| scholarly article | Q13442814 |
| P50 | author | David Ron | Q18195722 |
| Heather P Harding | Q55457426 | ||
| Isabel Novoa | Q56451514 | ||
| Seiichi Oyadomari | Q90186844 | ||
| Céline Jousse | Q116774573 | ||
| P2093 | author name string | Yuhong Zhang | |
| Phoebe Lu | |||
| P2860 | cites work | Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1. | Q24291713 |
| Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 | Q24293501 | ||
| Perk is essential for translational regulation and cell survival during the unfolded protein response | Q28140062 | ||
| Translational control is required for the unfolded protein response and in vivo glucose homeostasis | Q28204066 | ||
| Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase | Q28296183 | ||
| Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency | Q28365535 | ||
| The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas | Q28505821 | ||
| Regulated translation initiation controls stress-induced gene expression in mammalian cells | Q28506388 | ||
| Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha | Q28512201 | ||
| Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival | Q28593963 | ||
| Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response | Q29547299 | ||
| An integrated stress response regulates amino acid metabolism and resistance to oxidative stress | Q29547441 | ||
| Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeast | Q29614487 | ||
| The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice | Q34286263 | ||
| Initiation factor eIF2 alpha phosphorylation in stress responses and apoptosis. | Q34383407 | ||
| Signal integration via PKR. | Q34467907 | ||
| Oxytosis: A novel form of programmed cell death | Q34564400 | ||
| Transcriptional and translational control in the Mammalian unfolded protein response | Q34762452 | ||
| Translational control in the endoplasmic reticulum stress response | Q35001600 | ||
| Translational regulation in the cellular response to biosynthetic load on the endoplasmic reticulum. | Q35133775 | ||
| The carboxyl terminus of the murine MyD116 gene substitutes for the corresponding domain of the gamma(1)34.5 gene of herpes simplex virus to preclude the premature shutoff of total protein synthesis in infected human cells. | Q35853252 | ||
| The gamma(1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1alpha to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA- | Q35964369 | ||
| A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis | Q36084388 | ||
| Regulation of antioxidant metabolism by translation initiation factor 2alpha | Q36379914 | ||
| Suppression of protein synthesis in brain during hibernation involves inhibition of protein initiation and elongation | Q36737028 | ||
| Isolation of genetic suppressor elements (GSEs) from random fragment cDNA libraries in retroviral vectors | Q36855973 | ||
| Complexes containing activating transcription factor (ATF)/cAMP-responsive-element-binding protein (CREB) interact with the CCAAT/enhancer-binding protein (C/EBP)-ATF composite site to regulate Gadd153 expression during the stress response | Q38326929 | ||
| Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2 | Q39315996 | ||
| Stress-induced gene expression requires programmed recovery from translational repression | Q39735685 | ||
| Packaging system for rapid production of murine leukemia virus vectors with variable tropism | Q40067097 | ||
| The gamma134.5 protein of herpes simplex virus 1 has the structural and functional attributes of a protein phosphatase 1 regulatory subunit and is present in a high molecular weight complex with the enzyme in infected cells | Q41018806 | ||
| The role of monoamine metabolism in oxidative glutamate toxicity. | Q41158837 | ||
| Translational regulation of yeast GCN4. A window on factors that control initiator-trna binding to the ribosome | Q41575247 | ||
| Delineation of a negative feedback regulatory loop that controls protein translation during endoplasmic reticulum stress | Q42163338 | ||
| The function of GADD34 is a recovery from a shutoff of protein synthesis induced by ER stress: elucidation by GADD34-deficient mice | Q44489907 | ||
| Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response | Q74359929 | ||
| P433 | issue | 4 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | Protein phosphatase 1, regulatory subunit 15B | Q21988462 |
| P1104 | number of pages | 9 | |
| P304 | page(s) | 767-775 | |
| P577 | publication date | 2003-11-01 | |
| P1433 | published in | Journal of Cell Biology | Q1524550 |
| P1476 | title | Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cells | |
| P478 | volume | 163 |
| Q36465629 | A Missense Mutation in PPP1R15B Causes a Syndrome Including Diabetes, Short Stature, and Microcephaly |
| Q55111385 | A Sephin1-insensitive tripartite holophosphatase dephosphorylates translation initiation factor 2α. |
| Q30525662 | A subunit of eukaryotic translation initiation factor 2α-phosphatase (CreP/PPP1R15B) regulates membrane traffic |
| Q51732451 | AP-SWATH reveals direct involvement of VCP/p97 in integrated stress response signaling through facilitating CReP/PPP1R15B degradation. |
| Q35379139 | Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation |
| Q33262919 | Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins |
| Q42496198 | Adaptive basal phosphorylation of eIF2α is responsible for resistance to cellular stress-induced cell death in Pten-null hepatocytes |
| Q35845921 | An eIF2α-binding motif in protein phosphatase 1 subunit GADD34 and its viral orthologs is required to promote dephosphorylation of eIF2α. |
| Q36483172 | An inhibitor of HIV-1 protease modulates constitutive eIF2α dephosphorylation to trigger a specific integrated stress response. |
| Q36674887 | Anti-leukemic mechanisms of pegylated arginase I in acute lymphoblastic T-cell leukemia |
| Q24300342 | Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 protein |
| Q27311670 | BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates |
| Q40343371 | Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression |
| Q28512249 | CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum |
| Q37407462 | Cell death/proliferation roles for nc886, a non-coding RNA, in the protein kinase R pathway in cholangiocarcinoma |
| Q36362409 | Cellular response to endoplasmic reticulum stress: a matter of life or death |
| Q41846357 | Cellular serine/threonine phosphatase activity during human cytomegalovirus infection |
| Q47434210 | Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration |
| Q90726536 | Circulatory miR-98-5p levels are deregulated during diabetes and it inhibits proliferation and promotes apoptosis by targeting PPP1R15B in keratinocytes |
| Q33298506 | Comparison of gene expression between upland and lowland rice cultivars under water stress using cDNA microarray |
| Q42156227 | Complementary Roles of GADD34- and CReP-Containing Eukaryotic Initiation Factor 2α Phosphatases during the Unfolded Protein Response |
| Q42823590 | Constitutive role of GADD34 and CReP in cancellation of phospho-eIF2α-dependent translational attenuation and insulin biosynthesis in pancreatic β cells |
| Q37784822 | Control of Redox State and Redox Signaling by Neural Antioxidant Systems |
| Q39939464 | Control of cellular GADD34 levels by the 26S proteasome |
| Q38120310 | Control of oncogenesis by eIF2α phosphorylation: implications in PTEN and PI3K-Akt signaling and tumor treatment |
| Q36815722 | Coordinate regulation of eIF2α phosphorylation by PPP1R15 and GCN2 is required during Drosophila development |
| Q35859494 | Coordinated Regulation of the Neutral Amino Acid Transporter SNAT2 and the Protein Phosphatase Subunit GADD34 Promotes Adaptation to Increased Extracellular Osmolarity |
| Q35668793 | DNA Damage Regulates Translation through β-TRCP Targeting of CReP |
| Q48009325 | Decoding the selectivity of eIF2α holophosphatases and PPP1R15A inhibitors. |
| Q53179318 | Dephosphorylation of eIF2α is essential for protein synthesis increase and cell cycle progression after sea urchin fertilization. |
| Q37797970 | Diabetes as a disease of endoplasmic reticulum stress |
| Q35827837 | Diversity and selectivity in mRNA translation on the endoplasmic reticulum |
| Q47390509 | Dysregulation of mRNA translation and energy metabolism in cancer. |
| Q52327584 | EIF2B2 mutations in Vanishing White Matter Disease hyper- suppress translation and delay recovery during the integrated stress response. |
| Q36074357 | ENDOPLASMIC RETICULUM STRESS IN SEPSIS. |
| Q53616050 | ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation. |
| Q28548490 | Embryonic Stem Cell Growth Factors Regulate eIF2α Phosphorylation |
| Q36052285 | Endoplasmic Reticulum Stress and Unfolded Protein Response Pathways: Potential for Treating Age-related Retinal Degeneration |
| Q38073952 | Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration |
| Q41689677 | Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells |
| Q43274869 | Endoplasmic reticulum stress plays critical role in brain damage after cerebral ischemia/reperfusion in rats |
| Q36943108 | Enhanced integrated stress response promotes myelinating oligodendrocyte survival in response to interferon-gamma |
| Q39745125 | Essential role of PACT-mediated PKR activation in tunicamycin-induced apoptosis |
| Q37629201 | Eukaryotic and archaeal translation initiation factor 2: a heterotrimeric tRNA carrier. |
| Q37046975 | Eukaryotic initiation factor 2α phosphorylation mediates fetal hemoglobin induction through a post-transcriptional mechanism |
| Q28534646 | Eukaryotic initiation factor 2α--a downstream effector of mammalian target of rapamycin--modulates DNA repair and cancer response to treatment |
| Q64252262 | Evaluation of the Antiviral Activity of Sephin1 Treatment and Its Consequences on eIF2α Phosphorylation in Response to Viral Infections |
| Q37984815 | Exploiting the selectivity of protein phosphatase 1 for pharmacological intervention |
| Q33337465 | Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3. |
| Q56877864 | Flaviviral regulation of the unfolded protein response: can stress be beneficial? |
| Q36362397 | From acute ER stress to physiological roles of the Unfolded Protein Response |
| Q47165495 | Functional Genomic Analyses of Mendelian and Sporadic Disease Identify Impaired eIF2α Signaling as a Generalizable Mechanism for Dystonia |
| Q38694508 | Functional validation of ATF4 and GADD34 in Neuro2a cells by CRISPR/Cas9-mediated genome editing. |
| Q90590745 | Functions and therapeutic potential of protein phosphatase 1: Insights from mouse genetics |
| Q33948525 | Fusel alcohols regulate translation initiation by inhibiting eIF2B to reduce ternary complex in a mechanism that may involve altering the integrity and dynamics of the eIF2B body. |
| Q35379160 | G-actin provides substrate-specificity to eukaryotic initiation factor 2α holophosphatases |
| Q36002704 | GADD34-deficient mice develop obesity, nonalcoholic fatty liver disease, hepatic carcinoma and insulin resistance |
| Q80540867 | GCN2 phosphorylation of eIF2alpha activates NF-kappaB in response to UV irradiation |
| Q39074648 | Genetic characterization of a second novel picornavirus from an amphibian host, smooth newt (Lissotriton vulgaris). |
| Q40505852 | Glucose-stimulated protein synthesis in pancreatic beta-cells parallels an increase in the availability of the translational ternary complex (eIF2-GTP.Met-tRNAi) and the dephosphorylation of eIF2 alpha. |
| Q40538991 | Growing rats respond to a sulfur amino acid-deficient diet by phosphorylation of the alpha subunit of eukaryotic initiation factor 2 heterotrimeric complex and induction of adaptive components of the integrated stress response |
| Q26992217 | Guards and culprits in the endoplasmic reticulum: glucolipotoxicity and β-cell failure in type II diabetes |
| Q53688765 | HRI-mediated translational repression reduces proteotoxicity and sensitivity to bortezomib in human pancreatic cancer cells. |
| Q36015026 | Heme-regulated eIF2α kinase activated Atf4 signaling pathway in oxidative stress and erythropoiesis |
| Q29147428 | Homozygous mutation in the eukaryotic translation initiation factor 2alpha phosphatase gene, PPP1R15B, is associated with severe microcephaly, short stature and intellectual disability |
| Q38699474 | Hydrogen sulfide modulates eukaryotic translation initiation factor 2α (eIF2α) phosphorylation status in the integrated stress-response pathway |
| Q39742461 | Hyperoxia inhibits protein synthesis and increases eIF2α phosphorylation in the newborn rat lung |
| Q35868391 | IRE1α-Dependent Decay of CReP/Ppp1r15b mRNA Increases Eukaryotic Initiation Factor 2α Phosphorylation and Suppresses Protein Synthesis |
| Q24295116 | Identification of the human testis protein phosphatase 1 interactome |
| Q33623745 | Impaired embryonic development in mice overexpressing the RNA-binding protein TIAR. |
| Q41939417 | Inactivation of the 3-phosphoglycerate dehydrogenase gene in mice: changes in gene expression and associated regulatory networks resulting from serine deficiency |
| Q39325585 | Integrated Stress Response as a Therapeutic Target for CNS Injuries |
| Q37229342 | Intracellular death platform steps-in: targeting prostate tumors via endoplasmic reticulum (ER) apoptosis |
| Q40041944 | Investigations of Pro- and Anti-Apoptotic Factors Affecting African Swine Fever Virus Replication and Pathogenesis. |
| Q54577779 | Loss of GADD34 induces early age-dependent deviation to the myeloid lineage. |
| Q95840450 | Mechanisms, regulation and functions of the unfolded protein response |
| Q61801081 | Molecular targets for modulating the protein translation vital to proteostasis and neuron degeneration in Parkinson's disease |
| Q24296809 | Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stress |
| Q24301971 | Nck-1 antagonizes the endoplasmic reticulum stress-induced inhibition of translation |
| Q24319666 | Nck-1 interacts with PKR and modulates its activation by dsRNA |
| Q46943401 | Nck-1 selectively modulates eIF2alphaSer51 phosphorylation by a subset of eIF2alpha-kinases |
| Q38005599 | New insights into translational regulation in the endoplasmic reticulum unfolded protein response |
| Q37034440 | Nuclear Matrix Protein 4 Is a Novel Regulator of Ribosome Biogenesis and Controls the Unfolded Protein Response via Repression of Gadd34 Expression |
| Q35936953 | Nucleofection induces transient eIF2α phosphorylation by GCN2 and PERK. |
| Q24604933 | OGFOD1, a novel modulator of eukaryotic translation initiation factor 2alpha phosphorylation and the cellular response to stress |
| Q35964463 | OLA1 regulates protein synthesis and integrated stress response by inhibiting eIF2 ternary complex formation. |
| Q42450774 | PPM1l encodes an inositol requiring-protein 1 (IRE1) specific phosphatase that regulates the functional outcome of the ER stress response |
| Q42058506 | PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz. |
| Q30486959 | Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis |
| Q37100863 | Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development |
| Q52308796 | Preemptive activation of the integrated stress response protects mice from diet-induced obesity and insulin resistance via fibroblast growth factor 21 induction. |
| Q51185924 | Prion Properties of SOD1 in Amyotrophic Lateral Sclerosis and Potential Therapy. |
| Q34283514 | Proline biosynthesis is required for endoplasmic reticulum stress tolerance in Saccharomyces cerevisiae |
| Q38236704 | Protein phosphatase 1 catalytic isoforms: specificity toward interacting proteins |
| Q35779135 | Protein phosphatase 1 subunit Ppp1r15a/GADD34 regulates cytokine production in polyinosinic:polycytidylic acid-stimulated dendritic cells |
| Q24304927 | Protein phosphatase 1α interacting proteins in the human brain |
| Q37701984 | Protein phosphatase PP1/GLC7 interaction domain in yeast eIF2γ bypasses targeting subunit requirement for eIF2α dephosphorylation |
| Q24301080 | Protein phosphatase-1 regulates Akt1 signal transduction pathway to control gene expression, cell survival and differentiation |
| Q36418004 | Protein-folding homeostasis in the endoplasmic reticulum and nutritional regulation |
| Q92723713 | Quercetin Regulates the Integrated Stress Response to Improve Memory |
| Q55260956 | Regulation of Cytokine Production by the Unfolded Protein Response; Implications for Infection and Autoimmunity. |
| Q37352508 | Regulation of the transcriptome by ER stress: non-canonical mechanisms and physiological consequences. |
| Q28580205 | Regulatory proteins of eukaryotic initiation factor 2-alpha subunit (eIF2 alpha) phosphatase, under ischemic reperfusion and tolerance |
| Q36301288 | Ribosome Reinitiation Directs Gene-specific Translation and Regulates the Integrated Stress Response |
| Q52596424 | Ribosome profiling uncovers selective mRNA translation associated with eIF2 phosphorylation in erythroid progenitors. |
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| Q54457075 | Role of glutamine depletion in directing tissue-specific nutrient stress responses to L-asparaginase. |
| Q39503784 | Rotavirus infection activates the UPR but modulates its activity |
| Q40184948 | SIRT1 associates with eIF2-alpha and regulates the cellular stress response |
| Q36591295 | Salubrinal-Mediated Upregulation of eIF2α Phosphorylation Increases Doxorubicin Sensitivity in MCF-7/ADR Cells |
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