BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha

scientific article

BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.MOLCEL.2009.02.017
P3181OpenCitations bibliographic resource ID3803829
P932PMC publication ID2818874
P698PubMed publication ID19328063
P5875ResearchGate publication ID24240581

P50authorLaurie GlimcherQ6501587
Fabio MartinonQ37393756
Diego Rojas-RiveraQ79257563
P2093author name stringJohn C Reed
Peter Walter
Jonathan H Lin
Claudio Hetz
Fernanda Lisbona
Peter Thielen
Alvaro Glavic
Derrick Todd
Christina Kress
Sebastian Zamorano
P2860cites workPlasma cell differentiation requires the transcription factor XBP-1Q24291453
Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1Q24302166
Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1Q24303558
The daily job of night killers: alternative roles of the BCL-2 family in organelle physiologyQ37031106
The unfolded protein response of B-lymphocytes: PERK-independent development of antibody-secreting cellsQ37181198
The xbp-1 gene is essential for development in DrosophilaQ38305993
Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.Q38311676
Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein.Q39962425
A role for proapoptotic BID in the DNA-damage responseQ40381562
The disulfide isomerase Grp58 is a protective factor against prion neurotoxicity.Q40445820
Proapoptotic BID is an ATM effector in the DNA-damage responseQ46669145
Ire1 regulated XBP1 mRNA splicing is essential for the unfolded protein response (UPR) in Drosophila melanogasterQ47071152
The proapoptotic BCL-2 family member BIM mediates motoneuron loss in a model of amyotrophic lateral sclerosisQ80352679
Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeastQ24314476
AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress responseQ24314664
Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alphaQ24322072
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein responseQ24672592
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein responseQ27938493
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagyQ28131727
Proteasome inhibitors disrupt the unfolded protein response in myeloma cellsQ28155919
BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosisQ28189945
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNAQ28214814
Cell death: critical control pointsQ28240722
Protein-tyrosine phosphatase 1B potentiates IRE1 signaling during endoplasmic reticulum stressQ28506667
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1Q28507338
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glandsQ28510479
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein ResponseQ28585314
Dual role of proapoptotic BAD in insulin secretion and beta cell survivalQ28586275
XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networksQ28591575
Role of Bax and Bak in mitochondrial morphogenesisQ28591724
BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stressQ28592598
BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosisQ28594183
Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiaeQ29546523
IRE1 signaling affects cell fate during the unfolded protein responseQ29615502
Evolutionarily conserved cytoprotection provided by Bax Inhibitor-1 homologs from animals, plants, and yeastQ31031519
Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteinsQ33262919
The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis.Q33777806
XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiationQ34345459
Cytoprotective gene bi-1 is required for intrinsic protection from endoplasmic reticulum stress and ischemia-reperfusion injuryQ34479417
Bax inhibitor-1 regulates endoplasmic reticulum stress-associated reactive oxygen species and heme oxygenase-1 expressionQ34631694
BAX Inhibitor-1, an ancient cell death suppressor in animals and plants with prokaryotic relativesQ35838773
XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum.Q36322684
ER stress signaling and the BCL-2 family of proteins: from adaptation to irreversible cellular damageQ36940021
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
Endoplasmic reticulum to nucleus signaling 1Q21115427
negative regulation of endoribonuclease activityQ21132768
Transmembrane BAX inhibitor motif containing 6Q21132769
Transmembrane BAX inhibitor motif containing 6Q21493974
Endoplasmic reticulum (ER) to nucleus signalling 1Q21495585
X-box binding protein 1Q21992827
Bax Inhibitor-1 Dmel_CG7188Q29819724
P304page(s)679-691
P577publication date2009-03-01
P1433published inMolecular CellQ3319468
P1476titleBAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha
P478volume33

Reverse relations

cites work (P2860)
Q34311770A BAX/BAK and cyclophilin D-independent intrinsic apoptosis pathway
Q24297587A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells
Q35354864A review of the mammalian unfolded protein response.
Q40794488ALS-linked protein disulfide isomerase variants cause motor dysfunction
Q38866761Activation of endoplasmic reticulum stress is involved in the activity of icariin against human lung adenocarcinoma cells.
Q26765956Adaptive preconditioning in neurological diseases – therapeutic insights from proteostatic perturbations
Q85154129Alternative Functions of the BCL-2 Protein Family at the Endoplasmic Reticulum
Q55260078Arabidopsis GAAP1 and GAAP3 Modulate the Unfolded Protein Response and the Onset of Cell Death in Response to ER Stress.
Q90050722Arabidopsis GAAP1 to GAAP3 Play Redundant Role in Cell Death Inhibition by Suppressing the Upregulation of Salicylic Acid Pathway Under Endoplasmic Reticulum Stress
Q21134705Astrocytic αVβ3 integrin inhibits neurite outgrowth and promotes retraction of neuronal processes by clustering Thy-1
Q34009020B cell signature during inactive systemic lupus is heterogeneous: toward a biological dissection of lupus
Q36472450BAX inhibitor-1 is a Ca(2+) channel critically important for immune cell function and survival
Q39592117BAX inhibitor-1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response.
Q39378629BCL-2 family: integrating stress responses at the ER to control cell demise
Q36000128BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α.
Q49850608Bax Inhibitor-1 protects from Non-Alcoholic Steatohepatitis by limiting IRE1α signaling
Q37335416Bax Inhibitor-1, a conserved cell death suppressor, is a key molecular switch downstream from a variety of biotic and abiotic stress signals in plants
Q37836378Bax inhibitor 1 in apoptosis and disease.
Q47716050Bax inhibitor-1 is required for resisting the Early Brain Injury induced by subarachnoid hemorrhage through regulating IRE1-JNK pathway
Q37877541Bax inhibitor-1: a highly conserved endoplasmic reticulum-resident cell death suppressor.
Q30353961Bax-inhibitor-1 knockdown phenotypes are suppressed by Buffy and exacerbate degeneration in a Drosophila model of Parkinson disease.
Q24306658Bifunctional Apoptosis Regulator (BAR), an Endoplasmic Reticulum (ER)-associated E3 Ubiquitin Ligase, Modulates BI-1 Protein Stability and Function in ER Stress
Q48974498CPR5 modulates salicylic acid and the unfolded protein response to manage tradeoffs between plant growth and stress responses
Q83230214Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stress
Q98564760Caveolin-1 suppresses tumor formation through the inhibition of the unfolded protein response
Q43297157Cell biology. Lethal traffic jam.
Q92972076Cell death induced by the ER stressor thapsigargin involves death receptor 5, a non-autophagic function of MAP1LC3B, and distinct contributions from unfolded protein response components
Q38241810Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 1. An overview.
Q34945470Cytomegalovirus downregulates IRE1 to repress the unfolded protein response
Q36747723Defects in IRE1 enhance cell death and fail to degrade mRNAs encoding secretory pathway proteins in the Arabidopsis unfolded protein response.
Q43534834Deletion of Nck1 attenuates hepatic ER stress signaling and improves glucose tolerance and insulin signaling in liver of obese mice
Q34510834Direct association of unfolded proteins with mammalian ER stress sensor, IRE1β
Q26863590Drosophila as a model for unfolded protein response research
Q37786022Drugs targeting Bcl-2 family members as an emerging strategy in cancer
Q37719188ER stress and the unfolded protein response in intestinal inflammation.
Q57027930ER stress signalling has an activating transcription factor 6α (ATF6)-dependent 'off-switch'
Q27027638ER stress-induced cell death mechanisms
Q37220092Effect of BI-1 on insulin resistance through regulation of CYP2E1.
Q34996061Effects of antibiotics and a proto-oncogene homolog on destruction of protein translocator SecY.
Q34073228Embryonic stem cell (ESC)-mediated transgene delivery induces growth suppression, apoptosis and radiosensitization, and overcomes temozolomide resistance in malignant gliomas
Q26778141Endoplasmic Reticulum Stress Signaling in Plant Immunity--At the Crossroad of Life and Death
Q26799567Endoplasmic Reticulum Stress in the Diabetic Kidney, the Good, the Bad and the Ugly
Q39440786Endoplasmic Reticulum Stress, a Driver or an Innocent Bystander in Endothelial Dysfunction Associated with Hypertension?
Q36820563Endoplasmic reticulum (ER) stress response and its physiological roles in plants
Q38073952Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration
Q41917839Endoplasmic reticulum involvement in yeast cell death.
Q24306871Endoplasmic reticulum protein BI-1 modulates unfolded protein response signaling and protects against stroke and traumatic brain injury
Q35988912Endoplasmic reticulum protein BI-1 regulates Ca²⁺-mediated bioenergetics to promote autophagy
Q35055531Endoplasmic reticulum stress and the unfolded protein response in nonalcoholic fatty liver disease
Q26864238Endoplasmic reticulum stress and type 2 diabetes
Q35882857Endoplasmic reticulum stress implicated in the development of renal fibrosis
Q36031838Endoplasmic reticulum stress in liver disease
Q57243233Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications
Q89999381Endoplasmic reticulum stress, degeneration of pancreatic islet β-cells, and therapeutic modulation of the unfolded protein response in diabetes
Q37577306Endoplasmic reticulum stress, inflammation, and perinatal brain damage
Q37811174Endoplasmic reticulum stress-sensing mechanisms in yeast and mammalian cells
Q30502486Enhanced lysosomal activity is involved in Bax inhibitor-1-induced regulation of the endoplasmic reticulum (ER) stress response and cell death against ER stress: involvement of vacuolar H+-ATPase (V-ATPase).
Q42350805Erratum: Proteostasis control by the unfolded protein response
Q37844020Fatty acids and the endoplasmic reticulum in nonalcoholic fatty liver disease
Q37596032Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome
Q33732697Fortilin binds IRE1α and prevents ER stress from signaling apoptotic cell death
Q94686254Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response
Q37188852Glucosidase II β-subunit, a novel substrate for caspase-3-like activity in rice, plays as a molecular switch between autophagy and programmed cell death
Q39281472Golgi anti-apoptotic protein: a tale of camels, calcium, channels and cancer
Q21145793HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical interaction
Q35182826Heightened induction of proapoptotic signals in response to endoplasmic reticulum stress in primary fibroblasts from a mouse model of longevity
Q33673551Hepatic Bax inhibitor-1 inhibits IRE1alpha and protects from obesity-associated insulin resistance and glucose intolerance
Q37282044IRE1: ER stress sensor and cell fate executor
Q55283549IRE1α Implications in Endoplasmic Reticulum Stress-Mediated Development and Pathogenesis of Autoimmune Diseases.
Q95595105IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A
Q38089906Implications of endoplasmic reticulum stress, the unfolded protein response and apoptosis for molecular cancer therapy. Part I: targeting p53, Mdm2, GADD153/CHOP, GRP78/BiP and heat shock proteins
Q34805515Inhibition of hepatic glycogen synthesis by hyperhomocysteinemia mediated by TRB3
Q33633401Linking ER Stress to Autophagy: Potential Implications for Cancer Therapy.
Q41830043Loss of calmodulin binding to Bax inhibitor-1 affects Pseudomonas-mediated hypersensitive response-associated cell death in Arabidopsis thaliana.
Q38297313METABOLISM. S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction.
Q30496639Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering
Q95840450Mechanisms, regulation and functions of the unfolded protein response
Q38394944Membrane aberrancy and unfolded proteins activate the endoplasmic reticulum stress sensor Ire1 in different ways
Q37844235Monitoring and manipulating mammalian unfolded protein response
Q38467774Multiple Mechanisms of Unfolded Protein Response-Induced Cell Death
Q36540356Nonmuscle myosin IIB links cytoskeleton to IRE1α signaling during ER stress.
Q47373951Nuclear mRNA degradation tunes the gain of the unfolded protein response in Saccharomyces cerevisiae.
Q38235868Organelle-specific initiation of cell death
Q39367760Overactivation of Ras signaling pathway in CD133+ MPNST cells
Q37739513Oxidative protein folding in the endoplasmic reticulum: tight links to the mitochondria-associated membrane (MAM).
Q36379500PERK regulated miR-424(322)-503 cluster fine-tunes activation of IRE1 and ATF6 during Unfolded Protein Response.
Q42450774PPM1l encodes an inositol requiring-protein 1 (IRE1) specific phosphatase that regulates the functional outcome of the ER stress response
Q92002537PRKCSH contributes to tumorigenesis by selective boosting of IRE1 signaling pathway
Q38367339Pancreatic adaptive responses in alcohol abuse: Role of the unfolded protein response.
Q34373108Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis
Q90154496Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress
Q40188396Plant Bax Inhibitor-1 interacts with ATG6 to regulate autophagy and programmed cell death.
Q33786940Prion protein misfolding affects calcium homeostasis and sensitizes cells to endoplasmic reticulum stress
Q33812818Proteasome inhibition represses unfolded protein response and Nox4, sensitizing vascular cells to endoplasmic reticulum stress-induced death
Q38340790Protective effect of bile acids on the onset of fructose-induced hepatic steatosis in mice
Q37687467Protein disulfide isomerase A6 controls the decay of IRE1α signaling via disulfide-dependent association
Q34317895Proteomic profiling of differentially expressed proteins from Bax inhibitor-1 knockout and wild type mice.
Q38540196Proteostasis control by the unfolded protein response
Q35469778Proteostasis regulation at the endoplasmic reticulum: a new perturbation site for targeted cancer therapy
Q47665197Pseudogenization of testis-specific Lfg5 predates human/Neanderthal divergence
Q35438034Quercetin affects Hsp70/IRE1α mediated protection from death induced by endoplasmic reticulum stress
Q28577788Rapamycin inhibits postprandial-mediated X-box-binding protein-1 splicing in rat liver
Q46594879Recombinant antibody production in Arabidopsis seeds triggers an unfolded protein response
Q47184259Recovery from temporary endoplasmic reticulum stress in plants relies on the tissue-specific and largely independent roles of bZIP28 and bZIP60, as well as an antagonizing function of BAX-Inhibitor 1 upon the pro-adaptive signaling mediated by bZIP2
Q33886820Regulation of basal cellular physiology by the homeostatic unfolded protein response
Q90950292Regulation of the ER stress response by a mitochondrial microprotein
Q38153592Regulatory crosstalk within the mammalian unfolded protein response
Q92604878Repurposing Brigatinib for the Treatment of Colorectal Cancer Based on Inhibition of ER-phagy
Q38210545Role of the unfolded protein response in β cell compensation and failure during diabetes
Q91892215SPHK1 deficiency protects mice from acetaminophen-induced ER stress and mitochondrial permeability transition
Q88669930Salicylic acid-independent role of NPR1 is required for protection from proteotoxic stress in the plant endoplasmic reticulum
Q34803666Signaling cell death from the endoplasmic reticulum stress response
Q26825731Spliced leader RNA silencing (SLS) - a programmed cell death pathway in Trypanosoma brucei that is induced upon ER stress
Q37894253Stressed out about obesity: IRE1α-XBP1 in metabolic disorders
Q35041384TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages.
Q38190369TMBIM protein family: ancestral regulators of cell death
Q28594126TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis
Q36777311TMBIM6 (transmembrane BAX inhibitor motif containing 6) enhances autophagy and reduces renal dysfunction in a cyclosporine A-induced nephrotoxicity model
Q38852387Targeting ABL-IRE1α signaling spares ER-stressed pancreatic β cells to reverse autoimmune diabetes
Q35663661The Bax inhibitor MrBI-1 regulates heat tolerance, apoptotic-like cell death, and virulence in Metarhizium robertsii
Q34236873The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore.
Q35883879The Levels of a Universally Conserved tRNA Modification Regulate Cell Growth
Q38853404The Protein-disulfide Isomerase ERp57 Regulates the Steady-state Levels of the Prion Protein.
Q41953903The Sec61 translocon limits IRE1α signaling during the unfolded protein response.
Q34576070The Unfolded Protein Response, Degradation from Endoplasmic Reticulum and Cancer
Q39249695The Unfolded Protein Response: At the Intersection between Endoplasmic Reticulum Function and Mitochondrial Bioenergetics
Q33851683The characteristics of Bax inhibitor-1 and its related diseases
Q38039415The endoplasmic reticulum in plant immunity and cell death.
Q39407246The human immunodeficiency virus-1 protease inhibitor nelfinavir impairs proteasome activity and inhibits the proliferation of multiple myeloma cells in vitro and in vivo
Q34807567The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells
Q38093057The role of the unfolded protein response in diabetes mellitus
Q54978911The serine/threonine-protein kinase/endoribonuclease IRE1α protects the heart against pressure overload-induced heart failure.
Q37444924The unfolded protein response and its relevance to connective tissue diseases.
Q35595494The unfolded protein response is shaped by the NMD pathway
Q29615499The unfolded protein response: controlling cell fate decisions under ER stress and beyond
Q24293771The unfolded protein response: integrating stress signals through the stress sensor IRE1α
Q47198003Transmembrane BAX Inhibitor Motif-6 (TMBIM6) protects against cisplatin-induced testicular toxicity
Q33701588Triptolide activates unfolded protein response leading to chronic ER stress in pancreatic cancer cells
Q90080201Type I interferons and endoplasmic reticulum stress in health and disease
Q38792083Unfolded protein response in pollen development and heat stress tolerance
Q37488392Unfolded protein response signaling and metabolic diseases
Q41889596Unfolded protein responses with or without unfolded proteins?
Q93032488Viral-mediated gene delivery of TMBIM6 protects the neonatal brain via disruption of NPR-CYP complex coupled with upregulation of Nrf-2 post-HI
Q84569624WITHDRAWN: Activation of p38 MAPK attenuates endoplasmic reticulum stress by up-regulating XBP1s
Q38219971When supply does not meet demand-ER stress and plant programmed cell death
Q34310315X-box binding protein 1 is essential for the anti-oxidant defense and cell survival in the retinal pigment epithelium
Q24655821XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy
Q50090199XBP1 and PERK Have Distinct Roles in Aβ-Induced Pathology.
Q26998690Xenobiotic perturbation of ER stress and the unfolded protein response
Q27938652Yeast Bax inhibitor, Bxi1p, is an ER-localized protein that links the unfolded protein response and programmed cell death in Saccharomyces cerevisiae.

Search more.