Endoplasmic Reticulum Stress Protein GRP78 Modulates Lipid Metabolism to Control Drug Sensitivity and Antitumor Immunity in Breast Cancer

scientific article published on October 2016

Endoplasmic Reticulum Stress Protein GRP78 Modulates Lipid Metabolism to Control Drug Sensitivity and Antitumor Immunity in Breast Cancer is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1158/0008-5472.CAN-15-2616
P932PMC publication ID5117832
P698PubMed publication ID27698188

P50authorDavid D RobertsQ42408238
Katherine CookQ42681142
Leena Hilakivi-ClarkeQ119139100
P2093author name stringDavid R Soto-Pantoja
Robert Clarke
M Idalia Cruz
Anni Wärri
Alan Zwart
Pamela A G Clarke
P2860cites workThe CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumorsQ24631515
Lipid biology of breast cancerQ27013858
Cancer statistics, 2014Q27861018
GRP78/BiP/HSPA5/Dna K is a universal therapeutic target for human diseaseQ28254667
Antiestrogens, aromatase inhibitors, and apoptosis in breast cancerQ28268250
PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiationQ28507769
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Cancer cells resistant to therapy promote cell surface relocalization of GRP78 which complexes with PI3K and enhances PI(3,4,5)P3 productionQ28534981
Mitochondrial carnitine palmitoyltransferase 1a (CPT1a) is part of an outer membrane fatty acid transfer complexQ28567616
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liverQ29547646
AMPK: a nutrient and energy sensor that maintains energy homeostasisQ29615410
Tumor cell metabolism: cancer's Achilles' heelQ29619809
Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistanceQ33556664
Hydroxychloroquine inhibits autophagy to potentiate antiestrogen responsiveness in ER+ breast cancer.Q33813981
Knockdown of estrogen receptor-α induces autophagy and inhibits antiestrogen-mediated unfolded protein response activation, promoting ROS-induced breast cancer cell deathQ34072615
Monoclonal antibody against cell surface GRP78 as a novel agent in suppressing PI3K/AKT signaling, tumor growth, and metastasis.Q34118737
Regulation of food intake by oleoylethanolamideQ34403399
CD47 in the tumor microenvironment limits cooperation between antitumor T-cell immunity and radiotherapyQ34621578
NF-κB signaling is required for XBP1 (unspliced and spliced)-mediated effects on antiestrogen responsiveness and cell fate decisions in breast cancerQ34745409
Bortezomib enhances the efficacy of fulvestrant by amplifying the aggregation of the estrogen receptor, which leads to a proapoptotic unfolded protein responseQ35596882
Estrogen receptor-α signaling and localization regulates autophagy and unfolded protein response activation in ER+ breast cancerQ35634154
Endoplasmic reticulum stress, the unfolded protein response, autophagy, and the integrated regulation of breast cancer cell fate.Q35855031
Heat shock 70 kDa protein 5/glucose-regulated protein 78 "AMP"ing up autophagyQ36521680
Glucose-regulated protein 78 controls cross-talk between apoptosis and autophagy to determine antiestrogen responsivenessQ36622926
Endoplasmic reticulum stress, the unfolded protein response, and gene network modeling in antiestrogen resistant breast cancerQ37072811
Cancer metabolism: fatty acid oxidation in the limelightQ37155867
GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in miceQ37170811
Monounsaturated fatty acids generated via stearoyl CoA desaturase-1 are endogenous inhibitors of fatty acid amide hydrolaseQ37340913
Cholesterol metabolism and resistance to tamoxifen.Q38051937
Targeting GRP78 and antiestrogen resistance in breast cancerQ38111800
The IRE1alpha-XBP1 pathway of the unfolded protein response is required for adipogenesisQ39843795
GRP78/BiP inhibits endoplasmic reticulum BIK and protects human breast cancer cells against estrogen starvation-induced apoptosisQ40144533
Acquisition of hormone-independent growth in MCF-7 cells is accompanied by increased expression of estrogen-regulated genes but without detectable DNA amplifications.Q41578634
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.Q42041480
MCF7/LCC9: an antiestrogen-resistant MCF-7 variant in which acquired resistance to the steroidal antiestrogen ICI 182,780 confers an early cross-resistance to the nonsteroidal antiestrogen tamoxifenQ42815735
Expression and splicing of the unfolded protein response gene XBP-1 are significantly associated with clinical outcome of endocrine-treated breast cancerQ46665995
Tamoxifen treatment for breast cancer enforces a distinct gene-expression profile on the human endometrium: an exploratory studyQ46831175
Tamoxifen and toremifene lower serum cholesterol by inhibition of delta 8-cholesterol conversion to lathosterol in women with breast cancer.Q53971615
Polyunsaturated fatty acid-induced cytotoxicity against tumor cells and its relationship to lipid peroxidationQ68277142
Differential killing of human carcinoma cells supplemented with n-3 and n-6 polyunsaturated fatty acidsQ68740692
Overexpression of the glucose-regulated stress gene GRP78 in malignant but not benign human breast lesionsQ73639378
Linoleic acid induces MCP-1 gene expression in human microvascular endothelial cells through an oxidative mechanismQ74179062
Lipotoxicity, an imbalance between lipogenesis de novo and fatty acid oxidationQ81127015
ER stress triggers MCP-1 expression through SET7/9-induced histone methylation in the kidneys of db/db miceQ87146747
P4510describes a project that usesImageJQ1659584
P433issue19
P407language of work or nameEnglishQ1860
P921main subjectendoplasmic reticulumQ79927
P304page(s)5657-5670
P577publication date2016-10-01
P1433published inCancer ResearchQ326097
P1476titleEndoplasmic Reticulum Stress Protein GRP78 Modulates Lipid Metabolism to Control Drug Sensitivity and Antitumor Immunity in Breast Cancer
P478volume76

Reverse relations

cites work (P2860)
Q38621233"UPRegulation" of CD47 by the endoplasmic reticulum stress pathway controls anti-tumor immune responses
Q64096895A Pathophysiological Model of Non-Alcoholic Fatty Liver Disease Using Precision-Cut Liver Slices
Q90593641Combination of anthracyclines and anti-CD47 therapy inhibit invasive breast cancer growth while preventing cardiac toxicity by regulation of autophagy
Q99418051Dual blockade of CD47 and HER2 eliminates radioresistant breast cancer cells
Q61796567ER stress sensor, glucose regulatory protein 78 (GRP78) regulates redox status in pancreatic cancer thereby maintaining "stemness"
Q37618279Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice
Q92282534Endoplasmic Reticulum Stress Pathway, the Unfolded Protein Response, Modulates Immune Function in the Tumor Microenvironment to Impact Tumor Progression and Therapeutic Response
Q90441712GM2-GM3 gangliosides ratio is dependent on GRP94 through down-regulation of GM2-AP cofactor in brain metastasis cells
Q38692967GRP78 at the Centre of the Stage in Cancer and Neuroprotection
Q92508950GRP94 Is Involved in the Lipid Phenotype of Brain Metastatic Cells
Q64238292Immune targets in the tumor microenvironment treated by radiotherapy
Q89599348Impairment of Membrane Lipid Homeostasis by Bichalcone Analog TSWU-BR4 Attenuates Function of GRP78 in Regulation of the Oxidative Balance and Invasion of Cancer Cells
Q94957210KSHV infection skews macrophage polarisation towards M2-like/TAM and activates Ire1 α-XBP1 axis up-regulating pro-tumorigenic cytokine release and PD-L1 expression
Q49544341Perspectives of Reprogramming Breast Cancer Metabolism
Q46556374Regulation of tumor-stroma interactions by the Unfolded Protein Response.
Q98771779Targeting the GRP78 Pathway for Cancer Therapy
Q57105740The Unfolded Protein Response in Breast Cancer
Q42700708The meta and bioinformatics analysis of GRP78 expression in gastric cancer
Q44964898Unfolded protein response signaling impacts macrophage polarity to modulate breast cancer cell clearance and melanoma immune checkpoint therapy responsiveness
Q64932561miR‑495 enhances the efficacy of radiotherapy by targeting GRP78 to regulate EMT in nasopharyngeal carcinoma cells.

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