Ceramide triggers p53-dependent apoptosis in genetically defined fibrosarcoma tumour cells

scientific article published in May 1999

Ceramide triggers p53-dependent apoptosis in genetically defined fibrosarcoma tumour cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/SJ.BJC.6690411
P932PMC publication ID2362278
P698PubMed publication ID10360645
P5875ResearchGate publication ID12937623

P2093author name stringBodis S
Glanzmann C
Pruschy M
Resch H
Shi YQ
Aalame N
P2860cites workIonizing radiation acts on cellular membranes to generate ceramide and initiate apoptosisQ24679716
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machineryQ27860586
Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosisQ28274211
Tumor suppressor p53 is a direct transcriptional activator of the human bax geneQ28306186
p53-dependent apoptosis modulates the cytotoxicity of anticancer agentsQ29615031
Tumor spectrum analysis in p53-mutant miceQ29617436
p53 is required for radiation-induced apoptosis in mouse thymocytesQ29620281
Structure and function of the p53 tumor suppressor gene: clues for rational cancer therapeutic strategiesQ34400583
Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathwayQ34889125
Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cellsQ35088549
Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stressQ35204241
Ionizing radiation-induced cell deathQ40635189
Apoptosis in cancer therapy: crossing the thresholdQ40694262
Sphingolipid breakdown products: anti-proliferative and tumor-suppressor lipidsQ40800750
Apoptosis (the 1992 Frank Rose Memorial Lecture).Q40874676
The growth arrest and downregulation of c-myc transcription induced by ceramide are related events dependent on p21 induction, Rb underphosphorylation and E2F sequesteringQ40961144
Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosisQ41007018
The effect of UCN-01 (7-hydroxystaurosporine), a potent inhibitor of protein kinase C, on fractionated radiotherapy or daily chemotherapy of a murine fibrosarcomaQ41077781
Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.Q41218044
Molecular ordering of the cell death pathway. Bcl-2 and Bcl-xL function upstream of the CED-3-like apoptotic proteasesQ41224926
Role for ceramide in cell cycle arrest.Q41370969
Apoptosis and the dilemma of cancer chemotherapy.Q41372240
Potential molecular targets for manipulating the radiation responseQ41439150
Ceramide signaling in apoptosisQ41646613
Apoptosis caused by oxidized LDL is manganese superoxide dismutase and p53 dependentQ42543771
Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis.Q42555356
Ceramide and the induction of apoptosisQ45114791
A novel form of Epstein-Barr virus latency in normal B cells in vivoQ45789413
Thymocyte apoptosis induced by p53-dependent and independent pathways.Q54242475
Programmed cell death induced by ceramideQ70619078
p53 status and the efficacy of cancer therapy in vivoQ72839445
Loss of ceramide production confers resistance to radiation-induced apoptosisQ73221177
Bcr-Abl exerts its antiapoptotic effect against diverse apoptotic stimuli through blockage of mitochondrial release of cytochrome C and activation of caspase-3Q74213469
P433issue5-6
P407language of work or nameEnglishQ1860
P921main subjectceramidesQ424213
P304page(s)693-698
P577publication date1999-05-01
P1433published inBritish Journal of CancerQ326309
P1476titleCeramide triggers p53-dependent apoptosis in genetically defined fibrosarcoma tumour cells
P478volume80

Reverse relations

cites work (P2860)
Q24675372A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death
Q38067062Ceramide-orchestrated signalling in cancer cells.
Q43849857DAP kinase activity is critical for C(2)-ceramide-induced apoptosis in PC12 cells
Q24683786DRAL is a p53-responsive gene whose four and a half LIM domain protein product induces apoptosis
Q35754223Defining a role for sphingosine kinase 1 in p53-dependent tumors.
Q43189320P53-dependent upregulation of neutral sphingomyelinase-2: role in doxorubicin-induced growth arrest
Q48970037Pivotal role for acidic sphingomyelinase in cerebral ischemia-induced ceramide and cytokine production, and neuronal apoptosis
Q44755093Radiation-induced apoptosis of oligodendrocytes and its association with increased ceramide and down-regulated protein kinase B/Akt activity
Q39417915Renal apoptosis parallels ceramide content after prolonged ureteral obstruction in the neonatal rat.
Q34619554Senescence and apoptosis: dueling or complementary cell fates?
Q36404904The hyaluronic acid inhibitor 4-methylumbelliferone is an NSMase2 activator-role of Ceramide in MU anti-tumor activity
Q37805092p53 and regulation of bioactive sphingolipids

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