Tauroursodeoxycholic acid attenuates lipid accumulation in endoplasmic reticulum-stressed macrophages

scientific article published on January 2010

Tauroursodeoxycholic acid attenuates lipid accumulation in endoplasmic reticulum-stressed macrophages is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1097/FJC.0B013E3181C37D86
P932PMC publication ID3253999
P698PubMed publication ID19834331

P2093author name stringJun Ren
Yinan Hua
Nair Sreejayan
Meijun Zhu
Machender R Kandadi
P2860cites workScavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophagesQ24310677
Phosphorylation-dependent targeting of c-Jun ubiquitination by Jun N-kinaseQ28567939
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesQ28575190
CD36 is a receptor for oxidized low density lipoproteinQ28678362
Opposing roles for ATF6alpha and ATF6beta in endoplasmic reticulum stress response gene inductionQ28854565
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetesQ29615503
Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarctionQ29618673
Atherosclerosis. the road aheadQ29618972
A central role for JNK in obesity and insulin resistanceQ29619778
Macrophage differentiation to foam cellsQ30438116
Use of RNA interference-mediated gene silencing and adenoviral overexpression to elucidate the roles of AKT/protein kinase B isoforms in insulin actionsQ30925087
Effect of taurine-conjugated ursodeoxycholic acid on endoplasmic reticulum stress and apoptosis induced by advanced glycation end products in cultured mouse podocytesQ33353941
Lipoprotein disorders associated with type 2 diabetes mellitus and insulin resistanceQ34990620
Atherosclerosis in type 2 diabetes mellitus and insulin resistance: mechanistic links and therapeutic targetsQ35023612
Signaling the unfolded protein response from the endoplasmic reticulum.Q35740723
ER stress and the unfolded protein responseQ35986601
The proinflammatory and hypercoagulable state of diabetes mellitus.Q36173935
Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetesQ36321560
Drug insight: Mechanisms and sites of action of ursodeoxycholic acid in cholestasisQ36495172
Mechanisms linking diabetes mellitus to the development of atherosclerosis: a role for endoplasmic reticulum stress and glycogen synthase kinase-3.Q36538348
Endoplasmic reticulum stress: signaling the unfolded protein responseQ36844431
The endothelium and vascular inflammation in diabetesQ36892486
Insulin resistance, dyslipidemia, and cardiovascular diseaseQ36940375
Ursodeoxycholic acid: Mechanism of action and novel clinical applicationsQ37012207
The role for endoplasmic reticulum stress in diabetes mellitusQ37019672
Cardiovascular disease risk in type 2 diabetes mellitus: insights from mechanistic studiesQ37172727
Oxidation of LDL and its clinical implicationQ37215823
Increased CD36 protein as a response to defective insulin signaling in macrophagesQ38344254
Insulin receptor substrate-2-dependent interleukin-4 signaling in macrophages is impaired in two models of type 2 diabetes mellitusQ40559827
c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascadeQ40692121
Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activationQ40708272
Insulin receptor tyrosine kinase activity is reduced in monocytes from non-obese normoglycaemic insulin-resistant subjectsQ42503833
Insulin binding to circulating monocytes and erythrocytes in patients with non-insulin-dependent diabetes in the young.Q42522254
AMP-activated protein kinase and adipogenesis in sheep fetal skeletal muscle and 3T3-L1 cellsQ42815568
Role of mitogen-activated protein kinases and c-Jun/AP-1 trans-activating activity in the regulation of protease mRNAs and the malignant phenotype in NIH 3T3 fibroblasts.Q42823190
Differentiation between human and animal isolates of Cryptosporidium parvum using rDNA sequencing and direct PCR analysisQ43213790
Hepatitis C virus envelope proteins regulate CHOP via induction of the unfolded protein responseQ43524712
Insulin resistance, the metabolic syndrome, and risk of incident cardiovascular disease: a population-based studyQ43747863
The effect of ursodeoxycholic acid on the survivin in thapsigargin-induced apoptosisQ44332750
Involvement of endoplasmic reticulum stress in insulin resistance and diabetesQ45127777
Downstream effects on human low density lipoprotein of homocysteine exported from endothelial cells in an in vitro system.Q45171661
Decreased Akt kinase activity and insulin resistance in C57BL/KsJ-Leprdb/db mice.Q54034599
Defect in Phosphorylation of Insulin Receptors in Cells from an Insulin-Resistant Patient with Normal Insulin BindingQ54477603
Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions.Q54610885
Ceramides reduce CD36 cell surface expression and oxidised LDL uptake by monocytes and macrophagesQ57358999
Transcriptional activation of the lipoprotein lipase and apolipoprotein E genes accompanies differentiation in some human macrophage-like cell linesQ68463394
C-reactive protein: linking inflammation to cardiovascular complicationsQ74428465
Effect of bile acids on lipid peroxidation: the role of ironQ74760853
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectendoplasmic reticulumQ79927
P304page(s)49-55
P577publication date2010-01-01
P1433published inJournal of Cardiovascular PharmacologyQ2125808
P1476titleTauroursodeoxycholic acid attenuates lipid accumulation in endoplasmic reticulum-stressed macrophages
P478volume55

Reverse relations

cites work (P2860)
Q28534831Abnormal trafficking of endogenously expressed BMPR2 mutant allelic products in patients with heritable pulmonary arterial hypertension
Q38817806BMP type II receptor as a therapeutic target in pulmonary arterial hypertension.
Q37583467Endoplasmic reticulum stress promotes macrophage-derived foam cell formation by up-regulating cluster of differentiation 36 (CD36) expression
Q46891717Glycoursodeoxycholic acid reduces matrix metalloproteinase-9 and caspase-9 activation in a cellular model of superoxide dismutase-1 neurodegeneration
Q39177176Increased monocyte-derived reactive oxygen species in type 2 diabetes: role of endoplasmic reticulum stress
Q34478713RETRACTED: Endoplasmic reticulum chaperon tauroursodeoxycholic acid alleviates obesity-induced myocardial contractile dysfunction
Q35872374Refined Qingkailing Protects MCAO Mice from Endoplasmic Reticulum Stress-Induced Apoptosis with a Broad Time Window
Q92300956The effect of palmitic acid on inflammatory response in macrophages: an overview of molecular mechanisms
Q34503392Unsaturated FAs prevent palmitate-induced LOX-1 induction via inhibition of ER stress in macrophages

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