| scholarly article | Q13442814 |
| P356 | DOI | 10.4155/FMC.13.107 |
| P8608 | Fatcat ID | release_yhsr46kedrh6xdsgcmeefdwkb4 |
| P932 | PMC publication ID | 4216473 |
| P698 | PubMed publication ID | 23919551 |
| P2093 | author name string | Barbara S Beckman | |
| Jiawang Liu | |||
| Maryam Foroozesh | |||
| P2860 | cites work | Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform | Q22253469 |
| Molecular cloning and characterization of a human mitochondrial ceramidase | Q22253989 | ||
| Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization | Q24294548 | ||
| Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis | Q24314251 | ||
| Ceramide 1-phosphate stimulates proliferation of C2C12 myoblasts | Q24607910 | ||
| Role of ABCC1 in export of sphingosine-1-phosphate from mast cells | Q24671687 | ||
| Characterization of Salmonella typhimurium YegS, a putative lipid kinase homologous to eukaryotic sphingosine and diacylglycerol kinases | Q27644271 | ||
| Mechanistic Insights into the Hydrolysis and Synthesis of Ceramide by Neutral Ceramidase | Q27653166 | ||
| The structural requirements for ceramide activation of serine-threonine protein phosphatases | Q28189436 | ||
| Ceramide-1-phosphate blocks apoptosis through inhibition of acid sphingomyelinase in macrophages | Q28206524 | ||
| Ceramide-induced inhibition of Akt is mediated through protein kinase Czeta: implications for growth arrest | Q28207697 | ||
| Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activation | Q28240307 | ||
| Direct binding to ceramide activates protein kinase Czeta before the formation of a pro-apoptotic complex with PAR-4 in differentiating stem cells | Q28251494 | ||
| Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis | Q28274211 | ||
| Molecular cloning and functional characterization of murine sphingosine kinase | Q28281335 | ||
| Purification, characterization, and biosynthesis of human acid ceramidase | Q28301145 | ||
| N-acylated serinol is a novel ceramide mimic inducing apoptosis in neuroblastoma cells | Q28378267 | ||
| Purification and characterization of a novel ceramidase from Pseudomonas aeruginosa | Q28492756 | ||
| (1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol as an inhibitor of ceramidase | Q71119928 | ||
| Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide | Q72639477 | ||
| Use of sphingosine-1-phosphate 1 receptor agonist, KRP-203, in combination with a subtherapeutic dose of cyclosporine A for rat renal transplantation | Q79150735 | ||
| Synthesis of a novel ceramide analogue via Tebbe methylenation and evaluation of its antiproliferative activity | Q81626041 | ||
| Sphingosine 1-phosphate stimulates proliferation and migration of satellite cells: role of S1P receptors | Q83007380 | ||
| Expedient and practical synthesis of CERT-dependent ceramide trafficking inhibitor HPA-12 and its analogues | Q83477349 | ||
| 3,4-Disubstituted oxazolidin-2-ones as constrained ceramide analogs with anticancer activities | Q85054423 | ||
| Induction of apoptotic cell death by a ceramide analog in PC-3 prostate cancer cells | Q95814869 | ||
| The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors | Q44722923 | ||
| Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: role of Bcl-2 expression | Q45215121 | ||
| KRP-203, a novel synthetic immunosuppressant, prolongs graft survival and attenuates chronic rejection in rat skin and heart allografts | Q45218848 | ||
| Positively charged ceramide is a potent inducer of mitochondrial permeabilization. | Q45275677 | ||
| Cytotoxicity and acid ceramidase inhibitory activity of 2-substituted aminoethanol amides. | Q46400639 | ||
| Synthesis and evaluation of sphingoid analogs as inhibitors of sphingosine kinases | Q46453201 | ||
| Sphingosine 1-phosphate is involved in cytoprotective actions of calcitriol in human fibroblasts and enhances the intracellular Bcl-2/Bax rheostat | Q46479790 | ||
| Effects of a novel immunomodulating agent, FTY720, on tumor growth and angiogenesis in hepatocellular carcinoma. | Q46709590 | ||
| Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720. | Q46751827 | ||
| Caspase-dependent and -independent cell death of Jurkat human leukemia cells induced by novel synthetic ceramide analogs | Q46883020 | ||
| Inhibitory activity of 6-O-angeloylprenolin from Centipeda minima on farnesyl protein transferase | Q46955200 | ||
| Dimethylsphingosine and FTY720 inhibit the SK1 form but activate the SK2 form of sphingosine kinase from rat heart | Q46969568 | ||
| Novel ceramide analogs as potential chemotherapeutic agents in breast cancer | Q47243607 | ||
| Ceramide 1-phosphate inhibits serine palmitoyltransferase and blocks apoptosis in alveolar macrophages | Q47878059 | ||
| Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized | Q47888807 | ||
| Inhibition of sphingosine kinase in vitro and in platelets. Implications for signal transduction pathways | Q48528203 | ||
| B-535a, b and c, new sphingosine kinase inhibitors, produced by a marine bacterium; taxonomy, fermentation, isolation, physico-chemical properties and structure determination | Q48744563 | ||
| Synthesis and apoptogenic activity of fluorinated ceramide and dihydroceramide analogues. | Q49169688 | ||
| Rapid distribution of liposomal short-chain ceramide in vitro and in vivo. | Q50648780 | ||
| Ceramide 1-phosphate stimulates macrophage proliferation through activation of the PI3-kinase/PKB, JNK and ERK1/2 pathways. | Q53501743 | ||
| PDMP sensitizes neuroblastoma to paclitaxel by inducing aberrant cell cycle progression leading to hyperploidy. | Q53631731 | ||
| 1-phenyl-2-decanoylamino-3-morpholino-1-propanol chemosensitizes neuroblastoma cells for taxol and vincristine. | Q54057209 | ||
| Improved Inhibitors of Glucosylceramide Synthase | Q57479442 | ||
| Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells | Q57546999 | ||
| Ceramide-mediated biology. Determination of structural and stereospecific requirements through the use of N-acyl-phenylaminoalcohol analogs | Q68047304 | ||
| Effect of an inhibitor of glucosylceramide synthesis on cultured rabbit skin fibroblasts | Q68439691 | ||
| Effect of chemically well-defined sphingosine and its N-methyl derivatives on protein kinase C and src kinase activities | Q69113678 | ||
| Preparation of the active isomer of 1-phenyl-2-decanoylamino-3-morpholino-1-propanol, inhibitor of murine glucocerebroside synthetase | Q70032519 | ||
| Analogs of ceramide that inhibit glucocerebroside synthetase in mouse brain | Q70524788 | ||
| Stereospecific induction of apoptosis in U937 cells by N-octanoyl-sphingosine stereoisomers and N-octyl-sphingosine. The ceramide amide group is not required for apoptosis | Q71033813 | ||
| Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720 | Q28512961 | ||
| Design, synthesis and activity as acid ceramidase inhibitors of 2-oxooctanoyl and N-oleoylethanolamine analogues | Q28576919 | ||
| Bax directly induces release of cytochrome c from isolated mitochondria | Q28588847 | ||
| Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer | Q32061450 | ||
| Ceramide induces mitochondrial activation and apoptosis via a Bax-dependent pathway in human carcinoma cells | Q33183746 | ||
| Physiology and pathophysiology of sphingolipid metabolism and signaling | Q33930354 | ||
| Mitochondrial ceramide-rich macrodomains functionalize Bax upon irradiation | Q33939529 | ||
| Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signaling | Q33991690 | ||
| Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme | Q34000718 | ||
| Sphingosine 1-phosphate and cancer | Q34121255 | ||
| Stereoselective synthesis and structure-activity relationship of novel ceramide trafficking inhibitors. (1R,3R)-N-(3-hydroxy-1-hydroxymethyl-3-phenylpropyl)dodecanamide and its analogues. | Q34220369 | ||
| N,N-dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets | Q34370823 | ||
| The Sphingosine Kinase 1 Inhibitor 2-(p-Hydroxyanilino)-4-(p-chlorophenyl)thiazole Induces Proteasomal Degradation of Sphingosine Kinase 1 in Mammalian Cells | Q34385814 | ||
| LCL124, a cationic analog of ceramide, selectively induces pancreatic cancer cell death by accumulating in mitochondria | Q34453596 | ||
| "Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets | Q34593159 | ||
| C16-Ceramide Analog Combined with Pc 4 Photodynamic Therapy Evokes Enhanced Total Ceramide Accumulation, Promotion of DEVDase Activation in the Absence of Apoptosis, and Augmented Overall Cell Killing | Q34736432 | ||
| A novel immunosuppressive agent FTY720 induced Akt dephosphorylation in leukemia cells | Q35045183 | ||
| (R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells | Q35141306 | ||
| Property-based design of a glucosylceramide synthase inhibitor that reduces glucosylceramide in the brain. | Q35715564 | ||
| Induction of brain tumor stem cell apoptosis by FTY720: a potential therapeutic agent for glioblastoma | Q35845241 | ||
| Biologically active sphingolipids in cancer pathogenesis and treatment | Q35852313 | ||
| Ceramide--antiestrogen nanoliposomal combinations--novel impact of hormonal therapy in hormone-insensitive breast cancer | Q36392653 | ||
| Ceramide and glucosylceramide upregulate expression of the multidrug resistance gene MDR1 in cancer cells | Q36600615 | ||
| Mitochondrially targeted ceramide LCL-30 inhibits colorectal cancer in mice | Q36608774 | ||
| Preferential killing of multidrug-resistant KB cells by inhibitors of glucosylceramide synthase | Q36619817 | ||
| The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells | Q36677955 | ||
| Targeting the conversion of ceramide to sphingosine 1-phosphate as a novel strategy for cancer therapy | Q36845513 | ||
| Protein phosphatase 2A inactivates Bcl2's antiapoptotic function by dephosphorylation and up-regulation of Bcl2-p53 binding | Q37041933 | ||
| Sphingosine 1-phosphate regulates matrix metalloproteinase-9 expression and breast cell invasion through S1P3-Gαq coupling | Q38473518 | ||
| Effective inhibition of acid and neutral ceramidases by novel B-13 and LCL-464 analogues | Q39212042 | ||
| 3-Deoxy-3,4-dehydro analogs of XM462. Preparation and activity on sphingolipid metabolism and cell fate. | Q39358065 | ||
| GCS overexpression is associated with multidrug resistance of human HCT-8 colon cancer cells | Q39378630 | ||
| Anti-proliferative effects of the novel ceramide analog (S)-2-(benzylideneamino)-3-hydroxy-N-tetrade-cylpropanamide in chemoresistant cancer | Q39389995 | ||
| Sphingosine-1-phosphate receptor-3 signaling up-regulates epidermal growth factor receptor and enhances epidermal growth factor receptor-mediated carcinogenic activities in cultured lung adenocarcinoma cells | Q39394808 | ||
| Synergistic cytotoxicity in solid tumor cell lines between N-(4-hydroxyphenyl)retinamide and modulators of ceramide metabolism | Q39553593 | ||
| Synthesis, NMR characterization and divergent biological actions of 2'-hydroxy-ceramide/dihydroceramide stereoisomers in MCF7 cells. | Q39654212 | ||
| Novel anti-viability ceramide analogs: design, synthesis, and structure-activity relationship studies of substituted (S)-2-(benzylideneamino)-3-hydroxy-N-tetradecylpropanamides | Q39678863 | ||
| Removal of sphingosine 1-phosphate receptor-3 (S1P(3)) agonism is essential, but inadequate to obtain immunomodulating 2-aminopropane-1,3-diol S1P(1) agonists with reduced effect on heart rate | Q39722937 | ||
| Novel D: -erythro N-octanoyl sphingosine analogs as chemo- and endocrine-resistant breast cancer therapeutics | Q39739522 | ||
| Inhibitory and stimulatory regulation of Rac and cell motility by the G12/13-Rho and Gi pathways integrated downstream of a single G protein-coupled sphingosine-1-phosphate receptor isoform | Q39740344 | ||
| Design, synthesis, and biological activity of a family of novel ceramide analogues in chemoresistant breast cancer cells | Q39810521 | ||
| Synthesis and evaluation of sphingosine analogues as inhibitors of sphingosine kinases | Q39847159 | ||
| Synthesis and bioevaluation of omega-N-amino analogs of B13. | Q39883816 | ||
| Ceramides: branched alkyl chains in the sphingolipid siblings of diacylglycerol improve biological potency. | Q39890580 | ||
| Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells | Q39976111 | ||
| Sphingosine-1-phosphate mediates transcriptional regulation of key targets associated with survival, proliferation, and pluripotency in human embryonic stem cells | Q39994548 | ||
| A role for ceramide in driving cancer cell resistance to doxorubicin. | Q40017408 | ||
| Design, synthesis, and preliminary biological evaluation of a novel triazole analogue of ceramide | Q40121362 | ||
| FTY720, a synthetic compound from Isaria sinclairii, inhibits proliferation and induces apoptosis in pancreatic cancer cells | Q40140527 | ||
| Lysosomotropic acid ceramidase inhibitor induces apoptosis in prostate cancer cells | Q40146520 | ||
| FTY720 induced Bcl-associated and Fas-independent apoptosis in human renal cancer cells in vitro and significantly reduced in vivo tumor growth in mouse xenograft. | Q40160486 | ||
| Short-chain 3-ketoceramides, strong apoptosis inducers against human leukemia HL-60 cells | Q40166804 | ||
| Synthesis and biological evaluation of novel PDMP analogues | Q40290857 | ||
| Potent antitumor activity of a novel cationic pyridinium-ceramide alone or in combination with gemcitabine against human head and neck squamous cell carcinomas in vitro and in vivo. | Q40309755 | ||
| Glucosylceramide synthase blockade down-regulates P-glycoprotein and resensitizes multidrug-resistant breast cancer cells to anticancer drugs | Q40427660 | ||
| Systemic delivery of liposomal short-chain ceramide limits solid tumor growth in murine models of breast adenocarcinoma. | Q40427915 | ||
| The ceramide analog, B13, induces apoptosis in prostate cancer cell lines and inhibits tumor growth in prostate cancer xenografts | Q40589097 | ||
| Intrinsic cytotoxicity and chemomodulatory actions of novel phenethylisothiocyanate sphingoid base derivatives in HL-60 human promyelocytic leukemia cells | Q40599299 | ||
| Liposomal delivery enhances short-chain ceramide-induced apoptosis of breast cancer cells | Q40634373 | ||
| Induction of apoptosis in human bladder cancer cells in vitro and in vivo caused by FTY720 treatment | Q40644323 | ||
| The immune modulator FTY720 targets sphingosine 1-phosphate receptors | Q40736684 | ||
| Bcl-2 overexpression prevents apoptosis induced by ceramidase inhibitors in malignant melanoma and HaCaT keratinocytes. | Q40737590 | ||
| Marked prevention of tumor growth and metastasis by a novel immunosuppressive agent, FTY720, in mouse breast cancer models. | Q40745321 | ||
| Sphingosine 1-phosphate released from platelets during clotting accounts for the potent endothelial cell chemotactic activity of blood serum and provides a novel link between hemostasis and angiogenesis. | Q40845943 | ||
| Sphingosine 1-phosphate stimulates cell migration through a G(i)-coupled cell surface receptor. Potential involvement in angiogenesis | Q40914150 | ||
| Early induction of apoptosis in androgen-independent prostate cancer cell line by FTY720 requires caspase-3 activation | Q40951829 | ||
| Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells | Q40984564 | ||
| In vitro and in vivo induction of apoptosis by sphingosine and N, N-dimethylsphingosine in human epidermoid carcinoma KB-3-1 and its multidrug-resistant cells | Q41128764 | ||
| Sphingosine and its methylated derivative N,N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines | Q41199667 | ||
| Structural and stereochemical studies of potent inhibitors of glucosylceramide synthase and tumor cell growth. | Q41364587 | ||
| Novel amide- and sulfonamide-based aromatic ethanolamines: effects of various substituents on the inhibition of acid and neutral ceramidases | Q42715770 | ||
| A novel inhibitor of ceramide trafficking from the endoplasmic reticulum to the site of sphingomyelin synthesis. | Q43458274 | ||
| Structural requirements of ceramide and sphingosine based inhibitors of mitochondrial ceramidase | Q43754165 | ||
| Synthesis and characterization of novel ceramide analogs for induction of apoptosis in human cancer cells | Q44215276 | ||
| Improved inhibitors of glucosylceramide synthase | Q44295948 | ||
| Synthesis of non-natural C2-homo-ceramide and its apoptotic activity against HL-60 cells | Q44363612 | ||
| Apoptotic activities of C2-ceramide and C2-dihydroceramide homologues against HL-60 cells | Q44466637 | ||
| Synthetic, non-natural sphingolipid analogs inhibit the biosynthesis of cellular sphingolipids, elevate ceramide and induce apoptotic cell death | Q44590183 | ||
| (3Z)-2-Acetylamino-3-octadecen-1-ol as a potent apoptotic agent against HL-60 cells | Q44707661 | ||
| P433 | issue | 12 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | ceramides | Q424213 |
| P304 | page(s) | 1405-21 | |
| P577 | publication date | 2013-08-01 | |
| P1433 | published in | Future Medicinal Chemistry | Q19280078 |
| P1476 | title | A review of ceramide analogs as potential anticancer agents | |
| P478 | volume | 5 |
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