Preemptive activation of the integrated stress response protects mice from diet-induced obesity and insulin resistance via fibroblast growth factor 21 induction.

scientific article published on 26 April 2018

Preemptive activation of the integrated stress response protects mice from diet-induced obesity and insulin resistance via fibroblast growth factor 21 induction. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/HEP.30060
P932PMC publication ID6203669
P698PubMed publication ID29698569

P50authorXu XuQ88483439
P2093author name stringDavid E Cohen
Ann-Hwee Lee
Jesper Gromada
Jae-Seon So
Curtis J Bare
Christopher Krumm
Corey Holman
P2860cites workFGF-21 as a novel metabolic regulatorQ24523933
Endoplasmic reticulum stress induces hepatic steatosis via increased expression of the hepatic very low-density lipoprotein receptorQ45200756
Mouse Atf5: molecular cloning of two novel mRNAs, genomic organization, and odorant sensory neuron localizationQ48284465
Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation.Q51362717
Heme-Regulated eIF2α Kinase Modulates Hepatic FGF21 and Is Activated by PPARβ/δ Deficiency.Q51597834
Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokineQ63609769
ATF4 and the integrated stress response are induced by ethanol and cytochrome P450 2E1 in human hepatocytesQ64380059
Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosisQ81441036
Recombineering-based procedure for creating Cre/loxP conditional knockouts in the mouseQ83240169
ATF4 deficiency protects mice from high-carbohydrate-diet-induced liver steatosisQ84283864
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stressQ28306995
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alphaQ28512201
Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cellsQ28513964
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesQ28575190
Fibroblast growth factor 21 is induced by endoplasmic reticulum stressQ28581415
An integrated stress response regulates amino acid metabolism and resistance to oxidative stressQ29547441
A highly efficient recombineering-based method for generating conditional knockout mutationsQ29615157
Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic statesQ29615208
Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21Q29615209
A subunit of eukaryotic translation initiation factor 2α-phosphatase (CreP/PPP1R15B) regulates membrane trafficQ30525662
Stress-induced translation of ATF5 mRNA is regulated by the 5'-untranslated regionQ34720944
Fibroblast growth factor 21 corrects obesity in miceQ34805555
The contribution of endoplasmic reticulum stress to liver diseasesQ34860549
DNA Damage Regulates Translation through β-TRCP Targeting of CRePQ35668793
An eIF2α-binding motif in protein phosphatase 1 subunit GADD34 and its viral orthologs is required to promote dephosphorylation of eIF2α.Q35845921
IRE1α-Dependent Decay of CReP/Ppp1r15b mRNA Increases Eukaryotic Initiation Factor 2α Phosphorylation and Suppresses Protein SynthesisQ35868391
Reducing endoplasmic reticulum stress does not improve steatohepatitis in mice fed a methionine- and choline-deficient dietQ36114917
An inhibitor of HIV-1 protease modulates constitutive eIF2α dephosphorylation to trigger a specific integrated stress response.Q36483172
The transcription factor network associated with the amino acid response in mammalian cellsQ36830376
Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver.Q36849447
Translational control and the unfolded protein responseQ36924278
CREBH-FGF21 axis improves hepatic steatosis by suppressing adipose tissue lipolysisQ37005595
Metabolic Responses to Dietary Protein Restriction Require an Increase in FGF21 that Is Delayed by the Absence of GCN2Q37116027
ATF4 protein deficiency protects against high fructose-induced hypertriglyceridemia in mice.Q37132127
Liver-enriched transcription factor CREBH interacts with peroxisome proliferator-activated receptor α to regulate metabolic hormone FGF21.Q37594100
FGF21-based pharmacotherapy--potential utility for metabolic disordersQ38202720
Liver-specific Gene Inactivation of the Transcription Factor ATF4 Alleviates Alcoholic Liver Steatosis in MiceQ38758523
FGF21-receptor agonists: an emerging therapeutic class for obesity-related diseasesQ39318225
The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPRQ39593058
Fasting induced up-regulation of activating transcription factor 5 in mouse liverQ39859438
Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in miceQ39975807
The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolismQ41909224
Stress Signaling in the Methionine-Choline–Deficient Model of Murine Fatty Liver DiseaseQ42391560
Phosphorylation of eIF2 directs ATF5 translational control in response to diverse stress conditionsQ42523594
Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese miceQ43224118
Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver diseaseQ44934521
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectinsulin resistanceQ1053470
P304page(s)2167-2181
P577publication date2018-11-05
P1433published inHepatologyQ15724398
P1476titlePreemptive Activation of the Integrated Stress Response Protects Mice From Diet-Induced Obesity and Insulin Resistance by Fibroblast Growth Factor 21 Induction
P478volume68

Reverse relations

cites work (P2860)
Q90664928Dietary intake of bioactive ingredients impacts liver and adipose tissue transcriptomes in a porcine model of prepubertal early obesity
Q92003593Effects of XIAP on high fat diet-induced hepatic steatosis: a mechanism involving NLRP3 inflammasome and oxidative stress
Q97522970Endoplasmic reticulum stress and liver diseases
Q90025468Harnessing the Integrated Stress Response to Counteract Metabolic Disease
Q92146409Knockout of the X-linked Fgf13 in the hypothalamic paraventricular nucleus impairs sympathetic output to brown fat and causes obesity
Q93192737Metabolic remodeling induced by mitokines in heart failure
Q101574061PPARα agonist and metformin co-treatment ameliorates NASH in mice induced by a choline-deficient, amino acid-defined diet with 45% fat
Q58696918Periodized low protein-high carbohydrate diet confers potent, but transient, metabolic improvements

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