Xenobiotic perturbation of ER stress and the unfolded protein response

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Xenobiotic perturbation of ER stress and the unfolded protein response is …
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review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1177/0192623312470764
P8608Fatcat IDrelease_uqui6ttlzndybjkiqrqwcl5qz4
P698PubMed publication ID23334697
P5875ResearchGate publication ID234702387

P2093author name stringJ. L. Stevens
J. W. Lawrence
M. A. Lafleur
P2860cites workHSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical interactionQ21145793
CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteinsQ22010670
Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stressQ22010800
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-betaQ22011091
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1Q22011167
Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activityQ24290192
Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stressQ24291026
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factorQ24292102
Protein synthesis and endoplasmic reticulum stress can be modulated by the hepatitis C virus envelope protein E2 through the eukaryotic initiation factor 2alpha kinase PERKQ24296386
Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stressQ24296809
A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cellsQ24297587
Proapoptotic BAX and BAK control multiple initiator caspasesQ24298402
JAB1 participates in unfolded protein responses by association and dissociation with IRE1Q24298558
ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeatsQ24298956
Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cellsQ24299603
Luman is capable of binding and activating transcription from the unfolded protein response elementQ24300509
An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12Q24300914
CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cellsQ24301679
Roles of CHOP/GADD153 in endoplasmic reticulum stressQ24302185
Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylationQ24303825
pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress responseQ24303865
Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory responseQ24304232
SUMO modification regulates the transcriptional activity of XBP1Q24307512
A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cellsQ24309442
BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alphaQ24310536
AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress responseQ24314664
Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alphaQ24320638
Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alphaQ24322072
BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducerQ24337349
Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell deathQ24338605
CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P.Q24338672
Endoplasmic reticulum stress: cell life and death decisions.Q24536108
Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK.Q24541469
Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myelomaQ24600346
ER stress controls iron metabolism through induction of hepcidinQ24630714
Ca(2+) transfer from the ER to mitochondria: when, how and whyQ24647997
Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell SurvivalQ24653078
XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cellsQ24658399
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein responseQ24672592
Oxidative protein folding in eukaryotes: mechanisms and consequencesQ24676827
Road to ruin: targeting proteins for degradation in the endoplasmic reticulumQ26866096
Involvement of Gadd153 in the pathogenic action of presenilin-1 mutations.Q38361754
Upregulation and overexpression of human X-box binding protein 1 (hXBP-1) gene in primary breast cancersQ38449959
ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1.Q38947838
Endoplasmic reticulum (ER) chaperone regulation and survival of cells compensating for deficiency in the ER stress response kinase, PERKQ39142751
IRE1beta inhibits chylomicron production by selectively degrading MTP mRNA.Q39422225
Activation of ATF4 mediates unwanted Mcl-1 accumulation by proteasome inhibitionQ39435523
Reactive oxygen species-mediated endoplasmic reticulum stress and mitochondrial dysfunction contribute to polydatin-induced apoptosis in human nasopharyngeal carcinoma CNE cellsQ39495353
Salubrinal, an eIF2α dephosphorylation inhibitor, enhances cisplatin-induced oxidative stress and nephrotoxicity in a mouse model.Q39535847
Baicalein protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stress-induced apoptosis through inhibition of reactive oxygen species production and CHOP inductionQ39642134
XBP1 Controls Maturation of Gastric Zymogenic Cells by Induction of MIST1 and Expansion of the Rough Endoplasmic ReticulumQ39659690
Apigenin protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stress-induced apoptosisQ39701311
Enhanced signaling downstream of ribonucleic Acid-activated protein kinase-like endoplasmic reticulum kinase potentiates lipotoxic endoplasmic reticulum stress in human islets.Q39751051
Implication of unfolded protein response in resveratrol-induced inhibition of K562 cell proliferationQ39769768
MCP-1 causes cardiomyoblast death via autophagy resulting from ER stress caused by oxidative stress generated by inducing a novel zinc-finger protein, MCPIP.Q39772786
IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.Q39814866
pXBP1(U), a negative regulator of the unfolded protein response activator pXBP1(S), targets ATF6 but not ATF4 in proteasome-mediated degradation.Q39898784
Ritonavir induces endoplasmic reticulum stress and sensitizes sarcoma cells toward bortezomib-induced apoptosisQ39958648
Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein.Q39962425
Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in miceQ39975807
Inhibition of endoplasmic reticulum stress counteracts neuronal cell death and protein aggregation caused by N-terminal mutant huntingtin proteinsQ40015897
Induction of GRP78 by valproic acid is dependent upon histone deacetylase inhibitionQ40120317
Effect of endoplasmic reticulum stress preconditioning on cytotoxicity of clinically relevant nephrotoxins in renal cell linesQ40148265
Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetesQ40176269
SIRT1 associates with eIF2-alpha and regulates the cellular stress responseQ40184948
Hepatitis B virus X protein (HBx) activates ATF6 and IRE1-XBP1 pathways of unfolded protein responseQ40210691
Assays for detecting the unfolded protein response.Q54617608
Measurement of ER stress response and inflammation in the mouse model of nonalcoholic fatty liver disease.Q54617615
Increased expression of endoplasmic reticulum stress proteins following chronic valproate treatment of rat C6 glioma cells.Q55475244
Activation of the unfolded protein response and alternative splicing of ATF6α in HLA-B27 positive lymphocytesQ59167170
The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocationQ28510062
XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glandsQ28510479
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulumQ28512249
Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cellsQ28513964
Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brainQ28572076
Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox stateQ28572472
Endoplasmic reticulum stress and trophic factor withdrawal activate distinct signaling cascades that induce glycogen synthase kinase-3 beta and a caspase-9-dependent apoptosis in cerebellar granule neuronsQ28573805
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesQ28575190
Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosisQ28576685
Mood stabilizing drug lithium increases expression of endoplasmic reticulum stress proteins in primary cultured rat cerebral cortical cellsQ28578375
Translation mediated by the internal ribosome entry site of the cat-1 mRNA is regulated by glucose availability in a PERK kinase-dependent mannerQ28580378
OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytesQ28580776
The protective effect of dantrolene on ischemic neuronal cell death is associated with reduced expression of endoplasmic reticulum stress markersQ28581980
Identification of ERp29, an endoplasmic reticulum lumenal protein, as a new member of the thyroglobulin folding complexQ28582404
mTORC1 serves ER stress-triggered apoptosis via selective activation of the IRE1-JNK pathwayQ28583302
Chronic valproate treatment increases expression of endoplasmic reticulum stress proteins in the rat cerebral cortex and hippocampusQ28584118
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein ResponseQ28585314
Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosisQ28586997
XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networksQ28591575
Regulation of glucose homeostasis through a XBP-1-FoxO1 interactionQ28592129
BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stressQ28592598
Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survivalQ28593963
ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein responseQ28611502
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein responseQ29547299
The unfolded protein response: from stress pathway to homeostatic regulationQ29547396
The mammalian unfolded protein responseQ29547400
An integrated stress response regulates amino acid metabolism and resistance to oxidative stressQ29547441
Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controlsQ29547730
Autophagy is activated for cell survival after endoplasmic reticulum stressQ29614485
Impairment of the ubiquitin-proteasome system by protein aggregationQ29614556
IRE1 signaling affects cell fate during the unfolded protein responseQ29615502
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetesQ29615503
Translocation of proteins into mitochondriaQ29616478
ER stress triggers apoptosis by activating BH3-only protein BimQ29617730
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunitiesQ29617768
Setting the standards: quality control in the secretory pathwayQ29620321
Protein import into mitochondriaQ29620420
Endoplasmic reticulum stress and unfolded protein response in renal pathophysiology: Janus facesQ30039723
Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clusteringQ30496639
Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteinsQ33262919
Substrate-specific translocational attenuation during ER stress defines a pre-emptive quality control pathwayQ33264756
Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein responseQ33264844
Small molecule regulators of autophagy identified by an image-based high-throughput screenQ33306309
Valproate, a mood stabilizer, induces WFS1 expression and modulates its interaction with ER stress protein GRP94Q33397723
In vitro activation of heat shock transcription factor DNA-binding by calcium and biochemical conditions that affect protein conformationQ33583065
IRE1α Disruption Causes Histological Abnormality of Exocrine Tissues, Increase of Blood Glucose Level, and Decrease of Serum Immunoglobulin LevelQ33707431
The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegansQ33757350
Plasma cell differentiation initiates a limited ER stress response by specifically suppressing the PERK-dependent branch of the unfolded protein responseQ33838972
How an inhibitor of the HIV-I protease modulates proteasome activityQ33882609
BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.Q33960826
Hyperthermia induces the ER stress pathwayQ34005542
Ryanodine receptors: structure, expression, molecular details, and function in calcium release.Q34024377
Activation of JNK and transcriptional repressor ATF3/LRF1 through the IRE1/TRAF2 pathway is implicated in human vascular endothelial cell death by homocysteineQ34103511
Wolcott-Rallison syndromeQ34148057
Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasisQ34169287
P58IPK, a novel endoplasmic reticulum stress-inducible protein and potential negative regulator of eIF2alpha signalingQ34179244
Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesisQ34192744
Mitochondrial calcium signaling driven by the IP3 receptorQ34478937
Drug-related hepatotoxicityQ34495071
Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expressionQ34563098
Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.Q34626231
Divergent effects of PERK and IRE1 signaling on cell viabilityQ27438124
Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PQ27681837
Autophagy in the Pathogenesis of DiseaseQ27860558
RNA-mediated response to heat shock in mammalian cellsQ28118457
Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complexQ28118708
Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein responseQ28139601
Perk is essential for translational regulation and cell survival during the unfolded protein responseQ28140062
The human endoplasmic reticulum molecular chaperone BiP is an autoantigen for rheumatoid arthritis and prevents the induction of experimental arthritisQ28142928
Proteasome inhibitors disrupt the unfolded protein response in myeloma cellsQ28155919
BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosisQ28189945
Translational control is required for the unfolded protein response and in vivo glucose homeostasisQ28204066
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNAQ28214814
Mechanisms of hepatotoxicityQ28216749
Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasisQ28258427
A molecular chaperone inducer protects neurons from ER stressQ28259344
Differential modulation of endotoxin responsiveness by human caspase-12 polymorphismsQ28260472
N-glycan processing in ER quality controlQ28271200
Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosisQ28277961
Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP KinaseQ28280649
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinaseQ28296183
The dsRNA protein kinase PKR: virus and cell controlQ28298945
Regulation of protein synthesis by heme-regulated eIF-2 alpha kinaseQ28299534
The ERAD inhibitor Eeyarestatin I is a bifunctional compound with a membrane-binding domain and a p97/VCP inhibitory groupQ28299691
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stressQ28306995
ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cellsQ28307506
Regulation of HSF1 function in the heat stress response: implications in aging and diseaseQ28307651
Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient miceQ28359871
Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overloadQ28506232
Regulated translation initiation controls stress-induced gene expression in mammalian cellsQ28506388
Protein-tyrosine phosphatase 1B potentiates IRE1 signaling during endoplasmic reticulum stressQ28506667
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cellsQ28508342
CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulumQ28509611
The unfolded protein response in nutrient sensing and differentiationQ34664763
Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivoQ34676901
Regulation of ER stress proteins by valproate: therapeutic implications.Q34692778
Intrinsic capacities of molecular sensors of the unfolded protein response to sense alternate forms of endoplasmic reticulum stressQ34698161
HIV-1 protease inhibitors nelfinavir and atazanavir induce malignant glioma death by triggering endoplasmic reticulum stress.Q34714150
TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages.Q35041384
The X-box binding protein-1 transcription factor is required for plasma cell differentiation and the unfolded protein responseQ35170906
A review of the mammalian unfolded protein response.Q35354864
p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasisQ35419603
Mammalian unfolded protein response inhibits cyclin D1 translation and cell-cycle progressionQ35552863
Resveratrol triggers the pro-apoptotic endoplasmic reticulum stress response and represses pro-survival XBP1 signaling in human multiple myeloma cells.Q35681914
Cdc37/Hsp90 protein-mediated regulation of IRE1α protein activity in endoplasmic reticulum stress response and insulin synthesis in INS-1 cellsQ35838863
Β-adrenergic receptor stimulation induces endoplasmic reticulum stress in adult cardiac myocytes: role in apoptosisQ35872556
ER chaperone functions during normal and stress conditionsQ35885336
Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viabilityQ35916071
The kinase inhibitor sorafenib induces cell death through a process involving induction of endoplasmic reticulum stressQ35950143
The specialized unfolded protein response of B lymphocytes: ATF6α-independent development of antibody-secreting B cells.Q35981133
Endoplasmic reticulum stress in liver diseaseQ36031838
Membrane biogenesis during B cell differentiation: most endoplasmic reticulum proteins are expressed coordinatelyQ36383421
Quality control of mitochondria: protection against neurodegeneration and ageingQ36446844
The endoplasmic reticulum: folding, calcium homeostasis, signaling, and redox controlQ36598776
An inhibitor of HIV-1 protease modulates proteasome activity, antigen presentation, and T cell responsesQ36638199
Activating transcription factor 4.Q36805075
Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetesQ36861224
Endoplasmic reticulum stress as a novel therapeutic target in heart diseasesQ36952146
Antioxidants reduce endoplasmic reticulum stress and improve protein secretionQ36985084
Endoplasmic reticulum stress and liver injuryQ36989688
The endoplasmic reticulum and the unfolded protein responseQ37006310
Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagyQ37075287
Heterotrimerization of heat-shock factors 1 and 2 provides a transcriptional switch in response to distinct stimuli.Q37112625
Valproic acid metabolism and its effects on mitochondrial fatty acid oxidation: a reviewQ37130104
GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in miceQ37170811
The unfolded protein response of B-lymphocytes: PERK-independent development of antibody-secreting cellsQ37181198
From endoplasmic-reticulum stress to the inflammatory responseQ37225354
Regulated Ire1-dependent decay of messenger RNAs in mammalian cellsQ37309146
Hepatic CYP3A suppression by high concentrations of proteasomal inhibitors: a consequence of endoplasmic reticulum (ER) stress induction, activation of RNA-dependent protein kinase-like ER-bound eukaryotic initiation factor 2alpha (eIF2alpha)-kinaseQ37314375
Inhibition of tumor progression by suppression of stress protein GRP78/BiP induction in fibrosarcoma B/C10ME.Q37433487
Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosisQ37465347
Caspases and kinases in a death gripQ37593693
Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactomeQ37596032
Endoplasmic reticulum stress in proteinuric kidney diseaseQ37610753
Endoplasmic reticulum stress and the unfolded protein responseQ37612124
Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2Q37622629
Role of ATF4 in regulation of autophagy and resistance to drugs and hypoxiaQ37627091
Endoplasmic reticulum stress as a progression factor for kidney injuryQ37666123
Oxidative protein folding in the endoplasmic reticulum: tight links to the mitochondria-associated membrane (MAM).Q37739513
An integrative overview on the mechanisms underlying the renal tubular cytotoxicity of gentamicinQ37786866
The heat shock factor family and adaptation to proteotoxic stressQ37800068
Protein quality control in the cytosol and the endoplasmic reticulum: brothers in arms.Q37802039
The mitochondrial UPR - protecting organelle protein homeostasisQ37806885
Bax inhibitor 1 in apoptosis and disease.Q37836378
Bax inhibitor-1: a highly conserved endoplasmic reticulum-resident cell death suppressor.Q37877541
A diversity of SERCA Ca2+ pump inhibitorsQ37877759
Mitochondrial permeability transition in Ca(2+)-dependent apoptosis and necrosisQ37878020
Mechanisms of ER stress-induced apoptosis in atherosclerosisQ37957844
Role of endoplasmic reticulum stress in metabolic disease and other disorders.Q37976132
Activation of the unfolded protein response is an early event in Alzheimer's and Parkinson's disease.Q37981067
Sensing endoplasmic reticulum stressQ37991599
Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.Q38311676
Effect on tumor cells of blocking survival response to glucose deprivationQ38337197
Regulation of autophagy by ATF4 in response to severe hypoxia.Q38343634
Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorderQ38350959
Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cellsQ40310345
Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosisQ40339610
Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cellsQ40339637
Heat shock protein 72 protects insulin-secreting beta cells from lipopolysaccharide-induced endoplasmic reticulum stressQ40371176
Modulating the endoplasmic reticulum stress response with trans-4,5-dihydroxy-1,2-dithiane prevents chemically induced renal injury in vivoQ40375854
Valproate protects cells from ER stress-induced lipid accumulation and apoptosis by inhibiting glycogen synthase kinase-3.Q40483325
Endoplasmic reticulum stress response is involved in nonsteroidal anti-inflammatory drug-induced apoptosisQ40558204
Hepatitis C virus suppresses the IRE1-XBP1 pathway of the unfolded protein responseQ40590374
Serine proteases mediate apoptosis-like cell death and phagocytosis under caspase-inhibiting conditions.Q40632735
Sequential waves of functionally related proteins are expressed when B cells prepare for antibody secretionQ40669445
Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activationQ40793113
Endoplasmic reticulum chaperones GRP78 and calreticulin prevent oxidative stress, Ca2+ disturbances, and cell death in renal epithelial cellsQ41092630
Caspases: intracellular signaling by proteolysisQ41656258
A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein responseQ41711854
Measuring ER stress and the unfolded protein response using mammalian tissue culture systemQ41898554
The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosisQ41904044
Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosisQ42004487
Human immunodeficiency virus protease inhibitors modulate Ca2+ homeostasis and potentiate alcoholic stress and injury in mice and primary mouse and human hepatocytesQ42037562
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.Q42041480
Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signallingQ42045464
Targeting endoplasmic reticulum protein transport: a novel strategy to kill malignant B cells and overcome fludarabine resistance in CLL.Q42115123
Delineation of a negative feedback regulatory loop that controls protein translation during endoplasmic reticulum stressQ42163338
Induction of liver steatosis and lipid droplet formation in ATF6alpha-knockout mice burdened with pharmacological endoplasmic reticulum stressQ42451739
The unfolded protein response is an important regulator of inflammatory genes in endothelial cellsQ42500350
ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stressQ42518206
Endoplasmic reticulum stress inhibition protects steatotic and non-steatotic livers in partial hepatectomy under ischemia-reperfusionQ42588208
cis-acting sequences involved in the translational control of GCN4 expressionQ42633634
The antioxidant edaravone attenuates ER-stress-mediated cardiac apoptosis and dysfunction in rats with autoimmune myocarditisQ42918164
Inhibition of hepatic carnitine palmitoyl-transferase I (CPT IA) by valproyl-CoA as a possible mechanism of valproate-induced steatosisQ43255616
Endoplasmic reticulum stress plays critical role in brain damage after cerebral ischemia/reperfusion in ratsQ43274869
Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosisQ43579795
Brain ischemia and reperfusion activates the eukaryotic initiation factor 2alpha kinase, PERK.Q43627961
Polyglutamine aggregates stimulate ER stress signals and caspase-12 activationQ44015045
Central role of glycogen synthase kinase-3beta in endoplasmic reticulum stress-induced caspase-3 activationQ44135113
Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neuronsQ44258606
JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosisQ44485247
A role for motoneuron subtype-selective ER stress in disease manifestations of FALS miceQ46070173
Up regulation of the GRP-78 and GADD-153 and down regulation of Bcl-2 proteins in primary glomerular diseases: a possible involvement of the ER stress pathway in glomerulonephritisQ46184114
Oxidized low-density lipoproteins trigger endoplasmic reticulum stress in vascular cells: prevention by oxygen-regulated protein 150 expression.Q46184567
Cyclosporine triggers endoplasmic reticulum stress in endothelial cells: a role for endothelial phenotypic changes and deathQ46262369
Cyclosporine-induced endoplasmic reticulum stress triggers tubular phenotypic changes and deathQ46373887
Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosisQ46434986
Presence of the functional CASPASE-12 allele in Indian subpopulationsQ46562085
Sodium 4-phenylbutyrate protects against liver ischemia reperfusion injury by inhibition of endoplasmic reticulum-stress mediated apoptosisQ46695184
Celecoxib upregulates endoplasmic reticulum chaperones that inhibit celecoxib-induced apoptosis in human gastric cellsQ46736495
Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicityQ46765805
CHOP deficiency attenuates cholestasis-induced liver fibrosis by reduction of hepatocyte injuryQ46823993
ClpP mediates activation of a mitochondrial unfolded protein response in C. elegansQ47069058
The unfolded protein response in health and diseaseQ47682274
Cotranslational targeting of XBP1 protein to the membrane promotes cytoplasmic splicing of its own mRNA.Q47942024
Lack of support for a genetic association of the XBP1 promoter polymorphism with bipolar disorder in probands of European origin.Q50797144
The role of brain-derived neurotrophic factor (BDNF)-induced XBP1 splicing during brain development.Q51899074
Ubiquitous calpains promote caspase-12 and JNK activation during endoplasmic reticulum stress-induced apoptosis.Q52569822
Proteasome inhibitor MG132-induced apoptosis via ER stress-mediated apoptotic pathway and its potentiation by protein tyrosine kinase p56lck in human Jurkat T cells.Q53227756
Endoplasmic reticulum stress in the kidney as a novel mediator of kidney injury.Q53402529
ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation.Q53616050
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)235-62
P577publication date2013-02-01
P1433published inToxicologic PathologyQ7830407
P1476titleXenobiotic perturbation of ER stress and the unfolded protein response
P478volume41

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