Uric acid induces fat accumulation via generation of endoplasmic reticulum stress and SREBP-1c activation in hepatocytes.

scientific article published on 11 August 2014

Uric acid induces fat accumulation via generation of endoplasmic reticulum stress and SREBP-1c activation in hepatocytes. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/LABINVEST.2014.98
P8608Fatcat IDrelease_cjfvl32sjrbhdphroygky3glpm
P698PubMed publication ID25111690
P5875ResearchGate publication ID264627741

P2093author name stringRichard J Johnson
Byung-Hoon Lee
Inho Jo
Eok-Soo Oh
Duk-Hee Kang
Hyun-Soo Shin
Hack Sun Choi
Joo-Won Park
Kang-Yo Lee
Yea-Jin Choi
P2860cites workCarbohydrate response element binding protein directly promotes lipogenic enzyme gene transcriptionQ24561983
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein responseQ24672592
Effects of nutrients and hormones on transcriptional and post-transcriptional regulation of acetyl-CoA carboxylase in rat liverQ28334215
Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathwaysQ28365886
Cross talk between mitochondria and NADPH oxidasesQ28391403
Changes in hepatic gene expression upon oral administration of taurine-conjugated ursodeoxycholic acid in ob/ob miceQ28476015
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant miceQ28591122
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetesQ29615503
Nonalcoholic fatty liver diseaseQ29619354
Elevated serum uric acid levels are associated with non-alcoholic fatty liver disease independently of metabolic syndrome features in the United States: Liver ultrasound data from the National Health and Nutrition Examination SurveyQ30572017
Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent modelQ34021867
Uric acid stimulates fructokinase and accelerates fructose metabolism in the development of fatty liverQ34462446
New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1cQ34682304
Pharmacological ER stress promotes hepatic lipogenesis and lipid droplet formationQ35747483
Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): two key regulators of glucose metabolism and lipid synthesis in liverQ36055803
Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress: potential role in fructose-dependent and -independent fatty liver.Q36418940
Ablation of ceramide synthase 2 causes chronic oxidative stress due to disruption of the mitochondrial respiratory chainQ36620822
Role of oxidative stress in the renal abnormalities induced by experimental hyperuricemia.Q36956768
Recent advances in nonalcholic fatty liver diseaseQ37137361
Endoplasmic reticulum stress in nonalcoholic fatty liver diseaseQ38027194
Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in miceQ39975807
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.Q42041480
Endoplasmic reticulum stress is involved in hepatic SREBP-1c activation and lipid accumulation in fructose-fed miceQ42717472
Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stressQ42829265
Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expressionQ44777483
Serum uric acid levels predict incident nonalcoholic fatty liver disease in healthy Korean men.Q51152441
Ablation of very long acyl chain sphingolipids causes hepatic insulin resistance in mice due to altered detergent-resistant membranes.Q53364131
Dietary regulation of stearoyl-CoA desaturase 1 gene expression in mouse liverQ67882024
Effects of nutrients and insulin on transcriptional and post-transcriptional regulation of glucose-6-phosphate dehydrogenase synthesis in rat liverQ69548644
Hypouricemic therapy: A novel potential therapeutic option for nonalcoholic fatty liver diseaseQ84776586
P433issue10
P921main subjectendoplasmic reticulumQ79927
P304page(s)1114-1125
P577publication date2014-08-11
P1433published inLaboratory InvestigationQ6467260
P1476titleUric acid induces fat accumulation via generation of endoplasmic reticulum stress and SREBP-1c activation in hepatocytes.
P478volume94

Reverse relations

cites work (P2860)
Q90692853A Sweet Connection? Fructose's Role in Hepatocellular Carcinoma
Q90721836Allopurinol Prevents the Lipogenic Response Induced by an Acute Oral Fructose Challenge in Short-Term Fructose Fed Rats
Q64276743Allopurinol potentiates the hepatoprotective effect of metformin and vitamin E in fructose-induced fatty liver in rats
Q90116646Association between serum uric acid and nonalcoholic fatty liver disease in community patients with type 2 diabetes mellitus
Q33693601Association between the hyperuricemia and nonalcoholic fatty liver disease risk in a Chinese population: A retrospective cohort study.
Q92712321Association of serum uric acid with visceral, subcutaneous and hepatic fat quantified by magnetic resonance imaging
Q50133288Associations of hyperuricemia and obesity with remission of nonalcoholic fatty liver disease among Chinese men: A retrospective cohort study.
Q59449558Cellular Stresses and Stress Responses in the Pathogenesis of Insulin Resistance
Q90464565Changing trajectories of serum uric acid and risk of non-alcoholic fatty liver disease: a prospective cohort study
Q40087252Clinical implication of serum uric acid level in pegylated interferon and ribavirin combination therapy for chronic hepatitis C infection
Q41693755Coevolution of URAT1 and Uricase during Primate Evolution: Implications for Serum Urate Homeostasis and Gout
Q91839857Converging Relationships of Obesity and Hyperuricemia with Special Reference to Metabolic Disorders and Plausible Therapeutic Implications
Q38359204Cytotoxin-induced NADPH oxides activation: roles in regulation of cell death
Q90523544Detection of Early Disease Risk Factors Associated with Metabolic Syndrome: A New Era with the NMR Metabolomics Assessment
Q94463825Determining the role for uric acid in non-alcoholic steatohepatitis development and the utility of urate metabolites in diagnosis: An opinion review
Q57212049Earliest evidence of caries lesion in hominids reveal sugar-rich diet for a Middle Miocene dryopithecine from Europe
Q47449487Endoplasmic reticulum stress inhibits expression of genes involved in thyroid hormone synthesis and their key transcriptional regulators in FRTL-5 thyrocytes.
Q30234756Fructose Intake, Serum Uric Acid, and Cardiometabolic Disorders: A Critical Review.
Q50147806Fructose and sugar: A major mediator of non-alcoholic fatty liver disease.
Q41770716Fructose: A Dietary Sugar in Crosstalk with Microbiota Contributing to the Development and Progression of Non-Alcoholic Liver Disease
Q42134741Heat Killed Lactobacillus reuteri GMNL-263 Reduces Fibrosis Effects on the Liver and Heart in High Fat Diet-Hamsters via TGF-β Suppression
Q38670507Hyperuricemia and nonalcoholic fatty liver disease: from bedside to bench and back
Q47937635Hyperuricemia is Associated with Increased Apo AI Fractional Catabolic Rates and Dysfunctional HDL in New Zealand Rabbits.
Q52678679Hyperuricemia, Acute and Chronic Kidney Disease, Hypertension, and Cardiovascular Disease: Report of a Scientific Workshop Organized by the National Kidney Foundation
Q58799660Increased Serum Uric Acid over five years is a Risk Factor for Developing Fatty Liver
Q36591048Intrahepatic Fat Content and Markers of Hepatic Fibrosis in Obese Children
Q58546160Joint associations of serum uric acid and ALT with NAFLD in elderly men and women: a Chinese cross-sectional study
Q51294048Lowering Uric Acid With Allopurinol Improves Insulin Resistance and Systemic Inflammation in Asymptomatic Hyperuricemia.
Q64229141Macronutrients and the Adipose-Liver Axis in Obesity and Fatty Liver
Q36404177Monosodium Urate Crystal-Induced Chondrocyte Death via Autophagic Process
Q39333577Non-alcoholic fatty liver disease-a chronic disease of the 21(st) century
Q36372585Perspective: A Historical and Scientific Perspective of Sugar and Its Relation with Obesity and Diabetes
Q47103070Physical exercises and weight loss in obese patients help to improve uric acid
Q40117885Physiological functions and pathogenic potential of uric acid: A review.
Q57066893Role of SREBPs in Liver Diseases: A Mini-review
Q26748461Role of Serum Uric Acid and Ferritin in the Development and Progression of NAFLD
Q28354735Role of Uric Acid Metabolism-Related Inflammation in the Pathogenesis of Metabolic Syndrome Components Such as Atherosclerosis and Nonalcoholic Steatohepatitis
Q57493394Roles of hyperuricemia in metabolic syndrome and cardiac-kidney-vascular system diseases
Q42577349Serum uric acid and non-alcoholic fatty liver disease in non-obesity Chinese adults
Q38595252Serum uric acid: a new therapeutic target for nonalcoholic fatty liver disease
Q37038253Sex-Specific Association between Serum Uric Acid and Nonalcoholic Fatty Liver Disease in Type 2 Diabetic Patients
Q46465311Tauroursodeoxycholic acid inhibits intestinal inflammation and barrier disruption in NAFLD mice.
Q42730512The Contribution of Singlet Oxygen to Insulin Resistance.
Q41111925The association between the serum levels of uric acid and alanine aminotransferase in a population-based cohort
Q93140666Urate transport capacity of glucose transporter 9 and urate transporter 1 in cartilage chondrocytes
Q33358818Uric Acid Puzzle: Dual Role as Anti-oxidantand Pro-oxidant
Q38982043Uric acid enhances PKC-dependent eNOS phosphorylation and mediates cellular ER stress: A mechanism for uric acid-induced endothelial dysfunction
Q26772053Uric acid in metabolic syndrome: From an innocent bystander to a central player
Q34682703Uric acid in the pathogenesis of metabolic, renal, and cardiovascular diseases: A review
Q89763311Uric acid induced hepatocytes lipid accumulation through regulation of miR-149-5p/FGF21 axis
Q53837718n-3 Polyunsaturated fatty acids protect against pancreatic β-cell damage due to ER stress and prevent diabetes development.

Search more.