Increased lipogenesis in spite of upregulated hepatic 5'AMP-activated protein kinase in human non-alcoholic fatty liver

scientific article published on 30 September 2016

Increased lipogenesis in spite of upregulated hepatic 5'AMP-activated protein kinase in human non-alcoholic fatty liver is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/HEPR.12825
P698PubMed publication ID27689765

P50authorHarald GrallertQ29840626
Tonia de Las Heras GalaQ42439274
Christian von LoeffelholzQ42440959
Michael BauerQ50638837
Igor M SauerQ57009734
Paula SingmannQ57064434
P2093author name stringPaul Horn
Andreas F H Pfeiffer
Jennifer Kriebel
Simone Wahl
Regine Heller
Johan F Lock
Martin Stockmann
Gerhard Jahreis
Andreas L Birkenfeld
Ralf A Claus
Stefanie Lieske
Tonia de Las Heras Gala
Christian von Loeffelholz
Stephanie Döcke
Nathaniel Raschzok
P2860cites workGuidelines for the use and interpretation of assays for monitoring autophagyQ21996341
Diagnosis and Classification of Diabetes MellitusQ22255454
Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathwayQ24607012
Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in manQ26776977
Amino acids and mTORC1: from lysosomes to diseaseQ27009377
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Autophagy regulates lipid metabolismQ29547421
Design and validation of a histological scoring system for nonalcoholic fatty liver diseaseQ29614930
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagyQ29615616
Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver diseaseQ29619334
Deficient chaperone-mediated autophagy in liver leads to metabolic dysregulationQ34143516
Fibroblast growth factor 21 is regulated by the IRE1α-XBP1 branch of the unfolded protein response and counteracts endoplasmic reticulum stress-induced hepatic steatosisQ34396839
Coactivation of Foxa2 through Pgc-1beta promotes liver fatty acid oxidation and triglyceride/VLDL secretionQ34651716
Independent Association between Nonalcoholic Fatty Liver Disease and Cardiovascular Disease: A Systematic Review and Meta-AnalysisQ34729697
Mapping autophagy on to your metabolic radarQ35696469
Fatty acid distribution of cord and maternal blood in human pregnancy: special focus on individual trans fatty acids and conjugated linoleic acidsQ35809110
Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liverQ35958436
The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolismQ36497151
Nonalcoholic steatohepatitis: pathologic features and differential diagnosisQ36580461
Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver diseaseQ36856713
Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight lossQ37105351
AMPK: a key regulator of energy balance in the single cell and the whole organism.Q37249357
Molecular mechanisms and therapeutic targets in steatosis and steatohepatitisQ37299002
Glycine and urea kinetics in nonalcoholic steatohepatitis in human: effect of intralipid infusionQ37337683
Insulin resistance and fuel homeostasis: the role of AMP-activated protein kinaseQ37401940
Suppression of the mTORC1/STAT3/Notch1 pathway by activated AMPK prevents hepatic insulin resistance induced by excess amino acidsQ37575390
From sugar to fat: How the transcription factor XBP1 regulates hepatic lipogenesisQ37596560
Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetesQ37624982
Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trialsQ37978785
Endoplasmic reticulum stress in nonalcoholic fatty liver diseaseQ38027194
Clinical Review: Nonalcoholic fatty liver disease: a novel cardiometabolic risk factor for type 2 diabetes and its complications.Q38072021
Mitochondrial dysfunction in non-alcoholic fatty liver disease and insulin resistance: cause or consequence?Q38126549
AICAR, an AMPK activator, has protective effects on alcohol-induced fatty liver in ratsQ38317237
FGF21 treatment ameliorates alcoholic fatty liver through activation of AMPK-SIRT1 pathwayQ38943985
Lipid-induced endoplasmic reticulum stress in liver cells results in two distinct outcomes: adaptation with enhanced insulin signaling or insulin resistanceQ39388424
ER stress and autophagy dysfunction contribute to fatty liver in diabetic miceQ39716920
AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cellsQ40515180
Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitisQ40960591
Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signalingQ41956357
Fatty acid metabolism in the liver, measured by positron emission tomography, is increased in obese individualsQ42946610
Comparison of lipid and fatty acid composition of the liver, subcutaneous and intra-abdominal adipose tissue, and serumQ43637127
Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetesQ43833528
Elevated hepatic chemerin mRNA expression in human non-alcoholic fatty liver diseaseQ44473003
Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient miceQ46141813
Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease.Q46442905
ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liverQ50336015
P433issue9
P304page(s)890-901
P577publication date2016-09-30
P1433published inHepatology ResearchQ15752035
P1476titleIncreased lipogenesis in spite of upregulated hepatic 5'AMP-activated protein kinase in human non-alcoholic fatty liver
P478volume47

Reverse relations

cites work (P2860)
Q55546958Deterioration of Organ Function As a Hallmark in Sepsis: The Cellular Perspective.
Q38287666Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity
Q41075841Growth hormone reverses dyslipidemia in adult offspring after maternal undernutrition
Q93164524Metabolic Biomarkers in Aging and Anti-Aging Research
Q89220189Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease
Q90597304Sustained ER stress promotes hyperglycemia by increasing glucagon action through the deubiquitinating enzyme USP14
Q58802792Thiazolidinedione induces a therapeutic effect on hepatosteatosis by regulating stearoyl-CoA desaturase-1, lipase activity, leptin and resistin

Search more.