Activation of sphingosine kinase 2 by endoplasmic reticulum stress ameliorates hepatic steatosis and insulin resistance in mice.

scientific article published on 22 April 2015

Activation of sphingosine kinase 2 by endoplasmic reticulum stress ameliorates hepatic steatosis and insulin resistance in mice. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/HEP.27804
P698PubMed publication ID25808625

P2093author name stringJae Sung Lee
Su-Yeon Lee
Bo-Rahm Kim
Cheol Soo Choi
Hui-Young Lee
Bo-Kyung Kim
Tae-Sik Park
Soon-Mi Shim
In-Kyung Hong
P2860cites workA regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein responseQ24305069
Endoplasmic reticulum stress and the inflammatory basis of metabolic diseaseQ24633352
Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistanceQ28291556
Biological characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a selective sphingosine kinase-2 inhibitor and anticancer agentQ28486289
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocationQ28510062
The mammalian unfolded protein responseQ29547400
Sphingosine-1-phosphate: an enigmatic signalling lipidQ29620563
Sphingosine kinase 1 regulates the Akt/FOXO3a/Bim pathway and contributes to apoptosis resistance in glioma cellsQ33916859
ER stress response: getting the UPR hand on misfolded proteinsQ33970911
Reducing plasma membrane sphingomyelin increases insulin sensitivityQ34208250
Enzymes of sphingolipid metabolism: from modular to integrative signalingQ34220989
Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinasesQ34234281
Triglyceride accumulation protects against fatty acid-induced lipotoxicityQ34866329
Orchestrating the unfolded protein response in health and diseaseQ35001604
Sphingosine kinase, sphingosine-1-phosphate, and apoptosisQ35047178
Lipid overload and overflow: metabolic trauma and the metabolic syndromeQ35568995
Cardiomyocyte specific deficiency of serine palmitoyltransferase subunit 2 reduces ceramide but leads to cardiac dysfunctionQ36002934
Endoplasmic reticulum stress in liver diseaseQ36031838
Lipid metabolism and liver inflammation. I. Hepatic fatty acid uptake: possible role in steatosis.Q36366205
Sphingosine kinase: biochemical and cellular regulation and role in diseaseQ36439269
Lipotoxic heart disease in obese rats: implications for human obesityQ37117677
Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2Q37622629
Sphingolipids and insulin resistance: the five Ws.Q37705954
Review article: Left ventricular dysfunction and heart failure in metabolic syndrome and diabetes without overt coronary artery disease--do we need to screen our patients?Q37724503
A protocol for rapid generation of recombinant adenoviruses using the AdEasy systemQ40124490
Sphingosine kinase 1 participates in insulin signalling and regulates glucose metabolism and homeostasis in KK/Ay diabetic miceQ40177082
Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumptionQ41119321
The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesisQ41791624
Endoplasmic reticulum stress promotes LIPIN2-dependent hepatic insulin resistanceQ41889666
SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolismQ42810891
Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubesQ42834541
HOMA insulin sensitivity index and the risk of all-cause mortality and cardiovascular disease events in the general population: the Australian Diabetes, Obesity and Lifestyle Study (AusDiab) studyQ43247373
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscleQ43990155
Inhibition of sphingomyelin synthesis reduces atherogenesis in apolipoprotein E-knockout miceQ45151835
TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetesQ46835510
Mouse sphingosine kinase isoforms SPHK1a and SPHK1b differ in enzymatic traits including stability, localization, modification, and oligomerizationQ46861688
Obesity paradox in a cohort of 4880 consecutive patients undergoing percutaneous coronary interventionQ56970669
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectendoplasmic reticulumQ79927
insulin resistanceQ1053470
steatosisQ1365091
P304page(s)135-146
P577publication date2015-04-22
P1433published inHepatologyQ15724398
P1476titleActivation of sphingosine kinase 2 by endoplasmic reticulum stress ameliorates hepatic steatosis and insulin resistance in mice.
P478volume62

Reverse relations

cites work (P2860)
Q92602255A protective mechanism of probiotic Lactobacillus against hepatic steatosis via reducing host intestinal fatty acid absorption
Q57128749Bile acids as global regulators of hepatic nutrient metabolism
Q33649252Celecoxib-mediated activation of endoplasmic reticulum stress induces de novo ceramide biosynthesis and apoptosis in hepatoma HepG2 cells mobilization.
Q52671501Divergent Role of Sphingosine 1-Phosphate in Liver Health and Disease.
Q41573763Endoplasmic Reticulum Stress Inducer Tunicamycin Alters Hepatic Energy Homeostasis in Mice
Q91826367Fermented Cordyceps militaris Extract Prevents Hepatosteatosis and Adipocyte Hypertrophy in High Fat Diet-Fed Mice
Q37611624Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance
Q35965044Hydrophobic bile acid apoptosis is regulated by sphingosine-1-phosphate receptor 2 in rat hepatocytes and human hepatocellular carcinoma cells
Q90219783Lipid mediators of insulin signaling in diabetic kidney disease
Q38705659Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies
Q45324746RNAi screen reveals a role of SPHK2 in dengue virus-mediated apoptosis in hepatic cell lines
Q91892215SPHK1 deficiency protects mice from acetaminophen-induced ER stress and mitochondrial permeability transition
Q26773230Sphingolipids in High Fat Diet and Obesity-Related Diseases
Q45072762Sphingosine Kinases/Sphingosine 1-Phosphate Signaling in Hepatic Lipid Metabolism.
Q41279386Sphingosine kinase 2 inhibition synergises with bortezomib to target myeloma by enhancing endoplasmic reticulum stress.
Q39376014Sphingosine kinase and sphingosine-1-phosphate in liver pathobiology
Q91666473Sphingosine kinase-2 prevents macrophage cholesterol accumulation and atherosclerosis by stimulating autophagic lipid degradation
Q92279683Sphingosine-1-phosphate signaling and the gut-liver axis in liver diseases
Q37024780The role of lipids in the pathogenesis and treatment of type 2 diabetes and associated co-morbidities
Q37711953The role of sphingolipid signalling in diabetes‑associated pathologies (Review).
Q90024070The role of sphingosine kinase 2 in alcoholic liver disease
Q38909010The roles of bile acids and sphingosine-1-phosphate signaling in the hepatobiliary diseases.
Q91364063Tumor Microenvironment Regulation by the Endoplasmic Reticulum Stress Transmission Mediator Golgi Protein 73 in Mice
Q42370433Tumor necrosis factor-inducible gene 6 protein ameliorates chronic liver damage by promoting autophagy formation in mice.
Q92818439WITHDRAWN: Ceramide and Sphingosine 1-Phosphate in adipose dysfunction

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