The tumor suppressor DAPK inhibits cell motility by blocking the integrin-mediated polarity pathway.

scientific article

The tumor suppressor DAPK inhibits cell motility by blocking the integrin-mediated polarity pathway. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1083/JCB.200505138
P932PMC publication ID2063680
P698PubMed publication ID16476779
P5875ResearchGate publication ID7299775

P50authorRuey-Hwa ChenQ63646297
Jane Chung-Chen YaoQ73751120
P2093author name stringJean-Cheng Kuo
Won-Jing Wang
Pei-Rung Wu
P2860cites workEtk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activationQ22253232
Structural determinants of integrin recognition by talinQ24292811
Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell deathQ24310279
Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillinQ24318315
Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPKQ24336428
Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signalingQ24553489
DAP-kinase induces apoptosis by suppressing integrin activity and disrupting matrix survival signalsQ24672929
DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell deathQ24673427
Cell migration: integrating signals from front to backQ27860670
Cell migration: a physically integrated molecular processQ27860682
The phosphotyrosine binding-like domain of talin activates integrinsQ28212748
Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170Q28213976
Cdc42--the centre of polarityQ28250444
Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migrationQ28295800
Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarityQ28568803
Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzetaQ28583531
Rho GTPases control polarity, protrusion, and adhesion during cell movementQ29614244
Cell migration: Rho GTPases lead the wayQ29616711
Talin Binding to Integrin ß Tails: A Final Common Step in Integrin ActivationQ29617809
Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesivenessQ29620446
Integrin-mediated adhesion regulates cell polarity and membrane protrusion through the Rho family of GTPasesQ30500235
Live imaging of wound inflammation in Drosophila embryos reveals key roles for small GTPases during in vivo cell migrationQ30777752
Novel bile acid derivatives induce apoptosis via a p53-independent pathway in human breast carcinoma cellsQ31858506
DAP kinase-a proapoptotic gene that functions as a tumor suppressorQ34174358
Activation of rac and cdc42 video imaged by fluorescent resonance energy transfer-based single-molecule probes in the membrane of living cellsQ34324446
Ras GTPases: integrins' friends or foes?Q35564604
DAP-kinase as a target for drug design in cancer and diseases associated with accelerated cell deathQ35818579
A role for Cdc42 in macrophage chemotaxisQ36264673
Integrins control motile strategy through a Rho-cofilin pathway.Q36321708
Restoration of p53 tumor-suppressor activity in human tumor cells in vitro and in their xenografts in vivo by recombinant avian adenovirus CELO-p53.Q40606296
DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformationQ40833586
DAP-kinase participates in TNF-alpha- and Fas-induced apoptosis and its function requires the death domainQ40942632
Integrin activation by dithiothreitol or Mn2+ induces a ligand-occupied conformation and exposure of a novel NH2-terminal regulatory site on the beta1 integrin chainQ41045839
Selection of invasive and metastatic subpopulations from a human lung adenocarcinoma cell lineQ41089777
Rac mediates cytoskeletal rearrangements and increased cell motility induced by urokinase-type plasminogen activator receptor binding to vitronectinQ41812511
DAP-kinase is a Ca2+/calmodulin-dependent, cytoskeletal-associated protein kinase, with cell death-inducing functions that depend on its catalytic activityQ41848995
Rapid Ca2+-mediated activation of Rap1 in human plateletsQ42072243
Uncoordinated regulation of stress fibers and focal adhesions by DAP kinaseQ42834338
Death-associated protein (DAP) kinase plays a central role in ceramide-induced apoptosis in cultured hippocampal neuronsQ43800114
DAP kinase activity is critical for C(2)-ceramide-induced apoptosis in PC12 cellsQ43849857
A role for alphabeta1 integrins in focal adhesion function and polarized cytoskeletal dynamicsQ44580445
An alpha4 integrin-paxillin-Arf-GAP complex restricts Rac activation to the leading edge of migrating cellsQ45118374
DAP-kinase-mediated morphological changes are localization dependent and involve myosin-II phosphorylationQ47997547
Cdc42 controls the polarity of the actin and microtubule cytoskeletons through two distinct signal transduction pathways.Q53673562
DAP kinase links the control of apoptosis to metastasisQ59083516
TGF-beta induces apoptosis through Smad-mediated expression of DAP-kinaseQ77342591
P433issue4
P407language of work or nameEnglishQ1860
P1104number of pages13
P304page(s)619-631
P577publication date2006-02-01
P1433published inJournal of Cell BiologyQ1524550
P1476titleThe tumor suppressor DAPK inhibits cell motility by blocking the integrin-mediated polarity pathway
P478volume172

Reverse relations

cites work (P2860)
Q30278602A RIAM/lamellipodin-talin-integrin complex forms the tip of sticky fingers that guide cell migration
Q40011747A high throughput proteomics screen identifies novel substrates of death-associated protein kinase
Q36594832A quantitative evaluation of cell migration by the phagokinetic track motility assay
Q39990765An alternative transcript from the death-associated protein kinase 1 locus encoding a small protein selectively mediates membrane blebbing.
Q38044430Biochemical and functional characterization of the ROC domain of DAPK establishes a new paradigm of GTP regulation in ROCO proteins
Q36118896CD98hc (SLC3A2) participates in fibronectin matrix assembly by mediating integrin signaling.
Q28576822Cdc42 and RhoA have opposing roles in regulating membrane type 1-matrix metalloproteinase localization and matrix metalloproteinase-2 activation
Q26752753Cul3-KLHL20 ubiquitin ligase: physiological functions, stress responses, and disease implications
Q38165108DAP-kinase and autophagy
Q38156051DAPK and cytoskeleton-associated functions
Q36546788DAPK loss in colon cancer tumor buds: implications for migration capacity of disseminating tumor cells.
Q24338924DAPK2 positively regulates motility of neutrophils and eosinophils in response to intermediary chemoattractants
Q26738428Death Associated Protein Kinase 1 (DAPK1): A Regulator of Apoptosis and Autophagy
Q37624869Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death
Q37624866Death-associated protein kinase (DAPK) and signal transduction: blebbing in programmed cell death.
Q33858262Death-associated protein kinase 1 is an IRF3/7-interacting protein that is involved in the cellular antiviral immune response
Q34930808Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function
Q64066198Dual Role of the Alternative Reading Frame ARF Protein in Cancer
Q63529226Dynamics of p14ARF and Focal Adhesion Kinase-Mediated Autophagy in Cancer
Q38168688Evaluating DAPK as a therapeutic target.
Q54978013Evaluation of the prognostic and physiological functions of death associated protein kinase 1 in breast cancer.
Q38363786Function and dysfunction of leucine-rich repeat kinase 2 (LRRK2): Parkinson's disease and beyond
Q38225040Genetic, structural, and molecular insights into the function of ras of complex proteins domains.
Q37661492ITIH5 mediates epigenetic reprogramming of breast cancer cells
Q42176940Identification of Novel Death-Associated Protein Kinase 2 Interaction Partners by Proteomic Screening Coupled with Bimolecular Fluorescence Complementation
Q38304316Identification of a dominant negative functional domain on DAPK-1 that degrades DAPK-1 protein and stimulates TNFR-1-mediated apoptosis
Q36216177Identification of methylation markers for the prediction of nodal metastasis in oral and oropharyngeal squamous cell carcinoma
Q26996681Insights into the functions of the death associated protein kinases from C. elegans and other invertebrates
Q80946687Integrin activation
Q42826052Integrin signaling, cell survival, and anoikis: distinctions, differences, and differentiation
Q52584506Integrins and dystroglycan regulate astrocyte wound healing: the integrin beta1 subunit is necessary for process extension and orienting the microtubular network.
Q46072576Life and death partners: apoptosis, autophagy and the cross-talk between them
Q39967730Neogenin regulates neuronal survival through DAP kinase.
Q39718188Nutlin-3a induces cytoskeletal rearrangement and inhibits the migration and invasion capacity of p53 wild-type cancer cells
Q54979722PKC Dependent p14ARF Phosphorylation on Threonine 8 Drives Cell Proliferation.
Q52804185Phosphanegold(I) thiolates, Ph3PAu[SC(OR)=NC 6H 4Me-4] for R = Me, Et and iPr, induce apoptosis, cell cycle arrest and inhibit cell invasion of HT-29 colon cancer cells through modulation of the nuclear factor-κB activation pathway and ubiquitinatio
Q24602665Phosphoinositide signaling regulates the exocyst complex and polarized integrin trafficking in directionally migrating cells
Q35061356Polarized regulation of glycogen synthase kinase-3β is important for glioma cell invasion
Q33810122Protein phosphatase 2A (PP2A) holoenzymes regulate death-associated protein kinase (DAPK) in ceramide-induced anoikis
Q24646541Regulation of death-associated protein kinase. Stabilization by HSP90 heterocomplexes
Q39517528Ribosomal protein RPL41 induces rapid degradation of ATF4, a transcription factor critical for tumour cell survival in stress
Q36386977Secretomic analysis identifies alpha-1 antitrypsin (A1AT) as a required protein in cancer cell migration, invasion, and pericellular fibronectin assembly for facilitating lung colonization of lung adenocarcinoma cells
Q40200983Suppression of LPS-induced inflammatory responses by the hydroxyl groups of dexamethasone.
Q24306576The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses
Q38162089The DAP-kinase interactome
Q38162088The DAPK family: a structure-function analysis
Q46828504The N-terminal domains of talin cooperate with the phosphotyrosine binding-like domain to activate beta1 and beta3 integrins
Q93000405The Role of Calmodulin in Tumor Cell Migration, Invasiveness, and Metastasis
Q39876119The alternative splice variant of DAPK-1, s-DAPK-1, induces proteasome-independent DAPK-1 destabilization.
Q35868825The antithrombotic potential of selective blockade of talin-dependent integrin alpha IIb beta 3 (platelet GPIIb-IIIa) activation
Q36791542The effect of cell-matrix interactions and aging on the malignant process
Q38156052The functions and regulations of DAPK in cancer metastasis
Q42161785Tumoral tissue specific promoter hypermethylation of distinct tumor suppressor genes in a case with nonsmall cell lung carcinoma: a case report
Q64296840UNC5D, suppressed by promoter hypermethylation, inhibits cell metastasis by activating death-associated protein kinase 1 in prostate cancer
Q33646095Zebrafish Nanos interacts with and regulates the phosphorylation of Mylz2

Search more.