| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1020955887 |
| P356 | DOI | 10.1186/BCR2777 |
| P932 | PMC publication ID | 3046439 |
| P698 | PubMed publication ID | 21080941 |
| P5875 | ResearchGate publication ID | 47808589 |
| P50 | author | Mien-Chie Hung | Q1532952 |
| Gabriel N Hortobagyi | Q88225186 | ||
| Quanri Jin | Q125291430 | ||
| P2093 | author name string | Francisco J Esteva | |
| David H Hawke | |||
| Daniel Gomez-Cabello | |||
| Delphine Boulbes | |||
| Jong Min Baek | |||
| Linda X Yuan | |||
| Mong Hong Lee | |||
| Sai Ching Yeung | |||
| Ying Nai Wang | |||
| P2860 | cites work | Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin | Q24305421 |
| Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3 | Q24309266 | ||
| Fatty acid synthesis: a potential selective target for antineoplastic therapy | Q24561903 | ||
| Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells | Q24561962 | ||
| Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells | Q27824846 | ||
| Lapatinib plus capecitabine for HER2-positive advanced breast cancer | Q27851403 | ||
| Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene | Q27860693 | ||
| C75, a Fatty Acid Synthase Inhibitor, Modulates AMP-activated Protein Kinase to Alter Neuronal Energy Metabolism | Q28184212 | ||
| Phase I safety, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas | Q28256478 | ||
| Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene | Q28286890 | ||
| HER2 oncogenic function escapes EGFR tyrosine kinase inhibitors via activation of alternative HER receptors in breast cancer cells | Q28473274 | ||
| Heregulin induces tyrosine phosphorylation of HER4/p180erbB4 | Q28589513 | ||
| p63 promotes cell survival through fatty acid synthase | Q33466069 | ||
| Up-regulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells. | Q34650973 | ||
| Synthesis and antitumor activity of an inhibitor of fatty acid synthase | Q35112277 | ||
| Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells | Q35973421 | ||
| Targeting fatty acid synthase: potential for therapeutic intervention in her-2/neu-overexpressing breast cancer | Q36296179 | ||
| Survivin expression in normal human bronchial epithelial cells: an early and critical step in tumorigenesis induced by tobacco exposure | Q36838013 | ||
| Cross-talk between the ErbB/HER family and the type I insulin-like growth factor receptor signaling pathway in breast cancer | Q37335142 | ||
| Fine-tuning the lipogenic/lipolytic balance to optimize the metabolic requirements of cancer cell growth: molecular mechanisms and therapeutic perspectives. | Q37603645 | ||
| Molecular predictors of response to trastuzumab and lapatinib in breast cancer. | Q37660907 | ||
| Lapatinib, a dual HER1/HER2 tyrosine kinase inhibitor, augments basal cleavage of HER2 extracellular domain (ECD) to inhibit HER2-driven cancer cell growth | Q39675983 | ||
| Interaction between fatty acid synthase- and ErbB-systems in ovarian cancer cells | Q39847467 | ||
| Lapatinib, a HER2 tyrosine kinase inhibitor, induces stabilization and accumulation of HER2 and potentiates trastuzumab-dependent cell cytotoxicity | Q39908130 | ||
| Activation of AMPK is necessary for killing cancer cells and sparing cardiac cells | Q39966294 | ||
| Overexpression of fatty acid synthase gene activates HER1/HER2 tyrosine kinase receptors in human breast epithelial cells | Q40022130 | ||
| Implication of AMP-activated protein kinase and Akt-regulated survivin in lung cancer chemopreventive activities of deguelin | Q40033668 | ||
| Lapatinib induces apoptosis in trastuzumab-resistant breast cancer cells: effects on insulin-like growth factor I signaling. | Q40169783 | ||
| Antimetastatic activity of insulin-like growth factor binding protein-3 in lung cancer is mediated by insulin-like growth factor-independent urokinase-type plasminogen activator inhibition | Q40205282 | ||
| ErbB3-dependent motility and intravasation in breast cancer metastasis | Q40322067 | ||
| Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells | Q40344963 | ||
| Novel signaling molecules implicated in tumor-associated fatty acid synthase-dependent breast cancer cell proliferation and survival: Role of exogenous dietary fatty acids, p53-p21WAF1/CIP1, ERK1/2 MAPK, p27KIP1, BRCA1, and NF-kappaB. | Q40591494 | ||
| Activity of the phosphatidylcholine biosynthetic pathway modulates the distribution of fatty acids into glycerolipids in proliferating cells. | Q40901145 | ||
| Tyrosine phosphorylation of Shc proteins and formation of Shc/Grb2 complex correlate to the transformation of NIH3T3 cells mediated by the point-mutation activated neu. | Q41334947 | ||
| Nicotine-induced activation of AMP-activated protein kinase inhibits fatty acid synthase in 3T3L1 adipocytes: a role for oxidant stress | Q42826476 | ||
| Peroxisome proliferator-activated receptor-gamma protects ERBB2-positive breast cancer cells from palmitate toxicity. | Q43120090 | ||
| Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer | Q43270036 | ||
| Blockage of heregulin expression inhibits tumorigenicity and metastasis of breast cancer | Q43652262 | ||
| Multiple signaling pathways involved in activation of matrix metalloproteinase-9 (MMP-9) by heregulin-beta1 in human breast cancer cells | Q43848237 | ||
| Phase II study of weekly docetaxel and trastuzumab for patients with HER-2-overexpressing metastatic breast cancer | Q43937165 | ||
| Transcriptome analysis of HER2 reveals a molecular connection to fatty acid synthesis. | Q44272057 | ||
| Targeting fatty acid synthase-driven lipid rafts: a novel strategy to overcome trastuzumab resistance in breast cancer cells. | Q46393969 | ||
| Fatty acid metabolism in breast cancer cells: differential inhibitory effects of epigallocatechin gallate (EGCG) and C75. | Q46976847 | ||
| Phosphatidylinositol 3-kinase activity in epidermal growth factor-stimulated matrix metalloproteinase-9 production and cell surface association. | Q52542678 | ||
| Novel Inhibitors of Fatty Acid Synthase with Anticancer Activity | Q60696486 | ||
| Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cells | Q71148397 | ||
| P433 | issue | 6 | |
| P921 | main subject | fatty acid | Q61476 |
| phosphorylation | Q242736 | ||
| overexpression | Q61643320 | ||
| P304 | page(s) | R96 | |
| P577 | publication date | 2010-11-16 | |
| P1433 | published in | Breast Cancer Research | Q2208481 |
| P1476 | title | Fatty acid synthase phosphorylation: a novel therapeutic target in HER2-overexpressing breast cancer cells | |
| P478 | volume | 12 |
| Q64055450 | A cell-based high-throughput screen identifies tyrphostin AG 879 as an inhibitor of animal cell phospholipid and fatty acid biosynthesis |
| Q36085663 | A concordant expression pattern of fatty acid synthase and membranous human epidermal growth factor receptor 2 exists in gastric cancer and is associated with a poor prognosis in gastric adenocarcinoma patients |
| Q34010823 | A new class of protein cancer biomarker candidates: differentially expressed splice variants of ERBB2 (HER2/neu) and ERBB1 (EGFR) in breast cancer cell lines |
| Q49790910 | An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation |
| Q38836725 | Berberine Regulated Lipid Metabolism in the Presence of C75, Compound C, and TOFA in Breast Cancer Cell Line MCF-7. |
| Q28730808 | Blockade of fatty acid synthase triggers significant apoptosis in mantle cell lymphoma |
| Q91877701 | CD36-Mediated Metabolic Rewiring of Breast Cancer Cells Promotes Resistance to HER2-Targeted Therapies |
| Q90222661 | CD36: a key mediator of resistance to HER2 inhibitors in breast cancer |
| Q35029489 | Circulating fatty acid synthase: an exploratory biomarker to predict efficacy of the dual HER1/HER2 tyrosine kinase inhibitor lapatinib |
| Q37482878 | Crystal structure of FabZ-ACP complex reveals a dynamic seesaw-like catalytic mechanism of dehydratase in fatty acid biosynthesis |
| Q28541249 | De novo fatty acid biosynthesis contributes significantly to establishment of a bioenergetically favorable environment for vaccinia virus infection |
| Q47836759 | Deciphering metabolic rewiring in breast cancer subtypes |
| Q36405405 | Different fatty acid metabolism effects of (-)-epigallocatechin-3-gallate and C75 in adenocarcinoma lung cancer. |
| Q35159467 | Differential expression of lipid metabolism-related proteins in different breast cancer subtypes. |
| Q31047698 | Discovering gene re-ranking efficiency and conserved gene-gene relationships derived from gene co-expression network analysis on breast cancer data. |
| Q37619141 | Distinct splice variants and pathway enrichment in the cell-line models of aggressive human breast cancer subtypes |
| Q41846641 | Docosahexaenoic Acid Modulates a HER2-Associated Lipogenic Phenotype, Induces Apoptosis, and Increases Trastuzumab Action in HER2-Overexpressing Breast Carcinoma Cells |
| Q35763076 | Expression of Lipid Metabolism-Related Proteins in Metastatic Breast Cancer |
| Q37081998 | Expression of quiescin sulfhydryl oxidase 1 is associated with a highly invasive phenotype and correlates with a poor prognosis in Luminal B breast cancer |
| Q38835370 | Fatty acid metabolism in breast cancer subtypes |
| Q35784513 | Fatty acid synthase and liver triglyceride metabolism: housekeeper or messenger? |
| Q38949147 | Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells. |
| Q38073079 | Fatty acid synthase is a potential therapeutic target in estrogen receptor-/progesterone receptor-positive endometrioid endometrial cancer |
| Q36751137 | HER family kinase domain mutations promote tumor progression and can predict response to treatment in human breast cancer |
| Q50134174 | Homocysteine regulates fatty acid and lipid metabolism in yeast. |
| Q34028551 | Involvement of de novo synthesized palmitate and mitochondrial EGFR in EGF induced mitochondrial fusion of cancer cells |
| Q27013858 | Lipid biology of breast cancer |
| Q90749099 | Lipid metabolic reprogramming as an emerging mechanism of resistance to kinase inhibitors in breast cancer |
| Q38969211 | Metabolic Regulation of Apoptosis in Cancer. |
| Q39298900 | Metabolic shifts induced by fatty acid synthase inhibitor orlistat in non-small cell lung carcinoma cells provide novel pharmacodynamic biomarkers for positron emission tomography and magnetic resonance spectroscopy |
| Q35000624 | Modulation of tumor fatty acids, through overexpression or loss of thyroid hormone responsive protein spot 14 is associated with altered growth and metastasis |
| Q26770270 | O-GlcNAcylation and the Metabolic Shift in High-Proliferating Cells: All the Evidence Suggests that Sugars Dictate the Flux of Lipid Biogenesis in Tumor Processes |
| Q39609137 | PPARs: Interference with Warburg' Effect and Clinical Anticancer Trials. |
| Q36087653 | Palmitate-induced ER stress increases trastuzumab sensitivity in HER2/neu-positive breast cancer cells |
| Q33915087 | Palmitoylation: a protein S-acylation with implications for breast cancer |
| Q38415402 | Phosphoproteomics of the goat milk fat globule membrane: New insights into lipid droplet secretion from the mammary epithelial cell |
| Q34749776 | Profiling of serum metabolites in canine lymphoma using gas chromatography mass spectrometry |
| Q28393883 | Role of TGF-β signaling in generation of CD39+CD73+ myeloid cells in tumors |
| Q57713471 | Stearidonic acid-enriched flax oil reduces the growth of human breast cancer in vitro and in vivo |
| Q33653609 | Thyroid hormone responsive protein Spot14 enhances catalysis of fatty acid synthase in lactating mammary epithelium |
| Q42421222 | [6]-Gingerol inhibits de novo fatty acid synthesis and carnitine palmitoyltransferase-1 activity which triggers apoptosis in HepG2. |
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