The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism

scientific article

The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1172/JCI62819
P932PMC publication ID3533268
P698PubMed publication ID23257357

P50authorPhilipp E. SchererQ60572448
Jay D HortonQ89378224
P2093author name stringMark A Lehrman
Ningguo Gao
Joseph A Hill
Yingfeng Deng
Guosheng Liang
Joyce J Repa
Jin Ye
William L Holland
Zhao V Wang
Anwarul Ferdous
Caroline Tao
P2860cites workXBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factorQ24292102
A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein responseQ24305069
Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic miceQ24311328
Generalised uridine diphosphate galactose-4-epimerase deficiencyQ24675951
Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction.Q24804951
The role of the proteasomal ATPases and activator monoubiquitylation in regulating Gal4 binding to promotersQ27936877
Glycogen storage disease type I and G6Pase-β deficiency: etiology and therapyQ28296663
The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathwayQ28298223
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1Q28507338
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocationQ28510062
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesQ28575190
Rapamycin inhibits postprandial-mediated X-box-binding protein-1 splicing in rat liverQ28577788
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein ResponseQ28585314
Regulation of glucose homeostasis through a XBP-1-FoxO1 interactionQ28592129
The unfolded protein response: from stress pathway to homeostatic regulationQ29547396
The mammalian unfolded protein responseQ29547400
Towards a knowledge-based Human Protein AtlasQ29617987
Microscale nonreductive release of O-linked glycans for subsequent analysis through MALDI mass spectrometry and capillary electrophoresisQ30797035
Enhanced metabolic flexibility associated with elevated adiponectin levelsQ33703749
Drug treatment of lipid disordersQ33707765
Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesisQ33734679
Progressive adaptation of hepatic ketogenesis in mice fed a high-fat diet.Q33916541
Molecular basis of disorders of human galactose metabolism: past, present, and future.Q34043036
The Leloir pathway: a mechanistic imperative for three enzymes to change the stereochemical configuration of a single carbon in galactose.Q34062664
UDP-galactose 4' epimerase (GALE) is essential for development of Drosophila melanogasterQ34098135
The enzymatic transformation of uridine diphosphate glucose into a galactose derivativeQ34297292
The glucose-regulated proteins: stress induction and clinical applicationsQ34336908
Classical galactosaemia revisited.Q34547104
XBP1S associates with RUNX2 and regulates chondrocyte hypertrophyQ36298468
The structural and molecular biology of type III galactosemia.Q36447739
Hypoxia signalling through mTOR and the unfolded protein response in cancerQ37290935
Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1aQ37360326
Redox control of endoplasmic reticulum functionQ37650539
Enhanced protein production using HBV X protein (HBx), and synergy when used in combination with XBP1s in BHK21 cellsQ39801823
XBP1 is essential for survival under hypoxic conditions and is required for tumor growth.Q40519913
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.Q42041480
Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis.Q42832143
Tissue-specific postprandial clearance is the major determinant of PPARgamma-induced triglyceride lowering in the rat.Q46275858
Glycoconjugates as noninvasive probes of intrahepatic metabolism: III. Application to galactose assimilation by the intact ratQ51625999
Structure and function of low-density-lipoprotein receptors in epimerase-deficient galactosemiaQ69497750
Non-radioactive analysis of lipid-linked oligosaccharide compositions by fluorophore-assisted carbohydrate electrophoresisQ79372170
Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-IIQ81144490
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)455-468
P577publication date2012-12-21
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleThe Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism
P478volume123

Reverse relations

cites work (P2860)
Q51245026Adipocyte Xbp1s overexpression drives uridine production and reduces obesity.
Q37597070Adipocyte spliced form of X-box-binding protein 1 promotes adiponectin multimerization and systemic glucose homeostasis
Q33858526Apolipoprotein B100 quality control and the regulation of hepatic very low density lipoprotein secretion.
Q37594453Arcuate AgRP neurons mediate orexigenic and glucoregulatory actions of ghrelin
Q43128898Can UPR integrate fasting and stem cell regeneration?
Q91891922Chronic activation of hexosamine biosynthesis in the heart triggers pathological cardiac remodeling
Q92255067Coupling of COPII vesicle trafficking to nutrient availability by the IRE1α-XBP1s axis
Q37002642Deficiency of liver Comparative Gene Identification-58 causes steatohepatitis and fibrosis in mice
Q50528588Driving Cancer Tumorigenesis and Metastasis Through UPR Signaling.
Q41899777Effects of Fat and Sugar, Either Consumed or Infused toward the Brain, on Hypothalamic ER Stress Markers.
Q38925531Endoplasmic reticulum proteostasis in hepatic steatosis.
Q57243233Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications
Q38287666Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity
Q51246528Fasting exacerbates hepatic growth differentiation factor 15 to promote fatty acid β-oxidation and ketogenesis via activating XBP1 signaling in liver.
Q33631394Flavin-Containing Monooxygenase 3 Reduces Endoplasmic Reticulum Stress in Lipid-Treated Hepatocytes
Q64949783Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation.
Q47847017Hepatic GALE Regulates Whole-Body Glucose Homeostasis by Modulating Tff3 Expression.
Q51324999Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARα axis signalling.
Q64096707Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism
Q42746415Heterotypic Signals from Neural HSF-1 Separate Thermotolerance from Longevity.
Q37658270IRE1α-XBP1 pathway promotes melanoma progression by regulating IL-6/STAT3 signaling
Q64896373IRE1α-XBP1 signaling pathway regulates IL-6 expression and promotes progression of hepatocellular carcinoma.
Q38816036Increased lipogenesis in spite of upregulated hepatic 5'AMP-activated protein kinase in human non-alcoholic fatty liver
Q47104419Induction of fibroblast growth factor 21 does not require activation of the hepatic X-box binding protein 1 in mice
Q38732966Inflammation Improves Glucose Homeostasis through IKKβ-XBP1s Interaction
Q35140256Inflammation and ER stress regulate branched-chain amino acid uptake and metabolism in adipocytes
Q37597073Insulin regulates the unfolded protein response in human adipose tissue.
Q34077404Insulin resistance is associated with diminished endoplasmic reticulum stress responses in adipose tissue of healthy and diabetic subjects
Q27015015Involvement of the IRE1α-XBP1 pathway and XBP1s-dependent transcriptional reprogramming in metabolic diseases
Q48380334Ire1α in Pomc Neurons Is Required for Thermogenesis and Glycemia
Q36107299Liver Perilipin 5 Expression Worsens Hepatosteatosis But Not Insulin Resistance in High Fat-Fed Mice
Q49843619Liver function and dysfunction - a unique window into the physiological reach of ER stress and the unfolded protein response
Q47411951PGC-1α functions as a co-suppressor of XBP1s to regulate glucose metabolism
Q28256472Protein quality control and metabolism: bidirectional control in the heart
Q64971224Quality Control in the Endoplasmic Reticulum: Crosstalk between ERAD and UPR pathways.
Q90636660Renal tubular cell spliced X-box binding protein 1 (Xbp1s) has a unique role in sepsis-induced acute kidney injury and inflammation
Q37648367Spliced X-box binding protein 1 couples the unfolded protein response to hexosamine biosynthetic pathway
Q90597304Sustained ER stress promotes hyperglycemia by increasing glucagon action through the deubiquitinating enzyme USP14
Q37692541The AdipoChaser mouse: A model tracking adipogenesis in vivo.
Q58778511The IRE1α-XBP1s pathway promotes insulin-stimulated glucose uptake in adipocytes by increasing PPARγ activity
Q42765673The Multifaceted Roles of Adipose Tissue-Therapeutic Targets for Diabetes and Beyond: The 2015 Banting Lecture
Q26776377The Role of Organelle Stresses in Diabetes Mellitus and Obesity: Implication for Treatment
Q55372811The exposure to uteroplacental insufficiency is associated with activation of unfolded protein response in postnatal life.
Q93350086The role of X-box binding protein 1 in the hepatic response to refeeding in mice
Q28587096The role of adipocyte XBP1 in metabolic regulation during lactation
Q38162132The unfolded protein response in fatty liver disease
Q92482677UPRER promotes lipophagy independent of chaperones to extend life span
Q91734604Understanding intrinsic hematopoietic stem cell aging
Q92795478Unravel the molecular mechanism of XBP1 in regulating the biology of cancer cells
Q55411030Unveiling “Musica Universalis” of the Cell: A Brief History of Biological 12-Hour Rhythms.
Q104073438XBP1 links the 12-hour clock to NAFLD and regulation of membrane fluidity and lipid homeostasis
Q38291938XBP1s Is an Anti-lipogenic Protein
Q30370983Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis.

Search more.