IRE1α-Dependent Decay of CReP/Ppp1r15b mRNA Increases Eukaryotic Initiation Factor 2α Phosphorylation and Suppresses Protein Synthesis

scientific article published in June 2015

IRE1α-Dependent Decay of CReP/Ppp1r15b mRNA Increases Eukaryotic Initiation Factor 2α Phosphorylation and Suppresses Protein Synthesis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.00215-15
P932PMC publication ID4508316
P698PubMed publication ID26031337

P50authorAnn-Hwee LeeQ85270146
P2093author name stringScot R Kimball
Jae-Seon So
Sang-Hyun Min
Sungyun Cho
P2860cites workThe unfolded protein response: integrating stress signals through the stress sensor IRE1αQ24293771
A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cellsQ24309442
Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alphaQ24322072
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
Translational control is required for the unfolded protein response and in vivo glucose homeostasisQ28204066
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinaseQ28296183
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stressQ28306995
The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreasQ28505821
Regulated translation initiation controls stress-induced gene expression in mammalian cellsQ28506388
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alphaQ28512201
Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cellsQ28513964
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein ResponseQ28585314
XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networksQ28591575
Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survivalQ28593963
The unfolded protein response: from stress pathway to homeostatic regulationQ29547396
The mammalian unfolded protein responseQ29547400
Tripartite management of unfolded proteins in the endoplasmic reticulumQ33941135
Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasisQ34169287
Both Transcriptional Regulation and Translational Control of ATF4 Are Central to the Integrated Stress ResponseQ34236755
XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiationQ34345459
Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretionQ35008217
IRE1α activation protects mice against acetaminophen-induced hepatotoxicityQ35760821
Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice.Q36330343
Protein-folding homeostasis in the endoplasmic reticulum and nutritional regulationQ36418004
Endoplasmic reticulum stress sensing in the unfolded protein responseQ36626672
Eukaryotic initiation factor 2 phosphorylation and translational control in metabolism.Q36830383
Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian developmentQ37100863
Regulated Ire1-dependent decay of messenger RNAs in mammalian cellsQ37309146
Function of IRE1 alpha in the placenta is essential for placental development and embryonic viabilityQ37377347
New insights into translational regulation in the endoplasmic reticulum unfolded protein responseQ38005599
Getting RIDD of RNA: IRE1 in cell fate regulationQ38198370
The unfolded-protein-response sensor IRE-1α regulates the function of CD8α+ dendritic cells.Q38309617
Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.Q38311676
Identification of a consensus element recognized and cleaved by IRE1 alpha.Q38343711
IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.Q39814866
Delineation of a negative feedback regulatory loop that controls protein translation during endoplasmic reticulum stressQ42163338
Initiation of protein synthesis in a cell-free system prepared from rat hepatocytes.Q45901355
Neuronal ER stress impedes myeloid-cell-induced vascular regeneration through IRE1α degradation of netrin-1.Q48134071
PERK is essential for neonatal skeletal development to regulate osteoblast proliferation and differentiation.Q51951390
PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis.Q52000258
GCN2 phosphorylation of eIF2alpha activates NF-kappaB in response to UV irradiationQ80540867
P433issue16
P407language of work or nameEnglishQ1860
P304page(s)2761-2770
P577publication date2015-06-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleIRE1α-Dependent Decay of CReP/Ppp1r15b mRNA Increases Eukaryotic Initiation Factor 2α Phosphorylation and Suppresses Protein Synthesis
P478volume35

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cites work (P2860)
Q510385425,7,3',4'-Tetramethoxyflavone protects chondrocytes from ER stress-induced apoptosis through regulation of the IRE1α pathway.
Q36483172An inhibitor of HIV-1 protease modulates constitutive eIF2α dephosphorylation to trigger a specific integrated stress response.
Q42156227Complementary Roles of GADD34- and CReP-Containing Eukaryotic Initiation Factor 2α Phosphatases during the Unfolded Protein Response
Q28548490Embryonic Stem Cell Growth Factors Regulate eIF2α Phosphorylation
Q35867141Endoplasmic Reticulum-Associated rht-PA Processing in CHO Cells: Influence of Mild Hypothermia and Specific Growth Rates in Batch and Chemostat Cultures
Q38925531Endoplasmic reticulum proteostasis in hepatic steatosis.
Q102220441Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1α
Q60909527Linking Endoplasmic Reticular Stress and Alternative Splicing
Q52308796Preemptive activation of the integrated stress response protects mice from diet-induced obesity and insulin resistance via fibroblast growth factor 21 induction.
Q47104159Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival.
Q37282125Systemic blockade of ACVR2B ligands prevents chemotherapy-induced muscle wasting by restoring muscle protein synthesis without affecting oxidative capacity or atrogenes.
Q90080201Type I interferons and endoplasmic reticulum stress in health and disease

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