| review article | Q7318358 |
| scholarly article | Q13442814 |
| P2093 | author name string | Christopher L Gentile | |
| Michael J Pagliassotti | |||
| Melinda A Frye | |||
| P2860 | cites work | Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1 | Q22011167 |
| Inhibition of nuclear factor-kappaB or Bax prevents endoplasmic reticulum stress- but not nitric oxide-mediated apoptosis in INS-1E cells | Q39833077 | ||
| Preventing oxidative stress: a new role for XBP1. | Q39879215 | ||
| Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death | Q39912377 | ||
| Oxidative stress is independently associated with non-alcoholic fatty liver disease (NAFLD) in subjects with and without type 2 diabetes | Q39929013 | ||
| Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice | Q39975807 | ||
| Transcriptional regulation of Bim by FoxO3A mediates hepatocyte lipoapoptosis | Q40108223 | ||
| Insulin protects liver cells from saturated fatty acid-induced apoptosis via inhibition of c-Jun NH2 terminal kinase activity | Q40146370 | ||
| Saturated fatty acid-mediated endoplasmic reticulum stress and apoptosis are augmented by trans-10, cis-12-conjugated linoleic acid in liver cells | Q40147046 | ||
| Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells | Q40313352 | ||
| CREB-H: a novel mammalian transcription factor belonging to the CREB/ATF family and functioning via the box-B element with a liver-specific expression | Q24291231 | ||
| Roles of CHOP/GADD153 in endoplasmic reticulum stress | Q24302185 | ||
| Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response | Q24304232 | ||
| BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha | Q24310536 | ||
| Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha | Q24322072 | ||
| Endoplasmic reticulum stress: cell life and death decisions. | Q24536108 | ||
| Endoplasmic reticulum stress and the inflammatory basis of metabolic disease | Q24633352 | ||
| The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress | Q24648021 | ||
| Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival | Q24653078 | ||
| Oxidative protein folding in eukaryotes: mechanisms and consequences | Q24676827 | ||
| Fenofibrate and PBA prevent fatty acid-induced loss of adiponectin receptor and pAMPK in human hepatoma cells and in hepatitis C virus-induced steatosis | Q27489896 | ||
| Signal transduction by the JNK group of MAP kinases | Q28142592 | ||
| Nonalcoholic fatty liver disease: an underrecognized cause of cryptogenic cirrhosis | Q28178292 | ||
| The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor alpha in the pathogenesis of non-alcoholic steatohepatitis | Q28345942 | ||
| Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death | Q28363890 | ||
| Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum | Q28506206 | ||
| Regulation of hepatic lipogenesis by the transcription factor XBP1 | Q28507784 | ||
| CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum | Q28509611 | ||
| Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state | Q28572472 | ||
| Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria | Q28573343 | ||
| Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes | Q28575190 | ||
| Opposing roles for ATF6alpha and ATF6beta in endoplasmic reticulum stress response gene induction | Q28854565 | ||
| Increased oxidative stress in obesity and its impact on metabolic syndrome | Q29012150 | ||
| Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes | Q29615503 | ||
| Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane | Q29616354 | ||
| ER stress triggers apoptosis by activating BH3-only protein Bim | Q29617730 | ||
| Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities | Q29617768 | ||
| Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB | Q29619314 | ||
| Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease | Q29619334 | ||
| A central role for JNK in obesity and insulin resistance | Q29619778 | ||
| BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis | Q29620466 | ||
| The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients. | Q33300966 | ||
| Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals | Q33345339 | ||
| Hepatic Bax inhibitor-1 inhibits IRE1alpha and protects from obesity-associated insulin resistance and glucose intolerance | Q33673551 | ||
| Linking endoplasmic reticulum stress to cell death in hepatocytes: roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell death | Q33840334 | ||
| Expression of p53, Bax and Bcl-2 proteins in hepatocytes in non-alcoholic fatty liver disease | Q33869030 | ||
| Bcl-2 and Bcl-X(L) block thapsigargin-induced nitric oxide generation, c-Jun NH(2)-terminal kinase activity, and apoptosis | Q33958973 | ||
| Reduced endoplasmic reticulum luminal calcium links saturated fatty acid-mediated endoplasmic reticulum stress and cell death in liver cells | Q33974369 | ||
| Targeting the JNK MAPK cascade for inhibition: basic science and therapeutic potential. | Q34306096 | ||
| A novel signal transduction pathway from the endoplasmic reticulum to the nucleus is mediated by transcription factor NF-kappa B. | Q34313045 | ||
| Cytoprotective gene bi-1 is required for intrinsic protection from endoplasmic reticulum stress and ischemia-reperfusion injury | Q34479417 | ||
| Role of CHOP in hepatic apoptosis in the murine model of intragastric ethanol feeding | Q34524224 | ||
| Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death | Q34564595 | ||
| Fatty acids regulate CREBh via transcriptional mechanisms that are dependent on proteasome activity and insulin | Q34610542 | ||
| Triglyceride accumulation protects against fatty acid-induced lipotoxicity | Q34866329 | ||
| Nonalcoholic steatohepatitis: Summary of an AASLD Single Topic Conference | Q35115696 | ||
| Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses | Q35169632 | ||
| Transport of proteins across the endoplasmic reticulum membrane | Q35235780 | ||
| The BCL-2 family reunion | Q35568029 | ||
| Hepatic steatosis in obese patients: clinical aspects and prognostic significance. | Q35669794 | ||
| Tumour necrosis factor alpha signalling through activation of Kupffer cells plays an essential role in liver fibrosis of non-alcoholic steatohepatitis in mice | Q35760220 | ||
| Intraluminal calcium as a primary regulator of endoplasmic reticulum function | Q36217035 | ||
| From acute ER stress to physiological roles of the Unfolded Protein Response | Q36362397 | ||
| The unfolded protein response: a stress signaling pathway critical for health and disease. | Q36375860 | ||
| The role of glutathione in disulphide bond formation and endoplasmic-reticulum-generated oxidative stress. | Q36445293 | ||
| Protein folding in the endoplasmic reticulum and the unfolded protein response. | Q36446464 | ||
| The endoplasmic reticulum: folding, calcium homeostasis, signaling, and redox control | Q36598776 | ||
| Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: present and future | Q36895509 | ||
| Initiation and execution of lipotoxic ER stress in pancreatic beta-cells | Q36910693 | ||
| Forgotten but not gone: the rediscovery of fatty heart, the most common unrecognized disease in America | Q36968866 | ||
| Endoplasmic reticulum stress markers are associated with obesity in nondiabetic subjects | Q36971939 | ||
| Antioxidants reduce endoplasmic reticulum stress and improve protein secretion | Q36985084 | ||
| Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword? | Q36989869 | ||
| The endoplasmic reticulum and the unfolded protein response | Q37006310 | ||
| Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance | Q37038490 | ||
| Cytokines in the pathogenesis of fatty liver and disease progression to steatohepatitis: implications for treatment | Q37051418 | ||
| GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice | Q37170811 | ||
| From endoplasmic-reticulum stress to the inflammatory response | Q37225354 | ||
| Hepatocyte nuclear factor 4alpha is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H | Q37280552 | ||
| Insulin resistance, inflammation, and non-alcoholic fatty liver disease | Q37301920 | ||
| Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis | Q37310184 | ||
| Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells | Q37343526 | ||
| c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice | Q37376335 | ||
| NFkappaB prevents apoptosis and liver dysfunction during liver regeneration | Q37378197 | ||
| Apoptosis in insulin-secreting cells. Evidence for the role of intracellular Ca2+ stores and arachidonic acid metabolism | Q37380683 | ||
| The role of the lipogenic pathway in the development of hepatic steatosis. | Q37386081 | ||
| Activation of the Akt-NF-kappaB pathway by subtilase cytotoxin through the ATF6 branch of the unfolded protein response | Q37389501 | ||
| Oxidative folding: cellular strategies for dealing with the resultant equimolar production of reactive oxygen species | Q37401266 | ||
| Bcl-2 family on guard at the ER. | Q37412841 | ||
| Cellular responses to endoplasmic reticulum stress and apoptosis | Q37440836 | ||
| JNK1-dependent PUMA expression contributes to hepatocyte lipoapoptosis | Q37446730 | ||
| Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2 | Q37622629 | ||
| Nonalcoholic fatty liver disease: pathology and pathogenesis | Q37676210 | ||
| Nonalcoholic fatty liver disease: a review and update | Q37681360 | ||
| Bcl-2-mediated alterations in endoplasmic reticulum Ca2+ analyzed with an improved genetically encoded fluorescent sensor | Q37700695 | ||
| Risk of Cardiovascular Disease in Patients with Nonalcoholic Fatty Liver Disease | Q37794163 | ||
| The involvement of calcium in transport of secretory proteins from the endoplasmic reticulum | Q37919245 | ||
| Underglycosylation of ATF6 as a novel sensing mechanism for activation of the unfolded protein response. | Q38346445 | ||
| The liver-enriched transcription factor CREBH is nutritionally regulated and activated by fatty acids and PPARalpha. | Q38348083 | ||
| Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease | Q38358419 | ||
| Decreased survival of subjects with elevated liver function tests during a 28-year follow-up. | Q38447369 | ||
| CHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosis | Q39709114 | ||
| Palmitoleate attenuates palmitate-induced Bim and PUMA up-regulation and hepatocyte lipoapoptosis | Q39731721 | ||
| Nonalcoholic fatty liver disease and risk of future cardiovascular events among type 2 diabetic patients | Q40370241 | ||
| Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitro | Q40386417 | ||
| Bid is upstream of lysosome-mediated caspase 2 activation in tumor necrosis factor alpha-induced hepatocyte apoptosis | Q40398343 | ||
| A pilot trial of pentoxifylline in nonalcoholic steatohepatitis. | Q40464366 | ||
| Endoplasmic reticulum stress stimulates the expression of cyclooxygenase-2 through activation of NF-kappaB and pp38 mitogen-activated protein kinase | Q40524016 | ||
| Ultraviolet light activates NFkappaB through translational inhibition of IkappaBalpha synthesis | Q40548006 | ||
| NF-kappa B inhibition by omega -3 fatty acids modulates LPS-stimulated macrophage TNF-alpha transcription | Q40696197 | ||
| Bcl-X(L) specifically activates Bak to induce swelling and restructuring of the endoplasmic reticulum | Q41889229 | ||
| UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. | Q42041480 | ||
| ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress | Q42518206 | ||
| Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase | Q42563412 | ||
| Serum apoptotic caspase activity in chronic hepatitis C and nonalcoholic Fatty liver disease | Q42992398 | ||
| Nonalcoholic steatohepatitis: An expanded clinical entity | Q43036189 | ||
| Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice | Q43238371 | ||
| Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis | Q43292661 | ||
| Palmitate-induced apoptosis can occur through a ceramide-independent pathway | Q43559742 | ||
| Nutritional and metabolic considerations in the etiology of nonalcoholic steatohepatitis | Q43802817 | ||
| Tumor necrosis factor alpha promoter polymorphisms and insulin resistance in nonalcoholic fatty liver disease | Q43879331 | ||
| Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients | Q44615824 | ||
| Contribution of hepatic de novo lipogenesis and reesterification of plasma non esterified fatty acids to plasma triglyceride synthesis during non-alcoholic fatty liver disease | Q44664390 | ||
| A lipidomic analysis of nonalcoholic fatty liver disease. | Q44931121 | ||
| Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease | Q44934521 | ||
| Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway | Q44967749 | ||
| Fatty acyl CoA-mediated inhibition of endoplasmic reticulum assembly | Q44994598 | ||
| Systemic levels of lipid peroxidation and its metabolic and dietary correlates in patients with nonalcoholic steatohepatitis | Q45016055 | ||
| The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years | Q45787554 | ||
| Liver NF-kappaB and AP-1 DNA binding in obese patients | Q46150605 | ||
| Effects of palmitate on ER and cytosolic Ca2+ homeostasis in beta-cells | Q46164585 | ||
| The lowering of hepatic fatty acid uptake improves liver function and insulin sensitivity without affecting hepatic fat content in humans | Q46573417 | ||
| Endoplasmic reticulum stress increases glucose-6-phosphatase and glucose cycling in liver cells | Q46751890 | ||
| NF-kappaB activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitis | Q46802365 | ||
| CHOP deficiency attenuates cholestasis-induced liver fibrosis by reduction of hepatocyte injury | Q46823993 | ||
| JNK1 but not JNK2 promotes the development of steatohepatitis in mice | Q46865809 | ||
| Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. | Q53555710 | ||
| Hepatocyte Apoptosis, Expression of Death Receptors, and Activation of NF-κB in the Liver of Nonalcoholic and Alcoholic Steatohepatitis Patients | Q57760193 | ||
| Activation of NF-kappa B by ER stress requires both Ca2+ and reactive oxygen intermediates as messengers | Q71440960 | ||
| Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis | Q73735584 | ||
| Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response | Q74359929 | ||
| Gene expression of tumor necrosis factor alpha and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients | Q77318114 | ||
| Toll-like receptor-2 is essential for the development of palmitate-induced insulin resistance in myotubes | Q79785476 | ||
| Influence of TNF gene polymorphisms in Japanese patients with NASH and simple steatosis | Q80064434 | ||
| Beneficial effects of pentoxifylline on hepatic steatosis, fibrosis and necroinflammation in patients with non-alcoholic steatohepatitis | Q80183305 | ||
| Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis | Q81441036 | ||
| ER stress signaling by regulated proteolysis of ATF6 | Q81604029 | ||
| ER stress signaling by regulated splicing: IRE1/HAC1/XBP1 | Q81604032 | ||
| Serum cytokine and soluble cytokine receptor levels in patients with non-alcoholic steatohepatitis | Q82294435 | ||
| Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis | Q82677113 | ||
| Systemic inflammation in nonalcoholic fatty liver disease is characterized by elevated levels of CCL2 | Q83161496 | ||
| P433 | issue | 1 | |
| P921 | main subject | endoplasmic reticulum | Q79927 |
| metabolic dysfunction–associated steatotic liver disease | Q1546498 | ||
| fatty liver disease | Q6058862 | ||
| fatty acid | Q61476 | ||
| P304 | page(s) | 8-16 | |
| P577 | publication date | 2010-12-02 | |
| P1433 | published in | BioFactors | Q15767404 |
| P1476 | title | Fatty acids and the endoplasmic reticulum in nonalcoholic fatty liver disease | |
| P478 | volume | 37 |
| Q35132830 | Alpha linolenic acid in maternal diet halts the lipid disarray due to saturated fatty acids in the liver of mice offspring at weaning |
| Q37601151 | Astaxanthin reduces hepatic endoplasmic reticulum stress and nuclear factor-κB-mediated inflammation in high fructose and high fat diet-fed mice |
| Q53511517 | Astragaloside IV attenuates free fatty acid-induced ER stress and lipid accumulation in hepatocytes via AMPK activation. |
| Q90600279 | Attenuation of High-Fat Diet-Induced Rat Liver Oxidative Stress and Steatosis by Combined Hydroxytyrosol- (HT-) Eicosapentaenoic Acid Supplementation Mainly Relies on HT |
| Q53252736 | Bicyclol attenuates tetracycline-induced fatty liver associated with inhibition of hepatic ER stress and apoptosis in mice. |
| Q49852909 | Changes induced by non-alcoholic fatty liver disease in liver sinusoidal endothelial cells and hepatocytes: spectroscopic imaging of single live cells at the subcellular level. |
| Q45206590 | Decoction vs extracts-mixed solution: effect of yiqihuoxue formula on non-alcoholic fatty liver disease in rats |
| Q54291501 | Dietary fat source alters hepatic gene expression profile and determines the type of liver pathology in rats overfed via total enteral nutrition. |
| Q43961291 | Dietary fatty acids modulate liver mitochondrial cardiolipin content and its fatty acid composition in rats with non alcoholic fatty liver disease. |
| Q35152201 | Different fatty acids inhibit apoB100 secretion by different pathways: unique roles for ER stress, ceramide, and autophagy |
| Q33636667 | Endoplasmic reticulum (ER) stress in cumulus-oocyte complexes impairs pentraxin-3 secretion, mitochondrial membrane potential (DeltaPsi m), and embryo development |
| Q38557011 | Endoplasmic reticulum stress and Oxidative stress in the pathogenesis of Non-alcoholic fatty liver disease |
| Q35614922 | Endoplasmic reticulum stress and lipid metabolism: mechanisms and therapeutic potential |
| Q39031005 | Endoplasmic reticulum stress and the development of endothelial dysfunction |
| Q42846735 | Exendin-4 attenuates endoplasmic reticulum stress through a SIRT1-dependent mechanism |
| Q40216244 | Gastric bypass surgery is protective from high-fat diet-induced non-alcoholic fatty liver disease and hepatic endoplasmic reticulum stress |
| Q51454017 | HNF-4alpha Negatively Regulates Hepcidin Expression Through BMPR1A in HepG2 Cells. |
| Q37082259 | Hepatic oleate regulates liver stress response partially through PGC-1α during high-carbohydrate feeding |
| Q35753386 | Hugan Qingzhi Exerts Anti-Inflammatory Effects in a Rat Model of Nonalcoholic Fatty Liver Disease |
| Q38955646 | Liraglutide reduces lipid accumulation in steatotic L‑02 cells by enhancing autophagy |
| Q33791133 | Liver fat: a relevant target for dietary intervention? Summary of a Unilever workshop |
| Q37014966 | Long-term exposure to abnormal glucose levels alters drug metabolism pathways and insulin sensitivity in primary human hepatocytes |
| Q59791398 | Maternal Protein Restriction Induces Alterations in Hepatic Unfolded Protein Response-Related Molecules in Adult Rat Offspring |
| Q36478196 | Misregulation of PPAR Functioning and Its Pathogenic Consequences Associated with Nonalcoholic Fatty Liver Disease in Human Obesity |
| Q38260582 | Molecular insights into the mechanisms of liver-associated diseases in early-lactating dairy cows: hypothetical role of endoplasmic reticulum stress |
| Q50957769 | Non-Alcoholic Fatty Liver Disease. |
| Q89377158 | Nonalcoholic Fatty Liver Disease: Time to Take the Bull by the Horns |
| Q28291312 | Nuclear factor-erythroid 2-related factor 1 regulates expression of proteasome genes in hepatocytes and protects against endoplasmic reticulum stress and steatosis in mice |
| Q90715049 | Pomegranate prevents binge alcohol-induced gut leakiness and hepatic inflammation by suppressing oxidative and nitrative stress |
| Q51036933 | SIRT1/HSF1/HSP pathway is essential for exenatide-alleviated, lipid-induced hepatic endoplasmic reticulum stress. |
| Q37163044 | Saturated fatty acids activate ERK signaling to downregulate hepatic sortilin 1 in obese and diabetic mice. |
| Q26991757 | Signal transductions and nonalcoholic fatty liver: a mini-review |
| Q90613619 | Targeting Inflammation by Flavonoids: Novel Therapeutic Strategy for Metabolic Disorders |
| Q36298151 | Undernourishment in utero Primes Hepatic Steatosis in Adult Mice Offspring on an Obesogenic Diet; Involvement of Endoplasmic Reticulum Stress |
| Q38793946 | Undernourishment in utero and hepatic steatosis in later life: A potential issue in Japanese people |
| Q37606854 | Up-regulation of endoplasmic reticulum stress induced genes of the unfolded protein response in the liver of periparturient dairy cows |
| Q35022972 | Zidovudine (AZT) and hepatic lipid accumulation: implication of inflammation, oxidative and endoplasmic reticulum stress mediators |
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