Beta-amyloid-induced synthesis of the ganglioside GD3 is a requisite for cell cycle reactivation and apoptosis in neurons

scientific article published on 01 May 2002

Beta-amyloid-induced synthesis of the ganglioside GD3 is a requisite for cell cycle reactivation and apoptosis in neurons is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.22-10-03963.2002
P932PMC publication ID6757645
P698PubMed publication ID12019315

P50authorMaria Angela SortinoQ57001715
Andrea CaricasoleQ130272400
Roberto CarnevaleQ41536831
P2093author name stringFrancesca Martini
Luisa Lenti
Agata Copani
Ferdinando Nicoletti
Ruggero De Maria
Patrizio Sale
Roberto Gradini
Daniela Melchiorri
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Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain.Q48487273
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Commitment to apoptosis by GD3 ganglioside depends on opening of the mitochondrial permeability transition pore.Q51088828
The induction of multiple cell cycle events precedes target-related neuronal deathQ52206831
Expression of TGF-beta s and their receptors during implantation and organogenesis of the mouse embryo.Q52212762
Re-entry into the cell cycle: a mechanism for neurodegeneration in Alzheimer disease.Q53230030
GD3 ganglioside directly targets mitochondria in a bcl-2-controlled fashionQ57082830
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GM1 Ganglioside in the Nuclear Membrane Modulates Nuclear Calcium Homeostasis During Neurite OutgrowthQ71978534
Mitotic signaling by beta-amyloid causes neuronal deathQ73263325
Apoptogenic ganglioside GD3 directly induces the mitochondrial permeability transitionQ78101724
Axonogenesis in neuro-2a cells correlates with GM1 upregulation in the nuclear and plasma membranesQ78108281
Alzheimer's disease: genes, proteins, and therapyQ28131806
Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNAQ29547801
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Phosphoinositide 3-kinase regulates crosstalk between Trk A tyrosine kinase and p75(NTR)-dependent sphingolipid signaling pathwaysQ32134813
Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F x DP, in B-amyloid-induced neuronal deathQ33178580
E2F1 mediates death of B-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase 3.Q33180163
Gangliosides prevent glutamate and kainate neurotoxicity in primary neuronal cultures of neonatal rat cerebellum and cortexQ33652653
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Activation of cell-cycle-associated proteins in neuronal death: a mandatory or dispensable path?Q34133245
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Alzheimer's disease and Abeta toxicity: from top to bottomQ34325378
Caspases, apoptosis, and Alzheimer disease: causation, correlation, and confusionQ34369442
Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosis.Q34438239
Glycosphingolipid glycosyltransferases in human fetal brainQ34882711
Mitotic mechanisms in Alzheimer's disease?Q36236501
Acidic sphingomyelinase (ASM) is necessary for fas-induced GD3 ganglioside accumulation and efficient apoptosis of lymphoid cellsQ36400469
Apoptosis is induced by beta-amyloid in cultured central nervous system neuronsQ36501389
Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease.Q37374362
Comparison of ganglioside profiles in nuclei and whole cells of NG108-15 and NG-CR72 lines: changes in response to different neuritogenic stimuliQ40820985
GD3 synthase gene expression in PC12 cells results in the continuous activation of TrkA and ERK1/2 and enhanced proliferation.Q40899338
Down-regulation of GD3 ganglioside and its O-acetylated derivative by stable transfection with antisense vector against GD3-synthase gene expression in hamster melanoma cells: effects on cellular growth, melanogenesis, and dendricityQ40904216
Increased tumorigenicity and invasiveness of C6 rat glioma cells transfected with the human alpha-2,8 sialyltransferase cDNA.Q40931019
A reappraisal of ganglioside GD3 expression in the CNS.Q41043441
The GM2-1 ganglioside islet autoantigen in insulin-dependent diabetes mellitus is expressed in secretory granules and is not beta-cell specific.Q41072853
DNA replication precedes neuronal cell death in Alzheimer's disease.Q42502934
Glutamate-induced neuronal death in primary cultures of cerebellar granule cells: protection by synthetic derivatives of endogenous sphingolipidsQ45235224
Embryonic stem cells with a disrupted GD3 synthase gene undergo neuronal differentiation in the absence of b-series gangliosidesQ47792166
P433issue10
P304page(s)3963-3968
P577publication date2002-05-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleBeta-amyloid-induced synthesis of the ganglioside GD3 is a requisite for cell cycle reactivation and apoptosis in neurons
P478volume22

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cites work (P2860)
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