DAP kinase activity is critical for C(2)-ceramide-induced apoptosis in PC12 cells

scientific article published in January 2002

DAP kinase activity is critical for C(2)-ceramide-induced apoptosis in PC12 cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1046/J.0014-2956.2002.00029.X
P698PubMed publication ID11784307
P5875ResearchGate publication ID11574623

P2093author name stringShigeo Uchino
Takeshi Hioki
Takehisa Ishii
Mutsuya Yamamoto
Sadayo Nakajima-Iijima
P2860cites workZIP kinase identified as a novel myosin regulatory light chain kinase in HeLa cellsQ22009929
Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell deathQ24310279
ZIP kinase, a novel serine/threonine kinase which mediates apoptosisQ24314699
Death-associated proteins: from gene identification to the analysis of their apoptotic and tumour suppressive functionsQ28277623
Mitochondria and apoptosisQ29547905
A functional genetic screen identifies regions at the C-terminal tail and death-domain of death-associated protein kinase that are critical for its proapoptotic activityQ30839612
Ceramide induces apoptosis to immature cerebellar granule cells in cultureQ33178433
Signal transduction through lipid second messengersQ34395640
Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemiaQ36368602
Ceramide: an intracellular signal for apoptosisQ40497600
The lipids C2- and C16-ceramide form large stable channels. Implications for apoptosisQ40649042
Differential modulation of apoptosis sensitivity in CD95 type I and type II cells.Q40938605
Cloning and characterization of Dlk, a novel serine/threonine kinase that is tightly associated with chromatin and phosphorylates core histonesQ40990389
Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosisQ41007018
Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.Q41218044
Activation of Ca2+/calmodulin-dependent protein kinase (CaM-kinase) IV by CaM-kinase kinase in Jurkat T lymphocytesQ41258093
DAP-kinase is a Ca2+/calmodulin-dependent, cytoskeletal-associated protein kinase, with cell death-inducing functions that depend on its catalytic activityQ41848995
The death domain: a module shared by proteins with diverse cellular functions.Q42672391
Ceramide triggers p53-dependent apoptosis in genetically defined fibrosarcoma tumour cellsQ43201396
Neurotrophic factors prevent ceramide-induced apoptosis downstream of c-Jun N-terminal kinase activation in PC12 cells.Q47903738
Developmental changes in distribution of death-associated protein kinase mRNAs.Q52173169
DAP kinase links the control of apoptosis to metastasisQ59083516
Ceramide induces apoptosis via CPP32 activationQ71738609
Different effects of enzyme-generated ceramides and diacylglycerols in phospholipid membrane fusion and leakageQ71742617
Ceramide induces apoptosis in PC12 cellsQ73025799
Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosisQ73596247
Ceramide mimics tumour necrosis factor-alpha in the induction of cell cycle arrest in endothelial cells. Induction of the tumour suppressor p53 with decrease in retinoblastoma/protein levelsQ73955405
Ceramide formation leads to caspase-3 activation during hypoxic PC12 cell death. Inhibitory effects of Bcl-2 on ceramide formation and caspase-3 activationQ74326080
Ceramide can induce cell death in sensory neurons, whereas ceramide analogues and sphingosine promote survivalQ77463321
Mechanisms of cell death in hypoxia/reoxygenation injuryQ77900376
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectceramidesQ424213
P304page(s)139-147
P577publication date2002-01-01
P1433published inFEBS JournalQ1388041
P1476titleDAP kinase activity is critical for C(2)-ceramide-induced apoptosis in PC12 cells
P478volume269

Reverse relations

cites work (P2860)
Q40011747A high throughput proteomics screen identifies novel substrates of death-associated protein kinase
Q37140394Ceramide and neurodegeneration: susceptibility of neurons and oligodendrocytes to cell damage and death
Q33655851Control of death-associated protein kinase (DAPK) activity by phosphorylation and proteasomal degradation
Q24672929DAP-kinase induces apoptosis by suppressing integrin activity and disrupting matrix survival signals
Q47997547DAP-kinase-mediated morphological changes are localization dependent and involve myosin-II phosphorylation
Q38156051DAPK and cytoskeleton-associated functions
Q28771384DAPK catalytic activity in the hippocampus increases during the recovery phase in an animal model of brain hypoxic-ischemic injury
Q26738428Death Associated Protein Kinase 1 (DAPK1): A Regulator of Apoptosis and Autophagy
Q36264833Death-associated protein kinase 1 phosphorylates NDRG2 and induces neuronal cell death.
Q54574938Death-associated protein kinase 1 variation and Parkinson's disease.
Q34837310Death-associated protein kinase as a potential therapeutic target
Q35500554Death-associated protein kinase phosphorylates mammalian ribosomal protein S6 and reduces protein synthesis
Q36642323Demethylation restores SN38 sensitivity in cells with acquired resistance to SN38 derived from human cervical squamous cancer cells
Q41846875Endothelial apoptosis induced by inhibition of integrins alphavbeta3 and alphavbeta5 involves ceramide metabolic pathways
Q38168688Evaluating DAPK as a therapeutic target.
Q36691586Fatty acid synthase is a novel therapeutic target in multiple myeloma
Q51042581Hypermethylation of the death-associated protein kinase CpG island in canine B-cell lymphoid tumors
Q37661492ITIH5 mediates epigenetic reprogramming of breast cancer cells
Q54199487Inhibition of death-associated protein kinase 1 attenuates the phosphorylation and amyloidogenic processing of amyloid precursor protein.
Q57027542Novel Functions of Death-Associated Protein Kinases through Mitogen-Activated Protein Kinase-Related Signals
Q33810122Protein phosphatase 2A (PP2A) holoenzymes regulate death-associated protein kinase (DAPK) in ceramide-induced anoikis
Q34484983Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation
Q44532503Reversible suppression of glutamatergic neurotransmission of cerebellar granule cells in vivo by genetically manipulated expression of tetanus neurotoxin light chain.
Q34905825Structural and functional characterization of the recombinant death domain from death-associated protein kinase
Q34740887Structure and enzymology of a death-associated protein kinase
Q37626012The role of DAPK-BimEL pathway in neuronal death induced by oxygen-glucose deprivation
Q30480366The tumor suppressor DAPK inhibits cell motility by blocking the integrin-mediated polarity pathway.
Q42834338Uncoordinated regulation of stress fibers and focal adhesions by DAP kinase

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