Endoplasmic reticulum stress and liver diseases

scientific article published on 30 January 2019

Endoplasmic reticulum stress and liver diseases is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.LIVRES.2019.01.002
P932PMC publication ID7363397
P698PubMed publication ID32670671

P2093author name stringXiaoying Liu
Richard M Green
P2860cites workTauroursodeoxycholic acid attenuates progression of steatohepatitis in mice fed a methionine-choline-deficient dietQ87961922
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Dynamic changes in complexes of IRE1α, PERK, and ATF6α during endoplasmic reticulum stressQ88932489
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-betaQ22011091
Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stressQ24291026
Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alphaQ24322072
Different types of ground glass hepatocytes in chronic hepatitis B virus infection contain specific pre-S mutants that may induce endoplasmic reticulum stressQ24672497
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Role of endoplasmic reticulum stress in drug-induced toxicityQ26765518
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Modulation of the unfolded protein response by the human hepatitis B virusQ26999215
ER stress-induced cell death mechanismsQ27027638
Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1Q28276509
Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathwaysQ28365886
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Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosisQ28385517
HCV causes chronic endoplasmic reticulum stress leading to adaptation and interference with the unfolded protein responseQ28477137
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulumQ28512249
Activating transcription factor 6 is necessary and sufficient for alcoholic fatty liver disease in zebrafishQ28539163
Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox stateQ28572472
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein ResponseQ28585314
Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosisQ28586997
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein responseQ29547299
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stressQ29615495
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetesQ29615503
The natural history of nonalcoholic fatty liver disease: a population-based cohort studyQ29617161
Nonalcoholic fatty liver diseaseQ29619354
New Insights into the Pathogenesis of Alcohol-Induced ER Stress and Liver DiseasesQ33608283
Hepatic Bax inhibitor-1 inhibits IRE1alpha and protects from obesity-associated insulin resistance and glucose intoleranceQ33673551
ATF6 mediates a pro-inflammatory synergy between ER stress and TLR activation in the pathogenesis of liver ischemia-reperfusion injuryQ33819901
Saturated fatty acid induction of endoplasmic reticulum stress and apoptosis in human liver cells via the PERK/ATF4/CHOP signaling pathwayQ34128069
Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesityQ34181503
Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesisQ34192744
Fibroblast growth factor 21 is regulated by the IRE1α-XBP1 branch of the unfolded protein response and counteracts endoplasmic reticulum stress-induced hepatic steatosisQ34396839
Cytoprotective gene bi-1 is required for intrinsic protection from endoplasmic reticulum stress and ischemia-reperfusion injuryQ34479417
Role of CHOP in hepatic apoptosis in the murine model of intragastric ethanol feedingQ34524224
Activation of endoplasmic reticulum-specific stress responses associated with the conformational disease Z alpha 1-antitrypsin deficiency.Q40515875
Hepatitis C virus suppresses the IRE1-XBP1 pathway of the unfolded protein responseQ40590374
Activation of the promoters of genes associated with DNA damage, oxidative stress, ER stress and protein malfolding by the bile salt, deoxycholateQ40931435
The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesisQ41791624
Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in miceQ41825121
The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosisQ41904044
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.Q42041480
The involvement of endoplasmic reticulum stress in bile acid-induced hepatocellular injuryQ42128127
ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC developmentQ42199386
Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory responseQ42318815
Dysregulated expression of proteins associated with ER stress, autophagy and apoptosis in tissues from nonalcoholic fatty liver diseaseQ42362670
Induction of liver steatosis and lipid droplet formation in ATF6alpha-knockout mice burdened with pharmacological endoplasmic reticulum stressQ42451739
Endoplasmic reticulum stress inhibition protects steatotic and non-steatotic livers in partial hepatectomy under ischemia-reperfusionQ42588208
Hepatitis C virus envelope proteins regulate CHOP via induction of the unfolded protein responseQ43524712
In vivo hepatic endoplasmic reticulum stress in patients with chronic hepatitis C.Q44332232
Evidence for unfolded protein response activation in monocytes from individuals with alpha-1 antitrypsin deficiencyQ44553654
CHOP is a critical regulator of acetaminophen-induced hepatotoxicity.Q44693987
Mitochondrial autophagy and injury in the liver in alpha 1-antitrypsin deficiency.Q44698739
HIV protease inhibitors activate the unfolded protein response and disrupt lipid metabolism in primary hepatocytes.Q44922052
Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver diseaseQ44934521
CHOP-induced loss of intestinal epithelial stemness contributes to bile duct ligation-induced cholestatic liver injuryQ45067747
Global burden of NAFLD and NASH: trends, predictions, risk factors and preventionQ45067817
Endoplasmic reticulum stress induces hepatic steatosis via increased expression of the hepatic very low-density lipoprotein receptorQ45200756
Hepatitis B virus X protein inhibits apoptosis by modulating endoplasmic reticulum stress responseQ45323588
Functional interaction of endoplasmic reticulum stress and hepatitis B virus in the pathogenesis of liver diseasesQ45323758
Endoplasmic reticulum stress induced by hepatitis B virus X protein enhances cyclo-oxygenase 2 expression via activating transcription factor 4.Q45369768
Reperfusion does not induce oxidative stress but sustained endoplasmic reticulum stress in livers of rats subjected to traumatic-hemorrhagic shock.Q45979492
Sodium 4-phenylbutyrate protects against liver ischemia reperfusion injury by inhibition of endoplasmic reticulum-stress mediated apoptosisQ46695184
CHOP deficiency attenuates cholestasis-induced liver fibrosis by reduction of hepatocyte injuryQ46823993
ATF4 overexpression induces early onset of hyperlipidaemia and hepatic steatosis and enhances adipogenesis in zebrafishQ47135098
MicroRNA-29a mitigation of endoplasmic reticulum and autophagy aberrance counteracts in obstructive jaundice-induced fibrosis in miceQ47438703
Farnesoid X Receptor Signaling Activates the Hepatic X-box Binding Protein 1 Pathway in vitro and in MiceQ47643998
The luminal domain of the ER stress sensor protein PERK binds misfolded proteins and thereby triggers PERK oligomerizationQ49545301
Bax Inhibitor-1 protects from Non-Alcoholic Steatohepatitis by limiting IRE1α signalingQ49850608
ER Stress Inhibits Liver Fatty Acid Oxidation while Unmitigated Stress Leads to Anorexia-Induced Lipolysis and Both Liver and Kidney Steatosis.Q50968208
Sodium 4-phenylbutyric acid prevents murine acetaminophen hepatotoxicity by minimizing endoplasmic reticulum stress.Q51531573
Preemptive activation of the integrated stress response protects mice from diet-induced obesity and insulin resistance via fibroblast growth factor 21 induction.Q52308796
HIV protease inhibitors induce endoplasmic reticulum stress and disrupt barrier integrity in intestinal epithelial cells.Q52607299
Cisplatin Enhances Hepatitis B Virus Replication and PGC-1α Expression through Endoplasmic Reticulum Stress.Q52689095
ER stress contributes to alpha-naphthyl isothiocyanate-induced liver injury with cholestasis in mice.Q52869908
Autophagy induced by exogenous bile acids is therapeutic in a model of α-1-AT deficiency liver disease.Q52873755
Tauroursodeoxycholic acid inhibits apoptosis induced by Z alpha-1 antitrypsin via inhibition of Bad.Q53547782
A possible involvement of endoplasmic reticulum stress in biliary epithelial autophagy and senescence in primary biliary cirrhosis.Q53648391
Dual role for inositol-requiring enzyme 1α in promoting the development of hepatocellular carcinoma during diet-induced obesity in mice.Q54123115
Translational attenuation and retinal degeneration in mice with an active integrated stress response.Q55017111
IRE1α prevents hepatic steatosis by processing and promoting the degradation of select microRNAs.Q64999429
Ultrastructural Liver Pathology in Patients with Minimal Liver Disease and α1-Antitrypsin Deficiency: A Comparison Between Heterozygous and Homozygous PatientsQ70225163
Acetaminophen induces ER dependent signaling in mouse liverQ79505704
Involvement of endoplasmic reticulum in glycochenodeoxycholic acid-induced apoptosis in rat hepatocytesQ79964648
Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1Q80979487
Distinct endoplasmic reticulum stress responses are triggered during human liver transplantationQ81779000
ATF4 deficiency protects mice from high-carbohydrate-diet-induced liver steatosisQ84283864
The integrated stress response system in cardiovascular diseaseQ87939562
HIV protease inhibitors disrupt lipid metabolism by activating endoplasmic reticulum stress and inhibiting autophagy activity in adipocytesQ34637857
Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stressQ34801719
Modulation of the unfolded protein response impedes tumor cell adaptation to proteotoxic stress: a PERK for hepatocellular carcinoma therapyQ34900620
Different fatty acids inhibit apoB100 secretion by different pathways: unique roles for ER stress, ceramide, and autophagyQ35152201
The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress.Q35551757
Regulation of apoptosis by endoplasmic reticulum pathways.Q35591699
Cytokines and the pathogenesis of non-alcoholic steatohepatitisQ35598104
Signaling the unfolded protein response from the endoplasmic reticulum.Q35740723
IRE1α activation protects mice against acetaminophen-induced hepatotoxicityQ35760821
Activating transcription factor 6 limits intracellular accumulation of mutant α(1)-antitrypsin Z and mitochondrial damage in hepatoma cells.Q35842192
Insulin resistance, ceramide accumulation, and endoplasmic reticulum stress in human chronic alcohol-related liver diseaseQ35944938
Endoplasmic reticulum stress in liver diseaseQ36031838
Hepatitis B Virus Middle Protein Enhances IL-6 Production via p38 MAPK/NF-κB Pathways in an ER Stress-Dependent MannerQ36081674
Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodentsQ36183590
Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice.Q36330343
Hepatitis B and C virus-induced hepatitis: Apoptosis, autophagy, and unfolded protein responseQ36373611
Hepatocyte X-box binding protein 1 deficiency increases liver injury in mice fed a high-fat/sugar dietQ36382065
Tauroursodeoxycholic acid dampens oncogenic apoptosis induced by endoplasmic reticulum stress during hepatocarcinogen exposureQ36413970
Hepatic Xbp1 Gene Deletion Promotes Endoplasmic Reticulum Stress-induced Liver Injury and ApoptosisQ36444262
The Dichotomy of Endoplasmic Reticulum Stress Response in Liver Ischemia-Reperfusion InjuryQ36515355
Hepatitis B virus pre-S mutants, endoplasmic reticulum stress and hepatocarcinogenesisQ36545096
Berberine prevents progression from hepatic steatosis to steatohepatitis and fibrosis by reducing endoplasmic reticulum stress.Q36560010
IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasisQ36600595
Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domainsQ36712468
Dissection of endoplasmic reticulum stress signaling in alcoholic and non-alcoholic liver injuryQ36800154
The endoplasmic reticulum and the unfolded protein responseQ37006310
IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.Q37091581
Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian developmentQ37100863
Chemical chaperones mediate increased secretion of mutant alpha 1-antitrypsin (alpha 1-AT) Z: A potential pharmacological strategy for prevention of liver injury and emphysema in alpha 1-AT deficiencyQ37118167
ATF4 protein deficiency protects against high fructose-induced hypertriglyceridemia in mice.Q37132127
GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in miceQ37170811
ATF6 modulates SREBP2-mediated lipogenesis.Q37260315
Endoplasmic reticulum polymers impair luminal protein mobility and sensitize to cellular stress in alpha1-antitrypsin deficiencyQ37410544
The adaptive endoplasmic reticulum stress response to lipotoxicity in progressive human nonalcoholic fatty liver diseaseQ37412003
The XBP1 Arm of the Unfolded Protein Response Induces Fibrogenic Activity in Hepatic Stellate Cells Through AutophagyQ37519318
Endoplasmic Reticulum Stress Regulates Hepatic Bile Acid Metabolism in MiceQ37673642
Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitisQ37953770
Ischaemia-reperfusion injury in liver transplantation--from bench to bedsideQ38066361
The unfolded protein response in fatty liver diseaseQ38162132
Endoplasmic reticulum stress in drug- and environmental toxicant-induced liver toxicityQ38193602
The integrated stress response in lung diseaseQ38194164
Unfolded protein response in hepatitis C virus infectionQ38218108
The impact of the endoplasmic reticulum protein-folding environment on cancer developmentQ38241996
Druggable sensors of the unfolded protein responseQ38261088
XBP1s Is an Anti-lipogenic ProteinQ38291938
Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed miceQ38354947
Alcoholic liver disease: mechanisms of injury and targeted treatmentQ38381594
CHOP favors endoplasmic reticulum stress-induced apoptosis in hepatocellular carcinoma cells via inhibition of autophagyQ38608106
Liver-specific Gene Inactivation of the Transcription Factor ATF4 Alleviates Alcoholic Liver Steatosis in MiceQ38758523
Unfolded proteins are Ire1-activating ligands that directly induce the unfolded protein responseQ38845249
The pathogenesis of drug-induced liver injuryQ38849978
Hepatic ischemia reperfusion injury: A systematic review of literature and the role of current drugs and biomarkersQ38851781
The integrated stress response.Q38954583
Hepatic deletion of X-box binding protein 1 impairs bile acid metabolism in miceQ39048675
Hepatic ATF6 Increases Fatty Acid Oxidation to Attenuate Hepatic Steatosis in Mice Through Peroxisome Proliferator-Activated Receptor α.Q39748140
IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.Q39814866
Hepatitis C virus NS4B induces unfolded protein response and endoplasmic reticulum overload response-dependent NF-kappaB activationQ39821567
Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in miceQ39975807
Interaction between caspase-8 activation and endoplasmic reticulum stress in glycochenodeoxycholic acid-induced apoptotic HepG2 cellsQ40069683
Hepatitis B virus X protein (HBx) activates ATF6 and IRE1-XBP1 pathways of unfolded protein responseQ40210691
Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cellsQ40313352
Hepatitis C virus non-structural protein NS4B can modulate an unfolded protein response.Q40330336
Accumulation of mutant alpha1-antitrypsin Z in the endoplasmic reticulum activates caspases-4 and -12, NFkappaB, and BAP31 but not the unfolded protein response.Q40369104
HIV protease inhibitors activate the unfolded protein response in macrophages: implication for atherosclerosis and cardiovascular diseaseQ40405379
Hepatitis C virus core triggers apoptosis in liver cells by inducing ER stress and ER calcium depletionQ40421534
P433issue1
P304page(s)55-64
P577publication date2019-01-30
P1433published inLiver ResearchQ96319940
P1476titleEndoplasmic reticulum stress and liver diseases
P478volume3

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