| scholarly article | Q13442814 |
| P356 | DOI | 10.1074/JBC.M411860200 |
| P698 | PubMed publication ID | 15509553 |
| P2093 | author name string | Munehide Matsuhisa | |
| Kentaro Ozawa | |||
| Satoshi Ogawa | |||
| Masatsugu Hori | |||
| Hideaki Kaneto | |||
| Taka-aki Matsuoka | |||
| Yoshimitsu Yamasaki | |||
| Dan Kawamori | |||
| Yoshihisa Nakatani | |||
| Masahiro Hatazaki | |||
| Kazutomi Yoshiuchi | |||
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | endoplasmic reticulum | Q79927 |
| insulin resistance | Q1053470 | ||
| preproinsulin | Q7240673 | ||
| P304 | page(s) | 847-851 | |
| P577 | publication date | 2004-10-27 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Involvement of endoplasmic reticulum stress in insulin resistance and diabetes | |
| P478 | volume | 280 |
| Q27013554 | (n-3) Fatty acids alleviate adipose tissue inflammation and insulin resistance: mechanistic insights |
| Q38349253 | 4-Phenyl butyric acid does not generally reduce glucose levels in rodent models of diabetes. |
| Q24540224 | A critical role for eukaryotic elongation factor 1A-1 in lipotoxic cell death |
| Q89485775 | A novel phosphorylation by AMP-activated kinase regulates RUNX2 from ubiquitination in osteogenesis over adipogenesis |
| Q33834810 | A novel potential biomarker for metabolic syndrome in Chinese adults: Circulating protein disulfide isomerase family A, member 4. |
| Q42824021 | A protective role for CD154 in hepatic steatosis in mice |
| Q24305069 | A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response |
| Q41764630 | Activating transcription factor 6 plays protective and pathological roles in steatosis due to endoplasmic reticulum stress in zebrafish |
| Q28658223 | Activating transcription factor 6 protects insulin receptor from ER stress-stimulated desensitization via p42/44 ERK pathway |
| Q37412895 | Adaptation and failure of pancreatic beta cells in murine models with different degrees of metabolic syndrome |
| Q38344499 | AdipoR2 is transcriptionally regulated by ER stress-inducible ATF3 in HepG2 human hepatocyte cells |
| Q37731905 | Adipose "talks" to distant organs to regulate insulin sensitivity and vascular function |
| Q64053566 | Adipose-derived stromal/stem cells from different adipose depots in obesity development |
| Q43970916 | Age-associated development of inflammation in Wistar rats: Effects of caloric restriction |
| Q37804862 | Alternative Macrophage Activation and Metabolism |
| Q35895767 | Amelioration of glucolipotoxicity-induced endoplasmic reticulum stress by a "chemical chaperone" in human THP-1 monocytes |
| Q42834922 | Amelioration of insulin resistance by Rk1 + Rg5 complex under endoplasmic reticulum stress conditions |
| Q90230220 | Anti-Metabolic Syndrome Effects of Fucoidan from Fucus vesiculosus via Reactive Oxygen Species-Mediated Regulation of JNK, Akt, and AMPK Signaling |
| Q37601151 | Astaxanthin reduces hepatic endoplasmic reticulum stress and nuclear factor-κB-mediated inflammation in high fructose and high fat diet-fed mice |
| Q51017044 | Atypical, bidirectional regulation of cadmium-induced apoptosis via distinct signaling of unfolded protein response. |
| Q36076590 | Autophagy contributes to retardation of cardiac growth in diabetic rats |
| Q42797937 | Autophagy-mediated insulin receptor down-regulation contributes to endoplasmic reticulum stress-induced insulin resistance |
| Q33838482 | BRD7 regulates XBP1s' activity and glucose homeostasis through its interaction with the regulatory subunits of PI3K |
| Q49850608 | Bax Inhibitor-1 protects from Non-Alcoholic Steatohepatitis by limiting IRE1α signaling |
| Q37000389 | Bax Inhibitor-1 regulates hepatic lipid accumulation via ApoB secretion |
| Q37728794 | Berberine reduces endoplasmic reticulum stress and improves insulin signal transduction in Hep G2 cells |
| Q37262812 | Beta-cell failure as a complication of diabetes |
| Q37326460 | Betaine Alleviates Hypertriglycemia and Tau Hyperphosphorylation in db/db Mice |
| Q26825679 | BiP and its nucleotide exchange factors Grp170 and Sil1: mechanisms of action and biological functions |
| Q37594114 | Bilirubin increases insulin sensitivity in leptin-receptor deficient and diet-induced obese mice through suppression of ER stress and chronic inflammation |
| Q39662992 | C/EBPβ is AMP kinase sensitive and up-regulates PEPCK in response to ER stress in hepatoma cells |
| Q43092908 | CHOP 5'UTR-c.279T>C and +nt30C>T variants are not associated with overweight condition or with tumors/cancer in Italians - a case-control study |
| Q43652536 | CHOP T/C and C/T haplotypes contribute to early-onset type 2 diabetes in Italians |
| Q57115313 | Calcium Signaling in Liver Injury and Regeneration |
| Q37804459 | Causes and cures for endoplasmic reticulum stress in lipotoxic β-cell dysfunction |
| Q46311024 | Cell Non-autonomous UPR(ER) Signaling. |
| Q38971267 | Cell Signaling and Stress Responses. |
| Q36080882 | Central nervous system endoplasmic reticulum stress in a murine model of type 2 diabetes |
| Q28251174 | Chaperoning to the metabolic party: The emerging therapeutic role of heat-shock proteins in obesity and type 2 diabetes |
| Q55326781 | Characterization of visceral and subcutaneous adipose tissue transcriptome in pregnant women with and without spontaneous labor at term: implication of alternative splicing in the metabolic adaptations of adipose tissue to parturition. |
| Q29615503 | Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes |
| Q37001677 | Chemical induction of the unfolded protein response in the liver increases glucose production and is activated during insulin-induced hypoglycaemia in rats |
| Q38292063 | Chromium alleviates glucose intolerance, insulin resistance, and hepatic ER stress in obese mice |
| Q39297354 | Controlling type-2 diabetes by inclusion of Cr-enriched yeast bread in the daily dietary pattern: a randomized clinical trial |
| Q24311464 | Crystal structure of Miner1: The redox-active 2Fe-2S protein causative in Wolfram Syndrome 2 |
| Q47290995 | Defective STIM-mediated store operated Ca2+ entry in hepatocytes leads to metabolic dysfunction in obesity. |
| Q34417300 | Delayed treatment with a novel neurotrophic compound reduces behavioral deficits in rabbit ischemic stroke |
| Q43534834 | Deletion of Nck1 attenuates hepatic ER stress signaling and improves glucose tolerance and insulin signaling in liver of obese mice |
| Q30241888 | Dendritic cells and adipose tissue |
| Q39975807 | Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice |
| Q36276111 | Diabetes alters sphingolipid metabolism in the retina: a potential mechanism of cell death in diabetic retinopathy |
| Q37797970 | Diabetes as a disease of endoplasmic reticulum stress |
| Q40485369 | Differential Development of Inflammation and Insulin Resistance in Different Adipose Tissue Depots Along Aging in Wistar Rats: Effects of Caloric Restriction |
| Q35040219 | Differential responses of hepatic endoplasmic reticulum stress and inflammation in diet-induced obese rats with high-fat diet rich in lard oil or soybean oil |
| Q37495667 | Discovery of a novel target for the dysglycemic chromogranin A fragment pancreastatin: interaction with the chaperone GRP78 to influence metabolism |
| Q36800154 | Dissection of endoplasmic reticulum stress signaling in alcoholic and non-alcoholic liver injury |
| Q35709954 | Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice |
| Q53262666 | Dose-related effects of ferric citrate supplementation on endoplasmic reticular stress responses and insulin signalling pathways in streptozotocin-nicotinamide-induced diabetes. |
| Q53830618 | Duodenal-Jejunal Bypass Surgery Ameliorates Glucose Homeostasis and Reduces Endoplasmic Reticulum Stress in the Liver Tissue in a Diabetic Rat Model. |
| Q35779442 | ER Stress and Lipid Metabolism in Adipocytes |
| Q36523562 | ER Stress and β-Cell Pathogenesis of Type 1 and Type 2 Diabetes and Islet Transplantation |
| Q36293033 | ER stress induces NLRP3 inflammasome activation and hepatocyte death. |
| Q43289260 | Effect of chromium supplementation on the diabetes induced-oxidative stress in liver and brain of adult rats |
| Q36254434 | Effect of endoplasmic reticulum stress on inflammation and adiponectin regulation in human adipocytes |
| Q34737898 | Effect of lipopolysaccharide on inflammation and insulin action in human muscle |
| Q36846138 | Effect of pioglitazone treatment on endoplasmic reticulum stress response in human adipose and in palmitate-induced stress in human liver and adipose cell lines. |
| Q37038292 | Effects of ritonavir on adipocyte gene expression: evidence for a stress-related response |
| Q34366572 | Emerging issues in radiogenic cataracts and cardiovascular disease |
| Q37116246 | Emerging role of adipose tissue hypoxia in obesity and insulin resistance |
| Q39139204 | Endoplasmic Reticulum (ER) Stress and Endocrine Disorders. |
| Q37784942 | Endoplasmic Reticulum Stress and Inflammation in Obesity and Diabetes |
| Q50957794 | Endoplasmic Reticulum Stress and Obesity. |
| Q36904643 | Endoplasmic reticulum is at the crossroads of autophagy, inflammation, and apoptosis signaling pathways and participates in the pathogenesis of diabetes mellitus |
| Q28279152 | Endoplasmic reticulum stress and atherosclerosis |
| Q27016164 | Endoplasmic reticulum stress and diabetic cardiomyopathy |
| Q41689677 | Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells |
| Q24633352 | Endoplasmic reticulum stress and the inflammatory basis of metabolic disease |
| Q30039723 | Endoplasmic reticulum stress and unfolded protein response in renal pathophysiology: Janus faces |
| Q36842308 | Endoplasmic reticulum stress in disease pathogenesis |
| Q46725830 | Endoplasmic reticulum stress is involved in myocardial apoptosis of streptozocin-induced diabetic rats |
| Q46972930 | Endoplasmic reticulum stress is sufficient for the induction of IL-1β production via activation of the NF-κB and inflammasome pathways. |
| Q36971939 | Endoplasmic reticulum stress markers are associated with obesity in nondiabetic subjects |
| Q90049531 | Endoplasmic reticulum stress may be involved in insulin resistance and lipid metabolism disorders of the white adipose tissues induced by high-fat diet containing industrial trans-fatty acids |
| Q37411313 | Endoplasmic reticulum stress-induced apoptosis in the development of diabetes: is there a role for adipose tissue and liver? |
| Q38287666 | Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity |
| Q35681034 | Epoxyeicosatrienoic acids and heme oxygenase-1 interaction attenuates diabetes and metabolic syndrome complications |
| Q42464125 | Exercise maintains euglycemia in association with decreased activation of c-Jun NH2-terminal kinase and serine phosphorylation of IRS-1 in the liver of ZDF rats |
| Q51572900 | Exercise training increases hepatic endoplasmic reticulum (er) stress protein expression in MTP-inhibited high-fat fed rats. |
| Q37148966 | FoxO1 integrates insulin signaling to VLDL production |
| Q34132566 | FoxO1 links hepatic insulin action to endoplasmic reticulum stress |
| Q36362397 | From acute ER stress to physiological roles of the Unfolded Protein Response |
| Q55062499 | Fucosylated chondroitin sulphate from Cusumaria frondosa mitigates hepatic endoplasmic reticulum stress and inflammation in insulin resistant mice. |
| Q37170811 | GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice |
| Q39737939 | Glucosamine-induced endoplasmic reticulum stress affects GLUT4 expression via activating transcription factor 6 in rat and human skeletal muscle cells. |
| Q40202640 | Glucosamine-induced increase in Akt phosphorylation corresponds to increased endoplasmic reticulum stress in astroglial cells |
| Q26992217 | Guards and culprits in the endoplasmic reticulum: glucolipotoxicity and β-cell failure in type II diabetes |
| Q58544185 | Heat Shock Proteins as a Potential Therapeutic Target in the Treatment of Gestational Diabetes Mellitus: What We Know so Far |
| Q37014131 | Heme oxygenase (HO-1) rescue of adipocyte dysfunction in HO-2 deficient mice via recruitment of epoxyeicosatrienoic acids (EETs) and adiponectin |
| Q95934146 | Hepatic NADH reductive stress underlies common variation in metabolic traits |
| Q64096707 | Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism |
| Q34873332 | Hepatic cannabinoid receptor type 1 mediates alcohol-induced regulation of bile acid enzyme genes expression via CREBH. |
| Q35057010 | Hepatic steatosis, inflammation, and ER stress in mice maintained long term on a very low-carbohydrate ketogenic diet. |
| Q37151026 | Hepatitis C virus infection: molecular pathways to metabolic syndrome |
| Q37137269 | High-density lipoprotein inhibits ox-LDL-induced adipokine secretion by upregulating SR-BI expression and suppressing ER Stress pathway |
| Q92810757 | Hoxa5 alleviates obesity-induced chronic inflammation by reducing ER stress and promoting M2 macrophage polarization in mouse adipose tissue |
| Q37587810 | IRS1Ser³⁰⁷ phosphorylation does not mediate mTORC1-induced insulin resistance |
| Q59127969 | Icariin Ameliorates Palmitate-Induced Insulin Resistance Through Reducing Thioredoxin-Interacting Protein (TXNIP) and Suppressing ER Stress in C2C12 Myotubes |
| Q40331913 | Identification of S-nitrosylated proteins after chronic exposure of colon epithelial cells to deoxycholate |
| Q38099615 | Immunometabolic role of long-chain omega-3 fatty acids in obesity-induced inflammation |
| Q33345339 | Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals |
| Q92993317 | Increased Serum Angiopoietin-Like 6 Ahead of Metabolic Syndrome in a Prospective Cohort Study |
| Q37267126 | Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo |
| Q26752511 | Inflammation Meets Metabolic Disease: Gut Feeling Mediated by GLP-1 |
| Q28236897 | Inflammation and cellular stress: a mechanistic link between immune-mediated and metabolically driven pathologies |
| Q27860923 | Inflammation and metabolic disorders |
| Q24523336 | Inflammation, stress, and diabetes |
| Q35857192 | Inflammatory cause of metabolic syndrome via brain stress and NF-κB. |
| Q83810163 | Infusion of glucose and lipids at physiological rates causes acute endoplasmic reticulum stress in rat liver |
| Q36183590 | Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents |
| Q36910693 | Initiation and execution of lipotoxic ER stress in pancreatic beta-cells |
| Q37597073 | Insulin regulates the unfolded protein response in human adipose tissue. |
| Q34077404 | Insulin resistance is associated with diminished endoplasmic reticulum stress responses in adipose tissue of healthy and diabetic subjects |
| Q35897730 | Interleukin-22 Alleviated Palmitate-Induced Endoplasmic Reticulum Stress in INS-1 Cells through Activation of Autophagy |
| Q34985745 | Intersection of the unfolded protein response and hepatic lipid metabolism |
| Q89621717 | Involvement of Endoplasmic Reticulum Stress in Palmitate-induced Apoptosis in HepG2 Cells |
| Q30496528 | Involvement of endoplasmic reticulum stress in myocardial apoptosis of streptozocin-induced diabetic rats |
| Q36334661 | Is insulin signaling molecules misguided in diabetes for ubiquitin-proteasome mediated degradation? |
| Q46865809 | JNK1 but not JNK2 promotes the development of steatohepatitis in mice |
| Q36926676 | JNK1/2 regulates ER-mitochondrial Ca2+ cross-talk during IL-1β-mediated cell death in RINm5F and human primary β-cells |
| Q91605042 | KSHV activates unfolded protein response sensors but suppresses downstream transcriptional responses to support lytic replication |
| Q47679965 | Lipid environment induces ER stress, TXNIP expression and inflammation in immune cells of individuals with type 2 diabetes |
| Q38872713 | Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment |
| Q49843619 | Liver function and dysfunction - a unique window into the physiological reach of ER stress and the unfolded protein response |
| Q89821165 | Mechanism of increased risk of insulin resistance in aging skeletal muscle |
| Q90685522 | Mechanisms of Insulin Action and Insulin Resistance |
| Q36748171 | Mechanistic insights into diabetes mellitus and oxidative stress |
| Q53582791 | Mice lacking the transcription factor Mist1 exhibit an altered stress response and increased sensitivity to caerulein-induced pancreatitis. |
| Q28081094 | Modulation of glucose transporter protein by dietary flavonoids in type 2 diabetes mellitus |
| Q38593252 | Molecular and cellular mechanisms linking inflammation to insulin resistance and β-cell dysfunction. |
| Q28262068 | Molecular mechanisms of chromium in alleviating insulin resistance |
| Q34578790 | Non-alcoholic fatty liver disease proteomics |
| Q35204838 | Obesity, insulin resistance and free fatty acids |
| Q37200269 | Obesity-induced insulin resistance and hyperglycemia: etiologic factors and molecular mechanisms |
| Q24612841 | Obstructive sleep apnea syndrome and fatty liver: Association or causal link? |
| Q31144447 | Ox-LDL induces ER stress and promotes the adipokines secretion in 3T3-L1 adipocytes |
| Q36663152 | Oxidative stress biology and cell injury during type 1 and type 2 diabetes mellitus |
| Q46368609 | Oxidative stress, ER stress, and the JNK pathway in type 2 diabetes |
| Q28573343 | Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria |
| Q36122184 | Phosphorylation of adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain, and leucine zipper motif 1 (APPL1) at Ser430 mediates endoplasmic reticulum (ER) stress-induced insulin resistance in hepatocytes |
| Q38141219 | Physical inactivity, insulin resistance, and the oxidative-inflammatory loop |
| Q51733555 | Pioglitazone Attenuates Palmitate-Induced Inflammation and Endoplasmic Reticulum Stress in Pancreatic β-Cells. |
| Q36809416 | Potential for therapeutic manipulation of the UPR in disease |
| Q33780095 | Production and pathogenicity of hepatitis C virus core gene products |
| Q37615650 | Progranulin causes adipose insulin resistance via increased autophagy resulting from activated oxidative stress and endoplasmic reticulum stress |
| Q37803271 | Prospects of yeast systems biology for human health: integrating lipid, protein and energy metabolism |
| Q36635369 | Proteasome dysfunction mediates obesity-induced endoplasmic reticulum stress and insulin resistance in the liver |
| Q34318367 | Protein Disulfide Isomerase Superfamily in Disease and the Regulation of Apoptosis |
| Q36678530 | Protein kinase Ctheta is required for autophagy in response to stress in the endoplasmic reticulum |
| Q30484247 | Proteinuria and hyperglycemia induce endoplasmic reticulum stress |
| Q45351517 | Proteomic and bioinformatic analysis of membrane proteome in type 2 diabetic mouse liver |
| Q40070947 | Proteomics analysis of cytokine-induced dysfunction and death in insulin-producing INS-1E cells: new insights into the pathways involved. |
| Q34478713 | RETRACTED: Endoplasmic reticulum chaperon tauroursodeoxycholic acid alleviates obesity-induced myocardial contractile dysfunction |
| Q30660710 | RTN1 mediates progression of kidney disease by inducing ER stress. |
| Q41889544 | Regulation of autophagy by glucose in Mammalian cells. |
| Q36059564 | Repression of GLUT4 expression by the endoplasmic reticulum stress response in 3T3-L1 adipocytes |
| Q37949231 | Resistance to type 2 diabetes mellitus: a matter of hormesis? |
| Q64889523 | Role of Cannabinoid Receptor Type 1 in Insulin Resistance and Its Biological Implications. |
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| Q36330343 | Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice. |
| Q36850263 | Soluble epoxide hydrolase deficiency or inhibition attenuates diet-induced endoplasmic reticulum stress in liver and adipose tissue. |
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| Q40300384 | The Genetic Basis of Type 2 Diabetes. |
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