Hepatic Bax inhibitor-1 inhibits IRE1alpha and protects from obesity-associated insulin resistance and glucose intolerance

scientific article

Hepatic Bax inhibitor-1 inhibits IRE1alpha and protects from obesity-associated insulin resistance and glucose intolerance is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M109.056648
P932PMC publication ID2825415
P698PubMed publication ID19996103

P50authorBéatrice Bailly-MaitreQ37376962
Ulrike ProtzerQ47157729
André KleinriddersQ55164881
Jens C BrüningQ62569552
P2093author name stringJohn C Reed
Jan Mauer
Sabine D Jordan
Brigitte Hampel
Michael Cuddy
Christina L Kress
Bengt F Belgardt
Beatrice Coornaert
Miriam John von Freyend
Diana Willmes
Manuela Essig
P2860cites workCoupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1Q22011167
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factorQ24292102
BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alphaQ24310536
Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeastQ24314476
Endoplasmic reticulum stress: cell life and death decisions.Q24536108
The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expressionQ24670887
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein responseQ24672592
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase BQ27860731
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNAQ28214814
ObesityQ28275029
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesQ28575190
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein ResponseQ28585314
BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stressQ28592598
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetesQ29615503
Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinaseQ29620235
Evolutionarily conserved cytoprotection provided by Bax Inhibitor-1 homologs from animals, plants, and yeastQ31031519
Molecular characterization of two plant BI-1 homologues which suppress Bax-induced apoptosis in human 293 cellsQ31125464
Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individualsQ33345339
Genetic epidemiology of diabetesQ33831947
Transfer of hepatitis B virus genome by adenovirus vectors into cultured cells and mice: crossing the species barrier.Q33851759
Inhibition of GSK-3 selectively reduces glucose-6-phosphatase and phosphatase and phosphoenolypyruvate carboxykinase gene expressionQ33945272
Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolismQ33965224
Cytoprotective gene bi-1 is required for intrinsic protection from endoplasmic reticulum stress and ischemia-reperfusion injuryQ34479417
The unfolding tale of the unfolded protein responseQ34486042
Bax inhibitor-1 regulates endoplasmic reticulum stress-associated reactive oxygen species and heme oxygenase-1 expressionQ34631694
Impaired Energy Homeostasis in C/EBPα Knockout MiceQ34662358
Transcription factor B cell lineage-specific activator protein regulates the gene for human X-box binding protein 1Q36366273
Selective versus total insulin resistance: a pathogenic paradoxQ37076798
Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight lossQ37105351
Molecular mechanisms and therapeutic targets in steatosis and steatohepatitisQ37299002
Bax inhibitor 1 regulates ER-stress-induced ROS accumulation through the regulation of cytochrome P450 2E1.Q39865292
Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in miceQ39975807
Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetesQ40176269
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.Q42041480
Direct monitoring of in vivo ER stress during the development of insulin resistance with ER stress-activated indicator transgenic mice.Q46857277
P4510describes a project that usesImageQuantQ112270642
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectobesityQ12174
insulin resistanceQ1053470
preproinsulinQ7240673
P1104number of pages10
P304page(s)6198-6207
P577publication date2009-12-07
P1433published inJournal of Biological ChemistryQ867727
P1476titleHepatic Bax inhibitor-1 inhibits IRE1alpha and protects from obesity-associated insulin resistance and glucose intolerance
P478volume285

Reverse relations

cites work (P2860)
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