Pharmacological ER stress promotes hepatic lipogenesis and lipid droplet formation

scientific article published on 6 January 2012

Pharmacological ER stress promotes hepatic lipogenesis and lipid droplet formation is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID3276380
P698PubMed publication ID22347525

P50authorKezhong ZhangQ64604817
P2093author name stringZeng-Quan Yang
Henry H Heng
Roberto Mendez
Jin-Sook Lee
P2860cites workXBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factorQ24292102
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Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
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IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNAQ28214814
Airborne particulate matter selectively activates endoplasmic reticulum stress response in the lung and liver tissuesQ28383992
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocationQ28510062
Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controlsQ29547730
Growth of human hepatoma cells lines with differentiated functions in chemically defined mediumQ29617962
The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteinsQ29620170
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Lipid droplets: proteins floating on a pool of fat.Q34343165
Role of peroxisome proliferator-activated receptor gamma and retinoid X receptor heterodimer in hepatogastroenterological diseasesQ34992771
Orchestrating the unfolded protein response in health and diseaseQ35001604
Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in miceQ35870151
Bortezomib: proteasome inhibition as an effective anticancer therapyQ36366801
Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered miceQ36479005
From endoplasmic-reticulum stress to the inflammatory responseQ37225354
Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD).Q37281827
Diabetes as a disease of endoplasmic reticulum stressQ37797970
PPARgamma2 regulates lipogenesis and lipid accumulation in steatotic hepatocytes.Q38332175
Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in miceQ39975807
Proteasome inhibitor PS-341 induces apoptosis through induction of endoplasmic reticulum stress-reactive oxygen species in head and neck squamous cell carcinoma cells.Q40291997
Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cellsQ40339637
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Increased synthesis of secreted proteins induces expression of glucose-regulated proteins in butyrate-treated Chinese hamster ovary cellsQ41758613
Effect of tunicamycin on epidermal glycoprotein and glycosaminoglycan synthesis in vitroQ41879507
The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosisQ41904044
A novel tumour promoter, thapsigargin, transiently increases cytoplasmic free Ca2+ without generation of inositol phosphates in NG115-401L neuronal cellsQ41989793
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.Q42041480
Induction of liver steatosis and lipid droplet formation in ATF6alpha-knockout mice burdened with pharmacological endoplasmic reticulum stressQ42451739
Regulation of hepatic gluconeogenesis by an ER-bound transcription factor, CREBH.Q43106855
Endoplasmic reticulum stress, hepatocyte CD1d and NKT cell abnormalities in murine fatty livers.Q53543252
An increase in liver PPARγ2 is an initial event to induce fatty liver in response to a diet high in butter: PPARγ2 knockdown improves fatty liver induced by high-saturated fatQ64374832
Inhibition of the sarcoplasmic reticulum Ca2+ transport ATPase by thapsigargin at subnanomolar concentrationsQ67901188
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)102-113
P577publication date2012-01-06
P1433published inAmerican Journal of Translational ResearchQ4744272
P1476titlePharmacological ER stress promotes hepatic lipogenesis and lipid droplet formation
P478volume4

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