Lipid biology of breast cancer

scientific article

Lipid biology of breast cancer is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BBALIP.2013.03.011
P8608Fatcat IDrelease_iicdwu442vhwjbgvo3hdcg54xi
P932PMC publication ID3926128
P698PubMed publication ID23562840

P2093author name stringJan Baumann
Christopher Sevinsky
Douglas S. Conklin
P2860cites workHypoxia stimulates migration of breast cancer cells via the PERK/ATF4/LAMP3-arm of the unfolded protein responseQ22000747
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complexQ24295120
BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylaseQ24297921
Regulation of cellular metabolism by protein lysine acetylationQ24300091
mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptideQ24305343
SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growthQ24309283
Mechanism of activation of protein kinase B by insulin and IGF-1Q24309528
Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocationQ24322925
Fatty acid synthesis: a potential selective target for antineoplastic therapyQ24561903
Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cellsQ24561962
Understanding the Warburg effect: the metabolic requirements of cell proliferationQ24604760
Comprehensive molecular portraits of human breast tumoursQ24630844
mTOR: from growth signal integration to cancer, diabetes and ageingQ24633662
mTOR signaling in growth control and diseaseQ24634174
MAM: more than just a housekeeperQ24648220
Overexpression of fatty acid synthase gene activates HER1/HER2 tyrosine kinase receptors in human breast epithelial cellsQ40022130
Acetyl-CoA carboxylase alpha is essential to breast cancer cell survivalQ40278693
Distinctive actions of membrane-targeted versus nuclear localized estrogen receptors in breast cancer cellsQ40435070
Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance.Q40480010
The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutationQ40561467
The eIF-2alpha kinases and the control of protein synthesisQ41198124
Nutrition, hormones, and breast cancer: is insulin the missing link?Q41227904
mTORC1 inhibition via rapamycin promotes triacylglycerol lipolysis and release of free fatty acids in 3T3-L1 adipocytes.Q41441726
IRS-1: essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cellsQ41527015
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.Q42041480
BRCA1 interacts with acetyl-CoA carboxylase through its tandem of BRCT domainsQ42809714
Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis.Q42832143
Peroxisome proliferator-activated receptor-gamma protects ERBB2-positive breast cancer cells from palmitate toxicity.Q43120090
Differential trafficking of Src, Lyn, Yes and Fyn is specified by the state of palmitoylation in the SH4 domainQ44075031
Regulation of fatty acid synthase expression in breast cancer by sterol regulatory element binding protein-1cQ44280816
Fatty acid synthetase and its mRNA are induced by progestins in breast cancer cellsQ44307619
Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberinQ44516189
A gene transcription signature of obesity in breast cancer.Q45404516
Pharmacological blockade of fatty acid synthase (FASN) reverses acquired autoresistance to trastuzumab (Herceptin by transcriptionally inhibiting 'HER2 super-expression' occurring in high-dose trastuzumab-conditioned SKBR3/Tzb100 breast cancer cellsQ50889342
Serum hormone levels in relation to reproductive and lifestyle factors in postmenopausal women (United States).Q50890538
Regulation of SREBP1c gene expression in skeletal muscle: role of retinoid X receptor/liver X receptor and forkhead-O1 transcription factor.Q51455793
BRCA1 and acetyl-CoA carboxylase: the metabolic syndrome of breast cancer.Q53542028
Metabolic syndrome and the risk of breast cancer in postmenopausal womenQ57559288
The effect of dietary fat and fiber on serum estrogen concentrations in premenopausal women under controlled dietary conditionsQ72078895
New amplified and highly expressed genes discovered in the ERBB2 amplicon in breast cancer by cDNA microarraysQ77220709
Obesity and cancerQ80476148
Endoplasmic reticulum stress causes the activation of sterol regulatory element binding protein-2Q80553475
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein responseQ24672592
The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferationQ24678674
High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphateQ27639493
Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTORQ27647018
The phosphoinositide 3-kinase pathwayQ27860738
Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. AdultsQ28131763
Fyn is induced by Ras/PI3K/Akt signaling and is required for enhanced invasion/migrationQ28235184
Asymmetrical Lipid Bilayer Structure for Biological MembranesQ28242238
Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptorQ28250779
Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1Q28276509
SREBP-1c transcription factor and lipid homeostasis: clinical perspectiveQ28291930
Specific interaction between S6K1 and CoA synthase: a potential link between the mTOR/S6K pathway, CoA biosynthesis and energy metabolismQ28297621
SIRT2 suppresses adipocyte differentiation by deacetylating FOXO1 and enhancing FOXO1's repressive interaction with PPARgammaQ28301961
PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiationQ28507769
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulumQ28509611
Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathwayQ28510620
ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein responseQ28611502
Acyl-coenzyme A synthetases in metabolic controlQ28647005
Metabolic regulation of invadopodia and invasion by acetyl-CoA carboxylase 1 and de novo lipogenesisQ28740280
ATP-citrate lyase links cellular metabolism to histone acetylationQ29615367
THE METABOLISM OF TUMORS IN THE BODYQ29616202
mTOR complex 1 regulates lipin 1 localization to control the SREBP pathwayQ30425628
Biodiversity of sphingoid bases ("sphingosines") and related amino alcoholsQ30843994
Plasmalogens in biological systems: their role in oxidative processes in biological membranes, their contribution to pathological processes and aging and plasmalogen analysisQ33466440
Eukaryotic initiation factor eIF2.Q33601625
An RNA interference screen identifies metabolic regulators NR1D1 and PBP as novel survival factors for breast cancer cells with the ERBB2 signatureQ33722873
Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesisQ33734679
Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storageQ33750671
PPARgamma: an essential regulator of adipogenesis and modulator of fat cell functionQ33770818
DHHC20: a human palmitoyl acyltransferase that causes cellular transformationQ33946275
Heat shock protein 27 is required for sex steroid receptor trafficking to and functioning at the plasma membraneQ33963946
Endoplasmic reticulum: ER stress regulates mitochondrial bioenergeticsQ33986242
The palmitoylation machinery is a spatially organizing system for peripheral membrane proteinsQ34111893
Effect of obesity on breast cancer developmentQ37685762
Phosphoinositide signalling pathways in metabolic regulationQ37762204
Effect of obesity on survival of women with breast cancer: systematic review and meta-analysisQ37767169
Inhibition of SRC family kinases and receptor tyrosine kinases by dasatinib: possible combinations in solid tumors.Q37888979
Obesity-induced metabolic stresses in breast and colon cancerQ37906710
Protein palmitoylation and subcellular traffickingQ37912382
Obesity as a risk factor for triple-negative breast cancers: a systematic review and meta-analysisQ38062392
N-terminally myristoylated Ras proteins require palmitoylation or a polybasic domain for plasma membrane localizationQ38306703
ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growthQ39470144
The IRE1alpha-XBP1 pathway of the unfolded protein response is required for adipogenesisQ39843795
Insulin-like growth factor-I activates gene transcription programs strongly associated with poor breast cancer prognosisQ39945691
A novel Epac-Rap-PP2A signaling module controls cAMP-dependent Akt regulationQ39972783
Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in miceQ39975807
Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosisQ40002274
ERα17p, a peptide reproducing the hinge region of the estrogen receptor α associates to biological membranes: A biophysical approachQ34199023
The SREBP pathway--insights from Insigs and insectsQ34223258
PORCN moonlights in a Wnt-independent pathway that regulates cancer cell proliferationQ34235264
CD36: a multiligand moleculeQ34406219
Coenzyme A: back in actionQ34418810
Fatty acid synthase phosphorylation: a novel therapeutic target in HER2-overexpressing breast cancer cellsQ34613543
Up-regulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells.Q34650973
A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expressionQ34656781
Phospholipase D1 is an effector of Rheb in the mTOR pathway.Q34786317
Thematic Review Series: Glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolismQ34827108
Triglyceride accumulation protects against fatty acid-induced lipotoxicityQ34866329
Identification of the YES1 Kinase as a Therapeutic Target in Basal-Like Breast CancersQ34972623
CoA synthase is in complex with p85alphaPI3K and affects PI3K signaling pathway.Q34983963
Role of Akt/protein kinase B in metabolism.Q34997136
Lipotoxicity: when tissues overeatQ35168828
Fatty acid synthase as a potential therapeutic target in cancerQ35401716
Pharmacological ER stress promotes hepatic lipogenesis and lipid droplet formationQ35747483
KAT(ching) metabolism by the tail: insight into the links between lysine acetyltransferases and metabolismQ35892832
Breast density, body mass index, and risk of tumor marker-defined subtypes of breast cancerQ35918620
Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2.Q35965439
Endoplasmic reticulum stress in liver diseaseQ36031838
Triple layer control: phosphorylation, acetylation and ubiquitination of FOXO proteins.Q36140005
XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum.Q36322684
"Translating" tumor hypoxia: unfolded protein response (UPR)-dependent and UPR-independent pathwaysQ36540080
Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycinQ37110578
GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in miceQ37170811
Hypoxia signalling through mTOR and the unfolded protein response in cancerQ37290935
Phosphatidic acid signaling to mTOR: signals for the survival of human cancer cellsQ37380645
mTOR and the control of whole body metabolismQ37406462
Activation and clinical significance of the unfolded protein response in breast cancerQ37424111
Fine-tuning the lipogenic/lipolytic balance to optimize the metabolic requirements of cancer cell growth: molecular mechanisms and therapeutic perspectives.Q37603645
Targeting the endoplasmic reticulum-stress response as an anticancer strategyQ37616303
An emerging role of mTOR in lipid biosynthesis.Q37641438
Expression of the CD36 homolog (FAT) in fibroblast cells: effects on fatty acid transportQ37670096
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectbreast cancerQ128581
P304page(s)1509-17
P577publication date2013-10-01
P1433published inBiochimica et Biophysica ActaQ864239
P1476titleLipid biology of breast cancer
P478volume1831

Reverse relations

cites work (P2860)
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