Dendritic cell sphingosine-1-phosphate lyase regulates thymic egress

scientific article published on 17 October 2016

Dendritic cell sphingosine-1-phosphate lyase regulates thymic egress is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1084/JEM.20160287
P932PMC publication ID5110016
P698PubMed publication ID27810923

P2093author name stringAshok Kumar
Julie D Saba
Meng Zhang
Jung H Suh
Jesus Zamora-Pineda
P2860cites workOrally active 7-substituted (4-benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as active-site inhibitors of sphingosine 1-phosphate lyase for the treatment of multiple sclerosisQ24297350
Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1Q24657671
Kruppel-like factor 2 regulates thymocyte and T-cell migrationQ28253004
The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in miceQ28588851
Inducible gene targeting in miceQ29614544
An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrowQ29615498
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1Q29619644
Specific expression of lacZ and cre recombinase in fetal thymic epithelial cells by multiplex gene targeting at the Foxn1 locusQ33288108
Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesionsQ33396938
Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesisQ34022315
Intracellular localization of sphingosine kinase 1 alters access to substrate pools but does not affect the degradative fate of sphingosine-1-phosphateQ34053079
Selective imprinting of gut-homing T cells by Peyer's patch dendritic cellsQ34211233
Oral fingolimod (FTY720) for relapsing multiple sclerosisQ34565985
Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell developmentQ34577749
"Inside-out" signaling of sphingosine-1-phosphate: therapeutic targetsQ34593159
Dendritic cells in the thymus contribute to T-regulatory cell inductionQ34601754
Neural crest-derived pericytes promote egress of mature thymocytes at the corticomedullary junctionQ35022130
Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAsQ35145464
Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte traffickingQ35208814
Lipid phosphate phosphatase 3 enables efficient thymic egressQ35213578
Thymic regulatory T cell niche size is dictated by limiting IL-2 from antigen-bearing dendritic cells and feedback competitionQ35629787
The outs and the ins of sphingosine-1-phosphate in immunityQ36011196
Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissuesQ36145233
Heterogeneity of thymic dendritic cellsQ36157476
Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen.Q36229473
A central role for thymic emigrants in peripheral T cell homeostasisQ36433740
Immunohistochemical analysis of sphingosine phosphate lyase expression during murine developmentQ36581831
Elimination of antigen-presenting cells and autoreactive T cells by Fas contributes to prevention of autoimmunityQ36955782
The alliance of sphingosine-1-phosphate and its receptors in immunityQ37010807
Thymus organogenesisQ37096077
Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: role of lipid phosphate phosphatase-1 and sphingosine kinase 1.Q37137690
Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymusQ37234298
Autoreactive thymic B cells are efficient antigen-presenting cells of cognate self-antigens for T cell negative selectionQ37240479
Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and diseaseQ37259737
Tolerance has its limits: how the thymus copes with infectionQ37427754
Differential processing of self-antigens by subsets of thymic stromal cells.Q37980554
Clonal deletion of thymocytes by circulating dendritic cells homing to the thymusQ38466522
Sphingosine-1-phosphate (S1P) displays sustained S1P1 receptor agonism and signaling through S1P lyase-dependent receptor recyclingQ39007576
B lymphocyte-specific, Cre-mediated mutagenesis in miceQ39719513
Inhibition of sphingosine 1-phosphate lyase for the treatment of rheumatoid arthritis: discovery of (E)-1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone oxime (LX2931) and (1R,2S,3R)-1-(2-(isoxazol-3-yl)-1H-imidazol-4-yl)butane-Q42797225
Isolation of mouse peritoneal cavity cellsQ42858996
Discontinued postnatal thymocyte development in sphingosine 1-phosphate-lyase-deficient mice.Q43277471
Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone.Q44805708
Immunological effects of transgenic constitutive expression of the type 1 sphingosine 1-phosphate receptor by mouse lymphocytesQ45256161
Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradientsQ46265539
Targeted expression of Cre recombinase in macrophages and osteoclasts in transgenic miceQ50775674
Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance.Q53253030
Antigen Challenge Inhibits Thymic EmigrationQ62230303
Regulation of IL-4 gene expression by distal regulatory elements and GATA-3 at the chromatin levelQ73835273
Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometryQ79860458
P4510describes a project that usesImageJQ1659584
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectdendritic cellQ506253
P304page(s)2773-2791
P577publication date2016-10-17
P1433published inJournal of Experimental MedicineQ3186912
P1476titleDendritic cell sphingosine-1-phosphate lyase regulates thymic egress
P478volume213

Reverse relations

cites work (P2860)
Q40140813A type 2 cytokine axis for thymus emigration.
Q91997764Cancer-induced inflammation and inflammation-induced cancer in colon: a role for S1P lyase
Q51137358Ceramide synthase 2 facilitates S1P-dependent egress of thymocytes into the circulation in mice
Q92617618Pro-Survival Lipid Sphingosine-1-Phosphate Metabolically Programs T Cells to Limit Anti-tumor Activity
Q45376715Redefining thymus medulla specialization for central tolerance
Q48247517S1P Lyase Regulation of Thymic Egress and Oncogenic Inflammatory Signaling
Q49950035Sphingolipid metabolism in cancer signalling and therapy
Q40165434Sphingosine 1-Phosphate Lyase Enhances the Activation of IKKε To Promote Type I IFN-Mediated Innate Immune Responses to Influenza A Virus Infection
Q57069615Sphingosine phosphate lyase insufficiency syndrome (SPLIS): A novel inborn error of sphingolipid metabolism
Q55262443Sphingosine-1-Phosphate Receptor 1 Is Involved in Non-Obese Diabetic Mouse Thymocyte Migration Disorders.
Q50421705T-cell egress from the thymus: Should I stay or should I go?
Q62272072The emerging alliance of sphingosine-1-phosphate signalling and immune cells: from basic mechanisms to implications in hypertension
Q41593279The novel sphingosine-1-phosphate receptors antagonist AD2900 affects lymphocyte activation and inhibits T-cell entry into the lymph nodes

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