Distinct stress and cell destruction pathways are engaged by TNF and ceramide during apoptosis of MCF-7 cells

scientific article published on April 2004

Distinct stress and cell destruction pathways are engaged by TNF and ceramide during apoptosis of MCF-7 cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.YEXCR.2003.11.021
P698PubMed publication ID15023539

P2093author name stringNicholas J Donato
Jim Klostergaard
P2860cites workTAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinaseQ24310066
The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activationQ24318742
Cloned mammalian neutral sphingomyelinase: functions in sphingolipid signaling?Q24319856
Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosisQ28274211
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosisQ28292299
Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signalsQ28295232
Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathwayQ28302102
Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymeraseQ28302692
A novel cytoplasmic domain of the p55 tumor necrosis factor receptor initiates the neutral sphingomyelinase pathwayQ28640099
Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell deathQ29620021
Sphingolipid signalling domains floating on rafts or buried in caves?Q33840820
A human cell line from a pleural effusion derived from a breast carcinomaQ34207627
Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosis.Q34438239
Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathwayQ34889125
Ceramide in apoptosis: an overview and current perspectivesQ35047136
Ceramide and cell death receptor clusteringQ35047148
Fas-induced apoptosis of T cells occurs independently of ceramide generationQ36654745
Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alphaQ37617716
PARP is important for genomic stability but dispensable in apoptosisQ40442742
Febrile and acute hyperthermia enhance TNF-induced necrosis of murine L929 fibrosarcoma cells via caspase-regulated production of reactive oxygen intermediatesQ40605748
Fas, ceramide and serum withdrawal induce apoptosis via a common pathway in a type II Jurkat cell line.Q40735901
The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signalingQ40751632
On the complexities of ceramide changes in cells undergoing apoptosis: lack of evidence for a second messenger function in apoptotic inductionQ40817832
The mode of ceramide action: the alkyl chain protrusion modelQ40892079
Mass spectrometric identification of increased C16 ceramide levels during apoptosisQ40922788
JNK and p53 stress signaling cascades are altered in MCF-7 cells resistant to tumor necrosis factor-mediated apoptosisQ40959065
Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.Q41218044
Partial Inhibition of Multidrug Resistance by Safingol Is Independent of Modulation of P-glycoprotein Substrate Activities and Correlated with Inhibition of Protein Kinase CQ41272448
Role for ceramide in cell cycle arrest.Q41370969
A novel SAPK/JNK kinase, MKK7, stimulated by TNFalpha and cellular stressesQ41767215
Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.Q41972615
Regulation of Raf-1 kinase by TNF via its second messenger ceramide and cross-talk with mitogenic signallingQ42034188
Heat shock and ceramide have different apoptotic pathways in radiation induced fibrosarcoma (RIF) cellsQ43950053
Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinaseQ44087049
Disruption of HSP90 function reverts tumor necrosis factor-induced necrosis to apoptosisQ44222499
Neurotrophic factors prevent ceramide-induced apoptosis downstream of c-Jun N-terminal kinase activation in PC12 cells.Q47903738
Analysis of human breast adenocarcinoma MCF7 resistance to tumor necrosis factor-induced cell death. Lack of correlation between JNK activation and ceramide pathway.Q54120148
Ceramide-Induced Apoptosis Is Mediated by Caspase Activation Independently from Retinoblastoma Protein Post-Translational ModificationQ59283429
Sphingomyelin-derived lipids differentially regulate the extracellular signal-regulated kinase 2 (ERK-2) and c-Jun N-terminal kinase (JNK) signal cascades in airway smooth muscleQ71118080
Cellular stresses and cytokines activate multiple mitogen-activated-protein kinase kinase homologues in PC12 and KB cellsQ71149530
Ceramide activates the stress-activated protein kinasesQ71742988
Inactivation of interleukin-1 beta converting enzyme by peptide (acyloxy)methyl ketonesQ72326670
Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signalingQ72710788
De novo-synthesized ceramide signals apoptosis in astrocytes via extracellular signal-regulated kinaseQ73127880
Ceramide-enhanced urokinase-type plasminogen activator (uPA) release is mediated by protein kinase C in cultured microgliaQ73260072
Sphingosine 1-phosphate inhibits activation of caspases that cleave poly(ADP-ribose) polymerase and lamins during Fas- and ceramide-mediated apoptosis in Jurkat T lymphocytesQ74105987
Inhibition of sphingolipid induced apoptosis by caspase inhibitors indicates that sphingosine acts in an earlier part of the apoptotic pathway than ceramideQ74440446
Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell deathQ74473415
Characterization of cytotoxicity induced by sphingolipids in multidrug-resistant leukemia cellsQ77448881
Death by a thousand cuts: an ever increasing list of caspase substratesQ77812586
Ceramide-induced apoptosis occurs independently of caspases and is decreased by leupeptinQ78192835
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectceramidesQ424213
P304page(s)523-533
P577publication date2004-04-01
P1433published inExperimental Cell ResearchQ1524289
P1476titleDistinct stress and cell destruction pathways are engaged by TNF and ceramide during apoptosis of MCF-7 cells
P478volume294

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cites work (P2860)
Q37357098Altering the sphingolipid acyl chain composition prevents LPS/GLN-mediated hepatic failure in mice by disrupting TNFR1 internalization
Q83506404Apoptosis, angiogenesis, inflammation, and oxidative stress: basic interactions in patients with early and metastatic breast cancer
Q26822419Ceramide-induced apoptosis in renal tubular cells: a role of mitochondria and sphingosine-1-phoshate
Q38067062Ceramide-orchestrated signalling in cancer cells.
Q25257522Dexamethasone protection from TNF-alpha-induced cell death in MCF-7 cells requires NF-kappaB and is independent from AKT.
Q37712385Mechanism of immune evasion in breast cancer
Q34642945Role of mitochondrial Bax, caspases, and MAPKs for ceramide-induced apoptosis in renal proximal tubular cells
Q34920381The role of cytokines in breast cancer development and progression