Berberine prevents progression from hepatic steatosis to steatohepatitis and fibrosis by reducing endoplasmic reticulum stress.

scientific article published on 9 February 2016

Berberine prevents progression from hepatic steatosis to steatohepatitis and fibrosis by reducing endoplasmic reticulum stress. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/SREP20848
P932PMC publication ID4746620
P698PubMed publication ID26857750
P5875ResearchGate publication ID293808841

P50authorJiqiu WangQ58220592
Bo LiQ86052052
P2093author name stringJian Yang
Zhiguo Zhang
Yifei Zhang
Guang Ning
Dongsheng Cai
Zhijian Zhang
Lina Jin
Xiangjian Meng
Huizhi Zhang
Shuangshuang Yao
P2860cites workER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPsQ24290776
A simple method for the isolation and purification of total lipides from animal tissuesQ25939009
Multiple hits, including oxidative stress, as pathogenesis and treatment target in non-alcoholic steatohepatitis (NASH)Q27007515
Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver DiseaseQ27301440
Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathwaysQ28365886
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liverQ29547646
Design and validation of a histological scoring system for nonalcoholic fatty liver diseaseQ29614930
Molecular mechanisms and new treatment strategies for non-alcoholic steatohepatitis (NASH)Q33755566
Dynamic changes in the localization of thermally unfolded nuclear proteins associated with chaperone-dependent protectionQ33946970
Berberine reduces methylation of the MTTP promoter and alleviates fatty liver induced by a high-fat diet in rats.Q34053063
Nonalcoholic steatohepatitis: definition and pathologyQ34215155
New peroxisome proliferator-activated receptor agonists: potential treatments for atherogenic dyslipidemia and non-alcoholic fatty liver diseaseQ34398065
CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitisQ34432561
Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statinsQ34552498
Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK activityQ34603754
PPARalpha expression protects male mice from high fat-induced nonalcoholic fatty liverQ34667494
Chemical chaperones: a pharmacological strategy for disorders of protein folding and traffickingQ35001649
Tissue distribution of berberine and its metabolites after oral administration in ratsQ35035856
Pharmacologic ER stress induces non-alcoholic steatohepatitis in an animal model.Q35907138
Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonistQ35991437
Association between catalase gene polymorphisms and risk of chronic hepatitis B, hepatitis B virus-related liver cirrhosis and hepatocellular carcinoma in Guangxi population: a case-control studyQ36009191
Endoplasmic reticulum stress in liver diseaseQ36031838
Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered miceQ36479005
Hepatitis B virus pre-S mutants, endoplasmic reticulum stress and hepatocarcinogenesisQ36545096
Central melanin-concentrating hormone influences liver and adipose metabolism via specific hypothalamic nuclei and efferent autonomic/JNK1 pathwaysQ36872285
Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagyQ36941185
Endoplasmic reticulum stress markers are associated with obesity in nondiabetic subjectsQ36971939
Antioxidants reduce endoplasmic reticulum stress and improve protein secretionQ36985084
Non-alcoholic fatty liver disease (NAFLD) and its connection with insulin resistance, dyslipidemia, atherosclerosis and coronary heart diseaseQ37002532
Ethanol metabolism and oxidative stress are required for unfolded protein response activation and steatosis in zebrafish with alcoholic liver diseaseQ37137783
GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in miceQ37170811
Kupffer cells in non-alcoholic fatty liver disease: the emerging view.Q37222183
c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in miceQ37376335
CYP2E1 potentiates binge alcohol-induced gut leakiness, steatohepatitis, and apoptosisQ37384997
Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver.Q37388544
Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stressQ37644382
Nonalcoholic fatty liver disease: pathology and pathogenesisQ37676210
Current therapeutic strategies in non-alcoholic fatty liver disease.Q37859419
Endoplasmic reticulum stress in nonalcoholic fatty liver diseaseQ38027194
Obese and diabetic db/db mice develop marked liver fibrosis in a model of nonalcoholic steatohepatitis: role of short-form leptin receptors and osteopontinQ38338847
Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant statesQ40250572
Berberine stimulates glucose transport through a mechanism distinct from insulin.Q42831138
Extensive intestinal first-pass elimination and predominant hepatic distribution of berberine explain its low plasma levels in rats.Q42969049
Isolation and culture of adult mouse hepatocytesQ43142214
Intracellular signaling pathways involved in acetaldehyde-induced collagen and fibronectin gene expression in human hepatic stellate cellsQ43601184
Association of nonalcoholic fatty liver disease with components of metabolic syndrome according to body mass index in Korean adultsQ43628070
In vivo hepatic endoplasmic reticulum stress in patients with chronic hepatitis C.Q44332232
Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver diseaseQ44934521
Metabolic significance of nonalcoholic fatty liver disease in nonobese, nondiabetic adults.Q45124709
Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberineQ46656835
Phyllanthus urinaria ameliorates the severity of nutritional steatohepatitis both in vitro and in vivoQ46834315
NASH: a hidden and silent fibroser finally revealed?Q53856506
[Therapeutic effect of berberine on 60 patients with type II diabetes mellitus and experimental research]Q68072355
Thermostability of a nuclear-targeted luciferase expressed in mammalian cells. Destabilizing influence of the intranuclear microenvironmentQ70824174
CCAAT/enhancing binding protein beta deletion in mice attenuates inflammation, endoplasmic reticulum stress, and lipid accumulation in diet-induced nonalcoholic steatohepatitisQ80229577
Berberine activates thermogenesis in white and brown adipose tissueQ86052055
P4510describes a project that usesImageJQ1659584
P407language of work or nameEnglishQ1860
P921main subjectendoplasmic reticulumQ79927
steatohepatitisQ2335423
steatosisQ1365091
P304page(s)20848
P577publication date2016-02-09
P1433published inScientific ReportsQ2261792
P1476titleBerberine prevents progression from hepatic steatosis to steatohepatitis and fibrosis by reducing endoplasmic reticulum stress
P478volume6

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cites work (P2860)
Q50931849Attenuation of hepatic steatosis by purple sweet potato colour is associated with blocking Src/ERK/C/EBPβ signalling in high-fat-diet-treated mice.
Q55397623Berberine Attenuates Macrophages Infiltration in Intracranial Aneurysms Potentially Through FAK/Grp78/UPR Axis.
Q90478758Berberine Inhibits Nod-Like Receptor Family Pyrin Domain Containing 3 Inflammasome Activation and Pyroptosis in Nonalcoholic Steatohepatitis via the ROS/TXNIP Axis
Q52661291Berberine Protects Against Palmitate-Induced Apoptosis in Tubular Epithelial Cells by Promoting Fatty Acid Oxidation.
Q90698640Berberine ameliorates blockade of autophagic flux in the liver by regulating cholesterol metabolism and inhibiting COX2-prostaglandin synthesis
Q36292252Berberine improves glucogenesis and lipid metabolism in nonalcoholic fatty liver disease
Q94479681Berberine inhibits free fatty acid and LPS-induced inflammation via modulating ER stress response in macrophages and hepatocytes
Q37744848Berberine-sonodynamic therapy induces autophagy and lipid unloading in macrophage
Q41573474Comprehensive Study of Multiple Stages Progressing to Nonalcoholic Steatohepatitis with Subsequent Fibrosis in SD Rats
Q64064784Coptidis Rhizoma: a comprehensive review of its traditional uses, botany, phytochemistry, pharmacology and toxicology
Q37554361Cytochrome P450-2E1 promotes fast food-mediated hepatic fibrosis
Q30234449Dietary Factors Promoting Brown and Beige Fat Development and Thermogenesis
Q97522970Endoplasmic reticulum stress and liver diseases
Q93016049Herbal drug discovery for the treatment of nonalcoholic fatty liver disease
Q39077570Insights into the Role and Interdependence of Oxidative Stress and Inflammation in Liver Diseases.
Q90602682Liver ASK1 protects from non-alcoholic fatty liver disease and fibrosis
Q98460000Modulation of gut microbiota mediates berberine-induced expansion of immuno-suppressive cells to against alcoholic liver disease
Q28067054Rhizoma Coptidis: A Potential Cardiovascular Protective Agent
Q28067321Role of berberine in Alzheimer's disease
Q28078754The Potential Mechanisms of Berberine in the Treatment of Nonalcoholic Fatty Liver Disease

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