The unfolded protein response in fatty liver disease

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The unfolded protein response in fatty liver disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1055/S-0033-1358522
P932PMC publication ID4110953
P698PubMed publication ID24222090

P2093author name stringRichard M Green
Anne Henkel
P2860cites workDistinct endoplasmic reticulum stress responses are triggered during human liver transplantationQ81779000
Infusion of glucose and lipids at physiological rates causes acute endoplasmic reticulum stress in rat liverQ83810163
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-betaQ22011091
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1Q22011167
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factorQ24292102
TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell deathQ24298384
CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cellsQ24301679
Unconventional splicing of XBP1 mRNA occurs in the cytoplasm during the mammalian unfolded protein responseQ24316572
Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alphaQ24322072
Human VAP-C negatively regulates hepatitis C virus propagationQ24337683
Endoplasmic reticulum stress: cell life and death decisions.Q24536108
Hepatitis C virus subgenomic replicons induce endoplasmic reticulum stress activating an intracellular signaling pathwayQ24537844
ER stress controls iron metabolism through induction of hepcidinQ24630714
Atf4 regulates obesity, glucose homeostasis, and energy expenditureQ24648259
The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signalingQ27008029
ADD66, a gene involved in the endoplasmic reticulum-associated degradation of alpha-1-antitrypsin-Z in yeast, facilitates proteasome activity and assembly.Q27932696
Unfolding new mechanisms of alcoholic liver disease in the endoplasmic reticulumQ28262304
Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1Q28276509
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinaseQ28296183
Tunicamycin induces ubiquitination and degradation of apolipoprotein B in HepG2 cellsQ28347626
Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathwaysQ28365886
HCV causes chronic endoplasmic reticulum stress leading to adaptation and interference with the unfolded protein responseQ28477137
Regulated translation initiation controls stress-induced gene expression in mammalian cellsQ28506388
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulumQ28509611
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulumQ28512249
Endoplasmic reticulum stress involved in heart and liver injury in iron-loaded ratsQ28572411
Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox stateQ28572472
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesQ28575190
Activation of the promoters of genes associated with DNA damage, oxidative stress, ER stress and protein malfolding by the bile salt, deoxycholateQ40931435
The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosisQ41904044
Taurine supplementation prevents ethanol-induced decrease in serum adiponectin and reduces hepatic steatosis in ratsQ42013343
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.Q42041480
Induction of liver steatosis and lipid droplet formation in ATF6alpha-knockout mice burdened with pharmacological endoplasmic reticulum stressQ42451739
Endoplasmic reticulum stress inhibition protects steatotic and non-steatotic livers in partial hepatectomy under ischemia-reperfusionQ42588208
Therapeutic strategies for Alzheimer disease based on endoplasmic reticulum stressQ42881347
Effects of oral folate supplementation on serum total homocysteine and cholesterol levels in hyperhomocysteinemic children.Q42940192
Tauroursodeoxycholic acid reduces endoplasmic reticulum stress, trypsin activation, and acinar cell apoptosis while increasing secretion in rat pancreatic aciniQ42952122
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In vivo hepatic endoplasmic reticulum stress in patients with chronic hepatitis C.Q44332232
The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophagesQ44542540
Evidence for unfolded protein response activation in monocytes from individuals with alpha-1 antitrypsin deficiencyQ44553654
Wogonin induced cytotoxicity in human hepatocellular carcinoma cells by activation of unfolded protein response and inactivation of AKT.Q44688680
Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver diseaseQ44934521
Involvement of endoplasmic reticulum stress in insulin resistance and diabetesQ45127777
Endoplasmic reticulum stress induces hepatic steatosis via increased expression of the hepatic very low-density lipoprotein receptorQ45200756
Serum folate and homocysteine levels in obese females with non-alcoholic fatty liverQ45276987
Cross-talk between PI3K/Akt and MEK/ERK pathways mediates endoplasmic reticulum stress-induced cell cycle progression and cell death in human hepatocellular carcinoma cells.Q46020821
Lipid-induced ER stress: synergistic effects of sterols and saturated fatty acidsQ46080547
S-adenosylmethionine attenuates hepatic lipid synthesis in micropigs fed ethanol with a folate-deficient dietQ46081358
Sodium 4-phenylbutyrate protects against liver ischemia reperfusion injury by inhibition of endoplasmic reticulum-stress mediated apoptosisQ46695184
Influence of folate on arterial permeability and stiffness in the absence or presence of hyperhomocysteinemia.Q46902318
Alpha-1 antitrypsin Z protein (PiZ) increases hepatic fibrosis in a murine model of cholestasis.Q50684835
Tauroursodeoxycholic acid affects PPARγ and TLR4 in Steatotic liver transplantation.Q50910081
Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein responseQ74359929
Hyperhomocysteinemia induces liver injury in rat: Protective effect of folic acid supplementationQ79891033
Methoxyflavones protect cells against endoplasmic reticulum stress and neurotoxinQ80258491
The folic acid metabolite L-5-methyltetrahydrofolate effectively reduces total serum homocysteine level in orthotopic liver transplant recipients: a double-blind placebo-controlled studyQ80376623
ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulumQ80935578
Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosisQ81441036
Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell deathQ28575464
ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signalsQ28646129
The unfolded protein response: from stress pathway to homeostatic regulationQ29547396
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetesQ29615503
The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological AssociationQ29617157
ER stress triggers apoptosis by activating BH3-only protein BimQ29617730
Expression of hereditary hemochromatosis C282Y HFE protein in HEK293 cells activates specific endoplasmic reticulum stress responsesQ33291582
Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individualsQ33345339
ER stress-inducible factor CHOP affects the expression of hepcidin by modulating C/EBPalpha activityQ33492751
Homocysteine supplementation attenuates the unfolded protein response in a murine nutritional model of steatohepatitisQ33553744
CCAAT/enhancer-binding protein beta deletion reduces adiposity, hepatic steatosis, and diabetes in Lepr(db/db) miceQ33943164
GLP-1 analogs reduce hepatocyte steatosis and improve survival by enhancing the unfolded protein response and promoting macroautophagyQ34034795
Saturated fatty acid induction of endoplasmic reticulum stress and apoptosis in human liver cells via the PERK/ATF4/CHOP signaling pathwayQ34128069
ER stress negatively modulates the expression of the miR-199a/214 cluster to regulates tumor survival and progression in human hepatocellular cancerQ34168267
Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesityQ34181503
Activation of ERAD pathway by human hepatitis B virus modulates viral and subviral particle productionQ34213852
Ursodeoxycholic acid for nonalcoholic steatohepatitisQ34366523
Activation of the unfolded protein response and autophagy after hepatitis C virus infection suppresses innate antiviral immunity in vitroQ34428880
Role of CHOP in hepatic apoptosis in the murine model of intragastric ethanol feedingQ34524224
Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expressionQ34563098
Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stressQ34801719
The contribution of endoplasmic reticulum stress to liver diseasesQ34860549
Triglyceride accumulation protects against fatty acid-induced lipotoxicityQ34866329
Z α-1 antitrypsin deficiency and the endoplasmic reticulum stress responseQ34962759
Subversion of cellular autophagy machinery by hepatitis B virus for viral envelopmentQ35077605
Modulation of the unfolded protein response is the core of microRNA-122-involved sensitivity to chemotherapy in hepatocellular carcinomaQ35095232
Dysregulation of the unfolded protein response in db/db mice with diet-induced steatohepatitisQ35490178
Experimental evidence for therapeutic potential of taurine in the treatment of nonalcoholic fatty liver diseaseQ35601541
Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: results of a randomized trialQ35681885
Signaling the unfolded protein response from the endoplasmic reticulum.Q35740723
Pharmacological ER stress promotes hepatic lipogenesis and lipid droplet formationQ35747483
Hyperhomocysteinemia, endoplasmic reticulum stress, and alcoholic liver injuryQ35799626
Activating transcription factor 6 limits intracellular accumulation of mutant α(1)-antitrypsin Z and mitochondrial damage in hepatoma cells.Q35842192
Insulin resistance, ceramide accumulation, and endoplasmic reticulum stress in human chronic alcohol-related liver diseaseQ35944938
Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed miceQ35954753
Oxidative Stress and the ER Stress Response in a Murine Model for Early-Stage Alcoholic Liver DiseaseQ36102239
Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodentsQ36183590
CD147 induces UPR to inhibit apoptosis and chemosensitivity by increasing the transcription of Bip in hepatocellular carcinomaQ36311151
Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice.Q36330343
Profiling impaired hepatic endoplasmic reticulum glycosylation as a consequence of ethanol ingestionQ36408473
The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolismQ36497151
C/EBP homologous protein (CHOP) contributes to suppression of metabolic genes during endoplasmic reticulum stress in the liverQ36596344
IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasisQ36600595
Endoplasmic reticulum stress signaling in diseaseQ36610455
Dissection of endoplasmic reticulum stress signaling in alcoholic and non-alcoholic liver injuryQ36800154
microRNA-199a-5p protects hepatocytes from bile acid-induced sustained endoplasmic reticulum stress.Q36890242
Translational control and the unfolded protein responseQ36924278
Endoplasmic reticulum stress markers are associated with obesity in nondiabetic subjectsQ36971939
Endoplasmic reticulum stress and liver injuryQ36989688
Endoplasmic reticulum stress--a double edged sword for Z alpha-1 antitrypsin deficiency hepatoxicityQ37114326
GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in miceQ37170811
Mice with a deletion in the gene for CCAAT/enhancer-binding protein beta are protected against diet-induced obesityQ37178851
ATF6 modulates SREBP2-mediated lipogenesis.Q37260315
Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cellsQ37388595
Elevated hepatic iron: a confounding factor in chronic hepatitis C.Q37459687
The Molecular Chaperone GRP78/BiP as a Therapeutic Target for Neurodegenerative Disorders: A Mini ReviewQ38113221
Inhibition of human betaine-homocysteine methyltransferase expression by S-adenosylmethionine and methylthioadenosineQ38310001
Mechanisms of alcohol-induced endoplasmic reticulum stress and organ injuriesQ38898700
Sorafenib enhances proteasome inhibitor-mediated cytotoxicity via inhibition of unfolded protein response and keratin phosphorylationQ39145068
Sorafenib-mediated targeting of the AAA⁺ ATPase p97/VCP leads to disruption of the secretory pathway, endoplasmic reticulum stress, and hepatocellular cancer cell deathQ39264795
Activation of the unfolded protein response contributed to the selective cytotoxicity of oroxylin A in human hepatocellular carcinoma HepG2 cellsQ39345662
Unfolded protein response suppresses cisplatin-induced apoptosis via autophagy regulation in human hepatocellular carcinoma cells.Q39480240
Oleate blocks palmitate-induced abnormal lipid distribution, endoplasmic reticulum expansion and stress, and insulin resistance in skeletal muscleQ39556161
Hepatitis C virus NS4B induces unfolded protein response and endoplasmic reticulum overload response-dependent NF-kappaB activationQ39821567
Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in miceQ39975807
Protective role of calreticulin in HFE hemochromatosisQ40043473
Characterization of endogenous betaine gamma-amino-n-butyric acid cotransporter glycoform and its hyperosmotic regulation in MDCK cellsQ40191010
Hepatitis B virus X protein (HBx) activates ATF6 and IRE1-XBP1 pathways of unfolded protein responseQ40210691
Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cellsQ40313352
Activation of endoplasmic reticulum-specific stress responses associated with the conformational disease Z alpha 1-antitrypsin deficiency.Q40515875
Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activationQ40708272
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)321-329
P577publication date2013-11-12
P1433published inSeminars in Liver DiseaseQ15724477
P1476titleThe unfolded protein response in fatty liver disease
P478volume33

Reverse relations

cites work (P2860)
Q58610328A Novel Regulatory Role of Apoptosis Antagonizing Transcription Factor in the Pathogenesis of NAFLD and HCC
Q64096895A Pathophysiological Model of Non-Alcoholic Fatty Liver Disease Using Precision-Cut Liver Slices
Q58697388A nonalcoholic fatty liver disease model in human induced pluripotent stem cell-derived hepatocytes, created by endoplasmic reticulum stress-induced steatosis
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Q42354312CSH guidelines for the diagnosis and treatment of drug-induced liver injury
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Q69394578Do inositol supplements enhance phosphatidylinositol supply and thus support endoplasmic reticulum function?
Q40246150Dysregulated IL-1β Secretion in Autoinflammatory Diseases: A Matter of Stress?
Q92265905ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy
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Q97522970Endoplasmic reticulum stress and liver diseases
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Q47565361ModuleDiscoverer: Identification of regulatory modules in protein-protein interaction networks
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Q91871195Mutual interaction between endoplasmic reticulum and mitochondria in nonalcoholic fatty liver disease
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Q38447648Nonalcoholic Fatty liver disease, diabetes, obesity, and hepatocellular carcinoma
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Q37640700The role of gastrointestinal hormones in hepatic lipid metabolism

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