Fenretinide treatment prevents diet-induced obesity in association with major alterations in retinoid homeostatic gene expression in adipose, liver, and hypothalamus.

scientific article published on 27 November 2012

Fenretinide treatment prevents diet-induced obesity in association with major alterations in retinoid homeostatic gene expression in adipose, liver, and hypothalamus. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2337/DB12-0458
P932PMC publication ID3581207
P698PubMed publication ID23193184
P5875ResearchGate publication ID233798969

P50authorMirela DelibegovicQ84021168
Nimesh ModyQ57321366
P2093author name stringGeorge D Mcilroy
Patrick N Stoney
Peter J McCaffery
Kirsty D Shearer
Carl Owen
P2860cites workN-(4-hydroxyphenyl)retinamide induces apoptosis of malignant hemopoietic cell lines including those unresponsive to retinoic acidQ72657599
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Retinoic acid receptor beta expression and growth inhibition of gynecologic cancer cells by the synthetic retinoid N-(4-hydroxyphenyl) retinamideQ41049278
In vitro and in vivo induction of brown adipocyte uncoupling protein (thermogenin) by retinoic acidQ41181250
N-(4-hydroxyphenyl)retinamide (4-HPR)-mediated biological actions involve retinoid receptor-independent pathways in human breast carcinomaQ41289818
Intracerebroventricular administration of neuropeptide Y induces hepatic insulin resistance via sympathetic innervationQ41777277
Effect of the synthetic retinoid fenretinide on dark adaptation and the ocular surfaceQ42503866
Inhibition of adipose conversion in 3T3-L2 cells by retinoic acidQ42829102
4-Hydroxyphenyl retinamide is a highly selective activator of retinoid receptorsQ46690362
Differential effects of retinoic acid on uncoupling protein-1 and leptin gene expressionQ47864671
Effects of STZ-Induced Diabetes and Fasting on Insulin Receptor mRNA Expression and Insulin Receptor Gene Transcription in Rat LiverQ51603391
Inhibition of cancer cell growth by all-trans retinoic acid and its analog N-(4-hydroxyphenyl) retinamide: a possible mechanism of action via regulation of retinoid receptors expression.Q54123342
A Novel Regulatory Pathway of Brown Fat ThermogenesisQ60636934
In vitro interaction of fenretinide with plasma retinol-binding protein and its functional consequencesQ67546270
Long-term tolerability of fenretinide (4-HPR) in breast cancer patientsQ67904678
Preadipocytes possess cellular retinoid binding proteins and their differentiation is inhibited by retinoidsQ72151835
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetesQ24309211
Loss of CAK phosphorylation of RAR{alpha} mediates transcriptional control of retinoid-induced cancer cell differentiationQ24317692
A new mathematical model for relative quantification in real-time RT-PCRQ27860781
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Impaired retinal function and vitamin A availability in mice lacking retinol-binding proteinQ28509835
Genetic evidence that retinaldehyde dehydrogenase Raldh1 (Aldh1a1) functions downstream of alcohol dehydrogenase Adh1 in metabolism of retinol to retinoic acidQ28587546
A coordinated phosphorylation cascade initiated by p38MAPK/MSK1 directs RARalpha to target promotersQ28594426
Solid phase-assisted synthesis and screening of a small library of N-(4-hydroxyphenyl)retinamide (4-HPR) analogsQ33263984
Cellular retinol-binding protein type I (CRBP-I) regulates adipogenesisQ33963887
Impaired retinoic acid (RA) signal leads to RARbeta2 epigenetic silencing and RA resistanceQ34150792
Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasisQ34184654
Classical and novel retinoids: their targets in cancer therapyQ34605217
Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscleQ34790967
Concerted action of aldehyde dehydrogenases influences depot-specific fat formation.Q34856359
Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association. October 7, 2003.Q35603208
Retinoic acid upregulates preadipocyte genes to block adipogenesis and suppress diet-induced obesityQ35902881
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Retinaldehyde represses adipogenesis and diet-induced obesity.Q36444754
Mechanisms of fenretinide-induced apoptosisQ36540587
Effect of fenretinide and low-dose tamoxifen on insulin sensitivity in premenopausal women at high risk for breast cancer.Q37008398
Long-term Fenretinide treatment prevents high-fat diet-induced obesity, insulin resistance, and hepatic steatosisQ37474455
Retinoic acid and vitamin D(3) powerfully inhibit in vitro leptin secretion by human adipose tissueQ38298323
Down-regulation of retinoic acid receptor beta in mammary carcinoma cell lines and its up-regulation in senescing normal mammary epithelial cells.Q38311559
Distribution of fenretinide in the mammary gland of breast cancer patientsQ38534184
N-(4-Hydroxyphenyl)retinamide, a new retinoid for prevention of breast cancer in the ratQ38537718
Distinct stages in adipogenesis revealed by retinoid inhibition of differentiation after induction of PPARgammaQ40018541
Retinoic acid blocks adipogenesis by inhibiting C/EBPbeta-mediated transcriptionQ40021186
Insulin Receptors and Insulin ResistanceQ40150685
Identification of the fenretinide metabolite 4-oxo-fenretinide present in human plasma and formed in human ovarian carcinoma cells through induction of cytochrome P450 26A1.Q40511114
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivs 3.0 UnportedQ19125045
P6216copyright statuscopyrightedQ50423863
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectobesityQ12174
P304page(s)825-836
P577publication date2012-11-27
P1433published inDiabetesQ895262
P1476titleFenretinide treatment prevents diet-induced obesity in association with major alterations in retinoid homeostatic gene expression in adipose, liver, and hypothalamus
P478volume62

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