| review article | Q7318358 |
| scholarly article | Q13442814 |
| P50 | author | Yung-Ming Jeng | Q56383907 |
| Lee-Ming Chuang | Q56854969 | ||
| Yi-Cheng Chang | Q37639369 | ||
| P2093 | author name string | Meng-Lun Hsieh | |
| Siow-Wey Hee | |||
| P2860 | cites work | Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin | Q22250892 |
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| Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells | Q24299603 | ||
| Impact of mitochondrial reactive oxygen species and apoptosis signal-regulating kinase 1 on insulin signaling | Q40286568 | ||
| Targeted deletion of autophagy-related 5 (atg5) impairs adipogenesis in a cellular model and in mice | Q40660312 | ||
| The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis | Q41791624 | ||
| UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. | Q42041480 | ||
| Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans | Q42247172 | ||
| Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia | Q42442810 | ||
| Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet | Q42442818 | ||
| Induction of liver steatosis and lipid droplet formation in ATF6alpha-knockout mice burdened with pharmacological endoplasmic reticulum stress | Q42451739 | ||
| Respiratory chain dysfunction in skeletal muscle does not cause insulin resistance | Q42501703 | ||
| Effects of lipoic acid on AMPK and adiponectin in adipose tissue of low- and high-fat-fed rats | Q42717684 | ||
| Association of anti-obesity activity of N-acetylcysteine with metallothionein-II down-regulation | Q42802572 | ||
| Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha | Q44043178 | ||
| A transgenic mouse model for monitoring endoplasmic reticulum stress | Q44711192 | ||
| Involvement of reactive oxygen species in Toll-like receptor 4-dependent activation of NF-kappa B. | Q44757031 | ||
| Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase | Q44934802 | ||
| Involvement of endoplasmic reticulum stress in insulin resistance and diabetes | Q45127777 | ||
| Autophagy in human type 2 diabetes pancreatic beta cells. | Q46050859 | ||
| N-acetylcysteine in high-sucrose diet-induced obesity: energy expenditure and metabolic shifting for cardiac health. | Q46256724 | ||
| Lipoic acid prevents fructose-induced changes in liver carbohydrate metabolism: role of oxidative stress | Q46552842 | ||
| Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes | Q46915798 | ||
| An open-label pilot trial of alpha-lipoic acid for weight loss in patients with schizophrenia without diabetes | Q47249844 | ||
| Effects of alpha-lipoic Acid on body weight in obese subjects | Q47399374 | ||
| Effects of α-lipoic acid and eicosapentaenoic acid in overweight and obese women during weight loss | Q47411684 | ||
| Study of Fatal Cases of Friedreich's Ataxia | Q49253895 | ||
| A subtype of diabetes mellitus associated with a mutation of mitochondrial DNA. | Q50525235 | ||
| Glycemic and oxidative status of patients with type 2 diabetes mellitus following oral administration of alpha-lipoic acid: a randomized double-blinded placebo-controlled study. | Q51360408 | ||
| Endoplasmic reticulum stress and glycogen synthase kinase-3β activation in apolipoprotein E-deficient mouse models of accelerated atherosclerosis. | Q51402296 | ||
| Effect of modest vitamin E supplementation on blood glycated hemoglobin and triglyceride levels and red cell indices in type I diabetic patients. | Q51579284 | ||
| PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis. | Q52000258 | ||
| Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes. | Q52541455 | ||
| The mitochondria-targeted antioxidant MitoQ decreases features of the metabolic syndrome in ATM+/-/ApoE-/- mice. | Q53194946 | ||
| Caloric restriction decreases ER stress in liver and adipose tissue in ob/ob mice. | Q54628407 | ||
| Frataxin deficiency in pancreatic islets causes diabetes due to loss of β cell mass | Q56987703 | ||
| Improvement of Nonalcoholic Fatty Liver Disease With Carnitine-Orotate Complex in Type 2 Diabetes (CORONA): A Randomized Controlled Trial | Q57220944 | ||
| Systemic autophagy insufficiency compromises adaptation to metabolic stress and facilitates progression from obesity to diabetes | Q59516123 | ||
| Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine | Q63609769 | ||
| Vitamin E modifies neither fructosamine nor HbA1c levels in poorly controlled diabetes | Q73062172 | ||
| Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade | Q77795070 | ||
| Amelioration of lipid abnormalities by α-lipoic acid through antioxidative and anti-inflammatory effects | Q84143689 | ||
| Daily vitamin E supplementation does not improve metabolic and glycemic control in type 2 diabetic patients: a double blinded randomized controlled trial | Q84165081 | ||
| Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways | Q24309037 | ||
| The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule | Q24596804 | ||
| Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma | Q24598483 | ||
| Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma | Q24600346 | ||
| Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis | Q24625697 | ||
| Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease | Q24628936 | ||
| In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker | Q24633015 | ||
| How mitochondria produce reactive oxygen species | Q24643882 | ||
| Caloric restriction delays disease onset and mortality in rhesus monkeys | Q24655994 | ||
| Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1 | Q24679555 | ||
| PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis | Q24798075 | ||
| Mitohormesis | Q26862860 | ||
| The pathways of mitophagy for quality control and clearance of mitochondria | Q27009206 | ||
| Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (P | Q27681837 | ||
| Signal integration in the endoplasmic reticulum unfolded protein response | Q27860577 | ||
| EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome | Q28142981 | ||
| Activation signal of nuclear factor-kappa B in response to endoplasmic reticulum stress is transduced via IRE1 and tumor necrosis factor receptor-associated factor 2 | Q28185092 | ||
| Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance | Q28186874 | ||
| Translational control is required for the unfolded protein response and in vivo glucose homeostasis | Q28204066 | ||
| Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress | Q28251449 | ||
| Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2 | Q28272571 | ||
| Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance | Q28291556 | ||
| A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress | Q28306995 | ||
| Vitamin E reduction of protein glycosylation in diabetes. New prospect for prevention of diabetic complications? | Q28334713 | ||
| Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes | Q28506402 | ||
| AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1 | Q28506431 | ||
| PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation | Q28507769 | ||
| Regulation of hepatic lipogenesis by the transcription factor XBP1 | Q28507784 | ||
| Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes | Q28575190 | ||
| Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction | Q28592129 | ||
| Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity | Q28822090 | ||
| Increased oxidative stress in obesity and its impact on metabolic syndrome | Q29012150 | ||
| Overexpression of Atg5 in mice activates autophagy and extends lifespan | Q29038178 | ||
| Autophagy: renovation of cells and tissues | Q29547206 | ||
| MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity. | Q37100064 | ||
| Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss | Q37105351 | ||
| GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice | Q37170811 | ||
| Autophagy in Myf5+ progenitors regulates energy and glucose homeostasis through control of brown fat and skeletal muscle development | Q37214016 | ||
| Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells | Q37343526 | ||
| Activation of the Akt-NF-kappaB pathway by subtilase cytotoxin through the ATF6 branch of the unfolded protein response | Q37389501 | ||
| Autophagy regulates adipose mass and differentiation in mice | Q37403082 | ||
| Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis | Q37446431 | ||
| Unfolded protein response signaling and metabolic diseases | Q37488392 | ||
| Deficiency of NPGPx, an oxidative stress sensor, leads to obesity in mice and human | Q37621022 | ||
| Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2 | Q37622629 | ||
| Role of carnitine in the regulation of glucose homeostasis and insulin sensitivity: evidence from in vivo and in vitro studies with carnitine supplementation and carnitine deficiency | Q37963740 | ||
| The machinery of macroautophagy | Q38173673 | ||
| Human IAPP-induced pancreatic β cell toxicity and its regulation by autophagy | Q38974302 | ||
| Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance | Q39241662 | ||
| α-Lipoic acid regulates lipid metabolism through induction of sirtuin 1 (SIRT1) and activation of AMP-activated protein kinase | Q39372653 | ||
| Frataxin deficiency in pancreatic islets causes diabetes due to loss of beta cell mass | Q39814673 | ||
| Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice | Q39975807 | ||
| PKC-theta knockout mice are protected from fat-induced insulin resistance | Q39989111 | ||
| PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes | Q29547229 | ||
| Regulation mechanisms and signaling pathways of autophagy | Q29547416 | ||
| Autophagy regulates lipid metabolism | Q29547421 | ||
| Mitochondrial respiratory-chain diseases | Q29614474 | ||
| Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice | Q29614547 | ||
| Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes | Q29614548 | ||
| Mitochondrial dysfunction in the elderly: possible role in insulin resistance | Q29618783 | ||
| The effect of vitamin E on endothelial function of micro- and macrocirculation and left ventricular function in type 1 and type 2 diabetic patients | Q33210300 | ||
| Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response | Q33264844 | ||
| Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. | Q33896647 | ||
| alpha-Lipoic acid increases energy expenditure by enhancing adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor-gamma coactivator-1alpha signaling in the skeletal muscle of aged mice | Q33900969 | ||
| Autophagy defends pancreatic β cells from human islet amyloid polypeptide-induced toxicity | Q33944212 | ||
| Amyloidogenic peptide oligomer accumulation in autophagy-deficient β cells induces diabetes | Q33944267 | ||
| Series introduction: the molecular and physiological basis of insulin resistance: emerging implications for metabolic and cardiovascular diseases | Q33973808 | ||
| Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women. | Q34024266 | ||
| Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis | Q34169287 | ||
| A novel peptide in the calcitonin gene related peptide family as an amyloid fibril protein in the endocrine pancreas | Q34182765 | ||
| Autophagy in hypothalamic AgRP neurons regulates food intake and energy balance | Q34204941 | ||
| Impaired mitochondrial substrate oxidation in muscle of insulin-resistant offspring of type 2 diabetic patients | Q34370850 | ||
| Mitochondrial function in normal and diabetic beta-cells | Q34462332 | ||
| Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress. | Q34572339 | ||
| Sodium phenylbutyrate, a drug with known capacity to reduce endoplasmic reticulum stress, partially alleviates lipid-induced insulin resistance and beta-cell dysfunction in humans | Q34615491 | ||
| Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion | Q35008217 | ||
| Effect of resveratrol on glucose control and insulin sensitivity: a meta-analysis of 11 randomized controlled trials | Q35138752 | ||
| Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. | Q35614877 | ||
| Endoplasmic reticulum stress triggers autophagy | Q35690087 | ||
| Loss of autophagy in pro-opiomelanocortin neurons perturbs axon growth and causes metabolic dysregulation | Q35754237 | ||
| Targeting Nrf2 by dihydro-CDDO-trifluoroethyl amide enhances autophagic clearance and viability of β-cells in a setting of oxidative stress | Q35801045 | ||
| Loss of Atg12, but not Atg5, in pro-opiomelanocortin neurons exacerbates diet-induced obesity | Q35853081 | ||
| Loss of autophagy in hypothalamic POMC neurons impairs lipolysis | Q35880397 | ||
| Orphan nuclear receptor estrogen-related receptor γ (ERRγ) is key regulator of hepatic gluconeogenesis | Q36052342 | ||
| Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity | Q36082167 | ||
| Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice | Q36330856 | ||
| PERK is required in the adult pancreas and is essential for maintenance of glucose homeostasis | Q36435206 | ||
| The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism | Q36497151 | ||
| Endoplasmic reticulum stress markers are associated with obesity in nondiabetic subjects | Q36971939 | ||
| P275 | copyright license | Creative Commons Attribution 3.0 Unported | Q14947546 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | stress | Q123414 |
| type 2 diabetes | Q3025883 | ||
| obesity | Q12174 | ||
| organelle | Q45948 | ||
| P5008 | on focus list of Wikimedia project | ScienceSource | Q55439927 |
| P304 | page(s) | 972891 | |
| P577 | publication date | 2015-11-03 | |
| P1433 | published in | Cellular Oncology | Q2160503 |
| Analytical and Quantitative Cytology and Histology | Q15753548 | ||
| P1476 | title | The Role of Organelle Stresses in Diabetes Mellitus and Obesity: Implication for Treatment | |
| P478 | volume | 2015 |
| Q28076447 | An Updated Mini Review of Vitamin D and Obesity: Adipogenesis and Inflammation State |
| Q47961633 | Autophagy impairment by caspase-1-dependent inflammation mediates memory loss in response to β-Amyloid peptide accumulation |
| Q64925695 | Comparison of endoplasmic reticulum stress and mitochondrial biogenesis responses after 12 weeks of treadmill running and ladder climbing exercises in the cardiac muscle of middle-aged obese rats. |
| Q37669778 | Does bariatric surgery improve adipose tissue function? |
| Q39373640 | Obesity Exacerbates Sepsis-Induced Oxidative Damage in Organs |
| Q37214857 | The influence of oxidative stress and autophagy cross regulation on pregnancy outcome |
| Q55295690 | The role of endoplasmic reticulum-mitochondria contact sites in the control of glucose homeostasis: an update. |
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