Q39751424
Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicinQ40059172
Sphingolipids and the sphingosine kinase inhibitor, SKI II, induce BCL-2-independent apoptosis in human prostatic adenocarcinoma cellsQ40078636
Sphingosine kinase 1 regulates differentiation of human and mouse lung fibroblasts mediated by TGF-beta1.Q40104489
The immunomodulator FTY720 is phosphorylated and released from plateletsQ40123102
S1P stimulates chemotactic migration and invasion in OVCAR3 ovarian cancer cellsQ40161177
Sphingosine kinase type 2 activation by ERK-mediated phosphorylationQ40168870
Newly developed reconstituted high-density lipoprotein containing sphingosine-1-phosphate induces endothelial tube formationQ40267989
Sphingosine 1-phosphate receptor expression profile and regulation of migration in human thyroid cancer cellsQ40271531
A pilot clinical/pharmacological study of the protein kinase C-specific inhibitor safingol alone and in combination with doxorubicinQ33504255
A lymphoid tissue-specific receptor, EDG6, with potential immune modulatory functions mediated by extracellular lysophospholipids.Q33681343
The S1P2 receptor negatively regulates platelet-derived growth factor-induced motility and proliferation.Q33770369
S1P3 receptor-induced reorganization of epithelial tight junctions compromises lung barrier integrity and is potentiated by TNF.Q33878942
Physiology and pathophysiology of sphingolipid metabolism and signalingQ33930354
Sphingolipid transport in eukaryotic cells.Q33944782
Sphingosine 1-phosphate, a key cell signaling moleculeQ34128454
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathwayQ34128457
Sphingosine 1-phosphate: synthesis and releaseQ34233389
Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metaboliteQ34339041
Sphingosine kinase 1 is an intracellular effector of phosphatidic acidQ34341056
N,N-dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human plateletsQ34370823
Role of sphingosine kinase 2 in cell migration toward epidermal growth factorQ34425898
Alkaline sphingomyelinase: an old enzyme with novel implicationsQ34516413
Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo.Q34546048
Oral fingolimod (FTY720) for relapsing multiple sclerosisQ34565985
Protein kinase D-mediated phosphorylation and nuclear export of sphingosine kinase 2.Q34652231
Ceramidases in the regulation of ceramide levels and functionQ34661426
Cardiovascular effects of sphingosine-1-phosphate and other sphingomyelin metabolitesQ35048357
Egress: a receptor-regulated step in lymphocyte traffickingQ35216962
FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function.Q35804361
Endothelial cell barrier regulation by sphingosine 1-phosphateQ35838988
Mechanisms of cardioprotection by lysophospholipidsQ35838996
Biologically active sphingolipids in cancer pathogenesis and treatmentQ35852313
Vascular sphingosine-1-phosphate S1P1 and S1P3 receptorsQ35873296
Rapid induction of medullary thymocyte phenotypic maturation and egress inhibition by nanomolar sphingosine 1-phosphate receptor agonistQ35978652
HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3.Q36056673
Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organsQ36072414
Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: the role of sphingosine kinase-1Q36117441
Sphingosine 1-phosphate and its receptors: an autocrine and paracrine networkQ36184401
Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survivalQ36256204
Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylationQ36267274
Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxisQ36399383
Signal transduction underlying the vascular effects of sphingosine 1-phosphate and sphingosylphosphorylcholineQ36434460
Antitumor activity of sphingosine kinase inhibitorsQ40288624
Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineagesQ40306295
Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis.Q40310350
Sphingosine kinase 1 is up-regulated in colon carcinogenesisQ40345686
Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting sphingosine kinase-1.Q40352532
The mechanism of membrane targeting of human sphingosine kinase 1.Q40358838
Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cellsQ40367377
Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: roles of sphingosine kinase isoforms in growth of glioblastoma cell linesQ40384186
S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fateQ40405662
Sphingosine kinase activation regulates hepatocyte growth factor induced migration of endothelial cellsQ40533285
Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53.Q40584948
The immune modulator FTY720 targets sphingosine 1-phosphate receptorsQ40736684
Extracellular export of sphingosine kinase-1 enzyme. Sphingosine 1-phosphate generation and the induction of angiogenic vascular maturationQ40763807
Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxisQ40777268
Sphingosine kinase-mediated calcium signaling by muscarinic acetylcholine receptors.Q40801018
An oncogenic role of sphingosine kinaseQ40837836
Sphingosine 1-phosphate released from platelets during clotting accounts for the potent endothelial cell chemotactic activity of blood serum and provides a novel link between hemostasis and angiogenesis.Q40845943
Sphingosine 1-phosphate stimulates cell migration through a G(i)-coupled cell surface receptor. Potential involvement in angiogenesisQ40914150
Cell membrane signaling as target in cancer therapy. II: Inhibitory effect of N,N,N-trimethylsphingosine on metastatic potential of murine B16 melanoma cell line through blocking of tumor cell-dependent platelet aggregation.Q41656945
Interaction of sphingosine 1-phosphate with plasma components, including lipoproteins, regulates the lipid receptor-mediated actionsQ42090948
N,N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide.Q42461110
Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphateQ42556020
Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogensQ42805681
SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolismQ42810891
The signal modulator protein 14-3-3 is a target of sphingosine- or N,N-dimethylsphingosine-dependent kinase in 3T3(A31) cellsQ42820452
Analysis of sphingosine 1-phosphate receptors involved in constriction of isolated cerebral arteries with receptor null mice and pharmacological toolsQ42952142
Sphingosine 1-phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthmaQ43601724
S-15183a and b, new sphingosine kinase inhibitors, produced by a fungusQ43692744
First human trial of FTY720, a novel immunomodulator, in stable renal transplant patientsQ43931513
Critical role of ABCA1 transporter in sphingosine 1-phosphate release from astrocytesQ44091518
Cutting edge: suppression of T cell chemotaxis by sphingosine 1-phosphateQ44172187
Sphingosine-1-phosphate receptor agonism impairs the efficiency of the local immune response by altering trafficking of naive and antigen-activated CD4+ T cellsQ44368643
Amelioration of experimental autoimmune encephalomyelitis in Lewis rats by FTY720 treatmentQ44370378
Sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P2.Q44385104
Pharmacodynamics of single doses of the novel immunosuppressant FTY720 in stable renal transplant patients.Q44482860
Sphingosine kinase transmits estrogen signaling in human breast cancer cells.Q44526063
Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesisQ44572814
Pharmacodynamics, pharmacokinetics, and safety of multiple doses of FTY720 in stable renal transplant patients: a multicenter, randomized, placebo-controlled, phase I studyQ44616726
Clostridium perfringens alpha-toxin activates the sphingomyelin metabolism system in sheep erythrocytesQ44711006
The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptorsQ44722923
Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rateQ44734550
Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidneyQ44916450
Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice.Q44987202
Therapeutic effects of a new lymphocyte homing reagent FTY720 in interleukin-10 gene-deficient mice with colitisQ45004851
Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720.Q45086529
Lung injury: sphingosine-1-phosphate to the rescueQ45124288
Attenuation of shock-induced acute lung injury by sphingosine kinase inhibitionQ45173949
Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: role of Bcl-2 expressionQ45215121
KRP-203, a novel synthetic immunosuppressant, prolongs graft survival and attenuates chronic rejection in rat skin and heart allograftsQ45218848
Edg8/S1P5: an oligodendroglial receptor with dual function on process retraction and cell survival.Q45259405
The heart rate decrease caused by acute FTY720 administration is mediated by the G protein-gated potassium channel I.Q45262225
Sphingosine-1-phosphate receptor expression in cardiac fibroblasts is modulated by in vitro culture conditionsQ46061167
Sphingosine 1-phosphate (S1P) signaling is required for maintenance of hair cells mainly via activation of S1P2.Q46117845
Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradientsQ46265539
Quantitative analysis of sphingoid base-1-phosphates as bisacetylated derivatives by liquid chromatography-tandem mass spectrometryQ46377682
Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphateQ46494392
Immunohistochemical distribution of sphingosine kinase 1 in normal and tumor lung tissueQ46516547
Type 4 sphingosine 1-phosphate G protein-coupled receptor (S1P4) transduces S1P effects on T cell proliferation and cytokine secretion without signaling migrationQ46620860
Regulation of sphingosine 1-phosphate-induced endothelial cytoskeletal rearrangement and barrier enhancement by S1P1 receptor, PI3 kinase, Tiam1/Rac1, and alpha-actininQ46728817
Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720.Q46751827
Suppression of mast cell degranulation by a novel ceramide kinase inhibitor, the F-12509A olefin isomer K1.Q46849690
Sphingosine kinase-1 as a chemotherapy sensor in prostate adenocarcinoma cell and mouse modelsQ46853200
Sphingosine 1-phosphate is released from the cytosol of rat platelets in a carrier-mediated mannerQ46863524
Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptorQ46927225
Efficacy of mycophenolic acid combined with KRP-203, a novel immunomodulator, in a rat heart transplantation modelQ46968445
Indomethacin differentiates the renal effects of sphingosine-1-phosphate and sphingosylphosphorylcholineQ46978325
A novel sphingosine 1-phosphate receptor agonist, 2-amino-2-propanediol hydrochloride (KRP-203), regulates chronic colitis in interleukin-10 gene-deficient mice.Q46979859
Enzymatic measurement of sphingosine 1-phosphateQ48163685
Multiple actions of dimethylsphingosine in 1321N1 astrocytes.Q48186524
Essential roles of sphingosine 1-phosphate/S1P1 receptor axis in the migration of neural stem cells toward a site of spinal cord injury.Q48415894
Inhibition of sphingosine kinase in vitro and in platelets. Implications for signal transduction pathwaysQ48528203
Activation of casein kinase II by sphingosine.Q48623665
B-535a, b and c, new sphingosine kinase inhibitors, produced by a marine bacterium; taxonomy, fermentation, isolation, physico-chemical properties and structure determinationQ48744563
Erythrocytes store and release sphingosine 1-phosphate in blood.Q51084957
Sphingomyelin synthesis in rat liver occurs predominantly at the cis and medial cisternae of the Golgi apparatus.Q52483696
Sphingosine kinase inhibitor suppresses a Th1 polarization via the inhibition of immunostimulatory activity in murine bone marrow-derived dendritic cells.Q53577932
Sphingosine-1-phosphate receptor agonists suppress concanavalin A-induced hepatic injury in mice.Q53624480
S1P(1)-selective agonist, SEW2871, ameliorates ischemic acute renal failure.Q54611404
A novel immunomodulator KRP-203 combined with cyclosporine prolonged graft survival and abrogated transplant vasculopathy in rat heart allografts.Q54672484
Lack of sphingosine 1-phosphate-degrading enzymes in erythrocytesQ57952121
FTY720 versus MMF with Cyclosporine in de novo Renal Transplantation: A 1-Year, Randomized Controlled Trial in Europe and AustralasiaQ63431636
Effect of chemically well-defined sphingosine and its N-methyl derivatives on protein kinase C and src kinase activitiesQ69113678
Programmed cell death induced by ceramideQ70619078
Toxicity of the protein kinase C inhibitor safingol administered alone and in combination with chemotherapeutic agentsQ72035556
Sphingosine 1-phosphate, a bioactive sphingolipid abundantly stored in platelets, is a normal constituent of human plasma and serumQ73436742
Sphingosine 1-phosphate induces sinus tachycardia and coronary vasoconstriction in the canine heartQ73571790
A high-performance liquid chromatographic method to measure sphingosine 1-phosphate and related compounds from sphingosine kinase assays and other biological samplesQ73881103
F-12509A, a new sphingosine kinase inhibitor, produced by a discomyceteQ74044934
Ceramide and apoptosisQ77875070
Use of sphingosine-1-phosphate 1 receptor agonist, KRP-203, in combination with a subtherapeutic dose of cyclosporine A for rat renal transplantationQ79150735
Randomized controlled trial of FTY720 versus MMF in de novo renal transplantationQ79468611
Oral-intravenous crossover study of fingolimod pharmacokinetics, lymphocyte responses and cardiac effectsQ79581116
The sphingosine kinase-sphingosine-1-phosphate axis is a determinant of mast cell function and anaphylaxisQ79905421
Sphingosine kinase inhibitor suppresses dendritic cell migration by regulating chemokine receptor expression and impairing p38 mitogen-activated protein kinaseQ80145738
High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptorQ80284338
A sphingosine kinase 1 mutation sensitizes the myocardium to ischemia/reperfusion injuryQ80567231
Sphingosine 1-phosphate accelerates wound healing in diabetic miceQ80648055
A novel sphingosine-1-phosphate receptor agonist KRP-203 attenuates rat autoimmune myocarditisQ80730157
FTY720/cyclosporine regimens in de novo renal transplantation: a 1-year dose-finding studyQ83984696
P433issue2
P304page(s)181-195
P577publication date2008-06-13
P1433published inPharmacological ReviewsQ2085079
P1476title"Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets
P478volume60

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Q36320677Expression of sphingosine 1-phosphate receptors in the rat dorsal root ganglia and defined single isolated sensory neurons
Q34183703Extracellular and Intracellular Actions of Sphingosine-1-Phosphate
Q34162587FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells
Q35819965FTY720 inhibited proinflammatory cytokine release and osteoclastogenesis induced by Aggregatibacter actinomycetemcomitans
Q33854428FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages.
Q34718530FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons.
Q34551954Fenretinide causes emphysema, which is prevented by sphingosine 1-phoshate
Q37765473Fingolimod is a potential novel therapy for multiple sclerosis
Q48649157Fingolimod may support neuroprotection via blockade of astrocyte nitric oxide
Q37851885Fingolimod: an oral disease-modifying therapy for relapsing multiple sclerosis
Q98471366Follicle-stimulating hormone promotes the proliferation of epithelial ovarian cancer cells by activating sphingosine kinase
Q43984955Gene expression of ceramide kinase, galactosyl ceramide synthase and ganglioside GD3 synthase is associated with prognosis in breast cancer
Q90296101Generation of sphingosine-1-phosphate is enhanced in biliary tract cancer patients and is associated with lymphatic metastasis
Q33831886Genetic evidence for involvement of neuronally expressed S1P₁ receptor in nociceptor sensitization and inflammatory pain
Q39624007Gilenya (FTY720) inhibits acid sphingomyelinase by a mechanism similar to tricyclic antidepressants
Q35845653Growth and metabolism of Beauveria bassiana spores and mycelia
Q35238369High density lipoprotein stimulated migration of macrophages depends on the scavenger receptor class B, type I, PDZK1 and Akt1 and is blocked by sphingosine 1 phosphate receptor antagonists
Q40964594High levels of sphingolipids in human breast cancer.
Q40567317Host sphingosine kinase 1 worsens pancreatic cancer peritoneal carcinomatosis
Q38307041Identification and characterization of a mirror-image oligonucleotide that binds and neutralizes sphingosine 1-phosphate, a central mediator of angiogenesis
Q37233204Immunosuppressive human anti-lymphocyte autoantibodies specific for the type 1 sphingosine 1-phosphate receptor
Q42966392Impact of sphingosine kinase 2 deficiency on the development of TNF-alpha-induced inflammatory arthritis.
Q36898368Implication of sphingosin-1-phosphate in cardiovascular regulation
Q37662940Inducible overexpression of adiponectin receptors highlight the roles of adiponectin-induced ceramidase signaling in lipid and glucose homeostasis
Q38162168Inflammatory and microenvironmental factors involved in breast cancer progression
Q35661331Inhibition of Sphingosine Kinase 1 Ameliorates Angiotensin II-Induced Hypertension and Inhibits Transmembrane Calcium Entry via Store-Operated Calcium Channel
Q88990558Innate lymphoid cells-key immune integrators of overall body homeostasis
Q34373466Interdiction of sphingolipid metabolism to improve standard cancer therapies
Q92630730Interleukin-22 Mediates the Chemotactic Migration of Breast Cancer Cells and Macrophage Infiltration of the Bone Microenvironment by Potentiating S1P/SIPR Signaling
Q33386012Interrelationship between dendritic cell trafficking and Francisella tularensis dissemination following airway infection
Q37100281Interstitial Fluid Sphingosine-1-Phosphate in Murine Mammary Gland and Cancer and Human Breast Tissue and Cancer Determined by Novel Methods
Q28743138Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells: role of sphingosine kinase 1 and S1P lyase
Q34053079Intracellular localization of sphingosine kinase 1 alters access to substrate pools but does not affect the degradative fate of sphingosine-1-phosphate
Q35830897Inverse-phosphocholine lipids: a remix of a common phospholipid
Q36369205Involvement of Band3 in the efflux of sphingosine 1-phosphate from erythrocytes
Q46049440Involvement of the ABC-transporter ABCC1 and the sphingosine 1-phosphate receptor subtype S1P(3) in the cytoprotection of human fibroblasts by the glucocorticoid dexamethasone
Q40341970Is T790M mutation the key in development of resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs)?
Q39565607KAI1 inhibits HGF-induced invasion of pancreatic cancer by sphingosine kinase activity.
Q36607525Legionella pneumophila S1P-lyase targets host sphingolipid metabolism and restrains autophagy
Q92257208Light Stress-Induced Increase of Sphingosine 1-Phosphate in Photoreceptors and Its Relevance to Retinal Degeneration
Q37173179Lipid phosphate phosphatases and signaling
Q28088430Lipid phosphate phosphatases and their roles in mammalian physiology and pathology
Q34269858Lipotoxicity contributes to endothelial dysfunction: a focus on the contribution from ceramide.
Q91823189Long Noncoding RNA H19 Contributes to Cholangiocyte Proliferation and Cholestatic Liver Fibrosis in Biliary Atresia
Q37414484Lyase to live by: sphingosine phosphate lyase as a therapeutic target
Q34084937Lymphangiogenesis: A new player in cancer progression
Q47233200Lysophosphatidic Acid Signaling Axis Mediates Ceramide 1-Phosphate-Induced Proliferation of C2C12 Myoblasts
Q99418917MYPT1 O-GlcNAc modification regulates sphingosine-1-phosphate mediated contraction
Q97644512Macrophage Sphingosine 1-Phosphate Receptor 2 Blockade Attenuates Liver Inflammation and Fibrogenesis Triggered by NLRP3 Inflammasome
Q33829692Mammalian sphingosine kinase (SphK) isoenzymes and isoform expression: challenges for SphK as an oncotarget
Q92961499Manipulation of the Sphingolipid Rheostat Influences the Mediator of Flow-Induced Dilation in the Human Microvasculature
Q37457462Maternal fumonisin exposure as a risk factor for neural tube defects
Q37154242Mechanisms linking obesity and cancer
Q36377252Mechanisms of lipotoxicity in the cardiovascular system
Q38713803Mechanisms of sphingosine-1-phosphate-mediated vasoconstriction of rat afferent arterioles
Q30413877Memo has a novel role in S1P signaling and is [corrected] crucial for vascular development
Q42120428MiR-124 acts as a tumor suppressor by inhibiting the expression of sphingosine kinase 1 and its downstream signaling in head and neck squamous cell carcinoma
Q33636763Minireview: recent developments in the physiology and pathology of the lysophosphatidylinositol-sensitive receptor GPR55.
Q93335813Molecular mechanisms of biogenesis of apoptotic exosome-like vesicles and their roles as damage-associated molecular patterns
Q41829826Myocardial infarction differentially alters sphingolipid levels in plasma, erythrocytes and platelets of the rat.
Q36355889Myriocin treatment of CF lung infection and inflammation: complex analyses for enigmatic lipids
Q28078299NF-κB Pathways in the Pathogenesis of Multiple Sclerosis and the Therapeutic Implications
Q41127962NMR metabolomics highlights sphingosine kinase-1 as a new molecular switch in the orchestration of aberrant metabolic phenotype in cancer cells
Q35955451Neutralizing S1P inhibits intratumoral hypoxia, induces vascular remodelling and sensitizes to chemotherapy in prostate cancer
Q37588466Noncanonical transforming growth factor beta signaling in scleroderma fibrosis
Q33684331Normalization of diabetic wound healing
Q92012755Novel Insights into the Role of HDL-Associated Sphingosine-1-Phosphate in Cardiometabolic Diseases
Q37925819Nuclear sphingolipid metabolism
Q38092176Oncogenic properties of sphingosine kinases in haematological malignancies.
Q43838770Oral fingolimod in multiple sclerosis: therapeutic modulation of the sphingosine-1-phosphate system
Q87417830Oral treatment with SEW2871, a sphingosine-1-phosphate type 1 receptor agonist, ameliorates experimental colitis in interleukin-10 gene deficient mice
Q36996563Orphan G protein receptor GPR55 as an emerging target in cancer therapy and management
Q64076938Osteoporosis and skeletal dysplasia caused by pathogenic variants in SGMS2
Q37660877Outside the box signaling: secreted factors modulate GnRH receptor-mediated gonadotropin regulation
Q36410748Overexpression of sphingosine kinase 1 prevents ceramide accumulation and ameliorates muscle insulin resistance in high-fat diet-fed mice
Q38960964Oxidized LDL-induced angiogenesis involves sphingosine 1-phosphate: prevention by anti-S1P antibody
Q45073187Paradoxical Association of Postoperative Plasma Sphingosine-1-Phosphate with Breast Cancer Aggressiveness and Chemotherapy.
Q44324305Pharmacologic evaluation of sulfasalazine, FTY720, and anti-IL-12/23p40 in a TNBS-induced Crohn's disease model
Q35130512Pharmacological relevance and potential of sphingosine 1-phosphate in the vascular system
Q38763707Platelet-derived sphingosine-1-phosphate and inflammation: from basic mechanisms to clinical implications
Q37782076Polymer-drug conjugates for novel molecular targets
Q37002064Potential signaling pathway involved in sphingosine-1-phosphate-induced epithelial-mesenchymal transition in cancer
Q88961948Preclinical study of the antitumor effect of sphingosine-1-phosphate receptor 1 antibody (S1PR1-antibody) against human breast cancer cells
Q37658857Radiation countermeasure agents: an update
Q35101294Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin.
Q34559806Regulating survival and development in the retina: key roles for simple sphingolipids
Q35683960Regulation of glucose and lipid homeostasis by adiponectin: effects on hepatocytes, pancreatic β cells and adipocytes
Q37415111Regulation of vascular physiology and pathology by the S1P2 receptor subtype.
Q57802697Requirement for sphingosine kinase 1 in mediating phase 1 of the hypotensive response to anandamide in the anaesthetised mouse
Q38262594Resveratrol and its oligomers: modulation of sphingolipid metabolism and signaling in disease
Q34574599Role for peroxynitrite in sphingosine-1-phosphate-induced hyperalgesia in rats
Q90341490Role of Bioactive Sphingolipids in Inflammation and Eye Diseases
Q58760187Role of S1P/S1PR3 axis in release of CCL20 from human bronchial epithelial cells
Q92009926Role of Sphingosine Kinase 1 and Sphingosine-1-Phosphate Axis in Hepatocellular Carcinoma
Q40990718Role of Sphingosine-1-Phosphate in Transplant Vasculopathy Evoked by Anti-HLA Antibody
Q64891856Role of the S1P pathway and inhibition by fingolimod in preventing hemorrhagic transformation after stroke.
Q39506935Roles of ceramide synthase and ceramide clearence genes in nilotinib-induced cell death in chronic myeloid leukemia cells
Q34879183Roles of sphingosine 1-phosphate on tumorigenesis
Q37699303Roles of sphingosine-1-phosphate in reproduction
Q91738678Roles of sphingosine-1-phosphate signaling in cancer
Q39169246Runx1 Orchestrates Sphingolipid Metabolism and Glucocorticoid Resistance in Lymphomagenesis.
Q38626918S1P Provokes Tumor Lymphangiogenesis via Macrophage-Derived Mediators Such as IL-1β or Lipocalin-2.
Q35136728S1P is associated with protection in human and experimental cerebral malaria
Q33886533S1P metabolism in cancer and other pathological conditions
Q42735904S1P promotes breast cancer progression by angiogenesis and lymphangiogenesis
Q48849226S1P prophylaxis mitigates acute hypobaric hypoxia-induced molecular, biochemical, and metabolic disturbances: A preclinical report
Q38703649S1P receptor 1-Mediated Anti-Renin-Angiotensin System Cardioprotection: Pivotal Role of Mast Cell Aldehyde Dehydrogenase Type 2.
Q35633763S1P-Dependent trafficking of intracellular yersinia pestis through lymph nodes establishes Buboes and systemic infection
Q91782570S1P-S1PR1 Signaling: the "Sphinx" in Osteoimmunology
Q92914007SGPL1321 mutation: one main trigger for invasiveness of pediatric alveolar rhabdomyosarcoma
Q37997376Signaling and regulatory functions of bioactive sphingolipids as therapeutic targets in multiple sclerosis.
Q34345362Single-cell sphingosine kinase activity measurements in primary leukemia
Q35776618Sources, metabolism, and regulation of circulating sphingosine-1-phosphate
Q35138620Space radiation-associated lung injury in a murine model
Q92347503Sphingolipid metabolism and drug resistance in ovarian cancer
Q89977951Sphingolipids and Mitochondrial Dynamic
Q45072496Sphingolipids and Redox Signaling in Renal Regulation and Chronic Kidney Diseases
Q64965708Sphingolipids as Emerging Mediators in Retina Degeneration.
Q37527497Sphingolipids as determinants of apoptosis and chemoresistance in the MCF-7 cell model system
Q26773230Sphingolipids in High Fat Diet and Obesity-Related Diseases
Q49972804Sphingolipids role in the regulation of inflammatory response: From leukocyte biology to bacterial infection
Q47095059Sphingosine 1-Phosphate- and C-C Chemokine Receptor 2-Dependent Activation of CD4+ Plasmacytoid Dendritic Cells in the Bone Marrow Contributes to Signs of Sepsis-Induced Immunosuppression
Q36636026Sphingosine 1-phosphate (S1P) receptors 1 and 2 coordinately induce mesenchymal cell migration through S1P activation of complementary kinase pathways
Q35921615Sphingosine 1-phosphate (S1P) regulates glucose-stimulated insulin secretion in pancreatic beta cells
Q34121255Sphingosine 1-phosphate and cancer
Q38223679Sphingosine 1-phosphate and cancer: lessons from thyroid cancer cells
Q34474499Sphingosine 1-phosphate modulates antigen capture by murine Langerhans cells via the S1P2 receptor subtype
Q36532321Sphingosine 1-phosphate receptor 2 antagonist JTE-013 increases the excitability of sensory neurons independently of the receptor
Q27024207Sphingosine 1-phosphate signaling pathway in inner ear biology. New therapeutic strategies for hearing loss?
Q41980318Sphingosine 1-phosphate to p38 signaling via S1P1 receptor and Gαi/o evokes augmentation of capsaicin-induced ionic currents in mouse sensory neurons.
Q38185438Sphingosine 1-phosphate: a potential molecular target for ovarian cancer therapy?
Q47121464Sphingosine Kinase 1 and Sphingosine-1-Phosphate Signaling in Colorectal Cancer
Q30275552Sphingosine Kinase 2 Deficiency Attenuates Kidney Fibrosis via IFN-γ.
Q35845319Sphingosine Kinase 2 and Ceramide Transport as Key Targets of the Natural Flavonoid Luteolin to Induce Apoptosis in Colon Cancer Cells
Q42233131Sphingosine analog AAL-R promotes activation of LCMV-infected dendritic cells
Q33727889Sphingosine analog fingolimod (FTY720) increases radiation sensitivity of human breast cancer cells in vitro
Q42149287Sphingosine analogue AAL-R increases TLR7-mediated dendritic cell responses via p38 and type I IFN signaling pathways
Q54565672Sphingosine but not sphingosine-1-phosphate stimulates suicidal erythrocyte death.
Q38937332Sphingosine kinase 1 as a potential therapeutic target in epithelial ovarian cancer
Q27303619Sphingosine kinase 1 deficiency exacerbates LPS-induced neuroinflammation
Q45070648Sphingosine kinase 1 in breast cancer
Q38013700Sphingosine kinase 1 in viral infections.
Q39168123Sphingosine kinase 1 overexpression stimulates intestinal epithelial cell proliferation through increased c-Myc translation
Q38333309Sphingosine kinase 1/S1P pathway involvement in the GDNF-induced GAP43 transcription
Q46726983Sphingosine kinase 1/sphingosine-1-phosphate (S1P)/S1P receptor axis is involved in ovarian cancer angiogenesis
Q64933352Sphingosine kinase 2 inhibitor ABC294640 displays anti-epithelial ovarian cancer activities in vitro and in vivo.
Q37328806Sphingosine kinase regulation and cardioprotection
Q33586246Sphingosine kinase-1 (SphK-1) regulates Mycobacterium smegmatis infection in macrophages
Q37208958Sphingosine kinase-1, S1P transporter spinster homolog 2 and S1P2 mRNA expressions are increased in liver with advanced fibrosis in human
Q43269484Sphingosine kinase-1: a potential mediator of renal fibrosis
Q89987678Sphingosine kinase-2 is overexpressed in large granular lymphocyte leukaemia and promotes survival through Mcl-1
Q35204641Sphingosine kinase-2 maintains viral latency and survival for KSHV-infected endothelial cells
Q38408286Sphingosine kinases/sphingosine-1-phosphate and death Signalling in APP-transfected cells
Q38115668Sphingosine lysolipids in the CNS: endogenous cannabinoid antagonists or a parallel pain modulatory system?
Q37405258Sphingosine phosphate lyase regulates myogenic differentiation via S1P receptor-mediated effects on myogenic microRNA expression
Q91801206Sphingosine-1-Phosphate Facilitates Skin Wound Healing by Increasing Angiogenesis and Inflammatory Cell Recruitment with Less Scar Formation
Q35996098Sphingosine-1-Phosphate Lyase Deficient Cells as a Tool to Study Protein Lipid Interactions
Q26766425Sphingosine-1-Phosphate Signaling in Immune Cells and Inflammation: Roles and Therapeutic Potential
Q26775993Sphingosine-1-Phosphate and Its Receptors: A Mutual Link between Blood Coagulation and Inflammation
Q35059057Sphingosine-1-phosphate acting via the S1P₁ receptor is a downstream signaling pathway in ceramide-induced hyperalgesia
Q34474363Sphingosine-1-phosphate and immune regulation: trafficking and beyond
Q37176189Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor-beta-stimulated collagen production by cardiac fibroblasts
Q26852824Sphingosine-1-phosphate in chronic intestinal inflammation and cancer
Q37543777Sphingosine-1-phosphate in the lymphatic fluid determined by novel methods
Q34251293Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis.
Q38953409Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation
Q91863467Sphingosine-1-phosphate receptor 1 activation in astrocytes contributes to neuropathic pain
Q37726630Sphingosine-1-phosphate receptor 1 reporter mice reveal receptor activation sites in vivo
Q35146069Sphingosine-1-phosphate receptor 2
Q35121901Sphingosine-1-phosphate receptor 3 mediates sphingosine-1-phosphate induced release of weibel-palade bodies from endothelial cells.
Q30435328Sphingosine-1-phosphate receptors mediate neuromodulatory functions in the CNS
Q50861734Sphingosine-1-phosphate signalling-a key player in the pathogenesis of Angiotensin II-induced hypertension.
Q37358457Sphingosine-1-phosphate synthesis and functions in mast cells
Q42181059Sphingosine-1-phosphate transporters as targets for cancer therapy.
Q48547561Sphingosine-1-phosphate, regulated by FSH and VEGF, stimulates granulosa cell proliferation.
Q46119380Sphingosine-1-phosphate-induced nociceptor excitation and ongoing pain behavior in mice and humans is largely mediated by S1P3 receptor
Q50665340Sphingosine-1-phosphate/sphingosine kinase 1-dependent lymph node metastasis in esophageal squamous cell carcinoma.
Q90117111Sphingosine-1-phosphate: From insipid lipid to a key regulator
Q37697043Sphk1 promotes breast epithelial cell proliferation via NF-κB-p65-mediated cyclin D1 expression
Q28482973StarD7 knockdown modulates ABCG2 expression, cell migration, proliferation, and differentiation of human choriocarcinoma JEG-3 cells
Q89162813Survival benefit of sphingosin-1-phosphate and receptors expressions in breast cancer patients
Q37501281Symbiont-derived sphingolipids modulate mucosal homeostasis and B cells in teleost fish
Q37397209Synthetic analogs of FTY720 [2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol] differentially regulate pulmonary vascular permeability in vivo and in vitro
Q91713570T Lymphocytes: A Promising Immunotherapeutic Target for Pancreatitis and Pancreatic Cancer?
Q35831148TGFβ-Mediated induction of SphK1 as a potential determinant in human MDA-MB-231 breast cancer cell bone metastasis
Q35935087TNF-α- and tumor-induced skeletal muscle atrophy involves sphingolipid metabolism
Q42380774Targeted disruption of the S1P2 sphingosine 1-phosphate receptor gene leads to diffuse large B-cell lymphoma formation
Q37172893Targeting SphK1 as a new strategy against cancer
Q57399036Targeting sphingosine-1-phosphate lyase as an anabolic therapy for bone loss
Q37894772Targeting sphingosine-1-phosphate receptors in cancer
Q39379449Targeting sphingosine-1-phosphate signaling for cancer therapy
Q30486707The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors
Q34217756The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells.
Q26748848The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined
Q27657731The crystal structure of sphingosine-1-phosphate in complex with a Fab fragment reveals metal bridging of an antibody and its antigen
Q62272072The emerging alliance of sphingosine-1-phosphate signalling and immune cells: from basic mechanisms to implications in hypertension
Q26748927The emerging role of FTY720 (Fingolimod) in cancer treatment
Q34094557The immunosuppressant FTY720 (fingolimod) enhances glycosaminoglycan depletion in articular cartilage
Q37688434The interplay between bioactive sphingolipids and steroid hormones
Q36011196The outs and the ins of sphingosine-1-phosphate in immunity
Q37319760The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR.
Q38694191The role of Lutheran/basal cell adhesion molecule in human bladder carcinogenesis.
Q34271986The role of adiponectin in cancer: a review of current evidence
Q45051424The role of sphingosine 1-phosphate receptor 2 in bile-acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice
Q36241051The role of sphingosine-1-phosphate in breast cancer tumor-induced lymphangiogenesis.
Q57153732The role of sphingosine-1-phosphate in inflammation and cancer progression
Q38734489The role of sphingosine-1-phosphate in the tumor microenvironment and its clinical implications.
Q38909010The roles of bile acids and sphingosine-1-phosphate signaling in the hepatobiliary diseases.
Q34379689The sphingosine 1-phosphate receptor, S1PR₁, plays a prominent but not exclusive role in enhancing the excitability of sensory neurons
Q34986940The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension
Q48349932The sphingosine kinase 2 inhibitor ABC294640 displays anti-non-small cell lung cancer activities in vitro and in vivo.
Q39251134The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism
Q39253082The sphingosine kinase inhibitor N,N-dimethylsphingosine inhibits neointimal hyperplasia
Q38915115Therapeutic Strategies and Pharmacological Tools Influencing S1P Signaling and Metabolism
Q34527281Therapeutic opportunities for manipulating T(Reg) cells in autoimmunity and cancer
Q37930972Therapeutic potential of targeting sphingosine kinase 1 in prostate cancer
Q38909416Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies.
Q37071804Transcriptional modulation of SLC26A3 (DRA) by sphingosine-1-phosphate.
Q59354243Transient inhibition of sphingosine kinases confers protection to influenza A virus infected mice
Q33635116Twofer anti-vascular therapy targeting sphingosine-1-phosphate for breast cancer.
Q30353137Up-regulation of tumor suppressor genes by exogenous dhC16-Cer contributes to its anti-cancer activity in primary effusion lymphoma.
Q37293908Vascular biology: the role of sphingosine 1-phosphate in both the resting state and inflammation
Q39005334Vitamin D therapy in experimental allergic encephalomyelitis could be limited by opposing effects of sphingosine 1-phosphate and gelsolin dysregulation.
Q33773550Why is effective treatment of asthma so difficult? An integrated systems biology hypothesis of asthma
Q51831879β1-Blockade Prevents Post-Ischemic Myocardial Decompensation Via β3AR-Dependent Protective Sphingosine-1 Phosphate Signaling.