Overexpression of the adiponectin receptor AdipoR1 in rat skeletal muscle amplifies local insulin sensitivity

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Overexpression of the adiponectin receptor AdipoR1 in rat skeletal muscle amplifies local insulin sensitivity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1210/EN.2012-1368
P932PMC publication ID3498583
P698PubMed publication ID22989629
P5875ResearchGate publication ID230878747

P50authorNigel TurnerQ42468712
Kyle L. HoehnQ42545658
Jonathan P. WhiteheadQ42798286
P2093author name stringE W Kraegen
M E Cleasby
G J Cooney
S A Patel
J L Tomsig
L Sawbridge
N A Talbot
R T Lawrence
P2860cites workThe interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocationQ24293287
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Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinaseQ24309462
APPL1 binds to adiponectin receptors and mediates adiponectin signalling and functionQ24318702
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A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATIONQ25939000
Efficient selection for high-expression transfectants with a novel eukaryotic vectorQ27860810
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesityQ28506782
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivityQ29614241
Sphingosine-1-phosphate: an enigmatic signalling lipidQ29620563
Insulin stimulates fusion, but not tethering, of GLUT4 vesicles in skeletal muscle of HA-GLUT4-GFP transgenic miceQ30513556
Insulin resistance is associated with higher intramyocellular triglycerides in type I but not type II myocytes concomitant with higher ceramide contentQ33556682
Globular adiponectin, acting via AdipoR1/APPL1, protects H9c2 cells from hypoxia/reoxygenation-induced apoptosisQ33892702
Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemiaQ33946056
Diacylglycerol-mediated insulin resistanceQ34109119
The adaptor protein APPL1 increases glycogen accumulation in rat skeletal muscle through activation of the PI3-kinase signalling pathwayQ35043710
Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin.Q35101294
Regulation of adiponectin and its receptors in response to development of diet-induced obesity in miceQ58390488
A rapid method for the determination of glycogen content and radioactivity in small quantities of tissue or isolated hepatocytesQ67459517
Dose-response curves for in vivo insulin sensitivity in individual tissues in ratsQ69885313
In vivo insulin sensitivity in the rat determined by euglycemic clampQ70267055
A high-fat diet has a tissue-specific effect on adiponectin and related enzyme expressionQ79451644
Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor alphaQ80175296
Adiponectin resistance exacerbates insulin resistance in insulin receptor transgenic/knockout miceQ80257515
The role of intramuscular lipid in insulin resistanceQ35178599
APPL1 mediates adiponectin-induced LKB1 cytosolic localization through the PP2A-PKCzeta signaling pathwayQ35238437
Adiponectin increases skeletal muscle mitochondrial biogenesis by suppressing mitogen-activated protein kinase phosphatase-1.Q35976593
The adipocyte-myocyte axis in insulin resistance.Q36644671
Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistanceQ37105295
The adiponectin receptors AdipoR1 and AdipoR2 activate ERK1/2 through a Src/Ras-dependent pathway and stimulate cell growthQ37151146
Pleiotropic effects of sphingolipids in skeletal muscle.Q37230938
Lipid and insulin infusion-induced skeletal muscle insulin resistance is likely due to metabolic feedback and not changes in IRS-1, Akt, or AS160 phosphorylationQ37264198
Quantitative analysis of sphingolipids for lipidomics using triple quadrupole and quadrupole linear ion trap mass spectrometersQ37297885
Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activityQ37299866
Adiponectin activates AMP-activated protein kinase in muscle cells via APPL1/LKB1-dependent and phospholipase C/Ca2+/Ca2+/calmodulin-dependent protein kinase kinase-dependent pathwaysQ37372305
Adipokines as regulators of muscle metabolism and insulin sensitivityQ37486025
Sphingolipids and insulin resistance: the five Ws.Q37705954
Relationship between insulin sensitivity and plasma leptin concentration in lean and obese men.Q38356191
Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1.Q39720264
Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism.Q39940319
Sphingosine kinase 1 participates in insulin signalling and regulates glucose metabolism and homeostasis in KK/Ay diabetic miceQ40177082
Hyperglycemia- and hyperinsulinemia-induced alteration of adiponectin receptor expression and adiponectin effects in L6 myoblastsQ40343968
Acute bidirectional manipulation of muscle glucose uptake by in vivo electrotransfer of constructs targeting glucose transporter genesQ40381249
Globular adiponectin increases GLUT4 translocation and glucose uptake but reduces glycogen synthesis in rat skeletal muscle cells.Q40477131
Globular adiponectin resistance develops independently of impaired insulin-stimulated glucose transport in soleus muscle from high-fat-fed ratsQ42170113
Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitateQ42476162
Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivityQ42832775
Effect of high fat diet enriched with unsaturated and diet rich in saturated fatty acids on sphingolipid metabolism in rat skeletal muscle.Q43010075
Metformin prevents the development of acute lipid-induced insulin resistance in the rat through altered hepatic signaling mechanismsQ45161338
Adenovirus-mediated adiponectin expression augments skeletal muscle insulin sensitivity in male Wistar ratsQ46458709
The stimulatory effect of globular adiponectin on insulin-stimulated glucose uptake and fatty acid oxidation is impaired in skeletal muscle from obese subjectsQ46774709
Adiponectin multimeric complexes and the metabolic syndrome trait clusterQ46870222
Local activation of the IkappaK-NF-kappaB pathway in muscle does not cause insulin resistance.Q46888842
Opposing effects of adiponectin receptors 1 and 2 on energy metabolismQ48259094
Adiponectin sensitizes insulin signaling by reducing p70 S6 kinase-mediated serine phosphorylation of IRS-1.Q48300488
Sex differences in the effect of high-fat diet feeding on rat white adipose tissue mitochondrial function and insulin sensitivity.Q51354468
Ceramide content is higher in type I compared to type II fibers in obesity and type 2 diabetes mellitus.Q51360770
Excess Lipid Availability Increases Mitochondrial Fatty Acid Oxidative Capacity in MuscleQ54986901
Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells.Q55043111
Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actionsQ57249776
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectpreproinsulinQ7240673
overexpressionQ61643320
P304page(s)5231-5246
P577publication date2012-09-18
P1433published inEndocrinologyQ3054009
P1476titleOverexpression of the adiponectin receptor AdipoR1 in rat skeletal muscle amplifies local insulin sensitivity
P478volume153

Reverse relations

cites work (P2860)
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