| scholarly article | Q13442814 |
| retracted paper | Q45182324 |
| P356 | DOI | 10.1016/J.PLIPRES.2019.100991 |
| P698 | PubMed publication ID | 31442525 |
| P2093 | author name string | Susan Pyne | |
| Nigel J Pyne | |||
| Zijian Fang | |||
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| Rapid depot-specific activation of adipocyte precursor cells at the onset of obesity | Q35235848 | ||
| Tumor necrosis factor (TNF) receptor-associated factor (TRAF)-interacting protein (TRIP) negatively regulates the TRAF2 ubiquitin-dependent pathway by suppressing the TRAF2-sphingosine 1-phosphate (S1P) interaction | Q35351861 | ||
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| Preferential fat deposition in subcutaneous versus visceral depots is associated with insulin sensitivity | Q35498016 | ||
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| Sphingosine 1-phosphate (S1P) regulates glucose-stimulated insulin secretion in pancreatic beta cells | Q35921615 | ||
| Selective enhancement of insulin sensitivity in the mature adipocyte is sufficient for systemic metabolic improvements | Q35922882 | ||
| Fenretinide prevents lipid-induced insulin resistance by blocking ceramide biosynthesis | Q36006997 | ||
| The outs and the ins of sphingosine-1-phosphate in immunity | Q36011196 | ||
| Intrinsic differences in adipocyte precursor cells from different white fat depots. | Q36047557 | ||
| Suppression of PP2A is critical for protection of melanoma cells upon endoplasmic reticulum stress | Q36072016 | ||
| Sphingolipid content of human adipose tissue: relationship to adiponectin and insulin resistance. | Q36237414 | ||
| Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation | Q36267274 | ||
| Expression of ceramide-metabolising enzymes in subcutaneous and intra-abdominal human adipose tissue | Q36338624 | ||
| Antiobesity activity of a sphingosine 1-phosphate analogue FTY720 observed in adipocytes and obese mouse model | Q36374498 | ||
| Overexpression of sphingosine kinase 1 prevents ceramide accumulation and ameliorates muscle insulin resistance in high-fat diet-fed mice | Q36410748 | ||
| Adipose-specific disruption of signal transducer and activator of transcription 3 increases body weight and adiposity | Q36513125 | ||
| Dysfunctional adiposity and the risk of prediabetes and type 2 diabetes in obese adults | Q36566370 | ||
| Fenretinide mediated retinoic acid receptor signalling and inhibition of ceramide biosynthesis regulates adipogenesis, lipid accumulation, mitochondrial function and nutrient stress signalling in adipocytes and adipose tissue | Q36604243 | ||
| Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer. | Q36627430 | ||
| Fenretinide treatment prevents diet-induced obesity in association with major alterations in retinoid homeostatic gene expression in adipose, liver, and hypothalamus. | Q36635330 | ||
| Abdominal obesity and metabolic syndrome | Q36682671 | ||
| Ceramide Synthase 5 Is Essential to Maintain C16:0-Ceramide Pools and Contributes to the Development of Diet-induced Obesity | Q36727429 | ||
| Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases | Q24311877 | ||
| Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2 | Q24336131 | ||
| Ceramide synthases at the centre of sphingolipid metabolism and biology | Q24609859 | ||
| Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function | Q24629901 | ||
| The role of fatty acids in insulin resistance | Q26785440 | ||
| Dissecting adipose tissue lipolysis: molecular regulation and implications for metabolic disease | Q26824349 | ||
| The compartmentalization and translocation of the sphingosine kinases: mechanisms and functions in cell signaling and sphingolipid metabolism | Q26997087 | ||
| Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015 | Q27468570 | ||
| Implication of inflammatory signaling pathways in obesity-induced insulin resistance | Q27500365 | ||
| PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA) | Q28215068 | ||
| Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesity | Q28274712 | ||
| Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance | Q28291556 | ||
| Identification of sphingolipid metabolites that induce obesity via misregulation of appetite, caloric intake and fat storage in Drosophila | Q28536054 | ||
| Obesity induces a phenotypic switch in adipose tissue macrophage polarization | Q29547686 | ||
| Critical nodes in signalling pathways: insights into insulin action | Q29614735 | ||
| Mechanisms linking obesity to insulin resistance and type 2 diabetes | Q29614887 | ||
| Dynamics of fat cell turnover in humans | Q29615688 | ||
| Adipocyte differentiation from the inside out | Q29615690 | ||
| The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance | Q29616026 | ||
| Mechanisms for insulin resistance: common threads and missing links | Q29620447 | ||
| Sphingolipids and phospholipids in insulin resistance and related metabolic disorders. | Q30241943 | ||
| Obesity and type 2 diabetes: what can be unified and what needs to be individualized? | Q30501074 | ||
| Remodeling of lipid droplets during lipolysis and growth in adipocytes | Q30512876 | ||
| Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway. | Q33553780 | ||
| Acid sphingomyelinase deficiency in Western diet-fed mice protects against adipocyte hypertrophy and diet-induced liver steatosis | Q33600495 | ||
| Plasma membrane subdomain compartmentalization contributes to distinct mechanisms of ceramide action on insulin signaling | Q33688611 | ||
| Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. | Q33773569 | ||
| Sphingosine 1-phosphate lyase deficiency disrupts lipid homeostasis in liver | Q33796272 | ||
| Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling | Q33838623 | ||
| Regulation of lipolysis in adipocytes | Q33913668 | ||
| Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes | Q33918445 | ||
| Low abdominal subcutaneous preadipocyte adipogenesis is associated with visceral obesity, visceral adipocyte hypertrophy, and a dysmetabolic state | Q33946391 | ||
| Sex- and depot-dependent differences in adipogenesis in normal-weight humans | Q34005308 | ||
| Diacylglycerol-mediated insulin resistance | Q34109119 | ||
| The magnitude of association between overweight and obesity and the risk of diabetes: a meta-analysis of prospective cohort studies | Q34116943 | ||
| Functional Inhibitors of Acid Sphingomyelinase (FIASMAs): a novel pharmacological group of drugs with broad clinical applications | Q34117398 | ||
| De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway | Q34128457 | ||
| Role of sphingolipid mediator ceramide in obesity and renal injury in mice fed a high-fat diet | Q34128783 | ||
| B56alpha/protein phosphatase 2A inhibits adipose lipolysis in high-fat diet-induced obese mice | Q34132451 | ||
| Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice | Q34178121 | ||
| Identification of dihydroceramide desaturase as a direct in vitro target for fenretinide. | Q34182665 | ||
| Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism | Q34202240 | ||
| Insulin effects in muscle and adipose tissue | Q34210426 | ||
| Sphingosine-1-phosphate phosphatases | Q34233409 | ||
| Interactions of acid sphingomyelinase and lipid bilayers in the presence of the tricyclic antidepressant desipramine | Q34298313 | ||
| Mechanisms of insulin resistance in obesity | Q34331776 | ||
| Brown and beige fat: development, function and therapeutic potential | Q34375850 | ||
| Role of sphingosine kinase 2 in cell migration toward epidermal growth factor | Q34425898 | ||
| FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation | Q34490581 | ||
| Sphingosine‐1‐phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration | Q34502695 | ||
| Adipocyte lipolysis-stimulated interleukin-6 production requires sphingosine kinase 1 activity | Q34509799 | ||
| Abdominal subcutaneous and visceral adipose tissue and insulin resistance in the Framingham heart study | Q34551435 | ||
| Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate: is this an atherogenic mediator or an anti-atherogenic mediator? | Q34691487 | ||
| Lipid phosphate phosphatases and signaling | Q37173179 | ||
| Mechanism of Action and Clinical Potential of Fingolimod for the Treatment of Stroke | Q37209163 | ||
| Sphingosine kinase 1 is regulated by peroxisome proliferator-activated receptor α in response to free fatty acids and is essential for skeletal muscle interleukin-6 production and signaling in diet-induced obesity | Q37311833 | ||
| Regulation and physiological functions of G12/13-mediated signaling pathways | Q37391229 | ||
| PPARγ signaling and metabolism: the good, the bad and the future | Q37407887 | ||
| The phosphorylated form of FTY720 activates PP2A, represses inflammation and is devoid of S1P agonism in A549 lung epithelial cells | Q37416615 | ||
| Diabetes and apoptosis: lipotoxicity | Q37473207 | ||
| Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome | Q37580095 | ||
| The distinction of metabolically 'healthy' from 'unhealthy' obese individuals | Q37633348 | ||
| Sphingosine kinase 1 regulates adipose proinflammatory responses and insulin resistance | Q37656009 | ||
| Inducible overexpression of adiponectin receptors highlight the roles of adiponectin-induced ceramidase signaling in lipid and glucose homeostasis | Q37662940 | ||
| Forming functional fat: a growing understanding of adipocyte differentiation | Q37939532 | ||
| The cellular and signaling networks linking the immune system and metabolism in disease | Q37991199 | ||
| Inflammation and lipid signaling in the etiology of insulin resistance | Q38007632 | ||
| The control of the balance between ceramide and sphingosine-1-phosphate by sphingosine kinase: oxidative stress and the seesaw of cell survival and death | Q38011930 | ||
| Post-translational regulation of sphingosine kinases. | Q38026692 | ||
| The structure and function of the S1P1 receptor | Q38114177 | ||
| Sphingolipid homeostasis in the web of metabolic routes | Q38159174 | ||
| Divergent role of sphingosine 1-phosphate on insulin resistance | Q38224521 | ||
| Sphingosine 1-phosphate in blood: function, metabolism, and fate | Q38224523 | ||
| Macrophages, immunity, and metabolic disease | Q38230879 | ||
| Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1. | Q38291637 | ||
| Sphingosine-1-phosphate modulates both lipolysis and leptin production in differentiated rat white adipocytes | Q38309630 | ||
| Altered adipose and plasma sphingolipid metabolism in obesity: a potential mechanism for cardiovascular and metabolic risk | Q38310300 | ||
| Targeting sphingolipid metabolism in the treatment of obesity/type 2 diabetes | Q38392764 | ||
| Modulation of the expression of sphingosine 1-phosphate 2 receptors regulates the differentiation of pre-adipocytes | Q38421618 | ||
| Activation of S1P2 receptor, a possible mechanism of inhibition of adipogenic differentiation by sphingosine 1‑phosphate | Q38432541 | ||
| Sphingosine-1-phosphate inhibits the adipogenic differentiation of 3T3-L1 preadipocytes | Q38435916 | ||
| Adipocyte size as a determinant of metabolic disease and adipose tissue dysfunction | Q38570247 | ||
| Lipolysis and lipases in white adipose tissue - An update | Q38578856 | ||
| Ceramides - Lipotoxic Inducers of Metabolic Disorders | Q38594138 | ||
| Induction of Sphk1 activity in obese adipose tissue macrophages promotes survival | Q38655235 | ||
| Sphingosine 1-phosphate and sphingosine kinases in health and disease: Recent advances | Q38771485 | ||
| Targeting ceramide metabolism in obesity | Q38887432 | ||
| Endoplasmic reticulum stress in obesity and obesity-related disorders: An expanded view | Q38923148 | ||
| Sphingosine-1-phosphate inhibits differentiation of C3H10T1/2 cells into adipocyte | Q38935993 | ||
| De Novo Sphingolipid Biosynthesis Is Required for Adipocyte Survival and Metabolic Homeostasis | Q39013726 | ||
| Protein kinases: mechanisms and downstream targets in inflammation-mediated obesity and insulin resistance | Q39014996 | ||
| Increased plasma sphingosine-1-phosphate in obese individuals and its capacity to increase the expression of plasminogen activator inhibitor-1 in adipocytes. | Q39064972 | ||
| Sphingosine-1-phosphate promotes the nuclear translocation of β-catenin and thereby induces osteoprotegerin gene expression in osteoblast-like cell lines | Q39161729 | ||
| Adipocyte Ceramides Regulate Subcutaneous Adipose Browning, Inflammation, and Metabolism. | Q39211118 | ||
| Global estimates of diabetes prevalence for 2013 and projections for 2035. | Q39231145 | ||
| Role of palmitate-induced sphingoid base-1-phosphate biosynthesis in INS-1 β-cell survival. | Q39256028 | ||
| Sphingolipids and Lipoproteins in Health and Metabolic Disorders | Q39277798 | ||
| Sphingosine-1-phosphate rapidly increases cortisol biosynthesis and the expression of genes involved in cholesterol uptake and transport in H295R adrenocortical cells | Q39485300 | ||
| Mediator MED23 links insulin signaling to the adipogenesis transcription cascade | Q39529568 | ||
| Sphingosine 1-phosphate increases glucose uptake through trans-activation of insulin receptor. | Q39815554 | ||
| Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism. | Q39940319 | ||
| S1P(2) receptors mediate inhibition of glioma cell migration through Rho signaling pathways independent of PTEN. | Q40033973 | ||
| Muscle sphingolipids during rest and exercise: a C18:0 signature for insulin resistance in humans | Q40134781 | ||
| Sphingosine kinase type 2 activation by ERK-mediated phosphorylation | Q40168870 | ||
| Intramyocellular Ceramides: Subcellular Concentrations and Fractional De Novo Synthesis in Postabsorptive Humans | Q40209806 | ||
| Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis via phosphorylation-dependent and -independent mechanisms. | Q40295805 | ||
| Lipid phosphate phosphatase-1 regulates lysophosphatidic acid- and platelet-derived-growth-factor-induced cell migration | Q40339869 | ||
| The mechanism of membrane targeting of human sphingosine kinase 1. | Q40358838 | ||
| The G protein-coupled receptor S1P2 regulates Rho/Rho kinase pathway to inhibit tumor cell migration | Q40427696 | ||
| Intracellular ceramide synthesis and protein kinase Czeta activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells | Q40546613 | ||
| Sphingosine 1-phosphate is a ligand for peroxisome proliferator-activated receptor-γ that regulates neoangiogenesis. | Q40927773 | ||
| Local proliferation of macrophages contributes to obesity-associated adipose tissue inflammation | Q41838863 | ||
| Lipid mediators of insulin resistance: ceramide signalling down-regulates GLUT4 gene transcription in 3T3-L1 adipocytes | Q41998928 | ||
| FoxO1 controls insulin-dependent adipose triglyceride lipase (ATGL) expression and lipolysis in adipocytes | Q42131271 | ||
| Adiponectin serenades ceramidase to improve metabolism | Q42277803 | ||
| A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes | Q42450726 | ||
| Ceramide content is increased in skeletal muscle from obese insulin-resistant humans | Q42454790 | ||
| Regulation of lipolysis in small and large fat cells of the same subject | Q42495881 | ||
| Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate | Q42556020 | ||
| Selective inhibition of sphingosine kinase-1 protects adipose tissue against LPS-induced inflammatory response in Zucker diabetic fatty rats | Q42799060 | ||
| CCR4-NOT2 Promotes the Differentiation and Lipogenesis of 3T3-L1 Adipocytes via Upregulation of PPARx03B3;, CEBPα and Inhibition of P-GSK3α/β and β-Catenin | Q42818021 | ||
| FFA‐Induced Adipocyte Inflammation and Insulin Resistance: Involvement of ER Stress and IKKβ Pathways | Q42820703 | ||
| Targeting of PKCzeta and PKB to caveolin-enriched microdomains represents a crucial step underpinning the disruption in PKB-directed signalling by ceramide | Q42820917 | ||
| The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species | Q42823731 | ||
| Lysophosphatidic acid regulates blood glucose by stimulating myotube and adipocyte glucose uptake | Q42823813 | ||
| Increased dihydroceramide/ceramide ratio mediated by defective expression of degs1 impairs adipocyte differentiation and function | Q42834124 | ||
| Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes | Q42834541 | ||
| Regional impact of adipose tissue morphology on the metabolic profile in morbid obesity. | Q42911327 | ||
| Insulin-sensitive obesity | Q43008676 | ||
| Mechanisms of sphingosine-1-phosphate-induced akt-dependent smooth muscle cell migration | Q43136309 | ||
| Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis | Q44572814 | ||
| The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors | Q44722923 | ||
| Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistance | Q36793320 | ||
| Ablation of dihydroceramide desaturase 1, a therapeutic target for the treatment of metabolic diseases, simultaneously stimulates anabolic and catabolic signaling | Q36827084 | ||
| Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism | Q36861002 | ||
| Sphingolipid metabolism and obesity-induced inflammation | Q36898608 | ||
| Blockade of Sphingosine 1-Phosphate Receptor 2 Signaling Attenuates High-Fat Diet-Induced Adipocyte Hypertrophy and Systemic Glucose Intolerance in Mice | Q36911602 | ||
| Finding a way out: lymphocyte egress from lymphoid organs | Q37008187 | ||
| Location, location: protein trafficking and lipolysis in adipocytes | Q37044155 | ||
| Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance | Q37066869 | ||
| Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2. | Q37089114 | ||
| Sphingosine kinase is induced in mouse 3T3-L1 cells and promotes adipogenesis | Q37130779 | ||
| Acid Sphingomyelinase Deficiency Prevents Diet-induced Hepatic Triacylglycerol Accumulation and Hyperglycemia in Mice | Q37136747 | ||
| Sphingosine 1-phosphate receptors mediate the lipid-induced cAMP accumulation through cyclooxygenase-2/prostaglandin I2 pathway in human coronary artery smooth muscle cells | Q45206406 | ||
| Involvement of sphingosine 1-phosphate in palmitate-induced insulin resistance of hepatocytes via the S1P2 receptor subtype | Q45763186 | ||
| Sphingosine 1-phosphate induces differentiation of adipose tissue-derived mesenchymal stem cells towards smooth muscle cells | Q46065969 | ||
| In vitro hyperresponsiveness to tumor necrosis factor-alpha contributes to adipokine dysregulation in omental adipocytes of obese subjects | Q46143607 | ||
| FTY720, a sphingosine-1-phosphate receptor modulator, reverses high-fat diet-induced weight gain, insulin resistance and adipose tissue inflammation in C57BL/6 mice | Q46583624 | ||
| Regulation of sphingosine 1-phosphate-induced endothelial cytoskeletal rearrangement and barrier enhancement by S1P1 receptor, PI3 kinase, Tiam1/Rac1, and alpha-actinin | Q46728817 | ||
| CerS2 haploinsufficiency inhibits β-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance | Q46828201 | ||
| Overexpression of suppressor of cytokine signaling 3 in adipose tissue causes local but not systemic insulin resistance | Q46966519 | ||
| The Apolipoprotein M/S1P Axis Controls Triglyceride Metabolism and Brown Fat Activity | Q47214032 | ||
| Separation of human adipocytes by size: hypertrophic fat cells display distinct gene expression | Q47334934 | ||
| Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance | Q47431942 | ||
| Metabolic profiling of visceral adipose tissue from obese subjects with or without metabolic syndrome | Q50043252 | ||
| Intracellular localization of diacylglycerols and sphingolipids influences insulin sensitivity and mitochondrial function in human skeletal muscle | Q50130508 | ||
| Could Ceramides Become the New Cholesterol? | Q50145416 | ||
| PPP2R5B, a regulatory subunit of PP2A, contributes to adipocyte insulin resistance | Q50775191 | ||
| Short-Term Versus Long-Term Effects of Adipocyte Toll-Like Receptor 4 Activation on Insulin Resistance in Male Mice | Q50785259 | ||
| Adipose tissue inflammation and increased ceramide content characterize subjects with high liver fat content independent of obesity. | Q51467955 | ||
| Eleven residues determine the acyl chain specificity of ceramide synthases. | Q52327603 | ||
| Activation of sphingosine kinase 2 by endoplasmic reticulum stress ameliorates hepatic steatosis and insulin resistance in mice. | Q53227760 | ||
| Ceramide synthase 4 and de novo production of ceramides with specific N-acyl chain lengths are involved in glucolipotoxicity-induced apoptosis of INS-1 β-cells. | Q54372459 | ||
| P921 | main subject | ceramides | Q424213 |
| P304 | page(s) | 100991 | |
| P577 | publication date | 2019-08-20 | |
| P1433 | published in | Progress in Lipid Research | Q15757018 |
| P1476 | title | WITHDRAWN: Ceramide and Sphingosine 1-Phosphate in adipose dysfunction |
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