Sphingosine-1-phosphate rapidly increases cortisol biosynthesis and the expression of genes involved in cholesterol uptake and transport in H295R adrenocortical cells

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Sphingosine-1-phosphate rapidly increases cortisol biosynthesis and the expression of genes involved in cholesterol uptake and transport in H295R adrenocortical cells is …
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P356DOI10.1016/J.MCE.2011.08.003
P932PMC publication ID3508734
P698PubMed publication ID21864647
P5875ResearchGate publication ID51593066

P2093author name stringDonghui Li
Marion B Sewer
Natasha C Lucki
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Role of ABCC1 in export of sphingosine-1-phosphate from mast cellsQ24671687
Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5Q28138229
Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6Q28141106
Nrg-1 belongs to the endothelial differentiation gene family of G protein-coupled sphingosine-1-phosphate receptorsQ28143305
Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteinsQ28144427
Sphingosine kinase: a mediator of vital cellular functionsQ28185880
Stimulation of lipolysis and hormone-sensitive lipase via the extracellular signal-regulated kinase pathwayQ28189761
Hormone-sensitive lipase: control of intracellular tri-(di-)acylglycerol and cholesteryl ester hydrolysisQ28205459
The sphingosine 1-phosphate receptor S1P4 regulates cell shape and motility via coupling to Gi and G12/13Q28205972
Lysophospholipids--receptor revelationsQ28208260
Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesisQ28236461
The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR)Q28240898
Multiple signaling pathways regulating steroidogenesis and steroidogenic acute regulatory protein expression: more complicated than we thoughtQ28245222
Phosphorylation of steroidogenic acute regulatory protein (StAR) modulates its steroidogenic activityQ28257180
Identification of novel phosphorylation sites in hormone-sensitive lipase that are phosphorylated in response to isoproterenol and govern activation properties in vitroQ28257953
Adrenal cholesterol utilizationQ28282253
Signaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphateQ28294350
Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormonesQ28296995
Translational aspects of sphingolipid metabolismQ28307405
Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasiaQ28512871
Hormone-sensitive lipase is required for high-density lipoprotein cholesteryl ester-supported adrenal steroidogenesisQ28513009
Interaction of hormone-sensitive lipase with steroidogenic acute regulatory protein: facilitation of cholesterol transfer in adrenalQ28580168
Transcriptional regulation of the rat steroidogenic acute regulatory protein gene by steroidogenic factor 1Q28582526
Inhibition of adenylyl cyclase by Gi alphaQ28646204
Sphingosine-1-phosphate: an enigmatic signalling lipidQ29620563
Sphingosine 1-phosphate rapidly activates the mitogen-activated protein kinase pathway by a G protein-dependent mechanismQ30464956
RhoA and DIAPH1 mediate adrenocorticotropin-stimulated cortisol biosynthesis by regulating mitochondrial traffickingQ30496611
Functions of a new family of sphingosine-1-phosphate receptorsQ31640177
PBR, StAR, and PKA: partners in cholesterol transport in steroidogenic cells.Q33185727
Ser649 and Ser650 are the major determinants of protein kinase A-mediated activation of human hormone-sensitive lipase against lipid substratesQ33385449
Sphingosine-1-phosphate: extracellular mediator or intracellular second messenger?Q33697778
Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2.Q33796082
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Sphingosine 1-phosphate stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle. Role of endothelial differentiation gene 1, c-Src tyrosine kinase and phosphoinositide 3-kinaseQ40969972
Regulation of the acute production of steroids in steroidogenic cellsQ41083065
Functions of ceramide in coordinating cellular responses to stressQ41243489
Different response patterns of several ligands at the sphingosine-1-phosphate receptor subtype 3 (S1P(3))Q41426230
Regulation of steroidogenesis in NCI-H295 cells: a cellular model of the human fetal adrenalQ41570720
Molecular and cellular mechanisms used in the acute phase of stimulated steroidogenesisQ41721153
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Sphingosine 1-phosphate signalling through the G-protein-coupled receptor Edg-1.Q42060867
S1P1 receptor localization confers selectivity for Gi-mediated cAMP and contractile responsesQ42095285
Ceramide increases steroid hormone production in MA-10 Leydig cellsQ42477793
Translocation of hormone-sensitive lipase and perilipin upon lipolytic stimulation of rat adipocytesQ42483514
Sphingosine regulates the transcription of CYP17 by binding to steroidogenic factor-1.Q42499194
Possible involvement of ceramide in the regulation of rat Leydig cell functionQ42502163
Characterization of the promoter region of the mouse gene encoding the steroidogenic acute regulatory proteinQ42528953
Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphateQ42556020
Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogensQ42805681
Blocking L-type calcium channels reduced the threshold of cAMP-induced steroidogenic acute regulatory gene expression in MA-10 mouse Leydig cellsQ42957388
Differential regulation of 3beta-hydroxysteroid dehydrogenase type II and 17alpha-hydroxylase/lyase P450 in human adrenocortical carcinoma cells by epidermal growth factor and basic fibroblast growth factorQ43515778
ERKs regulate cyclic AMP-induced steroid synthesis through transcription of the steroidogenic acute regulatory (StAR) geneQ43643511
Nifedipine inhibits sphinogosine-1-phosphate-induced renovascular contraction in vitro and in vivoQ43727318
Comparison of sphingosine 1-phosphate-induced intracellular signaling pathways in vascular smooth muscles: differential role in vasoconstriction.Q44079678
Sphingosine-1-phosphate stimulates cortisol secretionQ44298198
Sphingosine 1-phosphate induces CREB activation in rat cerebral artery via a protein kinase C-mediated inhibition of voltage-gated K+ channels.Q44620636
Distinct roles of Ca2+, calmodulin, and protein kinase C in H2O2-induced activation of ERK1/2, p38 MAPK, and protein kinase B signaling in vascular smooth muscle cellsQ44802480
Mechanisms of extracellularly regulated kinases 1/2 activation in adrenal glomerulosa cells by lysophosphatidic acid and epidermal growth factorQ46520954
Molecular mechanisms of insulin-like growth factor-I mediated regulation of the steroidogenic acute regulatory protein in mouse leydig cellsQ46706007
Selective activation of G alpha i mediated signalling of S1P3 by FTY720-phosphate.Q46722992
Sphingosine 1-phosphate is released from the cytosol of rat platelets in a carrier-mediated mannerQ46863524
Prostaglandin F(2alpha) induces a rapid decline in progesterone production and steroidogenic acute regulatory protein expression in isolated rat corpus luteum without altering messenger ribonucleic acid expressionQ48129800
Increased steroid hormone secretion in mouse Leydig tumor cells after induction of cholesterol translocation by sphingomyelin degradation.Q54294375
Primary structure of the site on bovine hormone-sensitive lipase phosphorylated by cyclic AMP-dependent protein kinaseQ68274343
Identification and role of the basal phosphorylation site on hormone-sensitive lipaseQ68470773
Phosphorylation of hormone-sensitive lipase by cyclic AMP-dependent protein kinaseQ70180609
Direct evidence that cholesterol ester hydrolase from adrenal cortex is the same enzyme as hormone-sensitive lipase from adipose tissueQ70426500
Involvement of pertussis toxin-sensitive GTP-binding proteins in sphingosine 1-phosphate-induced activation of phospholipase C-Ca2+ system in HL60 leukemia cellsQ71006808
Sphingosine-1-phosphate inhibits actin nucleation and pseudopodium formation to control cell motility of mouse melanoma cellsQ71034353
Interleukin-1 beta stimulates sphingomyelin hydrolysis in cultured granulosa cells: evidence for a regulatory role of ceramide on progesterone and prostaglandin biosynthesisQ71103352
Confocal microscopy to analyze cytosolic and nuclear calcium in cultured vascular cellsQ72410956
Sphingosine-1-phosphate inhibits motility of human breast cancer cells independently of cell surface receptorsQ73336729
Adipocyte-derived products induce the transcription of the StAR promoter and stimulate aldosterone and cortisol secretion from adrenocortical cells through the Wnt-signaling pathwayQ79520934
Role of CaMKII in hydrogen peroxide activation of ERK1/2, p38 MAPK, HSP27 and actin reorganization in endothelial cellsQ80436404
Sphingosine-1-phosphate stimulates aldosterone secretion through a mechanism involving the PI3K/PKB and MEK/ERK 1/2 pathwaysQ80564384
Sphingosine 1-phosphate: a novel stimulator of aldosterone secretionQ82917476
Sphingosine 1-phosphate and sphingosine kinase are involved in a novel signaling pathway leading to acrosomal exocytosisQ33855307
The protection of hepatocyte cells from the effects of oxidative stress by treatment with vitamin E in conjunction with DTTQ33861172
Multiple roles for sphingolipids in steroid hormone biosynthesisQ33923721
Physiology and pathophysiology of sphingolipid metabolism and signalingQ33930354
Regulation of cytochrome P450 expression by sphingolipids.Q34042915
Sphingosine 1-phosphate, a key cell signaling moleculeQ34128454
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathwayQ34128457
Sphingosine-1-phosphate receptors: receptor specificity versus functional redundancyQ34322524
Adrenocortical cell linesQ34367352
Insights into the transcriptional regulation of steroidogenic enzymes and StAR.Q34436011
Activity-dependent CREB phosphorylation: convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathwayQ34496578
The Involvement of Specific PKC Isoenzymes in Phorbol Ester-Mediated Regulation of Steroidogenic Acute Regulatory Protein Expression and Steroid Synthesis in Mouse Leydig CellsQ34548942
SR-BI-mediated HDL cholesteryl ester delivery in the adrenal glandQ34657328
Sphingosine in apoptosis signalingQ35047156
ACTH modulation of transcription factors responsible for steroid hydroxylase gene expression in the adrenal cortexQ35136737
Involvement of multiple transcription factors in the regulation of steroidogenic acute regulatory protein gene expressionQ35595657
Structural and functional characteristics of S1P receptors.Q35839016
Adrenal corticosteroid biosynthesis, metabolism, and actionQ36105788
Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transductionQ36235805
Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survivalQ36256204
Signalling mechanisms regulating lipolysisQ36267103
Hormonal regulation of hormone-sensitive lipase in intact adipocytes: identification of phosphorylated sites and effects on the phosphorylation by lipolytic hormones and insulin.Q36268533
Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival.Q36294755
Sphingolipids in cancer: regulation of pathogenesis and therapyQ36592826
Biophysics of sphingolipids I. Membrane properties of sphingosine, ceramides and other simple sphingolipids.Q36637060
Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphateQ36797828
Sphingomyelinase inhibits in vitro Leydig cell function.Q36809813
Transcriptional regulation of adrenocortical steroidogenic gene expression.Q36929587
Autocrine and paracrine roles of sphingosine-1-phosphateQ36955411
Steroidogenic enzymesQ37168925
Regulation of the steroidogenic acute regulatory protein gene expression: present and future perspectivesQ37179102
Mechanism of hormone-stimulated lipolysis in adipocytes: translocation of hormone-sensitive lipase to the lipid storage dropletQ37198922
Role of basic leucine zipper proteins in transcriptional regulation of the steroidogenic acute regulatory protein geneQ37222247
Mechanisms of protein kinase C signaling in the modulation of 3',5'-cyclic adenosine monophosphate-mediated steroidogenesis in mouse gonadal cellsQ37244618
Regulation of steroid hormone biosynthesis by the cytoskeletonQ37251924
Hormonal activation of a kinase cascade localized at the mitochondria is required for StAR protein activity.Q37325131
Evidence that insulin and isoprenaline activate the cGMP-inhibited low-Km cAMP phosphodiesterase in rat fat cells by phosphorylationQ37671135
Sphingosine-1-phosphate modulates both lipolysis and leptin production in differentiated rat white adipocytesQ38309630
Different signaling pathway between sphingosine-1-phosphate and lysophosphatidic acid in Xenopus oocytes: functional coupling of the sphingosine-1-phosphate receptor to PLC-xbeta in Xenopus oocytesQ38335935
The cAMP-responsive element binding protein (CREB) regulates the expression of acid ceramidase (ASAH1) in H295R human adrenocortical cellsQ38622183
Sphingolipids differentially regulate mitogen-activated protein kinases and intracellular Ca2+ in vascular smooth muscle: effects on CREB activation.Q38756914
Steroidogenic factor 1-dependent promoter activity of the human steroidogenic acute regulatory protein (StAR) geneQ39496487
Ca(2+)/calmodulin-dependent protein kinase II promotes cell cycle progression by directly activating MEK1 and subsequently modulating p27 phosphorylationQ39908743
Mitochondrial A-kinase anchoring protein 121 binds type II protein kinase A and enhances steroidogenic acute regulatory protein-mediated steroidogenesis in MA-10 mouse leydig tumor cells.Q40054947
The immunomodulator FTY720 is phosphorylated and released from plateletsQ40123102
Lipoprotein utilization and cholesterol synthesis by the human fetal adrenal glandQ40126028
Regulation of Leydig cell steroidogenesis by extracellular signal-regulated kinase 1/2: role of protein kinase A and protein kinase C signalingQ40151235
Coregulator exchange and sphingosine-sensitive cooperativity of steroidogenic factor-1, general control nonderepressed 5, p54, and p160 coactivators regulate cyclic adenosine 3',5'-monophosphate-dependent cytochrome P450c17 transcription rateQ40205351
Protein-protein interactions mediate mitochondrial cholesterol transport and steroid biosynthesisQ40218346
Effect of epidermal growth factor and prostaglandin on the expression of aromatase (CYP19) in human adrenocortical carcinoma cell line NCI-H295R cellsQ40333720
Cyclic adenosine 5'-monophosphate-dependent sphingosine-1-phosphate biosynthesis induces human CYP17 gene transcription by activating cleavage of sterol regulatory element binding protein 1.Q40348144
ACTH regulates steroidogenic gene expression and cortisol biosynthesis in the human adrenal cortex via sphingolipid metabolism.Q40466723
Functional fluo-3/AM assay on P-glycoprotein transport activity in L1210/VCR cells by confocal microscopy.Q40473758
Calcium activation of ERK mediated by calmodulin kinase I.Q40554327
Calcium/calmodulin-dependent protein kinase II binds to Raf-1 and modulates integrin-stimulated ERK activationQ40637860
Regulation of the scavenger receptor BI and the LDL receptor by activators of aldosterone production, angiotensin II and PMA, in the human NCI-H295R adrenocortical cell lineQ40659829
SR-BI does not require raft/caveola localisation for cholesteryl ester selective uptake in the human adrenal cell line NCI-H295R.Q40672230
The NCI-H295 cell line: a pluripotent model for human adrenocortical studiesQ40686449
Peripheral-type benzodiazepine/diazepam binding inhibitor receptor: biological role in steroidogenic cell functionQ40855815
Angiotensin II and cyclic adenosine 3',5'-monophosphate induce human steroidogenic acute regulatory protein transcription through a common steroidogenic factor-1 elementQ40926677
Inhibitory effects of TNF alpha on mouse tumor Leydig cells: possible role of ceramide in the mechanism of actionQ40941235
P433issue1
P921main subjectcortisolQ190875
P304page(s)165-175
P577publication date2011-08-16
P1433published inMolecular and Cellular EndocrinologyQ1573600
P1476titleSphingosine-1-phosphate rapidly increases cortisol biosynthesis and the expression of genes involved in cholesterol uptake and transport in H295R adrenocortical cells
P478volume348

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Q92818439WITHDRAWN: Ceramide and Sphingosine 1-Phosphate in adipose dysfunction

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