Role of X-Box Binding Protein-1 in Fructose-Induced Lipogenesis in HepG2 Cells

article published in 2018

Role of X-Box Binding Protein-1 in Fructose-Induced Lipogenesis in HepG2 Cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4103/0366-6999.241799
P932PMC publication ID6166463
P698PubMed publication ID30246717

P2093author name stringJing Zhao
Chao Wang
Xian Yu
Guang-Yao Song
Lu-Ping Ren
Han-Ying Xing
Ya-Jun Zhu
P2860cites workXBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factorQ24292102
Fructose, insulin resistance, and metabolic dyslipidemiaQ24556527
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein responseQ24672592
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNAQ28214814
Intracellular signaling by the unfolded protein responseQ28250477
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysisQ28508851
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesQ28575190
XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networksQ28591575
Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver diseaseQ29619334
Hepatic Bax inhibitor-1 inhibits IRE1alpha and protects from obesity-associated insulin resistance and glucose intoleranceQ33673551
Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genesQ33878155
XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiationQ34345459
Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes?Q34924188
Pharmacological ER stress promotes hepatic lipogenesis and lipid droplet formationQ35747483
Nonalcoholic fatty liver disease: predisposing factors and the role of nutritionQ36734305
Endoplasmic reticulum stress markers are associated with obesity in nondiabetic subjectsQ36971939
Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight lossQ37105351
GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in miceQ37170811
Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver diseaseQ37310283
The role of the lipogenic pathway in the development of hepatic steatosis.Q37386081
The adaptive endoplasmic reticulum stress response to lipotoxicity in progressive human nonalcoholic fatty liver diseaseQ37412003
The role of fructose in the pathogenesis of NAFLD and the metabolic syndromeQ37724585
Endoplasmic reticulum stress: a new actor in the development of hepatic steatosis.Q37750327
Nonalcoholic steatohepatitis: the therapeutic challenge of a global epidemicQ37946188
Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasisQ38073225
A long-lasting dipeptidyl peptidase-4 inhibitor, teneligliptin, as a preventive drug for the development of hepatic steatosis in high-fructose diet-fed ob/ob miceQ38288859
Endoplasmic Reticulum Stress Response in Non-alcoholic Steatohepatitis: The Possible Role of Physical ExerciseQ38403149
Endoplasmic reticulum stress and Oxidative stress in the pathogenesis of Non-alcoholic fatty liver diseaseQ38557011
Genetic and epigenetic mechanisms of NASH.Q38673496
The IRE1alpha-XBP1 pathway of the unfolded protein response is required for adipogenesisQ39843795
Gastric bypass surgery is protective from high-fat diet-induced non-alcoholic fatty liver disease and hepatic endoplasmic reticulum stressQ40216244
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.Q42041480
Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humansQ44602540
The chemical chaperon 4-phenylbutyric acid ameliorates hepatic steatosis through inhibition of de novo lipogenesis in high-fructose-fed ratsQ44638833
Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice.Q45917922
Diet high in fructose promotes liver steatosis and hepatocyte apoptosis in C57BL/6J female mice: Role of disturbed lipid homeostasis and increased oxidative stressQ47841256
Long-term administration of tacrolimus and everolimus prevents high cholesterol-high fructose-induced steatosis in C57BL/6J mice by inhibiting de-novo lipogenesisQ49438485
Schisandra chinensis extract ameliorates nonalcoholic fatty liver via inhibition of endoplasmic reticulum stress.Q52880890
Protective Effect of Gomisin N against Endoplasmic Reticulum Stress-Induced Hepatic Steatosis.Q52885453
Role of human liver lipogenesis and reesterification in triglycerides secretion and in FFA reesterificationQ74254882
P433issue19
P407language of work or nameEnglishQ1860
P304page(s)2310-2319
P577publication date2018-10-05
P1433published inChinese Medical JournalQ5100534
P1476titleRole of X-Box Binding Protein-1 in Fructose-Induced Lipogenesis in HepG2 Cells
P478volume131

Reverse relations

cites work (P2860)
Q90049531Endoplasmic reticulum stress may be involved in insulin resistance and lipid metabolism disorders of the white adipose tissues induced by high-fat diet containing industrial trans-fatty acids
Q99545179β-catenin mediates the effect of GLP-1 receptor agonist on ameliorating hepatic steatosis induced by high fructose diet

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