Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation

scientific article published on July 1991

Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1083/JCB.114.1.155
P932PMC publication ID2289065
P698PubMed publication ID2050740

P2093author name stringH Zhang
S Spiegel
T Seki
A Olivera
G Brooker
N N Desai
P2860cites workSphingosine kinase in blood plateletsQ28240675
Arachidonic acid metabolismQ28287622
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Studies and perspectives of protein kinase C.Q34162282
Calcium wave evoked by activation of endogenous or exogenously expressed receptors in Xenopus oocytesQ37735438
Signaling through phosphatidylcholine breakdown.Q37806652
An update of the enzymology and regulation of sphingomyelin metabolismQ37923512
Functions of sphingolipids and sphingolipid breakdown products in cellular regulationQ38597926
Modulation of protein kinase C and diverse cell functions by sphingosine--a pharmacologically interesting compound linking sphingolipids and signal transductionQ38598657
Glycosphingolipids: structure, biological source, and propertiesQ38766443
Early signals in the mitogenic responseQ39504519
Sphingolipid base metabolism. Partial purification and properties of sphinganine kinase of brainQ40002151
Inositol trisphosphate and diacylglycerol as second messengersQ40094697
Lack of association of epidermal growth factor-, insulin-, and serum-induced mitogenesis with stimulation of phosphoinositide degradation in BALB/c 3T3 fibroblastsQ41363986
Lysosphingolipids inhibit protein kinase C: implications for the sphingolipidosesQ41382443
Phospholipase D catalyzes phospholipid metabolism in chemotactic peptide-stimulated HL-60 granulocytesQ41395569
Growth factor-like action of phosphatidic acidQ41472962
Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiationQ41700006
Increases in phosphatidic acid levels accompany sphingosine-stimulated proliferation of quiescent Swiss 3T3 cellsQ41710971
Ceramide 1-phosphate, a novel phospholipid in human leukemia (HL-60) cells. Synthesis via ceramide from sphingomyelinQ41721938
Intracellular calcium release mediated by sphingosine derivatives generated in cellsQ41730318
Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathwayQ41748195
Early changes in inositol lipids and their metabolites induced by platelet-derived growth factor in quiescent Swiss mouse 3T3 cellsQ41864773
A specific enhancing effect of N,N-dimethylsphingosine on epidermal growth factor receptor autophosphorylation. Demonstration of its endogenous occurrence (and the virtual absence of unsubstituted sphingosine) in human epidermoid carcinoma A431 cellQ42068240
A facile enzymatic synthesis of sphingosine-1-phosphate and dihydrosphingosine-1-phosphateQ42153936
Possible involvement of a GTP-binding protein in a late event during endogenous ganglioside-modulated cellular proliferationQ42798858
Ca2+ and pH responses to sequential additions of mitogens in single 3T3 fibroblasts: correlations with DNA synthesis.Q42802830
Mitogenesis of 3T3 fibroblasts induced by endogenous ganglioside is not mediated by cAMP, protein kinase C, or phosphoinositides turnoverQ42803125
Cellular ras activity and phospholipid metabolismQ42805155
Inositol trisphosphate formation and calcium mobilization in Swiss 3T3 cells in response to platelet-derived growth factorQ42818159
Assay of inorganic and organic phosphorus in the 0.1–5 nanomole rangeQ44547330
Two dimensional then layer chromatographic separation of polar lipids and determination of phospholipids by phosphorus analysis of spotsQ48919839
Metabolism of sphingosine bases. 13. Enzymatic synthesis of 1-phosphate esters of 4t-sphingenine (sphingosine), sphinganine (dihydrosphingosine), 4-hydroxysphinganine (phytosphingosine) and 3-dehydrosphinganine by erythrocytes.Q53782925
A ceramide analogue inhibits T cell proliferative response through inhibition of glycosphingolipid synthesis and enhancement of N,N-dimethylsphingosine synthesisQ68544672
Modulation of the free sphingosine levels in human neutrophils by phorbol esters and other factorsQ70391574
Enzymatic Formation of Dihydrosphingosine 1-PhosphateQ71473185
P433issue1
P407language of work or nameEnglishQ1860
P1104number of pages13
P304page(s)155-167
P577publication date1991-07-01
P1433published inJournal of Cell BiologyQ1524550
P1476titleSphingosine-1-phosphate, a novel lipid, involved in cellular proliferation
P478volume114

Reverse relations

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Q35047178Sphingosine kinase, sphingosine-1-phosphate, and apoptosis
Q28185880Sphingosine kinase: a mediator of vital cellular functions
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Q55564395Sphingosine-1-Phosphate-Specific G Protein-Coupled Receptors as Novel Therapeutic Targets for Atherosclerosis.
Q47825992Sphingosine-1-phosphate as an intercellular signaling molecule.
Q42805681Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens
Q26852824Sphingosine-1-phosphate in chronic intestinal inflammation and cancer
Q35086003Sphingosine-1-phosphate induces pro-remodelling response in airway smooth muscle cells
Q36235805Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transduction
Q44371529Sphingosine-1-phosphate inhibits acid sphingomyelinase and blocks apoptosis in macrophages
Q71034353Sphingosine-1-phosphate inhibits actin nucleation and pseudopodium formation to control cell motility of mouse melanoma cells
Q38935993Sphingosine-1-phosphate inhibits differentiation of C3H10T1/2 cells into adipocyte
Q44648524Sphingosine-1-phosphate inhibits human keratinocyte proliferation via Akt/protein kinase B inactivation
Q54342529Sphingosine-1-phosphate mediates epidermal growth factor-induced muscle satellite cell activation.
Q42444888Sphingosine-1-phosphate promotes mouse melanocyte survival via ERK and Akt activation
Q41065014Sphingosine-1-phosphate rapidly induces Rho-dependent neurite retraction: action through a specific cell surface receptor
Q37413862Sphingosine-1-phosphate receptor signalling in the heart
Q37317783Sphingosine-1-phosphate receptor-1 (S1P1) is expressed by lymphocytes, dendritic cells, and endothelium and modulated during inflammatory bowel disease
Q42525224Sphingosine-1-phosphate stimulates human Caco-2 intestinal epithelial proliferation via p38 activation and activates ERK by an independent mechanism
Q40607042Sphingosine-1-phosphate, a novel second messenger involved in cell growth regulation and signal transduction, affects growth and invasiveness of human breast cancer cells
Q90117111Sphingosine-1-phosphate: From insipid lipid to a key regulator
Q29620563Sphingosine-1-phosphate: an enigmatic signalling lipid
Q34980697Sphingosine-1-phosphate: dual messenger functions
Q33957118Sphingosine-1-phosphate: signaling inside and out.
Q41153301Sphingosine-induced inhibition of capacitative calcium influx in CFPAC-1 cells
Q42985690Sphingosylphosphocholine modulates the ryanodine receptor/calcium-release channel of cardiac sarcoplasmic reticulum membranes
Q42445967Sphingosylphosphorylcholine activates an amiloride-insensitive Na+-H+-exchange mechanism in GH4C1 cells
Q41656256Sphingosylphosphorylcholine is a remarkably potent mitogen for a variety of cell lines
Q35377676Spinster homolog 2 (spns2) deficiency causes early onset progressive hearing loss
Q42798604Stimulation of DNA synthesis by natural ceramide 1-phosphate
Q42826338Stimulation of nuclear sphingosine kinase activity by platelet-derived growth factor
Q38204271Structural biology of the S1P1 receptor
Q37160896Subcellular origin of sphingosine 1-phosphate is essential for its toxic effect in lyase-deficient neurons
Q34264490Subtype-specific, differential activities of the EDG family receptors for sphingosine-1-phosphate, a novel lysophospholipid mediator
Q42556020Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate
Q47982503Survival by Mac-1-mediated adherence and anoikis in phorbol ester-treated HL-60 cells
Q42823251Synthesis and evaluation of a photolyzable derivative of sphingosine 1-phosphate--caged SPP.
Q34255382Systemic distribution, subcellular localization and differential expression of sphingosine-1-phosphate receptors in benign and malignant human tissues
Q38116071Targeting the sphingosine kinase/sphingosine 1-phosphate pathway to treat chronic inflammatory kidney diseases
Q34364844Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond
Q26748848The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined
Q36790267The apolipoprotein m-sphingosine-1-phosphate axis: biological relevance in lipoprotein metabolism, lipid disorders and atherosclerosis
Q27657731The crystal structure of sphingosine-1-phosphate in complex with a Fab fragment reveals metal bridging of an antibody and its antigen
Q42982087The differential regulation of cyclic AMP by sphingomyelin-derived lipids and the modulation of sphingolipid-stimulated extracellular signal regulated kinase-2 in airway smooth muscle
Q27935031The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses
Q33918545The electrostatics of lipid surfaces
Q45287768The endocannabinoid anandamide induces apoptosis of rat decidual cells through a mechanism involving ceramide synthesis and p38 MAPK activation
Q30430805The enhancement of bone allograft incorporation by the local delivery of the sphingosine 1-phosphate receptor targeted drug FTY720.
Q40963836The identification of myriocin-binding proteins
Q38738515The immunomodulator FTY720 and its phosphorylated derivative activate the Smad signalling cascade and upregulate connective tissue growth factor and collagen type IV expression in renal mesangial cells
Q37293864The influence of sphingosine-1-phosphate receptor signaling on lymphocyte trafficking: how a bioactive lipid mediator grew up from an "immature" vascular maturation factor to a "mature" mediator of lymphocyte behavior and function.
Q34486205The interaction between C5a and sphingosine-1-phosphate in neutrophils for antineutrophil cytoplasmic antibody mediated activation
Q73212884The mycotoxin fumonisin B1 inhibits integrin-mediated cell-matrix adhesion
Q41769614The novel sphingosine 1-phosphate receptor AGR16 is coupled via pertussis toxin-sensitive and -insensitive G-proteins to multiple signalling pathways.
Q36011196The outs and the ins of sphingosine-1-phosphate in immunity
Q42830767The potent lipid mitogen sphingosylphosphocholine activates the DNA binding activity of upstream stimulating factor (USF), a basic helix-loop-helix-zipper protein
Q90318251The role of dihydrosphingolipids in disease
Q37928817The role of sphingolipids in respiratory disease
Q37128721The role of sphingosine-1-phosphate and its receptors in asthma
Q36241051The role of sphingosine-1-phosphate in breast cancer tumor-induced lymphangiogenesis.
Q36415172The sphingosine and diacylglycerol kinase superfamily of signaling kinases: localization as a key to signaling function
Q37402927The therapeutic potential of novel cannabinoid receptors
Q83324534Transcriptional activation of tyrosinase gene by human placental sphingolipid
Q73426568Tumor necrosis factor-alpha-mediated signal transduction in human neutrophils: involvement of sphingomyelin metabolites in the priming effect of TNF-alpha on the fMLP-stimulated superoxide production
Q29041393Tumor necrosis factor-  induces adhesion molecule expression through the sphingosine kinase pathway
Q35264010Tumor-suppressive sphingosine-1-phosphate receptor-2 counteracting tumor-promoting sphingosine-1-phosphate receptor-1 and sphingosine kinase 1 - Jekyll Hidden behind Hyde
Q44109350Two forms of membrane-bound sphingosine kinase in Tetrahymena and activity changes during growth and the cell cycle
Q41113014Understanding and controlling the cell cycle with natural products
Q38625631Unravelling the interplay of sphingolipids and TGF-β signaling in the human corneal stroma
Q47734379Vasoactive intestinal peptide induces both tyrosine hydroxylase activity and tetrahydrobiopterin biosynthesis in PC12 cells

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